Evolution, Medicine, and Public Health最新文献_第6页

Low birthweight is associated with epigenetic age acceleration in the first 3 years of life. 低出生体重与生命最初 3 年的表观遗传年龄加速有关。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-06-30 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad019

Edward B Quinn, Chu J Hsiao, Felicien M Maisha, Connie J Mulligan

{"title":"Low birthweight is associated with epigenetic age acceleration in the first 3 years of life.","authors":"Edward B Quinn, Chu J Hsiao, Felicien M Maisha, Connie J Mulligan","doi":"10.1093/emph/eoad019","DOIUrl":"10.1093/emph/eoad019","url":null,"abstract":"Background and objectives: The Developmental Origins of Health and Disease hypothesis posits that early life adversity is associated with poor adult health outcomes. Epidemiological evidence has supported this framework by linking low birthweight with adult health and mortality, but the mechanisms remain unclear. Accelerated epigenetic aging may be a pathway to connect early life experiences with adult health outcomes, based on associations of accelerated epigenetic aging with increased morbidity and mortality.Methodology: Sixty-seven mother-infant dyads were recruited in the eastern Democratic Republic of Congo. Birthweight data were collected at birth, and blood samples were collected at birth and follow-up visits up to age 3. DNA methylation data were generated with the Illumina MethylationEPIC array and used to estimate epigenetic age. A multilevel model was used to test for associations between birthweight and epigenetic age acceleration.Results: Chronological age was highly correlated with epigenetic age from birth to age 3 (r = 0.95, p < 2.2 × 10-16). Variation in epigenetic age acceleration increased over time. Birthweight, dichotomized around 2500 g, predicted epigenetic age acceleration over the first 3 years of life (b = -0.39, p = 0.005).Conclusions and implications: Our longitudinal analysis provides the first evidence for accelerated epigenetic aging that emerges between birth and age 3 and associates with low birthweight. These results suggest that early life experiences, such as low birthweight, may shape the trajectory of epigenetic aging in early childhood. Furthermore, accelerated epigenetic aging may be a pathway that links low birthweight and poor adult health outcomes.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"251-261"},"PeriodicalIF":3.3,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10360162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wealth, health and inequality in Agta foragers. 阿格塔觅食者的财富、健康和不平等。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-05-15 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad015

Abigail E Page, Milagros Ruiz, Mark Dyble, Daniel Major-Smith, Andrea B Migliano, Sarah Myers

{"title":"Wealth, health and inequality in Agta foragers.","authors":"Abigail E Page, Milagros Ruiz, Mark Dyble, Daniel Major-Smith, Andrea B Migliano, Sarah Myers","doi":"10.1093/emph/eoad015","DOIUrl":"10.1093/emph/eoad015","url":null,"abstract":"Background and objectives: There is significant evidence from large-scale, industrial and post-industrial societies that greater income and wealth inequality is negatively associated with both population health and increasing health inequalities. However, whether such relationships are inevitable and should be expected to impact the health of small-scale societies as they become more market-integrated is less clear.Methodology: Here, using mixed-effect models, we explore the relationship between health, wealth, wealth inequality and health inequalities in a small-scale foraging population from the Philippines, the Agta.Results: Across 11 camps, we find small to moderate degrees of wealth inequality (maximal Gini Coefficient 0.44) which is highest in the most permanent camps, where individuals engage more heavily in the formal market. However, in both adults (n = 161) and children (n = 215), we find little evidence that either wealth or wealth inequality associates with ill health, except for one measure of nutritional condition-red blood cell count.Conclusions and implications: We interpret these results in the light of high levels of cooperation among the Agta which may buffer against the detrimental effects of wealth inequality documented in industrial and post-industrial societies. We observe little intergenerational wealth transmission, highlighting the fluid nature of wealth, and thus wealth inequality, particularly in mobile communities. The deterioration of nutritional status, as indicated by red blood cell counts, requires further investigation before concluding the Agta's extensive cooperation networks may be beginning to breakdown in the face of increasing inequality.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"149-162"},"PeriodicalIF":3.3,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9579202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emotional factors, medical interventions and mode of birth among low-risk primiparous women in Poland. 波兰低风险初产妇的情绪因素、医疗干预和分娩方式。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-05-14 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad013

Ilona Nenko, Katarzyna Kopeć-Godlewska, Mary C Towner, Laura D Klein, Agnieszka Micek

