Progress in Medical Sciences最新文献_第7页

A Review On Unconventional Methods For The Diagnosis Of Drowning 溺水诊断的非常规方法综述

Progress in Medical Sciences Pub Date : 2020-12-31 DOI: 10.5455/pms.20191007023932

R. Ghosh, Saikat Das, S. Chowdhuri

{"title":"A Review On Unconventional Methods For The Diagnosis Of Drowning","authors":"R. Ghosh, Saikat Das, S. Chowdhuri","doi":"10.5455/pms.20191007023932","DOIUrl":"https://doi.org/10.5455/pms.20191007023932","url":null,"abstract":"Drowning is one of the most complex pathophysiological phenomena in forensic medicine. Till date, no accurate diagnostic test exists to diagnose death due to drowning. This is probably due to the close relation of drowning death with death caused by asphyxia. Although in the recent years, there have been various advances in the methods to diagnose drowning accurately. Among the conventional methods, the estimation of various ions from vitreous humor, pericardial fluid, pleural effusion fluid, and fluid from sphenoid sinus have been made more accurate by using state of the art equipments. The correlation with lung weight has also shown great results in improving the accuracy of diagnosis of drowning cases. Biomarkers like pulmonary surfactants and aquaporins have also shown great potential in developing a screening test to diagnose drowning death. Receptor for Advanced Glycation End Products (RAGE) is another such new biomarker. Its mRNA expression levels have shown great potential in diagnosing drowning deaths. These biomarkers as well as the modified conventional methods, such as impedance spectroscopy, postmortem computed tomography, and electrolyte estimation from various bodily fluids have shown the potential to increase the accuracy of diagnosing drowning deaths, manifold.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124562080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Estimation of Fall Risk in Geriatric Patients with Arrhythmias Prior and After Pacemaker Insertion 心脏起搏器植入前后心律失常老年患者跌倒风险的评估

Progress in Medical Sciences Pub Date : 2020-12-31 DOI: 10.47363/pms/2020(4)124

E. Koutsostathis

引用次数: 0

Hypothesis on the Nature of Embolic Cerebral Strokes 栓塞性脑卒中的性质假说

Progress in Medical Sciences Pub Date : 2020-12-31 DOI: 10.47363/pms/2020(4)121

V. Ermoshkin

引用次数: 0

Effect of Trema guineensis (celtidaceae) on ethanol-induced hypertension in Wistar rats. 金银耳对Wistar大鼠乙醇性高血压的影响。

Progress in Medical Sciences Pub Date : 2019-12-31 DOI: 10.5455/PMS.20181117061747

BalakiyÃ©m Kadissoli, A. Mouzou, T. Pakoussi, K. Eklu-Gadégbéku, K. Aklikokou, M. Gbéassor

{"title":"Effect of Trema guineensis (celtidaceae) on ethanol-induced hypertension in Wistar rats.","authors":"BalakiyÃ©m Kadissoli, A. Mouzou, T. Pakoussi, K. Eklu-Gadégbéku, K. Aklikokou, M. Gbéassor","doi":"10.5455/PMS.20181117061747","DOIUrl":"https://doi.org/10.5455/PMS.20181117061747","url":null,"abstract":"Objective: Trema guineensis is a traditional medicinal plant used to treat cardiovascular diseases in Africa. Here, we evaluated the effects of its hydro-alcoholic leaves on ethanol-induced hypertension. Method: Four groups of five rats each were used in this study. Group I, the control group, received distilled water (10 ml kg-1), Group II received ethanol (35°) at 3 g/kg, and Groups III and IV received ethanol (35°) at 3 g/kg followed by 200 and 400 mg/kg extract, respectively. Ethanol solutions were administered over 8 weeks. Results: The ethanol solutions increased body weight, blood pressure, superoxide dismutase (SOD), and malondialdehyde (MDA), and reduced glutathione (GSH) and nitric oxide (NO). As for the hematological parameters, the ethanol solutions reduced hemoglobin, red blood cells, white blood cells, platelets, polymorphonuclear cells, and lymphocytes, as well as corpuscular volume compared with the control group. The T. guineensis extract significantly prevented increased body weight, blood pressure, SOD, MDA, GSH, and NO. The extract also normalized hematological parameters. Conclusion: These results suggest that this extract contains antihypertensive properties that protect against ethanol-induced hypertension.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124815355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EXPERIENCE OF INTERPERSONAL VIOLENCE AND SUBJECTIVE LEVELS OFAGGRESSION AMONG HEALTHCARE STAFF IN A NIGERIAN HOSPITAL 尼日利亚一家医院医护人员的人际暴力经历和主观攻击程度

