Exposure and Health最新文献_第9页

To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity. 浪费还是不浪费？质疑微塑料和纳米塑料的潜在健康风险，重点关注其摄入和潜在致癌性。

IF 4.5 3区环境科学与生态学

Exposure and Health Pub Date : 2023-01-01 Epub Date: 2022-03-22 DOI: 10.1007/s12403-022-00470-8

Elisabeth S Gruber, Vanessa Stadlbauer, Verena Pichler, Katharina Resch-Fauster, Andrea Todorovic, Thomas C Meisel, Sibylle Trawoeger, Oldamur Hollóczki, Suzanne D Turner, Wolfgang Wadsak, A Dick Vethaak, Lukas Kenner

{"title":"To Waste or Not to Waste: Questioning Potential Health Risks of Micro- and Nanoplastics with a Focus on Their Ingestion and Potential Carcinogenicity.","authors":"Elisabeth S Gruber, Vanessa Stadlbauer, Verena Pichler, Katharina Resch-Fauster, Andrea Todorovic, Thomas C Meisel, Sibylle Trawoeger, Oldamur Hollóczki, Suzanne D Turner, Wolfgang Wadsak, A Dick Vethaak, Lukas Kenner","doi":"10.1007/s12403-022-00470-8","DOIUrl":"10.1007/s12403-022-00470-8","url":null,"abstract":"Micro- and nanoplastics (MNPs) are recognized as emerging contaminants, especially in food, with unknown health significance. MNPs passing through the gastrointestinal tract have been brought in context with disruption of the gut microbiome. Several molecular mechanisms have been described to facilitate tissue uptake of MNPs, which then are involved in local inflammatory and immune responses. Furthermore, MNPs can act as potential transporters (\"vectors\") of contaminants and as chemosensitizers for toxic substances (\"Trojan Horse effect\"). In this review, we summarize current multidisciplinary knowledge of ingested MNPs and their potential adverse health effects. We discuss new insights into analytical and molecular modeling tools to help us better understand the local deposition and uptake of MNPs that might drive carcinogenic signaling. We present bioethical insights to basically re-consider the \"culture of consumerism.\" Finally, we map out prominent research questions in accordance with the Sustainable Development Goals of the United Nations.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"15 1","pages":"33-51"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States. 利用系统评价来探索美国全氟烷基和多氟烷基物质暴露的疾病负担和成本。

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2023-01-01 Epub Date: 2022-07-26 DOI: 10.1007/s12403-022-00496-y

Vladislav Obsekov, Linda G Kahn, Leonardo Trasande

{"title":"Leveraging Systematic Reviews to Explore Disease Burden and Costs of Per- and Polyfluoroalkyl Substance Exposures in the United States.","authors":"Vladislav Obsekov, Linda G Kahn, Leonardo Trasande","doi":"10.1007/s12403-022-00496-y","DOIUrl":"10.1007/s12403-022-00496-y","url":null,"abstract":"Accelerating evidence confirms the contribution of per- and polyfluoroalkyl substances (PFAS) to disease burden and disability across the lifespan. Given that policy makers raise the high cost of remediation and of substituting PFAS with safer alternatives in consumer products as barriers to confronting adverse health outcomes associated with PFAS exposure, it is important to document the costs of inaction even in the presence of uncertainty. We therefore quantified disease burdens and related economic costs due to legacy PFAS exposures in the US in 2018. We leveraged systematic reviews and used meta-analytic inputs whenever possible, identified previously published exposure-response relationships, and calculated PFOA- and PFOS-attributable increases in 13 conditions. These increments were then applied to census data to determine total annual PFOA- and PFOS-attributable cases of disease, from which we calculated economic costs due to medical care and lost productivity using previously published cost-of-illness data. We identified PFAS-attributable disease costs in the US of $5.52 billion across five primary disease endpoints shown to be associated with PFAS exposure in meta-analyses. This estimate represented the lower bound, with sensitivity analyses revealing as much as $62.6 billion in overall costs. While further work is needed to assess probability of causation and establish with greater certainty effects of the broader category of PFAS, the results confirm further that public health and policy interventions are still necessary to reduce exposure to PFOA and PFOS and their endocrine-disrupting effects. This study demonstrates the large potential economic implications of regulatory inaction.Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00496-y.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"15 2","pages":"373-394"},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9857861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Exposure to Essential and Non-essential Elements During Infants' First Year of Life in the New Hampshire Birth Cohort Study. 新罕布夏出生队列研究中婴儿第一年饮食中必需和非必需元素的暴露。

