Food additives and contaminants最新文献_第10页

A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen. 不同浓度磺胺嘧啶在蛋鸡体内的药代动力学和残留评价模型。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601182870

Natthasit Tansakul, Frank Niedorf, Manfred Kietzmann

{"title":"A sulfadimidine model to evaluate pharmacokinetics and residues at various concentrations in laying hen.","authors":"Natthasit Tansakul, Frank Niedorf, Manfred Kietzmann","doi":"10.1080/02652030601182870","DOIUrl":"https://doi.org/10.1080/02652030601182870","url":null,"abstract":"Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg(-1) body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg(-1) BW) and via medicated feed for 7 consecutive days (30, 10, 3 mg kg(-1) BW). Drug levels were determined with HPLC-UV for plasma, yolk and albumen. Pharmacokinetic values, which were calculated using a first-order one-compartment model, residue levels and transfer rates into the eggs were found to be dose-dependent. Even low doses of 3 and 1 mg kg(-1) BW resulted in measurable residues in yolk and albumen 1 day after a single oral administration. After ingestion of medicated feed at 3 mg kg(-1) BW, mean drug levels at 0.14 +/- 0.01 microg g(-1) were found in albumen and at 0.09 +/- 0.01 microg ml(-1) in plasma. Generally, the residue levels in albumen and plasma were higher than in yolk. These findings demonstrate a residue risk for the consumer even after low level intake of drugs.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"598-604"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601182870","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Analytical methods for the determination of zeranol residues in animal products: a review. 动物产品中零醇残留量的分析方法综述。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601134533

S Wang, X H Wang

{"title":"Analytical methods for the determination of zeranol residues in animal products: a review.","authors":"S Wang, X H Wang","doi":"10.1080/02652030601134533","DOIUrl":"https://doi.org/10.1080/02652030601134533","url":null,"abstract":"Analytical methods for zeranol residues are reviewed. Zeranol was a widely used as an anabolic promoter, and it could give rise to very low residues in the edible tissues of food animals. Zeranol was officially banned in Europe due to safety concerns because of its potential carcinogenic and endocrine-disrupting biological activity. A few analytical methods for determination of zeranol are reported in the literature and most of the methods such as thin-layer chromatography (TLC), gas chromatography-mass spectrometry (GC/MS), high-performance liquid chromatography (HPLC), liquid chromatography-mass spectrometry (LC/MS) and immunoassay are reviewed in this paper. Specific aspects of analysing zeranol such as sample selection, sample handling, method selection and chromatographic conditions are discussed. The instrumental methods such as LC/MS and GC/MS provide sensitive and specific techniques, but are very laborious and expensive. These methods are suitable for confirmation but not for screening of large numbers of samples. A rapid, sensitive and specific assay is needed to detect positive samples in routine analysis, and immunoassay offers practical advantages over the conventional instrumental methods in rapid analysis of zeranol residues. Immunochemical methods such as enzyme-linked immunoabsorbant assay (ELISA) are simple, rapid and cost-effective, with adequate sensitivity and specificity to detect small molecules. This review can be considered as a basis for further research aimed at identifying the most efficient approaches for the analysis of zeranol.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"573-82"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601134533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Single-laboratory validation of a GC/MS method for the determination of 27 polycyclic aromatic hydrocarbons (PAHs) in oils and fats. GC/MS法测定油脂中27种多环芳烃(PAHs)的单实验室验证

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601135936

M Rose, S White, R Macarthur, R G Petch, J Holland, A P Damant

{"title":"Single-laboratory validation of a GC/MS method for the determination of 27 polycyclic aromatic hydrocarbons (PAHs) in oils and fats.","authors":"M Rose, S White, R Macarthur, R G Petch, J Holland, A P Damant","doi":"10.1080/02652030601135936","DOIUrl":"https://doi.org/10.1080/02652030601135936","url":null,"abstract":"A protocol for the measurement of 27 polycyclic aromatic hydrocarbons (PAHs) in vegetable oils by GC/MS has undergone single-laboratory validation. PAHs were measured in three oils (olive pomace, sunflower and coconut oil). Five samples of each oil (one unfortified, and four fortified at concentrations between 2 and 50 microg kg(-1)) were analysed in replicate (four times in separate runs). Two samples (one unfortified and one fortified at 2 microg kg(-1)) of five oils (virgin olive oil, grapeseed oil, toasted sesame oil, olive margarine and palm oil) were also analysed. The validation included an assessment of measurement bias from the results of 120 measurements of a certified reference material (coconut oil BCR CRM458 certified for six PAHs). The method is capable of reliably detecting 26 out of 27 PAHs, at concentration <2 microg kg(-1) which is the European Union maximum limit for benzo[a]pyrene, in vegetable oils, olive pomace oil, sunflower oil and coconut oil. Quantitative results were obtained that are fit for purpose for concentrations from <2 to 50 microg kg(-1) for 24 out of 27 PAHs in olive pomace oil, sunflower oil and coconut oil. The reliable detection of 2 microg kg(-1) of PAHs in five additional oils (virgin olive oil, grapeseed oil, toasted sesame oil, olive margarine and palm oil) has been demonstrated. The method failed to produce fit-for-purpose results for the measurement of dibenzo[a,h]pyrene, anthanthrene and cyclopenta[c,d]pyrene. The reason for the failure was the large variation in results. The likely cause was the lack of availability of (13)C isotope internal standards for these PAHs at the time of the study. The protocol has been shown to be fit-for-purpose and is suitable for formal validation by inter-laboratory collaborative study.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"635-51"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601135936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

