Federation proceedings最新文献_第6页

Genetically mast cell-deficient W/Wv mice as a tool for studies of differentiation and function of mast cells. 遗传肥大细胞缺陷小鼠作为肥大细胞分化和功能研究的工具。

Federation proceedings Pub Date : 1987-04-01

T Nakano, Y Kanakura, T Nakahata, H Matsuda, Y Kitamura

{"title":"Genetically mast cell-deficient W/Wv mice as a tool for studies of differentiation and function of mast cells.","authors":"T Nakano, Y Kanakura, T Nakahata, H Matsuda, Y Kitamura","doi":"","DOIUrl":"","url":null,"abstract":"Genetically mast cell-deficient W/Wv mice are useful for the analysis of mast cell biology, especially as recipients of bone marrow cells and skin pieces. Inasmuch as suspension and clonal cultures of mast cells have been developed, we combined these in vivo and in vitro systems. Suspension-cultured mast cells had morphological and biochemical characteristics similar to those of mucosal mast cells (MMC). However, i.p. injection of such cultured mast cells gave rise to development of cells with characteristics similar to those of connective tissue mast cells (CTMC). When peritoneal cells of normal +/+ mice were cultured in methylcellulose, pure mast cell colonies appeared. Cells from individual mast cell colonies were divided and injected into the skin and stomach wall of W/Wv mice; CTMC developed in the skin and MMC in the stomach mucosa. This indicates the presence of a common precursor for CTMC and MMC. Morphology of such bipotent mast cell precursors was studied by using micromanipulation. About 4% of morphologically identifiable peritoneal mast cells may function as the bipotent precursors. Although W/Wv mice showed a defect in resistance against ixodid ticks, injection of suspension-cultured mast cells normalized the defect. The four examples mentioned above indicate that combinations of in vivo and in vitro systems increase the usefulness of W/Wv mice.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 5","pages":"1920-3"},"PeriodicalIF":0.0,"publicationDate":"1987-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14679273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic activation of xenobiotic stilbene estrogens. 外源二苯乙烯雌激素的代谢激活。

Federation proceedings Pub Date : 1987-04-01

M Metzler

引用次数: 0

Federation of American Societies for Experimental Biology. 71st annual meeting, Washington, DC, March 29-April 2, 1987. Abstracts of papers 4421-7012; 9001-9008; M1-M164. Indexes of abstracts. 美国实验生物学学会联合会。第71届年会，1987年3月29日至4月2日，华盛顿特区。论文摘要4421-7012;9001 - 9008;M1-M164。摘要索引。

Federation proceedings Pub Date : 1987-03-05

引用次数: 0

Federation of American Societies for Experimental Biology. 71st annual meeting. Washington, DC, March 29-April 2, 1987. Abstracts of papers 1-4420. 美国实验生物学学会联合会。第71届年会。华盛顿特区，1987年3月29日至4月2日。论文摘要1-4420。

Federation proceedings Pub Date : 1987-03-01

引用次数: 0

Antagonism by methysergide of neurogenic vasoconstriction in the dog forelimb. 甲塞吉酯对犬前肢神经源性血管收缩的拮抗作用。

Federation proceedings Pub Date : 1987-02-01

B S Jandhyala, S D Kivlighn

{"title":"Antagonism by methysergide of neurogenic vasoconstriction in the dog forelimb.","authors":"B S Jandhyala, S D Kivlighn","doi":"","DOIUrl":"","url":null,"abstract":"In the flow-regulated dog forelimb, electrical stimulation of the efferent median nerve produced frequency-dependent increases in perfusion pressure. These vasoconstrictor effects were attenuated by a large dose of phentolamine, an alpha 1 and alpha 2 blocking drug. Administration of methysergide after phentolamine completely reversed the vasoconstrictor responses to vasodilation at most frequencies of stimulation. In the absence of phentolamine pretreatment, even a lower dose of methysergide reversed or caused biphasic responses (attenuated constriction followed by dilatation) during the nerve stimulation at the lower frequencies (0.5-4.0 Hz). This lower dose of methysergide completely abolished vascular effects of exogenous 5-hydroxytryptamine (5-HT) and potentiated those of norepinephrine; hence, the antagonism by methysergide of neurally mediated vasoconstriction is not caused by an action on alpha-adrenergic receptors. Unlike methysergide, selective 5-HT2 antagonists ketanserin and ritanserin have no modifying effect on exogenous 5-HT responses. These studies have provided pharmacological evidence that suggests that 5-HT may be the neurotransmitter mediating neurogenic vasoconstriction in the dog forelimb, and that this effect does not involve activation of 5-HT2 receptors.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 2","pages":"276-80"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14232922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of constriction produced by vasoactive agents. 血管活性物质产生的收缩模式。

Federation proceedings Pub Date : 1987-02-01

G J Grega, S W Adamski

{"title":"Patterns of constriction produced by vasoactive agents.","authors":"G J Grega, S W Adamski","doi":"","DOIUrl":"","url":null,"abstract":"The patterns of vasoconstriction produced by local infusions of constrictor agents and neurogenic stimuli are unique and varied. Although vasoconstrictors or neurogenic stimuli may produce similar increases in total resistance to blood flow, the effects on consecutive vascular segments may differ dramatically. Vasoconstrictors may affect primarily small vessels, large vessels, or a combination of both. The constrictor response may be restricted to precapillary vessels or may recruit both pre- and postcapillary vessels. The baroreceptors elicit a pattern of vasoconstriction distinct from that produced by electrical stimulation of a vasomotor nerve. Prearteriolar and venous resistance may contribute more than arterioles to increases in total vascular resistance produced by local infusions of vasoconstrictor agents or nerve stimulation. The constriction of large vessels also affects fluid filtration, vascular capacity, and the distribution of blood flow between shunt and exchange vessels. The waning of the resistance increase that occurs during prolonged infusions of vasoconstrictors varies, in part, as a function of the vessel segments that participate in the vasoconstrictor response. Large vessels participate in vasoconstrictor responses triggered by stimuli that impose a severe stress on the circulation. In contrast, small vessels participate primarily in normal vascular adjustments required to maintain blood pressure at the set point.","PeriodicalId":12183,"journal":{"name":"Federation proceedings","volume":"46 2","pages":"270-5"},"PeriodicalIF":0.0,"publicationDate":"1987-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14920134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The history of the Federation of American Societies for Experimental Biology. 美国实验生物学学会联合会的历史。

Federation proceedings Pub Date : 1987-02-01

R W Krauss

引用次数: 0

Origin of the American Physiological Society. 美国生理学会的起源。

Federation proceedings Pub Date : 1987-02-01

O E Reynolds, T A Appel

引用次数: 0

The beginnings of the American Society of Biological Chemists. 美国生物化学家协会的成立。

Federation proceedings Pub Date : 1987-02-01

C C Hancock