Expert Opinion on Therapeutic Targets最新文献_第9页

Bidirectional nexus between metabolic disease and aortic valve calcification: from pathogenic mechanisms to integrated multimorbidity management. 代谢性疾病与主动脉瓣钙化的双向关系：从致病机制到综合多病管理。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-02-03 DOI: 10.1080/14728222.2026.2625100

Xinyue Wang, Mincheng Yu, Jingzheng Chen, Jia Xu, Yi Liu, Zhongqun Wang

引用次数: 0

Targeting PICK1 in drug discovery: from PDZ inhibition to next-generation BAR and bivalent modalities. 靶向PICK1的药物发现：从PDZ抑制到下一代BAR和二价模式。

IF 4.4 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-02-06 DOI: 10.1080/14728222.2026.2625095

Emily Hendrix, Yi He

引用次数: 0

Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy. 桥接神经传递和肿瘤生物学：CHRM1在皮肤癌治疗中的新焦点。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-02-05 DOI: 10.1080/14728222.2026.2626525

Dhruv Sharma, Aniruddha Roy, Durga Dharmadana, Celine Valery, Minal Chaturvedi, Gautam Singhvi

{"title":"Bridging neurotransmission and tumor biology: the emerging focus on CHRM1 in skin cancer therapy.","authors":"Dhruv Sharma, Aniruddha Roy, Durga Dharmadana, Celine Valery, Minal Chaturvedi, Gautam Singhvi","doi":"10.1080/14728222.2026.2626525","DOIUrl":"10.1080/14728222.2026.2626525","url":null,"abstract":"Introduction: Skin cancer is one of the most prevalent types of cancer and has shown an upward trend recently. Among various types, melanoma skin cancer is known to be the most dangerous, exhibiting resistance to treatment, and is also prone to metastasis. Targeted and immunotherapeutic approaches, despite their potential, exhibit limitations. Recently, the research focus has shifted to various neurotransmitter-mediated pathways acting as a key mediator between tumor development and neuronal signaling. Among them, CHRM1 has garnered traction as a target that supports tumor growth and proliferation in skin cancer.Areas covered: This review aims to address the role of acetylcholine-mediated interaction between keratinocytes and melanocytes for its implications in skin cancer. It has a special focus on CHRM1 as a central mediator influencing key survival and growth pathways linked to cholinergic input. It functions in a context-dependent manner, indicating its role as a diagnostic marker and a therapeutic target.Expert opinion: Targeting CHRM1 represents a novel approach toward the treatment of skin cancer. The future advances in targeted delivery and rational drug combinations with existing therapies will be of critical significance against therapy resistance and opening the way for newer therapies.","PeriodicalId":12185,"journal":{"name":"Expert Opinion on Therapeutic Targets","volume":" ","pages":"137-146"},"PeriodicalIF":5.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blocking glycan production by targeting GALNT7 for prostate cancer therapy. 通过靶向GALNT7阻断前列腺癌治疗中的多糖生成。

IF 4.4 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-01-23 DOI: 10.1080/14728222.2026.2619761

Ziqian Peng, Kirsty Hodgson, Margarita Orozco-Moreno, Jennifer Munkley

引用次数: 0

MicroRNA-96 inhibition retarded the progression of atherosclerotic plaques via FOXO1/CYP7A1 mediated cholesterol-bile acid metabolism pathway. 抑制MicroRNA-96通过FOXO1/CYP7A1介导的胆固醇-胆汁酸代谢途径延缓动脉粥样硬化斑块的进展。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-01-29 DOI: 10.1080/14728222.2026.2620602