Progress in Medical Sciences Pub Date : 2019-12-31 DOI: 10.5455/pms.20190428010612

L. Oluwole, A. Obadeji, M. Dada

{"title":"EXPERIENCE OF INTERPERSONAL VIOLENCE AND SUBJECTIVE LEVELS OF\u0000AGGRESSION AMONG HEALTHCARE STAFF IN A NIGERIAN HOSPITAL","authors":"L. Oluwole, A. Obadeji, M. Dada","doi":"10.5455/pms.20190428010612","DOIUrl":"https://doi.org/10.5455/pms.20190428010612","url":null,"abstract":"Background: Workplace violence in the health sector is an issue of major public health. Little is known of assessment of aggression among victims of violence is quite relevant. Objective: A cross-sectional descriptive study of the occurrence of violence experienced by healthcare staff of a tertiary healthcare facility. Method: A descriptive cross-sectional study of 127 healthcare workers. The instrument comprised of an explorative questionnaire and an extract of the Buss–Perry Aggression Questionnaire. Results: Eighty-five (66.9%) of 127 respondents had experienced work-related violence. Verbal attack was most frequently reported (83.5%). Patients and relatives were the most cited perpetrators of violence. Nurses and doctors constituted 75% of health workers who were exposed to violence. Sociodemographic characteristics such as age group, sex, and experience at work were significant risks for violence. Study revealed the majority of respondents who experienced violence had elevated scores on the subjective aggression scale. Conclusion: Seventy percent of respondents experienced work-related violence; 62.4% of the perpetrators were patients and relatives. The reasons for violence included health workers long waiting time and health workers’ elevated scores on the subjective aggression scale. Training and educating health workers on identifying early signs of aggression and also anger management would help in reducing violence at the workplace.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125969504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Sub- acute Toxicity Study to Assess The effects of Methanol Extract of Date Palm Fruit on Kidney Functions in Adult Wistar Rats 枣椰果甲醇提取物对成年Wistar大鼠肾功能影响的亚急性毒性研究

Progress in Medical Sciences Pub Date : 2018-12-31 DOI: 10.5455/pms.20181023124229

K. Iteire, V. Emojevwe

{"title":"A Sub- acute Toxicity Study to Assess The effects of Methanol Extract of Date Palm Fruit on Kidney Functions in Adult Wistar Rats","authors":"K. Iteire, V. Emojevwe","doi":"10.5455/pms.20181023124229","DOIUrl":"https://doi.org/10.5455/pms.20181023124229","url":null,"abstract":"Background: Phoenix dactilifera (PD) has been used as a medicinal remedy for swollen limbs, aching legs, cough, sneezing, and acceleration of hair growth. Although studies have suggested the beneficial aspects of this agent to human health, it is not yet clear of the dosage that may become detrimental. Methods: Twenty adult albino rats divided into four groups of five rats each were used in this experiment. Methanol extract of PD was orally administered at doses of 4, 8, and 16 mg/kg to groups 2, 3, and 4, respectively, while group 1 (control) received distilled water. After 8 hours, blood was collected from the animals for the assessment of packed cell volume, serum urea, creatinine, glucose, potassium, chloride, and sodium. The data generated were expressed as the mean ± standard error of mean. The means were compared with Student’s t-test and analysis of variance with a p-value of 0.05 considered statistically significant. Results: In all parameters analyzed, kidney function was improved only at doses of 4 and 8 mg/kg, which was attributed to the antioxidant and free radical scavenging properties of PD. A higher dose of 16 mg/kg significantly increased the K+ (36.0 ± 4.5/22.6 ± 2.3 mEq/l) and serum urea (32.0 ± 3.8 mg/dl/25.2 ± 1.4 mg/dl) concentrations when compared with the control but other parameters measured were unchanged. These revealed that high doses of PD might impair normal renal functions. Conclusions: It was, therefore, concluded that methanol extract of PD fruit improved kidney functions at doses of 4 and 8 mg/kg and that at 16 mg/kg, PD might be deleterious to the kidney by impairing urea and potassium excretion.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"185 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116866432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Prevalence of childhood bronchial asthma and its associated factors: A community-based study in Egypt. 儿童支气管哮喘患病率及其相关因素:埃及社区研究

