Folia medica Cracoviensia最新文献_第4页

α-Lipoic acid increases the viability of nephrocytes and elevates sulfane sulfur level in plasma of patients with chronic kidney disease. α-硫辛酸能增强慢性肾病患者肾细胞的活力，并提高血浆中的烷硫水平。

Folia medica Cracoviensia Pub Date : 2024-06-30 DOI: 10.24425/fmc.2024.150140

Anna Bilska-Wilkosz, Kinga Głowacka, Kinga Kocemba-Pilarczyk, Bernadeta Marcykiewicz, Magdalena Górny, Małgorzata Iciek

{"title":"α-Lipoic acid increases the viability of nephrocytes and elevates sulfane sulfur level in plasma of patients with chronic kidney disease.","authors":"Anna Bilska-Wilkosz, Kinga Głowacka, Kinga Kocemba-Pilarczyk, Bernadeta Marcykiewicz, Magdalena Górny, Małgorzata Iciek","doi":"10.24425/fmc.2024.150140","DOIUrl":"https://doi.org/10.24425/fmc.2024.150140","url":null,"abstract":"Background: Kidney diseases are a major global health problem affecting millions of people. Despite this, there is as yet no effective drug therapy improving outcome in patients with renal disease. The aim of this study was to examine the nephroprotective effect of α-lipoic acid (ALA) in vitro and to examine the effect of ALA administered in vivo on the production of reactive sulfur species (RSS), including hydrogen sulfide (H2S) and compounds containing sulfane sulfur.Methods: The effect of ALA was studied in vitro by determining the viability of human embryonic kidney cells (HEK293) in normoxic and hypoxic conditions as well as in vivo in two groups of chronic kidney disease (CKD) patients: non-dialyzed (ND) and undergoing continuous ambulatory peritoneal dialysis (PD) after 30 days of ALA supplementation.Results: The results revealed that the viability of HEK293 cells was significantly decreased by hypoxic conditions, while ALA administered during hypoxia increased the viability to the level observed in normoxic conditions. Studies performed in plasma of CKD patients after ALA supplementation suggested that ALA did not affect the parameters of oxidative stress, while significantly increased the level of reactive sulfane sulfur in both ND and PD patients suffering from CKD. The results suggest that ALA can exert nephroprotective effects which are related to sulfane sulfur production.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 1","pages":"39-52"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xanthogranulomatous Pyelonephritis: A pooled quantitative analysis of published cases. 黄疽性肾盂肾炎：已发表病例的汇总定量分析。

Folia medica Cracoviensia Pub Date : 2024-06-30 DOI: 10.24425/fmc.2024.150143

Allison M Parrill, Allen Tsiyer, Joshua Fogel, Dhir Gala, Kristen Politi, Himani Patel, Harshit Bhatt, Alejandro Alvarez-Betancourt, Aaron Smith, Zae Kim, Bair Cadet, Jeffrey Nalesnik, John Mahoney

{"title":"Xanthogranulomatous Pyelonephritis: A pooled quantitative analysis of published cases.","authors":"Allison M Parrill, Allen Tsiyer, Joshua Fogel, Dhir Gala, Kristen Politi, Himani Patel, Harshit Bhatt, Alejandro Alvarez-Betancourt, Aaron Smith, Zae Kim, Bair Cadet, Jeffrey Nalesnik, John Mahoney","doi":"10.24425/fmc.2024.150143","DOIUrl":"10.24425/fmc.2024.150143","url":null,"abstract":"Xanthogranulomatous Pyelonephritis (XGP) is a serious and rare inflammatory disease of unknown etiology. This systematic review analyzes XGP cases. We performed a literature search for \"Pyelonephritis, Xanthogranulomatous.\" The primary composite outcome was recovery with post-surgery complications, partial recovery, death, or chronic kidney disease. The secondary outcome was any presentation or treatment complication. Predictor variables consisted of demographics, history, symptoms, and diagnosis/management. Among the 251 patients, the mean age was 36.1 years, and 57.4% were female. The most common symptom and finding were fever (55.0%) and renal stones (53.8%), respectively. There were 15.5% with the composite outcome. There were 51.0% with any presentation or treatment complication. Multivariate logistic regression analysis for the composite outcome showed that kidney of both/horseshoe (OR:3.86, 95% CI:1.01, 14.73, p = 0.048), dialysis required (OR:8.64, 95% CI:2.27, 32.94, p = 0.002), and operative treatment of nephrostomy or nephrostomy followed by nephrectomy (OR:4.57, 95% CI:1.58, 13.17, p = 0.01) were each significantly associated with increased odds. Fever (OR:3.04, 95% CI:1.63, 5.67, p <0.001) and renal stones (OR:2.55, 95% CI:1.35, 4.81, p = 0.004) were each significantly associated with increased odds for any presentation/treatment complication. In conclusion, XGP patients with involvement of both or horseshoe kidneys, dialysis requirements, or treatment of nephrostomy or nephrostomy followed by nephrectomy may require aggressive treatment to mitigate poor patient outcomes.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 1","pages":"63-74"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical examinations of professional and amateur athletes at a sports medicine clinic. Insights from a sports medicine specialist and cardiologist. 运动医学诊所对专业和业余运动员的体检。运动医学专家和心脏病专家的见解。