{"title":"Emotional factors, medical interventions and mode of birth among low-risk primiparous women in Poland.","authors":"Ilona Nenko, Katarzyna Kopeć-Godlewska, Mary C Towner, Laura D Klein, Agnieszka Micek","doi":"10.1093/emph/eoad013","DOIUrl":"10.1093/emph/eoad013","url":null,"abstract":"Background and objectives: Birth is a critical event in women's lives. Since humans have evolved to give birth in the context of social support, not having it in modern settings might lead to more complications during birth. Our aim was to model how emotional factors and medical interventions related to birth outcomes in hospital settings in Poland, where c-section rates have doubled in the last decade.Methodology: We analysed data from 2363 low-risk primiparous women who went into labor with the intention of giving birth vaginally. We used a model comparison approach to examine the relationship between emotional and medical variables and birth outcome (vaginal or c-section), including sociodemographic control variables in all models.Results: A model with emotional factors better explained the data than a control model (ΔAIC = 470.8); women with continuous personal support during labor had lower odds of a c-section compared to those attended by hospital staff only (OR = 0.12, 95% CI = 0.09 - 0.16). A model that included medical interventions also better explained the data than a control model (ΔAIC = 133.6); women given epidurals, in particular, had increased odds of a c-section over those who were not (OR = 3.55, 95% CI = 2.95 - 4.27). The best model included variables for both the level of personal support and the use of epidural (ΔAIC = 598.0).Conclusions and implications: Continuous personal support during childbirth may be an evolutionarily informed strategy for reducing complications, including one of the most common obstetrical complications in modern hospital settings, the c-section.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"139-148"},"PeriodicalIF":3.3,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10224696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9548045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social determinants of health and disease in companion dogs: a cohort study from the Dog Aging Project. 伴侣犬健康和疾病的社会决定因素：狗老龄化项目的队列研究。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-05-13 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad011

Brianah M McCoy, Layla Brassington, Kelly Jin, Greer A Dolby, Sandi Shrager, Devin Collins, Matthew Dunbar, Audrey Ruple, Noah Snyder-Mackler

{"title":"Social determinants of health and disease in companion dogs: a cohort study from the Dog Aging Project.","authors":"Brianah M McCoy, Layla Brassington, Kelly Jin, Greer A Dolby, Sandi Shrager, Devin Collins, Matthew Dunbar, Audrey Ruple, Noah Snyder-Mackler","doi":"10.1093/emph/eoad011","DOIUrl":"10.1093/emph/eoad011","url":null,"abstract":"Exposure to social environmental adversity is associated with health and survival across many social species, including humans. However, little is known about how these health and mortality effects vary across the lifespan and may be differentially impacted by various components of the environment. Here, we leveraged a relatively new and powerful model for human aging, the companion dog, to investigate which components of the social environment are associated with dog health and how these associations vary across the lifespan. We drew on comprehensive survey data collected on 21,410 dogs from the Dog Aging Project and identified five factors that together explained 33.7% of the variation in a dog's social environment. Factors capturing financial and household adversity were associated with poorer health and lower physical mobility in companion dogs, while factors that captured social support, such as living with other dogs, were associated with better health when controlling for dog age and weight. Notably, the effects of each environmental component were not equal: the effect of social support was 5× stronger than financial factors. The strength of these associations depended on the age of the dog, including a stronger relationship between the owner's age and the dog's health in younger as compared to older dogs. Taken together, these findings suggest the importance of income, stability and owner's age on owner-reported health outcomes in companion dogs and point to potential behavioral and/or environmental modifiers that can be used to promote healthy aging across species.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"187-201"},"PeriodicalIF":3.3,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10306367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9738856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study. 抗生素耐药性在无法治愈和最终致命感染中的演变:回顾性病例研究。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-05-06 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad012

Robert J Woods, Camilo Barbosa, Laura Koepping, Juan A Raygoza, Michael Mwangi, Andrew F Read

{"title":"The evolution of antibiotic resistance in an incurable and ultimately fatal infection: A retrospective case study.","authors":"Robert J Woods, Camilo Barbosa, Laura Koepping, Juan A Raygoza, Michael Mwangi, Andrew F Read","doi":"10.1093/emph/eoad012","DOIUrl":"10.1093/emph/eoad012","url":null,"abstract":"Background and objectives: The processes by which pathogens evolve within a host dictate the efficacy of treatment strategies designed to slow antibiotic resistance evolution and influence population-wide resistance levels. The aim of this study is to describe the underlying genetic and phenotypic changes leading to antibiotic resistance within a patient who died as resistance evolved to available antibiotics. We assess whether robust patterns of collateral sensitivity and response to combinations existed that might have been leveraged to improve therapy.Methodology: We used whole-genome sequencing of nine isolates taken from this patient over 279 days of a chronic infection with Enterobacter hormaechei, and systematically measured changes in resistance against five of the most relevant drugs considered for treatment.Results: The entirety of the genetic change is consistent with de novo mutations and plasmid loss events, without acquisition of foreign genetic material via horizontal gene transfer. The nine isolates fall into three genetically distinct lineages, with early evolutionary trajectories being supplanted by previously unobserved multi-step evolutionary trajectories. Importantly, although the population evolved resistance to all the antibiotics used to treat the infection, no single isolate was resistant to all antibiotics. Evidence of collateral sensitivity and response to combinations therapy revealed inconsistent patterns across this diversifying population.Conclusions: Translating antibiotic resistance management strategies from theoretical and laboratory data to clinical situations, such as this, will require managing diverse population with unpredictable resistance trajectories.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"163-173"},"PeriodicalIF":3.3,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10266578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On evolutionary medicine and health disparities. 关于进化医学和健康差异。

