Fetal Diagnosis and Therapy最新文献

{"title":"Consequences of Selective Fetal Growth Restriction in Perinatal Outcomes after Fetoscopic Laser Photocoagulation for Twin-to-Twin Transfusion Syndrome, Based on Single or Dual Survival.","authors":"Leticia Benítez, Romain Corroenne, Jessian Louis Munoz, Ahmed A Nassr, Roopali Donepudi, Michael A Belfort, Magdalena Sanz-Cortes","doi":"10.1159/000553016","DOIUrl":"10.1159/000553016","url":null,"abstract":"<p><strong>Introduction: </strong>Approximately half of twin-to-twin transfusion syndrome (TTTS) cases are complicated by selective fetal growth restriction (sFGR). Although fetoscopic laser photocoagulation (FLP) is the standard treatment, perinatal outcomes in cases with concomitant sFGR - particularly according to single or dual fetal survival after laser - are not well established. The objective of this study was to compare post-FLP obstetrical and neonatal outcomes between TTTS+sFGR and isolated TTTS, with separate analyses in pregnancies with immediate single or dual fetal survival.</p><p><strong>Methods: </strong>This was a retrospective cohort study including all TTTS cases treated with FLP at a single institution between November 2011 and April 2023. TTTS was diagnosed according to Quintero criteria. sFGR was defined as an estimated fetal weight <10th percentile in one twin with an inter-twin weight discordance ≥25% at the time of FLP. Outcomes included immediate post-FLP fetal demise (within 48 h after FLP), preterm premature rupture of membranes (PPROM), gestational age (GA) at delivery, and neonatal survival at birth and at 30 days, analyzed according to post-FLP single or dual fetal survival.</p><p><strong>Results: </strong>Among 424 cases, 188 (44.3%) had TTTS + sFGR. GA and cervical length at FLP were similar between groups, but TTTS+sFGR cases showed more severe disease, with a higher proportion of Quintero stage III. Dual fetal survival after FLP was lower in TTTS+sFGR compared with isolated TTTS (iTTTS; 79.6% vs. 88.5%). In pregnancies with single fetal survival post-FLP, TTTS+sFGR was associated with higher rates of delivery before 32 weeks (p = 0.03) and increased post-FLP PPROM (p = 0.03). Ex-donor fetuses in this group had significantly lower survival at birth and at 30 days compared with iTTTS. Even in cases with dual survival post-FLP, ex-donor survival at birth and at 30 days remained lower in TTTS + sFGR, while no other perinatal outcomes differed.</p><p><strong>Conclusion: </strong>When stratified by immediate single or dual post-FLP survival, pregnancies with TTTS complicated by sFGR showed consistently worse obstetrical and neonatal outcomes compared with isolated TTTS, particularly due to reduced ex-donor survival across both groups. Further studies are needed to elucidate the mechanisms underlying these findings.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-Trimester Growth Rate in Relation to Selective Fetal Growth Restriction in Monochorionic Twins.","authors":"Sara Moreira, Nicola Volpe, Tullio Ghi, Claudiana Olivieri, Álvaro Cohen, Paolo Volpe, Jader de Jesus Cruz","doi":"10.1159/000551897","DOIUrl":"10.1159/000551897","url":null,"abstract":"<p><strong>Introduction: </strong>Crown-rump length discrepancy (CRLd) is commonly used to predict selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twins, but its predictive value is limited. This study aimed to determine whether a first-trimester growth rate (GR) variable is associated with later sFGR.</p><p><strong>Methods: </strong>Retrospective cohort included MCDA-twin pregnancies with first-trimester ultrasound data. CRLd was calculated for each fetus dividing the delta CLR by the bigger CRL; GR was calculated for each fetus dividing CRL by gestational age. Pregnancies were classified as normal and sFGR. Generalized estimating equations were used to evaluate the independent associations of GR and CRLd with sFGR.</p><p><strong>Results: </strong>Among 335 pregnancies, 235 (70.1%) were normal, and 100 (29.85%) were sFGR. GR was lower in pregnancies that developed sFGR and differed within sFGR pairs. Pearson's correlation showed no significant relationship between GR and CRLd. After accounting for co-twin correlation, both lower GR and higher CRLd were independently associated with higher odds of sFGR.