Li Wang, Yiting Liu, Jin Zhang, Jie Wu, Yue Li, Lifei Wang, Yang Zhang, Bin Hong

{"title":"MicroRNA-96 inhibition retarded the progression of atherosclerotic plaques via FOXO1/CYP7A1 mediated cholesterol-bile acid metabolism pathway.","authors":"Li Wang, Yiting Liu, Jin Zhang, Jie Wu, Yue Li, Lifei Wang, Yang Zhang, Bin Hong","doi":"10.1080/14728222.2026.2620602","DOIUrl":"10.1080/14728222.2026.2620602","url":null,"abstract":"Background: Conversion of cholesterol into bile acids is a central pathway for cholesterol disposal, which was mainly controlled by cholesterol 7alpha-hydroxylase (Cyp7a1). In present study, we aimed to investigate the effect and the potential underlying mechanism of microRNA-96 (miR-96) on atherosclerosis development.Research design and methods: The anti-atherosclerosis effects of a miR-96 inhibitor (miR-96i) were evaluated using ApoE KO mice fed a high-fat diet, which was treated with miR-96i for 8 weeks. The regulatory mechanism was revealed and validated by RNA-seq transcriptomics, quantitative PCR and western blotting analyses in hepatic cells.Results: The authors identified that miR-96i significantly decreased serum cholesterol and bile acid levels and attenuated arterial plaque in mice. We further revealed that miR-96 regulated Cyp7a1 via a FOXO1-involved indirect pathway, in which miR-96 directly modulated FOXO1 in a posttranscriptional manner. A coordinated regulatory effect of miR-96 and miR-185 on FOXO1 was also observed. The full spectrum of mechanisms underlying the antiatherosclerotic activity beside miR-96-FOXO1-CYP7A1 axis remains to be elucidated.Conclusions: This study provides convincing evidence for the pivotal role of miR-96 in FOXO1 modulation and CYP7A1-involved cholesterol-bile acid metabolism, suggesting that miR-96 is a novel therapeutic target for the discovery and development of drugs against ACVD.","PeriodicalId":12185,"journal":{"name":"Expert Opinion on Therapeutic Targets","volume":" ","pages":"163-177"},"PeriodicalIF":5.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The IL-33 receptor ST2 as a therapeutic target for hemophilic arthropathy. IL-33受体ST2作为血友病关节病的治疗靶点。

IF 4.4 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-01-28 DOI: 10.1080/14728222.2026.2619746

Alexander G Lawrence, James S O'Donnell, Peter L Turecek, Padraic G Fallon

引用次数: 0

Molecular targets in gastric cancer for nanomedicine therapeutics: mechanistic insights and translational progress. 纳米药物治疗胃癌的分子靶点：机制见解和转化进展。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-01-30 DOI: 10.1080/14728222.2026.2620601

Mohd Saeed, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar, Prashant Kesharwani

{"title":"Molecular targets in gastric cancer for nanomedicine therapeutics: mechanistic insights and translational progress.","authors":"Mohd Saeed, Taha Alqahtani, Humood Al Shmrany, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar, Prashant Kesharwani","doi":"10.1080/14728222.2026.2620601","DOIUrl":"10.1080/14728222.2026.2620601","url":null,"abstract":"Introduction: Gastric cancer remains a leading cause of cancer mortality due to late diagnosis, aggressive progression, and limited treatment response. Nanomedicine offers promising avenues to exploit molecular targets and improve therapeutic precision. Engineered nanoparticles with tunable physicochemical properties enable targeted delivery, enhanced bioavailability, and deeper tumor penetration. Understanding key molecular drivers of gastric cancer is essential for designing effective nanotherapeutic strategies.Areas covered: This review summarizes major molecular targets relevant to nanomedicine development in gastric cancer, including HER2, VEGF/VEGFR, immune checkpoints, and tumor microenvironmental components. Advances in lipid-based, polymeric, and inorganic nanocarriers are discussed with emphasis on ligand-mediated targeting, overcoming drug resistance, modulating intracellular trafficking, and exploiting tumor-specific biomarkers. Progress in nanotechnology-enabled imaging, early detection platforms, and multifunctional theranostic systems that combine diagnosis and therapy is also highlighted. Key preclinical and emerging clinical findings are reviewed to illustrate translational progress and current limitations.Expert opinion: Nanomedicine holds strong potential to transform gastric cancer therapy through selective, target-driven interventions. However, successful translation requires better molecular stratification, deeper insight into nano - bio interactions, standardized toxicity evaluation, and scalable manufacturing. Integrating genomics, biomarkers, and AI-driven design will be crucial for developing nanotherapeutics that address specific molecular vulnerabilities in gastric cancer.","PeriodicalId":12185,"journal":{"name":"Expert Opinion on Therapeutic Targets","volume":" ","pages":"109-129"},"PeriodicalIF":5.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146061062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional roles of microRNAs in pancreatic islet autoimmunity: what do we know and where do we target? microrna在胰岛自身免疫中的功能作用：我们知道什么和我们的目标在哪里？

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-02-01 Epub Date: 2026-02-06 DOI: 10.1080/14728222.2026.2625101