New method for the rapid identification of tetracycline residues in foods of animal origin - using the PremiTest in combination with a metal ion chelation assay. 快速鉴定动物源性食品中四环素残留的新方法——使用PremiTest与金属离子螯合试验相结合。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601134525

S L Stead, M Caldow, A Sharma, H M Ashwin, M Sharman, A de-Rijk, J Stark

{"title":"New method for the rapid identification of tetracycline residues in foods of animal origin - using the PremiTest in combination with a metal ion chelation assay.","authors":"S L Stead, M Caldow, A Sharma, H M Ashwin, M Sharman, A de-Rijk, J Stark","doi":"10.1080/02652030601134525","DOIUrl":"https://doi.org/10.1080/02652030601134525","url":null,"abstract":"A post-screening classification assay for tetracycline compounds has been developed and integrated into the previously reported optimized PremiTest methodology. The new post-antimicrobial screening assay is based on a metal ion chelation using calcium and sodium chloride and has been shown to be specific towards the tetracycline class. The assay is both cost-effective and complementary to the post-screening procedures that have previously been developed for the beta-lactam and sulfonamide compounds. A validation study was conducted in accordance with 2002/657/EC (Commission Decision). The method is rugged and applicable to a range of tetracyclines of differing antimicrobial potencies over a wide concentration range. A blind trial was undertaken in which all antimicrobial residues in the unknown samples were successfully identified by the analyst following the integrated PremiTest procedure for the classification of antimicrobial compounds.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"583-9"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601134525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Evaluation of the chemical residue monitoring in animal-derived products in Switzerland. 瑞士动物源性产品化学残留监测评价。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601137346

P Presi, L Knopf, G Regula, B Pacciarelli, J Frey, K D C Stärk

引用次数: 4

Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues. 用于婴儿食品生产的安全苹果:农药处理制度的调查，使残留降到最低。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601013703

Jana Ticha, Jana Hajslova, Tomas Kovalczuk, Martin Jech, Jiri Honzicek, Vladimir Kocourek, Miroslav Lansky, Jana Kloutvorova, Vladan Falta

{"title":"Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues.","authors":"Jana Ticha, Jana Hajslova, Tomas Kovalczuk, Martin Jech, Jiri Honzicek, Vladimir Kocourek, Miroslav Lansky, Jana Kloutvorova, Vladan Falta","doi":"10.1080/02652030601013703","DOIUrl":"https://doi.org/10.1080/02652030601013703","url":null,"abstract":"A total of 19 pesticide preparations were used according to agricultural practice in six trials in apple orchards. Using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), premature Golden Delicious apples collected 64, 50, 36 days before harvest and mature fruit were examined for residues of active ingredients. No residues of triflumuron, triazamate, chlorpyrifos, etofenprox, fenoxycarb, kresoxim-methyl, cyprodinyl, difenoconazole or thiram were detected in the first sampling. Also, the levels of chlorpyrifos-methyl, penconazole, tebuconazole and tolylfluanid dropped during the pre-harvest interval. Detectable residues of pyridaben, thiacloprid, trifloxystrobin and tetraconazole in harvested fruits were below 0.01 mg kg(-1), which is the maximum concentration of residues acceptable by baby-food producers in any raw material. The only residues exceeding this concentration were captan and teflubenzuron. Based on the data, farmers can choose pesticides for optimal treatment of plants, while enabling growth of a safe crop suitable for baby-food production.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"605-20"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601013703","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Evaluation of the genotoxic and antioxidant effects of two novel feed additives (ethoxyquin complexes with flavonoids) by the comet assay and micronucleus test. 用彗星试验和微核试验评价两种新型饲料添加剂(甲氧基醌类黄酮配合物)的遗传毒性和抗氧化作用。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601101128