</p><p><strong>Conclusion: </strong>Reduced first-trimester GR and increased CRLd are independent early indicators of sFGR, and their combined assessment yields the best model fit.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Risk Factors for Omphalocele.","authors":"Anna Fogelström, Taqiyah Chowdhury, Eva Hagel, Anna Löf Granström, Carmen Mesas Burgos","doi":"10.1159/000553111","DOIUrl":"10.1159/000553111","url":null,"abstract":"<p><strong>Introduction: </strong>Omphalocele is a rare congenital abdominal wall defect characterized by the herniation of abdominal organs through the umbilical ring, covered by a protecting sac. The etiology is not fully understood, and little is known about the role of maternal factors. The aim of this study was to investigate the role of maternal risk factors in the development of omphalocele.</p><p><strong>Methods: </strong>A population-based case-control study was conducted using data from Swedish national registries between 1997 and 2016. The study included 207 mothers of children born with omphalocele (cases) and 2,070 controls, matched on the children's sex and birth year. Conditional logistic regression analysis was used to estimate odds ratios (OR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Maternal obesity (adjusted OR: 1.82, 95% CI: 1.14-2.88) and IVF conception (adjusted OR: 4.49, 95% CI: 1.76-11.4) were associated with an increased risk of omphalocele. Multiparity was associated to decreased risk (adjusted OR: 0.44, 95% CI: 0.25-0.77) as 58% of the omphalocele cases were firstborn.</p><p><strong>Conclusions: </strong>Maternal obesity and IVF conception are factors associated with an increased risk of omphalocele, whereas multiparity is linked to decreased risk.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13441263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights in Fetal Growth Trajectories of Spontaneous Twin Anemia Polycythemia Sequence Twins.","authors":"Margot J A van de Sande, Lisanne S A Tollenaar, Monique C Haak, Joanne E J T Verweij, Claar C M M Lap, Floor M M Prein, Enrico Lopriore, Femke Slaghekke","doi":"10.1159/000553073","DOIUrl":"10.1159/000553073","url":null,"abstract":"<p><strong>Introduction: </strong>Twin anemia polycythemia sequence (TAPS) is a monochorionic twin condition, where imbalanced blood flow causes anemia in the donor twin and polycythemia in the recipient twin. While TAPS donors are frequently small for gestational age (SGA, birth weight <10th centile), fetal growth patterns are yet poorly understood.</p><p><strong>Methods: </strong>We conducted a retrospective study of all spontaneous TAPS pregnancies diagnosed at Leiden University Medical Center between 2002 and 2024. Fetal growth was assessed by estimated fetal weight (EFW), with fetal growth restriction (FGR) defined as an EFW <10th centile. Secondary outcomes included SGA at birth and placental share distribution.</p><p><strong>Results: </strong>A total of 45 consecutive spontaneous TAPS pregnancies were included. Donors consistently had lower EFW than recipients. At 20 weeks, FGR was present in 42% (5/12) of donors versus 0% (0/11) of recipients (p < 0.001). No recipients developed FGR before 24 weeks. By 30 weeks, FGR affected 55% (6/11) of donors and 9% (1/11) of recipients (p = 0.028). At birth, 58% (22/38) of donors had a larger placental share than their cotwin.</p><p><strong>Conclusion: </strong>Despite a slightly larger placental share, TAPS donor twins are at higher risk of FGR. At birth, three out four TAPS donors are SGA compared to one out of five recipients.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148276698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Fetal Microneurosurgery for Intrauterine Correction of Encephalocele: A Prospective 1-Year Follow-Up Study.","authors":"Rogelio Cruz-Martínez, Néstor Pavón-Gómez, Iván Dávila-Escamilla, Carolina Cantarero, Felipe Chavelas-Ochoa, Solieth Martínez, Miguel Martínez-Rodríguez, Darling Ruiz, Karla Aguilar-Vidales","doi":"10.1159/000553013","DOIUrl":"10.1159/000553013","url":null,"abstract":"<p><strong>Introduction: </strong>We aim to describe the feasibility and outcomes of fetuses with occipital encephalocele treated with intrauterine repair by open microneurosurgery.