Wichí和阿根廷Criollos的表观遗传衰老差异:来自基因组历史和生态学的见解。

IF 3.3 3区 医学 Q2 EVOLUTIONARY BIOLOGY
Evolution, Medicine, and Public Health Pub Date : 2023-10-16 eCollection Date: 2023-01-01 DOI:10.1093/emph/eoad034
Vincenzo Iannuzzi, Stefania Sarno, Marco Sazzini, Paolo Abondio, Claudia Sala, Maria Giulia Bacalini, Davide Gentilini, Luciano Calzari, Federica Masciotta, Paolo Garagnani, Gastone Castellani, Edgardo Moretti, Maria Cristina Dasso, Federica Sevini, Zelda Alice Franceschi, Claudio Franceschi, Davide Pettener, Donata Luiselli, Cristina Giuliani
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引用次数: 0

摘要

背景和目的:基于DNA甲基化水平的表观遗传估计值已经成为人类衰老的有前途的生物标志物。这些估计值显示了人类群体之间的自然差异,但有关土著人口的数据在研究中仍然代表性不足。本研究的目的是研究两个不同的人群之间表观遗传估计值的差异,这两个人群都居住在阿根廷的大查科地区,美洲原住民Wichí,以及美洲原住民和第一批欧洲殖民者通婚的后代克里奥罗人。方法:我们使用Infinium MethylationEPIC (Illumina)分析了24位Wichí(平均年龄:39.2±12.9岁)和24位Criollos(平均年龄:41.1±14.0岁)的DNA甲基化水平,计算了16个表观遗传估计值。此外,我们使用HumanOmniExpress BeadChip (Illumina)检测了全基因组遗传变异,以深入了解这些人群的遗传历史。结果:我们的研究结果表明,根据五种表观遗传估计值,美洲原住民Wichí在表观遗传上比克里奥罗人更老。对Criollos人群的分析表明,全球祖先并不影响所观察到的差异,而本地(染色体)祖先显示,位于美洲原住民祖先过度代表的基因组区域的特定snp与表观遗传年龄加速测量(AgeAccelHannum)之间存在正相关。此外,我们证明了种群生态的差异也有助于观察到的表观遗传差异。结论和意义:总体而言,我们的研究表明,虽然基因组历史可能部分解释了观察到的表观遗传差异,但非遗传因素,如生活方式和生态因素,在表观遗传估计值的变异性中发挥了重要作用,从而促成了人类表观遗传衰老的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Epigenetic aging differences between Wichí and Criollos from Argentina: Insights from genomic history and ecology.

Background and objectives: Epigenetic estimators based on DNA methylation levels have emerged as promising biomarkers of human aging. These estimators exhibit natural variations across human groups, but data about indigenous populations remain underrepresented in research. This study aims to investigate differences in epigenetic estimators between two distinct human populations, both residing in the Gran Chaco region of Argentina, the Native-American Wichí, and admixed Criollos who are descendants of intermarriages between Native Americans and the first European colonizers, using a population genetic approach.

Methodology: We analyzed 24 Wichí (mean age: 39.2 ± 12.9 yo) and 24 Criollos (mean age: 41.1 ± 14.0 yo) for DNA methylation levels using the Infinium MethylationEPIC (Illumina) to calculate 16 epigenetic estimators. Additionally, we examined genome-wide genetic variation using the HumanOmniExpress BeadChip (Illumina) to gain insights into the genetic history of these populations.

Results: Our results indicate that Native-American Wichí are epigenetically older compared to Criollos according to five epigenetic estimators. Analyses within the Criollos population reveal that global ancestry does not influence the differences observed, while local (chromosomal) ancestry shows positive associations between specific SNPs located in genomic regions over-represented by Native-American ancestry and measures of epigenetic age acceleration (AgeAccelHannum). Furthermore, we demonstrate that differences in population ecologies also contribute to observed epigenetic differences.

Conclusions and implications: Overall, our study suggests that while the genomic history may partially account for the observed epigenetic differences, non-genetic factors, such as lifestyle and ecological factors, play a substantial role in the variability of epigenetic estimators, thereby contributing to variations in human epigenetic aging.

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来源期刊
Evolution, Medicine, and Public Health
Evolution, Medicine, and Public Health Environmental Science-Health, Toxicology and Mutagenesis
CiteScore
5.40
自引率
2.70%
发文量
37
审稿时长
8 weeks
期刊介绍: About the Journal Founded by Stephen Stearns in 2013, Evolution, Medicine, and Public Health is an open access journal that publishes original, rigorous applications of evolutionary science to issues in medicine and public health. It aims to connect evolutionary biology with the health sciences to produce insights that may reduce suffering and save lives. Because evolutionary biology is a basic science that reaches across many disciplines, this journal is open to contributions on a broad range of topics.
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