Giuseppina Emanuela Grieco, Laura Nigi, Guido Sebastiani, Francesco Dotta

{"title":"Functional roles of microRNAs in pancreatic islet autoimmunity: what do we know and where do we target?","authors":"Giuseppina Emanuela Grieco, Laura Nigi, Guido Sebastiani, Francesco Dotta","doi":"10.1080/14728222.2026.2625101","DOIUrl":"10.1080/14728222.2026.2625101","url":null,"abstract":"Introduction: Type 1 diabetes (T1D) results from a destructive dialog between stressed pancreatic beta-cells and immune system. While current disease-modifying approaches targeting these processes are being developed and tested, microRNAs have emerged as a molecular interface connecting both sides of islet autoimmunity.Areas covered: Specific miRNAs orchestrate beta-cell stress adaptation, immune activation, and intercellular communication, thus shaping disease trajectory and progression across stages. Recent discoveries identified distinct miRNA networks as ER-stress modulators and/or immune amplifiers and key regulators of beta-cell fate and circulating signals of ongoing inflammation.Expert opinion: The clinical translation of these insights remains hindered by limited access to human tissues, inconsistent candidate validation, and lack of delivery systems capable of targeting pancreatic beta-cells. Bridging mechanistic understanding with advanced delivery systems may transform miRNAs both as biomarkers and active therapeutic agents, opening a path toward precision interventions in T1D.","PeriodicalId":12185,"journal":{"name":"Expert Opinion on Therapeutic Targets","volume":" ","pages":"131-136"},"PeriodicalIF":5.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraspeckle component 1 in acute myeloid leukemia: prospects for therapeutic targeting. 急性髓系白血病中的副斑成分1：靶向治疗的前景。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-01-01 Epub Date: 2025-12-29 DOI: 10.1080/14728222.2025.2608021

Mingjiang Xu, Jianlong Wang

引用次数: 0

Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder and implications for the discovery and development of investigational agents. 调节补性NMDA受体电流：氯胺酮、艾氯胺酮和右美沙芬治疗重度抑郁症的机制及其对研究药物发现和开发的影响。

IF 5.1 2区医学

Expert Opinion on Therapeutic Targets Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1080/14728222.2026.2619757

Gia Han Le, Roger S McIntyre

{"title":"Modulating tonic NMDA receptor currents: mechanistic insights into ketamine, esketamine, and dextromethorphan for major depressive disorder and implications for the discovery and development of investigational agents.","authors":"Gia Han Le, Roger S McIntyre","doi":"10.1080/14728222.2026.2619757","DOIUrl":"10.1080/14728222.2026.2619757","url":null,"abstract":"Introduction: Up to 50% of adults with major depressive disorder (MDD) fail to achieve remission after two or more monoaminergic antidepressants and meet criteria for treatment-resistant depression (TRD). Low-dose intravenous ketamine, intranasal esketamine, and oral dextromethorphan represent the first glutamatergic treatments to exhibit rapid and robust efficacy in persons with TRD, yet their precise mechanisms remain unclear.Areas covered: Herein, we amplify an existing hypothesis and integrate preclinical, pharmacological, and clinical evidence implicating elevated tonic N-methyl-D-aspartate (NMDA) receptor currents, mediated predominantly by NR2C/D subunits, in the pathophysiology of TRD. We review in vivo proton magnetic resonance spectroscopy and electrophysiology studies that document sustained ambient-glutamate signaling in key limbic regions. We then synthesize mechanistic data on ketamine's dual pore-trapping and hydrophobic lateral-site binding, esketamine's preferential NR2D blockade, and dextromethorphan's pH-enhanced NR2C selectivity.Expert opinion: Selective dampening of NR2C/D-mediated tonic currents underlie rapid and sustained antidepressant effects of ketamine, esketamine, and dextromethorphan. Separately, ketamine and esketamine's affinity for NR2A/B subunits may constitute the core mechanism driving the dissociative effects which are not observed with dextromethorphan. Future drug discovery should emphasize subunit-biased ligands and allosteric modulators, guided by advanced receptor structural models and translational biomarkers, to enhance antidepressant efficacy and concurrently improve tolerability.","PeriodicalId":12185,"journal":{"name":"Expert Opinion on Therapeutic Targets","volume":" ","pages":"43-52"},"PeriodicalIF":5.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0