</p><p><strong>Methods: </strong>Between 2021 and 2025, a consecutive cohort of fetuses with occipital encephalocele referred to 2 fetal surgery centers in Nicaragua and Mexico were selected for intrauterine correction by open fetal microneurosurgery. Inclusion criteria were fetuses at less than 28 weeks with isolated occipital encephalocele, Chiari III malformation (obliteration of the cisterna magna with protrusion of cerebral tissue), and microcephaly. We report the procedure-related characteristics, perinatal and neurological outcomes (hydrocephalus, meningitis, seizures, cognitive delay, motor dysfunction, and visual impairment) within the first 12 months of age.</p><p><strong>Results: </strong>Twelve cases were evaluated during the study period but only 6 cases were selected for fetal intervention. Open fetal microneurosurgery was successfully performed in all cases at a median gestational age (GA) of 25+2 weeks+days, with a median surgical time of 93 min. Regression of Chiari and reversal of microcephaly was observed in 4/6 and 6/6 cases, respectively. The median GA at birth was 36+5 weeks+days. Preterm rupture of the membranes and preterm delivery was reported in 3/6 cases. No cases of perinatal death were reported. Within the first 12 months of age, none of the children developed meningitis, cognitive delay, or hydrocephalus requiring ventriculoperitoneal shunting. Motor dysfunction, seizures, and visual disorders were reported in 1/6, 1/6, and 3/6 cases, respectively.</p><p><strong>Conclusion: </strong>In this small series of fetuses with occipital encephalocele, open fetal microneurosurgery was feasible and was associated with promising outcomes.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Pyruvate Dehydrogenase Complex Deficiency Mimicking Cytomegalovirus Foetopathy on Prenatal Brain Imaging: A Case Report - An Alternative Diagnosis to Consider when Faced with Negative Infectious Work-Up.","authors":"Sara Cabet, Camila Rochet-Capellan, Aubane Riche, Pierre Azouri, Alexandre Vasiljevic, Laurent Guibaud","doi":"10.1159/000553047","DOIUrl":"10.1159/000553047","url":null,"abstract":"<p><strong>Introduction: </strong>We report a case of primary pyruvate dehydrogenase complex deficiency (PPDCD) presenting with prenatal neuroimaging features highly suggestive of cytomegalovirus (CMV) fetopathy, highlighting an important alternative diagnosis when infectious investigations are negative.</p><p><strong>Case presentation: </strong>A 32-year-old patient was referred at 29 weeks' gestation for fetal microcephaly, borderline ventriculomegaly, and a short corpus callosum. Detailed neurosonography and fetal MRI demonstrated a clastic pattern including a periventricular echogenic halo, germinolysis pseudocysts, delayed sylvian operculation, and reduced transverse cerebellar diameter - findings classically associated with congenital CMV infection. Despite this highly suggestive imaging phenotype, extensive infectious work-up was negative. Given the severity of cerebral lesions, pregnancy termination was elected. Neuropathological examination confirmed clastic lesions and showed inferior olivary nuclei heterotopia, dentato-olivary dysplasia, thalamic microcalcifications, and hypoplastic pyramidal tracts. This distinctive combination raised suspicion of a metabolic disorder affecting cerebral energy metabolism. Subsequent exome sequencing identified a de novo pathogenic duplication in the PDHA1 gene, confirming the diagnosis of PPDCD.</p><p><strong>Conclusion: </strong>This case demonstrates that PPDCD can closely mimic CMV fetopathy on prenatal brain imaging that one should evocate in case of such an imaging pattern and negative infectious testing. Its recognition has major implications for counseling and recurrence risk assessment.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-4"},"PeriodicalIF":1.7,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Prenatal Ultrasound and Fetal Magnetic Resonance Imaging in Diagnosing Congenital Anomalies of the Kidney and Urinary Tract: A Comparative Diagnostic Study.","authors":"Grace E Thompson, Logan B Wesemann, Eniola A Ogundipe, Emily C Meneses, Daniel S Han, Vijaya M Vemulakonda, Mariana L Meyers","doi":"10.1159/000552627","DOIUrl":"10.1159/000552627","url":null,"abstract":"<p><strong>Introduction: </strong>Prenatal diagnoses of congenital anomalies of the kidney and urinary tract (CAKUT) are critical for counseling families about potential postnatal outcomes. While ultrasound (US) remains the gold standard for prenatal diagnosis of CAKUT, fetal magnetic resonance imaging (MRI) has been increasingly used for complex anomalies. However, diagnostic accuracy of fetal MRI for CAKUT remains uncertain. This study aimed to compare prenatal US and MRI for the diagnosis of CAKUT.