Progress in Medical Sciences Pub Date : 2018-12-31 DOI: 10.5455/PMS.20180530095039

Eman M. Meatty, T. el-desoky, Hoda El-Domyaty, A. El-Gilany, N. Nasef

{"title":"Prevalence of childhood bronchial asthma and its associated factors: A community-based study in Egypt.","authors":"Eman M. Meatty, T. el-desoky, Hoda El-Domyaty, A. El-Gilany, N. Nasef","doi":"10.5455/PMS.20180530095039","DOIUrl":"https://doi.org/10.5455/PMS.20180530095039","url":null,"abstract":"Objective: To estimate the prevalence of bronchial asthma (BA) among children in Dekerness district, Egypt and to identify its risk factors in the community setting. Population and Methods: This is a community-based cross-sectional descriptive study carried out in Dekerness District, Dakahlia Governorate, Egypt during a period of 1 year from May 1, 2016 to April 30, 2017. The targeted population was children aged 2–17 years living in the study locality. A proportional multi-stage cluster sample was taken from both rural and urban areas. Data were collected by a questionnaire completed through direct interview with the mother or caregiver and the child. Asthma was diagnosed according to International Study of Asthma and Allergies in Childhood questionnaire. Results: This study included 1,500 children with 13.4% overall prevalence of BA. Using logistic regression analysis, the independent predictors of BA prevalence were age less than 5 years old, being a male, children with birth order of three or more, passive smoking, and positive family history of BA. Conclusion: BA is highly prevalent among children and adolescents in Dekerness district. This prevalence is higher than previous reports from school-based studies. There is a need for effective prevention and management programs.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117036306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

In silico prediction of drug molecule from Ipomoea sepiaria against Type 2 diabetes 黄花易普罗亚抗2型糖尿病药物分子的计算机预测

Progress in Medical Sciences Pub Date : 2018-12-31 DOI: 10.5455/PMS.20180924092134

Muniraj Menakha, M. Sangeetha, P. Mani, M. Al-Aboody, R. Vijayakumar

{"title":"In silico prediction of drug molecule from Ipomoea sepiaria against Type 2 diabetes","authors":"Muniraj Menakha, M. Sangeetha, P. Mani, M. Al-Aboody, R. Vijayakumar","doi":"10.5455/PMS.20180924092134","DOIUrl":"https://doi.org/10.5455/PMS.20180924092134","url":null,"abstract":"Background: Diabetes mellitus is a complex disorder, hence following a systematic approach to the care of the disease is very important to control further complications. Current evidence suggests that the TCF7L2 gene influences the risk for type 2 diabetes (T2DM) by reducing glucose-induced insulin secretion. Even though there are various new advances and medicines are available in the management of T2DM, there is a need for an alternative medicine to avoid unnecessary side effects and high cost. Nowadays, computer-aided drug designing tool is available to create ligand-target molecule. Aim: In the present study, we aim to elucidate the binding interaction of bioactive phytochemicals of Ipomoea sepiaria with TCF7L2 gene and to find out potential drug molecule against T2DM. Materials and Methods: Bioactive phytochemicals of I. sepiaria were derived from the ChemSpider database and in silico molecular docking analysis done with TCF7L2 gene using Hex8.0.0 docking program. The results were analysed based on their molecular interactions binding energy values. Results: A total of 25 bioactive phytochemicals were derived from I. sepiaria and considered as ligand molecules. Based on the molecular docking scores of protein-ligand complex, we characterized the important interacting residues of protein targets, which involved in the binding interaction. Conclusion: The present study concluded that the quercetin showed a high affinity with TCF7L2, thus indicating that this compound is a potent inhibitor of the TCF7L2 proteins and consider as a potential drug candidate against T2DM. The further in vitro studies are required to confirm these results.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128310535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Sub-chronic oral propylene glycol administration sustained normal liver function and histology: A suitable alternative vehicle for hydrophobic test-compounds 亚慢性口服丙二醇给药维持正常肝功能和组织学:疏水试验化合物的合适替代载体