A Błaszczyk, J Skolimowski

{"title":"Evaluation of the genotoxic and antioxidant effects of two novel feed additives (ethoxyquin complexes with flavonoids) by the comet assay and micronucleus test.","authors":"A Błaszczyk, J Skolimowski","doi":"10.1080/02652030601101128","DOIUrl":"https://doi.org/10.1080/02652030601101128","url":null,"abstract":"The complexes of antioxidant ethoxyquin (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline; EQ) with rutin or quercetin (EQ-R and EQ-Q, respectively) were studied in human lymphocytes for genotoxic and antioxidant activities with the use of the comet assay and micronucleus test. The study was undertaken to search for new potential antioxidants, and was motivated by reports of unfavourable side-effects observed in animals fed with feeds containing EQ, which is allowed up to 150 mg kg(-1) (0.015%) in complete animal feed. It was shown that EQ-R induced DNA damage in human lymphocytes when used at all the concentrations studied (1-25 microM), while after EQ-Q treatment, the genotoxic effect was observed mainly after higher doses (10 and 25 microM). An increase in the number of micronuclei was observed only for EQ-Q after a dose of 50 microM. The studied compounds decreased the degree of DNA damage induced by hydrogen peroxide (10 microM) in the comet assay. The results obtained in both tests showed that the antioxidant activity of EQ-Q was comparable with that of EQ, so further detailed studies are necessary to estimate its possible usefulness as a feed preservative.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"553-60"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601101128","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26711033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Investigation of patulin contamination in apple juice sold in retail outlets in Italy and South Africa. 调查意大利及南非零售店销售的苹果汁受展霉素污染情况。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030601137668

D R Katerere, S Stockenström, K M Thembo, G Balducci, G S Shephard

{"title":"Investigation of patulin contamination in apple juice sold in retail outlets in Italy and South Africa.","authors":"D R Katerere, S Stockenström, K M Thembo, G Balducci, G S Shephard","doi":"10.1080/02652030601137668","DOIUrl":"https://doi.org/10.1080/02652030601137668","url":null,"abstract":"A study of apple juice products sold in Italy and South Africa was initially carried out on 20 samples bought in Cesena, Italy, and Tygerberg in Cape Town, South Africa. The samples were bought at random and analysed for patulin contamination. All 12 of the Italian samples had no detectable levels of patulin, except one, which was just slightly above the lowest regulatory limit of 10 ng ml(-1). On the other hand, five of the eight South African samples were all contaminated with patulin levels above 10 ng ml(-1), with one showing a concentration of 75 ng ml(-1), well above the highest regulated limit of 50 ng ml(-1). This latter result led to a more targeted investigation with 14 samples being purchased in the low-income areas of Tygerberg where the initial samples were sourced. These samples confirmed that there might be a problem of mycotoxin contamination in apple juices products sold to low-income consumers because half of the samples showed patulin contamination of which four had levels well above the acceptable limits. This is the first study in South Africa to look at apple juice products in low-income areas and it points to a need to intervene and introduce quality systems in the supply chain of the manufacture and packaging of apple juice products by independent small business.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 6","pages":"630-4"},"PeriodicalIF":0.0,"publicationDate":"2007-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601137668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26710997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Non-dioxin-like PCBs in crops and related products: Levels and intakes in Serbia. 作物和相关产品中的非二恶英样多氯联苯:塞尔维亚的水平和摄入量。

Food additives and contaminants Pub Date : 2007-06-01 DOI: 10.1080/02652030701222683

Biljana Skrbic, Natasa Durisic-Mladenovic

引用次数: 15

Investigation of palladium and platinum levels in food by sector field inductively coupled plasma mass spectrometry. 扇形场电感耦合等离子体质谱法测定食品中钯和铂的含量。

Food additives and contaminants Pub Date : 2007-05-01 DOI: 10.1080/02652030601185691

Chiara Frazzoli, Roberta Cammarone, Sergio Caroli

{"title":"Investigation of palladium and platinum levels in food by sector field inductively coupled plasma mass spectrometry.","authors":"Chiara Frazzoli, Roberta Cammarone, Sergio Caroli","doi":"10.1080/02652030601185691","DOIUrl":"https://doi.org/10.1080/02652030601185691","url":null,"abstract":"Over the last two decades, there has been increased concern regarding the impact of some noble metals, such as Pd and Pt, on human health. These elements pollute the environment due to their widespread use as catalytic converters and in medical applications. The risk they pose to human health and the environment is still controversial; however, literature data point to diet as an important source of uptake by the human body. Within this context, the total Pd and Pt content of several Italian food commodities has been investigated. A total of 90 samples, including flour products, vegetables and foodstuffs of animal origin (meat, milk and eggs), were collected and freeze-dried. Samples were analyzed by sector field inductively coupled plasma mass spectrometry (SF-ICP-MS) after chopping or crushing followed by freeze-drying and microwave (MW)-assisted acid digestion in a Class-100 clean-room. A mathematical approach was adopted to correct the mass signals for still unresolved interference (mDeltam = 300, 10 000). The lowest and highest concentrations of Pt, i.e. 17 and 93 ng kg(-1) (dry weight, dw), were found in vegetables and flour products, respectively. The lowest Pd level (2830 ng kg(-1) dw) was found in eggs and the highest (47 800 ng kg(-1) dw) in vegetables.","PeriodicalId":12138,"journal":{"name":"Food additives and contaminants","volume":"24 5","pages":"546-52"},"PeriodicalIF":0.0,"publicationDate":"2007-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02652030601185691","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26711035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10