Exposure and Health最新文献

{"title":"Identifying Populations with Elevated PFAS Exposure by Targeted Serum Sample Pooling.","authors":"Sandra Nilsson, Jennifer Bräunig, Ava Mueller, Nis-Julius Sontag, Daman Langguth, Carl Kennedy, Peter Hobson, Kevin V Thomas, Jochen F Mueller, Leisa-Maree Toms","doi":"10.1007/s12403-025-00712-5","DOIUrl":"10.1007/s12403-025-00712-5","url":null,"abstract":"<p><p>Per- and polyfluoroalkyl substances (PFAS) are a focus of biomonitoring studies globally. In Australia, population PFAS serum concentrations have been determined since 2002 using pooled de-identified serum samples (<i>n</i> = 4800) collected from the population bi-annually, as a component of the Australian Human Biomonitoring (HBM) project. Locations of environmental PFAS contamination ('PFAS hotspots') are known to exist in Australia, but the extent of human exposure at many of these hotspots remains unknown. This study assesses if systematic use of geographical pooling of surplus pathology samples can be effective to identify if elevated PFAS exposure has occurred in populations residing near 'PFAS hotspots'. De-identified surplus pathology serum samples (<i>n</i> > 1800) were obtained and pooled from postcodes near three 'PFAS hotspots'. Samples were analyzed for PFAS and compared with the Australian HBM project. Selected PFAS were consistently higher compared to the Australian HBM project in pools from two of the three 'PFAS hotspots', suggesting that these populations may have experienced elevated exposure to PFAS. This study demonstrates that targeted serum pooling can be an effective tool for determining indications of population exposure to persistent chemicals in communities at risk. The technique has the potential to be used for rapid surveillance and as a trigger for further investigations of populations in proximity to sites with known contamination.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-025-00712-5.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"17 4","pages":"1083-1094"},"PeriodicalIF":4.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Toxic Tropane Alkaloids in Globally Sourced Soya, Cereals and Products Using Dilute-and-Shoot Technique Coupled with LC-MS/MS.","authors":"Rufielyn S Gravador, Brett Greer, Simon A Haughey, M Mar Aparicio-Muriana, Wilfred A Abia, Alexandra-Irina Mavrochefalos, Anne P Nugent, Christopher T Elliott","doi":"10.1007/s12403-025-00718-z","DOIUrl":"10.1007/s12403-025-00718-z","url":null,"abstract":"<p><p>For the first time, this study reports the content of tropane alkaloids (TAs) in soybean and soymeal samples sourced from 13 different countries, as well as in various cereals (including corn, millet, wheat, and sorghum) and a product (Super Cereals). The analysis was conducted using a fully validated solid-liquid extraction (SLE) with dilute-and-shoot (DnS) method along with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) triple quadrupole system. The samples were extracted using a solution of acetonitrile and water (60:40) with 1% formic acid. The limits of quantification (LOQ) were 0.10 µg kg^-1 and 0.25 µg kg^-1 for atropine and scopolamine, respectively. The extraction recovery was at least 80%, and the intra- and inter-day precision (relative standard deviation) were below 15% at 1, 5, and 50 µg kg^-1 atropine and scopolamine spiked levels. The validation parameters showed that the method was fit for the purpose of accurate LC-MS/MS quantification of atropine and scopolamine. The SLE with DnS is high-throughput, enabling the extraction of TAs in 2.3 min per sample or at least 60 samples in 140 min. Whereas typical TA extraction methods require lengthy and costly clean-up and concentration steps, the DnS does not require these steps, sophisticated equipment, or an expert operator for execution, which makes it a simpler and straightforward procedure for TA analysis in different grain-based food matrices. Application of the LC-MS/MS method showed that one in 80 millet or corn, 18 in 269 soybeans, 20 in 62 soymeal and 20 in 42 Super Cereals samples had atropine and scopolamine above the maximum level of 1 μg kg^-1 set by the EU Commission Regulation. TA contamination in these samples could either be due to the mixing with (visible) or exposure to (invisible) TA-producing plant material. The latter was proven through an exposure experiment, which showed that atropine and scopolamine from <i>Datura stramonium</i> seeds can be transferred to food grains (soybeans) invisibly with prolonged contact.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-025-00718-z.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"17 5","pages":"1193-1206"},"PeriodicalIF":4.