IF 3.3 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-04-27 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad008

C Brandon Ogbunugafor, Fatimah Jackson

引用次数: 0

Embedded racism: Inequitable niche construction as a neglected evolutionary process affecting health. 嵌入式种族主义：不公平的生态位构建是一个被忽视的影响健康的进化过程。

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-04-21 eCollection Date: 2023-01-01 DOI: 10.1093/emph/eoad007

Paula Ivey Henry, Meredith R Spence Beaulieu, Angelle Bradford, Joseph L Graves

{"title":"Embedded racism: Inequitable niche construction as a neglected evolutionary process affecting health.","authors":"Paula Ivey Henry, Meredith R Spence Beaulieu, Angelle Bradford, Joseph L Graves","doi":"10.1093/emph/eoad007","DOIUrl":"10.1093/emph/eoad007","url":null,"abstract":"Racial health disparities are a pervasive feature of modern experience and structural racism is increasingly recognized as a public health crisis. Yet evolutionary medicine has not adequately addressed the racialization of health and disease, particularly the systematic embedding of social biases in biological processes leading to disparate health outcomes delineated by socially defined race. In contrast to the sheer dominance of medical publications which still assume genetic 'race' and omit mention of its social construction, we present an alternative biological framework of racialized health. We explore the unifying evolutionary-ecological principle of niche construction as it offers critical insights on internal and external biological and behavioral feedback processes environments at every level of the organization. We Integrate insights of niche construction theory in the context of human evolutionary and social history and phenotype-genotype modification, exposing the extent to which racism is an evolutionary mismatch underlying inequitable disparities in disease. We then apply ecological models of niche exclusion and exploitation to institutional and interpersonal racial constructions of population and individual health and demonstrate how discriminatory processes of health and harm apply to evolutionarily relevant disease classes and life-history processes in which socially defined race is poorly understood and evaluated. Ultimately, we call for evolutionary and biomedical scholars to recognize the salience of racism as a pathogenic process biasing health outcomes studied across disciplines and to redress the neglect of focus on research and application related to this crucial issue.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"112-125"},"PeriodicalIF":3.7,"publicationDate":"2023-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9480128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Childbirth fear in the USA during the COVID-19 pandemic: key predictors and associated birth outcomes. COVID-19大流行期间美国的分娩恐惧:主要预测因素和相关的分娩结果

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-01-01 DOI: 10.1093/emph/eoad006

Z M Thayer, S A Geisel-Zamora, G Uwizeye, T E Gildner

{"title":"Childbirth fear in the USA during the COVID-19 pandemic: key predictors and associated birth outcomes.","authors":"Z M Thayer, S A Geisel-Zamora, G Uwizeye, T E Gildner","doi":"10.1093/emph/eoad006","DOIUrl":"https://doi.org/10.1093/emph/eoad006","url":null,"abstract":"Background and objectives: Childbirth fear, which has been argued to have an adaptive basis, exists on a spectrum. Pathologically high levels of childbirth fear is a clinical condition called tokophobia. As a chronic stressor in pregnancy, tokophobia could impact birth outcomes. Many factors associated with tokophobia, including inadequate labor support, were exacerbated by the COVID-19 pandemic.Methodology: We used longitudinally collected data from a convenience sample of 1775 pregnant persons in the USA to evaluate the association between general and COVID-19 pandemic-related factors and tokophobia using the fear of birth scale. We also assessed associations between tokophobia, low birth weight and preterm birth when adjusting for cesarean section and other covariates among a subset of participants (N = 993).Results: Tokophobia was highly prevalent (62%). Mothers who self-identified as Black (odds ratio (OR) = 1.90), had lower income (OR = 1.39), had less education (OR = 1.37), had a high-risk pregnancy (OR = 1.65) or had prenatal depression (OR = 4.95) had significantly higher odds of tokophobia. Concerns about how COVID-19 could negatively affect maternal and infant health and birth experience were also associated with tokophobia (ORs from 1.51 to 1.79). Tokophobia was significantly associated with increased odds of giving birth preterm (OR = 1.93).Conclusions and implications: Tokophobia increases the odds of preterm birth and is more prevalent among individuals who are Black, have a lower income, and have less education. Tokophobia may, therefore, be an underappreciated contributor to inequities in US birth outcomes. The COVID-19 pandemic likely compounded these effects.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"101-111"},"PeriodicalIF":3.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10114526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9444337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An evolutionary perspective on social inequality and health disparities: Insights from the producer-scrounger game. 社会不平等和健康差异的进化视角:来自生产者-拾荒者博弈的见解。