IF 4.5 3区环境科学与生态学

Exposure and Health Pub Date : 2023-01-01 Epub Date: 2022-06-16 DOI: 10.1007/s12403-022-00489-x

Antonio J Signes-Pastor, Vicki Sayarath, Brian Jackson, Kathryn L Cottingham, Tracy Punshon, Margaret R Karagas

{"title":"Dietary Exposure to Essential and Non-essential Elements During Infants' First Year of Life in the New Hampshire Birth Cohort Study.","authors":"Antonio J Signes-Pastor, Vicki Sayarath, Brian Jackson, Kathryn L Cottingham, Tracy Punshon, Margaret R Karagas","doi":"10.1007/s12403-022-00489-x","DOIUrl":"10.1007/s12403-022-00489-x","url":null,"abstract":"Even the low levels of non-essential elements exposure common in the US may have health consequences especially early in life. However, little is known about the infant's dynamic exposure to essential and non-essential elements. This study aims to evaluate exposure to essential and non-essential elements during infants' first year of life and to explore the association between the exposure and rice consumption. Paired urine samples from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) were collected at approximately 6 weeks (exclusively breastfed) and at 1 year of age after weaning (n = 187). A further independent subgroup of NHBCS infants with details about rice consumption at 1 year of age also was included (n = 147). Urinary concentrations of 8 essential (Co, Cr, Cu, Fe, Mn, Mo, Ni, and Se) and 9 non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, V, and U) elements were determined as a measure of exposure. Several essential (Co, Fe, Mo, Ni, and Se) and non-essential (Al, As, Cd, Hg, Pb, Sb, Sn, and V) elements had higher concentrations at 1 year than at 6 weeks of age. The highest increases were for urinary As and Mo with median concentrations of 0.20 and 1.02 µg/L at 6 weeks and 2.31 and 45.36 µg/L at 1 year of age, respectively. At 1 year of age, As and Mo urine concentrations were related to rice consumption. Further efforts are necessary to minimize exposure to non-essential elements while retaining essential elements to protect and promote children's health.Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00489-x.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"15 1","pages":"269-279"},"PeriodicalIF":4.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9971144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial-Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau. 青藏高原地表水氟化物时空变化及健康风险评价

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2023-01-01 DOI: 10.1007/s12403-022-00490-4

Yi Yang, Ru Zhang, Fengying Zhang, Yonghua Li

{"title":"Spatial-Temporal Variation and Health Risk Assessment of Fluoride in Surface Water in the Tibetan Plateau.","authors":"Yi Yang, Ru Zhang, Fengying Zhang, Yonghua Li","doi":"10.1007/s12403-022-00490-4","DOIUrl":"https://doi.org/10.1007/s12403-022-00490-4","url":null,"abstract":"The Tibetan Plateau (TP) is known as the \"Asian Water Tower\" and provides vital drinking water for residents of China and Southeast Asian countries. However, large-scale regional research on water quality in this climate-sensitive and ecologically-fragile area is still lacking. Considering that drinking from fluoride-contaminated water poses serious health concerns worldwide, especially in Asian counties, it is urgent to clarify the spatial-temporal distribution characteristics, influencing factors, and health risk of fluoride in surface water in the TP. In this study, a total of 2697 surface water samples from major rivers and typical lakes in the TP were systematically analysed. Overall, fluoride concentrations ranged from 0.003 to 6.240 mg L-1 and varied among water periods, water basins and even water types. Pearson's correlation analysis showed that the distribution of fluoride concentration was closely related to the regional climate and positively correlated with anthropogenic activities. Probabilistic health risk assessment revealed that potential hazards in the Inner Basin were the highest for all age groups (HR > 1), especially for infants and adults (HR > 3), while the risks in most other water basins were acceptable (HR < 1). Our findings can provide scientific support for fluorosis prevention, and guide water resource utilization in the TP and adjacent regions.Supplementary information: The online version contains supplementary material available at 10.1007/s12403-022-00490-4.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"15 2","pages":"281-297"},"PeriodicalIF":6.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9504414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A Systematic Workflow of Data Mining Confirms Widespread Occurrence of Antibiotic Contamination in Freshwater Reservoirs 数据挖掘的系统工作流程证实了淡水水库中抗生素污染的普遍存在