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A community-based health risk assessment following the Gold King Mine Spill: Results from the Gold King Mine Spill Diné Exposure Project.","authors":"Yoshira Ornelas Van Horne, Karletta Chief, Perry H Charley, Mae-Gilene Begay, Nathan Lothrop, Robert A Canales, Paloma I Beamer","doi":"10.1007/s12403-023-00583-8","DOIUrl":"10.1007/s12403-023-00583-8","url":null,"abstract":"<p><p>The Gold King Mine Spill (GKMS) disaster resulted in three million gallons of acid mine drainage-containing arsenic and lead being released into a tributary of the San Juan River. The San Juan River flows through the Navajo Nation and the Diné (Navajo) rely on this river for a variety of purposes lending to unique exposure pathways. We administered questionnaires in three Navajo communities in collaboration with the Navajo Nation Community Health Representatives to obtain frequency and duration data on 43 activities (e.g., praying with river water, fishing from the river). These activities were utilized to conduct a community-based probabilistic risk assessment from exposure to arsenic (As) and lead at three different time points (i.e., pre-GKMS, peak-GKMS, and post-GKMS) for four different exposure scenarios: 1) recreational, 2) cultural, 3) dietary, and 4) aggregate. The aggregate scenario combines exposure from engaging in recreational, cultural, and dietary related activities. Utilizing the Lifeline Community-Based Assessment Software ^™ distributions were incorporated for different exposure factors (e.g., hand-to-mouth contacts, transfer efficiency) along with Diné-specific activities (e.g., using the sediment as sunscreen) to estimate dose. The estimated lead and arsenic (As) hazard quotients (HQs) for the recreational, cultural, and dietary scenario for all time points were less than one, indicating no excess non-cancer risks. Only the dietary scenario resulted in an excess cancer risk, with less than 1% of the simulated estimates exceeding the 1 × 10^-04 cancer risk guideline from exposure to arsenic through the dietary scenario (e.g., consuming fish from the San Juan River) at all time points. This risk assessment is the first to incorporate the unique exposure pathways of the Diné people following the GKMS and highlights the need to incorporate community-specific pathways during the risk analysis process.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" ","pages":"643-660"},"PeriodicalIF":3.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47783863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recycled Household Ash in Rice Paddies of Bangladesh for Sustainable Production of Rice Without Altering Grain Arsenic and Cadmium.","authors":"Yogesh Gupta, Mahmud Hossain, M Rafiqul Islam, Md Moyeed Hasan Talukder, Md Atiqur Rahman Khokon, Mohammad Mahir Uddin, Humayun Kabir, Manus Carey, Kathryn Ralphs, Natalia Valadares de Moraes, Andrew A Meharg, Caroline Meharg","doi":"10.1007/s12403-023-00539-y","DOIUrl":"10.1007/s12403-023-00539-y","url":null,"abstract":"<p><p>In Bangladesh most agronomic biomass (straw, husk, dried dung) is burnt for domestic cooking use. Consequently, the soil is continuously stripped of mineral nutrients and carbon (C) substrate. Here we investigate if recycling of household ash (ash) as fertilizer can sustainably improve soil fertility as well as minimise accumulation of toxic elements (As, Cd) in rice grain. Large scale field trials across two geographic regions (Barind, Madhupur) and two seasons (wet, dry) and with application of 3 fertiliser treatments (NPKS, ash, NPKS + ash) were conducted. At the end of each season, the impact of region*season*treatment on soil microbial comunities, rice yield, and grain quality (As, Cd, nutrient elements) was assessed. When compared to conventional field application rates of NPKS (control), application of ash boosted rice yield by circa. 20% in both regions during wet and dry season, with no effect on rice grain carcinogenic inorganic arsenic (iAs), dimethylarsonic acid (DMA) or cadmium (Cd), but with potential to increase zinc (Zn). For soil microbial communities, a significant region and season effect as well as correlation with elements in rice grain was observed, amongst these Cd, Zn, iAs and DMA. This study illustrates that application of ash can reduce the requirement for expensive chemical fertiliser, whilst at the same time increasing rice yield and maintaining grain quality, making farming in Bangladesh more sustainable and productive. The study also implies that the combined impact of region, season, and soil microbes determines accumulation of elements in rice grain.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s12403-023-00539-y.