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-01-01 DOI: 10.1093/emph/eoad026

Jonathan C K Wells

{"title":"An evolutionary perspective on social inequality and health disparities: Insights from the producer-scrounger game.","authors":"Jonathan C K Wells","doi":"10.1093/emph/eoad026","DOIUrl":"https://doi.org/10.1093/emph/eoad026","url":null,"abstract":"There is growing concern with social disparities in health, whether relating to gender, ethnicity, caste, socio-economic position or other axes of inequality. Despite addressing inequality, evolutionary biologists have had surprisingly little to say on why human societies are prone to demonstrating exploitation. This article builds on a recent book, 'The Metabolic Ghetto', describing an overarching evolutionary framework for studying all forms of social inequality involving exploitation. The dynamic 'producer-scrounger' game, developed to model social foraging, assumes that some members of a social group produce food, and that others scrounge from them. An evolutionary stable strategy emerges when neither producers nor scroungers can increase their Darwinian fitness by changing strategy. This approach puts food systems central to all forms of human inequality, and provides a valuable lens through which to consider different forms of gender inequality, socio-economic inequality and racial/caste discrimination. Individuals that routinely adopt producer or scrounger tactics may develop divergent phenotypes. This approach can be linked with life history theory to understand how social dynamics drive health disparities. The framework differs from previous evolutionary perspectives on inequality, by focussing on the exploitation of foraging effort rather than inequality in ecological resources themselves. Health inequalities emerge where scroungers acquire different forms of power over producers, driving increasing exploitation. In racialized societies, symbolic categorization is used to systematically assign some individuals to low-rank producer roles, embedding exploitation in society. Efforts to reduce health inequalities must address the whole of society, altering producer-scrounger dynamics rather than simply targeting resources at exploited groups.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"294-308"},"PeriodicalIF":3.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10559791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double trouble: trypanosomatids with two hosts have lower infection prevalence than single host trypanosomatids. 双重困扰:双宿主锥虫比单宿主锥虫感染率低。

IF 3.7 3区医学

Evolution, Medicine, and Public Health Pub Date : 2023-01-01 DOI: 10.1093/emph/eoad014

Hawra Al-Ghafli, Seth M Barribeau

{"title":"Double trouble: trypanosomatids with two hosts have lower infection prevalence than single host trypanosomatids.","authors":"Hawra Al-Ghafli, Seth M Barribeau","doi":"10.1093/emph/eoad014","DOIUrl":"https://doi.org/10.1093/emph/eoad014","url":null,"abstract":"Trypanosomatids are a diverse family of protozoan parasites, some of which cause devastating human and livestock diseases. There are two distinct infection life cycles in trypanosomatids; some species complete their entire life cycle in a single host (monoxenous) while others infect two hosts (dixenous). Dixenous trypanosomatids are mostly vectored by insects, and the human trypanosomatid diseases are caused mainly by vectored parasites. While infection prevalence has been described for subsets of hosts and trypanosomatids, little is known about whether monoxenous and dixenous trypanosomatids differ in infection prevalence. Here, we use meta-analyses to synthesise all published evidence of trypanosomatid infection prevalence for the last two decades, encompassing 931 unique host-trypansomatid systems. In examining 584 studies that describe infection prevalence, we find, strikingly, that monoxenous species are two-fold more prevalent than dixenous species across all hosts. We also find that dixenous trypanosomatids have significantly lower infection prevalence in insects than their non-insect hosts. To our knowledge, these results reveal for the first time, a fundamental difference in infection prevalence according to host specificity where vectored species might have lower infection prevalence as a result of a potential 'jack of all trades, master of none' style trade-off between the vector and subsequent hosts.","PeriodicalId":12156,"journal":{"name":"Evolution, Medicine, and Public Health","volume":"11 1","pages":"202-218"},"PeriodicalIF":3.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10317189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9802537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0