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-23 DOI: 10.1007/s12403-022-00529-6

Zhao-Feng Guo, Wiebke J. Boeing, Yao-Yang Xu, E. Borgomeo, Dong Liu, Yong-guan Zhu

引用次数: 0

Characterisation, Sources and Health Risk of Heavy Metals in PM2.5 in Agra, India 印度阿格拉PM2.5中重金属的特征、来源和健康风险

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-21 DOI: 10.1007/s12403-022-00528-7

D. Sah, P. Verma, K. M. Kumari, A. Lakhani

引用次数: 3

Effects of Environmental Heavy Metal Interactions on Renal Impairment: Epidemiological Evidence from Rural Northeastern China 环境重金属相互作用对肾损害的影响——来自中国东北农村的流行病学证据

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-19 DOI: 10.1007/s12403-022-00524-x

Guohuan Yin, Xiaoyu Ge, Meiduo Zhao, Jing Xu, Ang Li, Yayuan Mei, Jingtao Wu, Xiaolin Liu, Lanping Wei, Qun Xu

引用次数: 1

Human Health Risk Estimation of Nanoatrazine 纳米阿特拉津的人体健康风险评估

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-15 DOI: 10.1007/s12403-022-00527-8

S. Shahane, Arun Kumar

引用次数: 1

Unlocking India's Potential in Managing Endocrine-Disrupting Chemicals (EDCs): Importance, Challenges, and Opportunities. 释放印度在管理干扰内分泌的化学品 (EDC) 方面的潜力：重要性、挑战和机遇。

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-12 DOI: 10.1007/s12403-022-00519-8

Brij Mohan Sharma, Martin Scheringer, Paromita Chakraborty, Girija K Bharat, Eirik Hovland Steindal, Leonardo Trasande, Luca Nizzetto

{"title":"Unlocking India's Potential in Managing Endocrine-Disrupting Chemicals (EDCs): Importance, Challenges, and Opportunities.","authors":"Brij Mohan Sharma, Martin Scheringer, Paromita Chakraborty, Girija K Bharat, Eirik Hovland Steindal, Leonardo Trasande, Luca Nizzetto","doi":"10.1007/s12403-022-00519-8","DOIUrl":"10.1007/s12403-022-00519-8","url":null,"abstract":"Endocrine-disrupting chemicals (EDCs) are a prime concern for the environment and health globally. Research shows that in developing countries such as India both the environment and human populations are severely exposed to EDCs and consequently experience rising incidents of adverse health effects such as diabetes and cancers. In this paper, we discuss the current EDC management approach in India, critically assess its limitations, and describe opportunities for potential improvements. Foremost, current EDC management actions and interventions in India are fragmented and outdated, and far behind the modern and comprehensive approaches adopted in the European Union and other developed countries. Strong and well-planned actions are required on various fronts of science, policy, commerce, and public engagement. These actions include the adoption of a dedicated and modern regulatory framework for managing EDCs, enhancing capacity and infrastructure for EDC monitoring in the environment and human population, employing public-private partnership programs for not only managing EDCs but also in the sectors that indirectly contribute toward the mismanagement of EDCs in the country, and raising awareness on EDCs and promoting health-preserving consumption habits among the public. As India hosts a large proportion of the global human population and biodiversity, the success or failure of its actions will substantially affect the direction of global efforts to manage EDCs and set an example for other developing countries.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":"1-15"},"PeriodicalIF":6.7,"publicationDate":"2022-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9744066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10404410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Groundwater Quality Assessment Using EWQI With Updated Water Quality Classification Criteria: A Case Study in and Around Zhouzhi County, Guanzhong Basin (China) 基于EWQI的地下水水质评价——以关中流域周治县及周边地区为例

IF 6.7 3区环境科学与生态学

Exposure and Health Pub Date : 2022-12-09 DOI: 10.1007/s12403-022-00526-9

Yongqiang Yang, Peiyue Li, V. Elumalai, Jing Ning, Fei Xu, Dawei Mu

引用次数: 12