Folia medica Cracoviensia Pub Date : 2024-06-30 DOI: 10.24425/fmc.2024.150142

Agnieszka Skrzypek, Ian Perera

引用次数: 0

Assessment of oral hygiene and quality of life in rehabilitated patients with fixed parcial dentures. 固定副义齿康复患者的口腔卫生和生活质量评估。

Folia medica Cracoviensia Pub Date : 2024-06-30 DOI: 10.24425/fmc.2024.150146

Ingrid Carneiro Cavalcante Souto, Rossana Pereira De Almeida, Lívia Fiorin, Otavio Marino Dos Santos Neto

{"title":"Assessment of oral hygiene and quality of life in rehabilitated patients with fixed parcial dentures.","authors":"Ingrid Carneiro Cavalcante Souto, Rossana Pereira De Almeida, Lívia Fiorin, Otavio Marino Dos Santos Neto","doi":"10.24425/fmc.2024.150146","DOIUrl":"https://doi.org/10.24425/fmc.2024.150146","url":null,"abstract":"Objective: Analyze the influence of oral hygiene guidance for the maintenance of fixed partial dentures (FPD) and the influence of this treatment on the quality of life (QL) of rehabilitated patients.Material and methods: The Simplified Oral Hygiene Index (OHI-S) and Bleeding on Probing Index (BOP) methods was employed to evaluate oral hygiene (OH), and the OHIP-14 questionnaire to assessment QL. The sample consisted of 33 patients (26 females and 7 males, mean age 51.53 years) in treatment with FPD. The OH and QL assessments were conducted in temporary FPD placing session and 30 days after definitive cementation. R e s u l t s: OHI-S and BOP showed increasing results (p <0.05) comparing initial and final assessments. There was a negative correlation between OHI-S and BOP, in both periods of analysis. The OHIP-14 showed a significant result according to the Likert scale scores, with an impact reduction from 9.33 to 0.57.Conclusions: It was concluded that FPD rehabilitations need of properly oral hygiene guidance, that could be influence on oral health status. In addition, the FPD rehabilitation improved the QL of the patients.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"64 1","pages":"97-110"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

150137 150137

Folia medica Cracoviensia Pub Date : 2024-03-29 DOI: 10.24425/fmc.2024.150137

引用次数: 0

Pelvic cavity and its spaces - anatomical overview. 骨盆腔及其空间--解剖概述。

Folia medica Cracoviensia Pub Date : 2023-12-30 DOI: 10.24425/fmc.2023.148761

Tomasz Iskra, Krzysztof Balawender, Wojciech Przybycień, Bartosz Rutowicz, Małgorzata Mazur, Bernard Solewski, Karolina Brzegowy-Solewska, Piotr Litwa, Maciej Sychta, Jerzy Walocha

引用次数: 0

Urachal remnants: from embryology to clinical practice. 泌尿道残留物：从胚胎学到临床实践。

Folia medica Cracoviensia Pub Date : 2023-12-30 DOI: 10.24425/fmc.2023.148760

Ioanna Gkalonaki, Ioannis Patoulias, Michail Anastasakis, Christina Panteli, Dimitrios Patoulias