</p><p><strong>Methods: </strong>We reviewed charts of gravid mothers with fetuses having suspected CAKUT seen at a tertiary fetal care center between 2012 and 2020. Data included prenatal US, fetal MRI, prenatal intervention, postnatal US, postnatal MRI, postnatal voiding cystourethrogram, postnatal diagnosis, and postnatal surgical intervention. Prenatal imaging and postnatal diagnoses were categorized into kidney, ureteral, and/or bladder anomalies. Diagnostic accuracy of prenatal imaging for identifying postnatal anomalies was evaluated using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Anatomic categories were stratified based on concordance between prenatal imaging findings and postnatal diagnosis (concordant, incomplete - imaging that captured accurate details but missed key nuances, or discordant).</p><p><strong>Results: </strong>Fetal MRI had statistically significant fewer rates of incomplete results compared to US. When anatomic categories were grouped together, fetal MRI had greater sensitivity, PPV, and NPV, and equivalent specificity compared to US. This relationship held true for kidney and ureteral anomalies. In the bladder, MRI and US had equivalent diagnostic accuracy. However, these results of sensitivity, specificity, PPV, and NPV within anatomic categories were not statistically significant.</p><p><strong>Conclusion: </strong>Although fetal MRI showed greater sensitivity, PPV, and NPV for detecting kidney and ureteral anomalies, these differences were not statistically significant. MRI should nonetheless be considered complementary to prenatal US as it may provide more detailed information, particularly for complex congenital kidney and ureteral anomalies. The data demonstrate meaningful clinical differences between US and MRI in diagnosing CAKUT. Further work is needed to validate these findings in a larger cohort.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Congenital High Airway Obstruction Syndrome at a Single Comprehensive Fetal Center.","authors":"Monica L Wagner, Jose L Peiro, Beth A Rymeski, Matthew M Smith, Alessandro de Alarcon, David N McKinney, Mounira A Habli, Foong-Yen Lim","doi":"10.1159/000552628","DOIUrl":"10.1159/000552628","url":null,"abstract":"<p><strong>Introduction: </strong>Congenital high airway obstruction syndrome (CHAOS) is characterized by over-distended lungs leading to impaired cardiac return and fetal hydrops. Survivors have been reported following prenatal spontaneous fistulization, fetal procedures to decompress the airway, or ex utero intrapartum treatment (EXIT). The long-term outcomes of survivors are unclear.</p><p><strong>Methods: </strong>We performed a retrospective chart review on patients diagnosed with CHAOS in our center between 2005 and 2025.</p><p><strong>Results: </strong>Of the 28 patients with CHAOS, three (10.7%) underwent a fetal procedure to decompress the airway. Three (10.7%) patients had evidence of spontaneous fistulization. Four (14.3%) patients terminated the pregnancy and four (14.3%) had in utero fetal demise. Twenty (71.4%) patients were live-born; of these, 14 (70%) died shortly after delivery and two (10%) died in the neonatal period. Seven (35%) patients underwent EXIT-to-tracheostomy at our center, of which four (57.1%) are long-term survivors ranging in age from 4 to 19 years old. Three patients have undergone airway reconstruction between 1.6 and 5.6 years of age; one remains tracheostomy dependent due to recurrent airway stenosis, 1 patient has undergone reconstruction and is likely to be decannulated soon, and 1 patient had successful reconstruction and was decannulated. The fourth patient has not yet undergone airway reconstruction.</p><p><strong>Conclusion: </strong>CHAOS remains a highly morbid diagnosis, but long-term survivorship and liberation from tracheostomy is possible.