</p>","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":"87-99"},"PeriodicalIF":4.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10830805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volatile Organic Compounds Detected in Amniotic Fluid of Women During Normal Pregnancy","authors":"R. Minet-Quinard, Nicolas Goncalves-Mendes, Denis Gallot, Bruno Pereira, C. Lambert, M. Brailova, L. Blanchon, D. Bouvier, Vincent Sapin","doi":"10.1007/s12403-023-00617-1","DOIUrl":"https://doi.org/10.1007/s12403-023-00617-1","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"29 8","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cadmium Levels in Locally Produced and Imported Dark Chocolate in Lebanon","authors":"Z. Daher, Nathalie El Deghel, Rim Al Habahbeh, Mirna Azoury","doi":"10.1007/s12403-023-00614-4","DOIUrl":"https://doi.org/10.1007/s12403-023-00614-4","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"11 2","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Evidence on the Effects of Endocrine-Disrupting Chemicals (EDCs) on Bone Growth and Health","authors":"Anna-Mariia Shulhai, Paola Palanza, Maria E. Street","doi":"10.1007/s12403-023-00607-3","DOIUrl":"https://doi.org/10.1007/s12403-023-00607-3","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"1 1","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139225419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities","authors":"Cassandra Lepetit, Mohamed Gaber, Ke Zhou, Haiying Chen, Julia Holmes, Phillip Summers, Kim A. Anderson, R. P. Scott, Carey N. Pope, Kirstin Hester, P. Laurienti, S. Quandt, T. Arcury, Pierre-Alexandre Vidi","doi":"10.1007/s12403-023-00609-1","DOIUrl":"https://doi.org/10.1007/s12403-023-00609-1","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"132 6","pages":""},"PeriodicalIF":6.7,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139256082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review: Artisanal Gold Mining in Africa—Environmental Pollution and Human Health Implications","authors":"Maureene Auma Ondayo, Michael J. Watts, Clive J. Mitchell, David C. P. King, Odipo Osano","doi":"10.1007/s12403-023-00611-7","DOIUrl":"https://doi.org/10.1007/s12403-023-00611-7","url":null,"abstract":"Abstract About nine million Artisanal and Small-scale Gold Mining (ASGM) workers in Africa and people living near ASGM activities are highly exposed to geogenic and anthropogenic potentially toxic elements (PTEs). Despite the hazards and risks posed by ASGM being well characterized, coordinated multidisciplinary environmental characterization with combined public health studies are limited, with often piecemeal and snapshot studies reported, as highlighted by this review. Furthermore, studies are often not connected with efforts to minimize hazards holistically. Given this, we systematically reviewed the scientific literature on human health hazards associated with ASGM in Africa through Google Scholar, Science Direct, and Pubmed databases. One hundred and seventy-three peer-reviewed papers published between 1996 and June 2023 from 30 African countries were identified. Toxicological environmental hazards were reported in 102 peer-reviewed papers, notably As, Cd, CN, Cr, Hg, Pb, respirable SiO 2 -laden dust, and radionuclides. Exposure to PTEs in human biomonitoring matrices and associated health impacts were documented in 71 papers. Hg was the most reported hazard. Gaps in research robustness, regulation and policy framework, technology, risk detection, surveillance, and management were found. Despite international and in-country mitigation efforts, ASGM-related hazards in Africa are worsening. This review paper highlights the need for coordinated action and multidisciplinary collaborative research to connect dispersed isolated studies to better characterize the associated disease burden associated with ASGM in Africa and sustainably maximize the wider benefits of ASGM whilst protecting public health and the environment.","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":"34 25","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135042441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace Metal Contents in Farm Soils and Potato Tubers Grown in Mymensingh District of Bangladesh and Their Implications for Human Health","authors":"Nipunika Sarker, Ananya Saha, Shaila Sharmin, Q. F. Quadir, M. H. Rashid, H. M. Zakir","doi":"10.1007/s12403-023-00612-6","DOIUrl":"https://doi.org/10.1007/s12403-023-00612-6","url":null,"abstract":"","PeriodicalId":12116,"journal":{"name":"Exposure and Health","volume":" 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135241563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}