Progress in Medical Sciences Pub Date : 2018-12-31 DOI: 10.47363/pms/2018(2)113

Oke Oluwamayowa Gracious

{"title":"Sub-chronic oral propylene glycol administration sustained normal liver function and histology: A suitable alternative vehicle for hydrophobic test-compounds","authors":"Oke Oluwamayowa Gracious","doi":"10.47363/pms/2018(2)113","DOIUrl":"https://doi.org/10.47363/pms/2018(2)113","url":null,"abstract":"Background: An undocumented controversy exists on the suitability/unsuitability of propylene glycol as a solvent or vehicle for hydrophobic test-compounds in animal experimentation(s). This is partly due to the paucity of evidence that aims to probe its histological effects beyond Hematoxylin and Eosin assessment. Objective: To determine the potential suitability/unsuitability of oral propylene glycol as a vehicle for hydrophobic test-compounds by assessing its histological and biochemical effects in female Wistar rats. Methods: The study recruited 10 Wistar rats which were divided into two groups of five rats each as follows: Group 1 received distilled water (2 ml/kg, po) for four consecutive weeks while group 2 received propylene glycol (2 ml/kg, po) for the same period of time. Results: Propylene glycol caused no alteration in liver function as indicated by the plasma levels of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and hepatic total protein level when both groups were compared (p > 0.05). No significant difference between both groups was also recorded in the oxidative stress status (glutathione and catalase) of their liver homogenates. Histological examinations using Hematoxylin and Eosin (H&E) (general histoarchitecture) as well as special stains such as Gordon and Sweet (reticular fiber formation), Masson’s trichrome (collagen fibers), and periodic acid-Schiff (glycogen content) did not reveal any feature of pathology. Quantification analyses of their liver sections, using image J, further revealed no significant difference (p > 0.05) in their histoarchitectural features. Conclusion: Propylene glycol is a suitable alternative vehicle for hydrophobic test-compounds in experimental studies, as its sub-chronic administration sustained normal liver function and histology","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122789977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of life of children with bronchial asthma and their caregivers: A hospital-based study 支气管哮喘患儿及其护理人员的生活质量:一项基于医院的研究

Progress in Medical Sciences Pub Date : 2018-12-31 DOI: 10.47363/pms/2018(2)108

A. El-Gilany

{"title":"Quality of life of children with bronchial asthma and their caregivers: A hospital-based study","authors":"A. El-Gilany","doi":"10.47363/pms/2018(2)108","DOIUrl":"https://doi.org/10.47363/pms/2018(2)108","url":null,"abstract":"Objectives: This study aims to describe the health-related quality of life (QOL) and their associated factors in children with bronchial asthma as well as their caregivers in Mansoura, Egypt. Methods: This cross-section hospital-based study included 171 dyad of children with physician diagnosed asthma and their caregivers attending the outpatients’ clinics of three hospitals. Data were collected using the Arabic versions of the pediatric asthma quality of life questionnaire (PAQLQ) and the pediatric asthma caregiver’s quality of life questionnaire (PACQLQ). Asthma severity was assessed using Global Initiative for Asthma guidelines. Results: The overall mean scores of the PAQLQ and its activity, emotion, and symptom domains were 4.7, 4.3, 4.9, and 4.7; respectively. The overall mean scores of the total PACQLQ and its activity and emotion domains were 4.2, 5.4, and 4.0; respectively. Children with low socioeconomic status (SES) had a significantly lower total, activity and emotion domains of PAQLQ scores. Low and very low SES of the family, uncontrolled, and severe asthma are associated with low QOL of both asthmatic child and his caregivers. Conclusions: Early control of severe asthma will contribute to a better QOL of affected children and their caregivers.","PeriodicalId":121507,"journal":{"name":"Progress in Medical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128281490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7