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventricle Width and Cerebrospinal Fluid Diversion Rate after Open Fetal Spina Bifida Repair: A 4-Year Follow-Up.","authors":"Julia Wawrla-Zepf, Ladina Rüegg, Martin Meuli, Luca Mazzone, Ueli Moehrlen, Sandra Fernandes Dias, Jenny C Kienzler, Nicole Ochsenbein-Kölble, Ladina Vonzun","doi":"10.1159/000552456","DOIUrl":"10.1159/000552456","url":null,"abstract":"<p><strong>Introduction: </strong>The objective of this study was to assess the postnatal cerebrospinal fluid diversion (CSFD) rates and associated prenatal risk factors (RFs) in patients with open fetal spina bifida (fSB) repair over a 4-year follow-up.</p><p><strong>Methods: </strong>In 185 patients, CSFD rate was determined at 1 year and incremental risk (IR) for CSFD at 2 and 4 years. Characteristics of children without CSFD were compared to those with CSFD, and multiple regression analysis evaluated RF.</p><p><strong>Results: </strong>Sixty-four children (35%) needed CSFD within the first year. These children had larger head circumference (HC) at screening (p = 0.001) and before delivery (p < 0.001) and larger ventricles at screening (Vp screening) and before delivery (Vp delivery) (each p < 0.001). Multiple regression identified only Vp screening, Vp delivery, and their delta as independent RF for CSFD. Vp values were higher in children needing CSFD within the first year compared with years 2-4 (p < 0.001 and p = 0.01), and larger Vp was associated with earlier CSFD in the first year (p = 0.02). IR for CSFD declined over follow-up.</p><p><strong>Conclusion: </strong>The 1-year CSFD rate after open fSB repair was 35%, with decreasing IR through year four. Larger Vp at screening, before delivery, and their delta were independent RF for CSFD, while HC was not.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of Antenatal Sonographic Parameters and Neurodevelopmental Outcomes in Fetal Growth Restriction.","authors":"Natalie T Simon, Roopjit Sahi, Emma E H Peek, John C Hobbins, Manesha Putra","doi":"10.1159/000552318","DOIUrl":"10.1159/000552318","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to explore preliminary associations between antenatal sonographic parameters and early childhood neurodevelopmental outcomes in fetuses with fetal growth restriction (FGR) or small for gestational age (SGA). FGR was defined as estimated fetal weight (EFW) <3rd percentile or abnormal Doppler. SGA was defined as EFW 3rd-10th percentile with normal Doppler.</p><p><strong>Methods: </strong>This pilot exploratory study (n = 32; 28 FGR, 4 SGA) included infants with available Bayley-III Scales of Infant and Toddler Development (BSID-III) scores from a larger prospective cohort of 90 FGR/SGA pregnancies. Sonographic parameters from the final predelivery ultrasound included abdominal circumference (AC), umbilical vein flow (UVF), corpus callosum length, cerebellar vermian height, transverse cerebellar diameter, and insular circumference-to-head circumference (IC/HC) ratio. Associations between sonographic parameters and BSID neurodevelopmental outcomes were assessed. Multivariate linear regression model was constructed for each BSID scale using significant predictors.</p><p><strong>Results: </strong>In this subset, AC (r = 0.516, p = 0.003) and EFW (r = 0.462, p = 0.008) were associated with motor scores; UVF was associated with language (r = 0.545, p = 0.001) and total scores (r = 0.440, p = 0.012); and IC/HC was associated with adaptive behavior (r = -0.478, p = 0.006). In multivariable models, AC remained associated with motor outcomes (β = 0.369, 95% CI 0.04-1.08), UVF with language outcomes (β = 0.408, 95% CI 0.07-0.67), and IC/HC with adaptive behavior (β = -0.474, 95% CI -826.04 to -170.78). After adjusting for gestational age at delivery, UVF and IC/HC associations remained significant. Findings should be interpreted cautiously, given the small sample size.</p><p><strong>Conclusion: </strong>AC, UVF, and IC/HC may have preliminary associations with early neurodevelopmental outcomes. These findings are hypothesis-generating and warrant validation in larger cohorts before clinical application.</p>","PeriodicalId":12189,"journal":{"name":"Fetal Diagnosis and Therapy","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}