引用次数: 0

HSPB1 mutation causing distal Hereditary Motor Neuropathy type 2B in a Polish family. 在一个波兰家族中，HSPB1 突变导致远端遗传性运动神经病 2B 型。

Folia medica Cracoviensia Pub Date : 2023-12-30 DOI: 10.24425/fmc.2023.148758

Katarzyna Homa, Kamila Żur-Wyrozumska

引用次数: 0

Patient Targeted Googling by nurses and midwives in Poland. 波兰护士和助产士以病人为目标的谷歌搜索。

Folia medica Cracoviensia Pub Date : 2023-12-30 DOI: 10.24425/fmc.2023.148756

Patrycja Zurzycka, Katarzyna Wojas, Zofia Musiał, Grażyna Pluto, Katarzyna Czyżowicz

{"title":"Patient Targeted Googling by nurses and midwives in Poland.","authors":"Patrycja Zurzycka, Katarzyna Wojas, Zofia Musiał, Grażyna Pluto, Katarzyna Czyżowicz","doi":"10.24425/fmc.2023.148756","DOIUrl":"https://doi.org/10.24425/fmc.2023.148756","url":null,"abstract":"Introduction: Patient Targeted Googling (PTG) is not a new phenomenon, but in Poland - according to the information available to the authors - there has been no research in this area among nurses and midwives. The above-mentioned activity is associated with many doubts and concerns of legal and ethical issues, and therefore there is a need to explore it.Objective: The aim of this study was to assess the prevalence of PTG among nurses and midwives in Poland.Material and methods: The study conducted among 300 working nurses and midwives used a diagnostic survey based on the author's survey questionnaire. Statistical analysis was performed using PQStat version: 1.8.4.142. Mann-Whitney U tests, chi-square and Fisher's correlations were used. The significance level was adopted at p <0.05 and highly significant at p <0.01.Results: The respondents' reasons for patient targeted googling were mainly lack of other sources of information, controlling adherence to recommendations, ascertaining the patient's mental disorders, behavior, substance abuse status and physical appearance. PTG without informing the patient was considered unethical and likely to violate the principle of informed consent and privacy. Respondents expressed the need for PTG training.Conclusions: The study presents the prevalence of PTG phenomenon among Polish nurses and midwives along with the different determinants of this activity.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"63 4","pages":"35-47"},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypertension and Gastrointestinal Bleed in COVID-19 Patients: Associations with Mortality, Acute Kidney Injury, Vasopressor Use, and Mechanical Ventilation Use. COVID-19 患者的高血压和消化道出血：高血压和胃肠道出血：与死亡率、急性肾损伤、使用血管加压素和使用机械通气的关系。

Folia medica Cracoviensia Pub Date : 2023-12-30 DOI: 10.24425/fmc.2023.148762

Igor Brodskiy, Joshua Fogel, Aaron Douen, Justin Wagner, John Trillo

{"title":"Hypertension and Gastrointestinal Bleed in COVID-19 Patients: Associations with Mortality, Acute Kidney Injury, Vasopressor Use, and Mechanical Ventilation Use.","authors":"Igor Brodskiy, Joshua Fogel, Aaron Douen, Justin Wagner, John Trillo","doi":"10.24425/fmc.2023.148762","DOIUrl":"https://doi.org/10.24425/fmc.2023.148762","url":null,"abstract":"There are mixed findings on the association of hypertension or gastrointestinal bleed (GIB) with mortality in COVID-19 patients but no research on the combination of both hypertension and GIB with mortality in COVID-19 patients. We study in COVID-19 patients the association of hypertension and GIB with mortality, acute kidney injury (AKI), vasopressor use, and/or mechanical ventilation. This is a retrospective study of COVID-19 patients who were categorized into groups of no GIB/no hypertension (n = 653), yes hypertension/no GIB (n = 1,620), yes GIB/no hypertension (n = 104), or yes GIB/yes hypertension (n = 334). Covariates included demographics and medical history variables. In the multi-variate logistic regression analysis for the composite outcome of mortality, AKI, vasopressor use, and/or mechanical ventilation use, yes hypertension/no GIB (OR: 1.47, 95% CI: 1.13, 1.89, p <0.001) and yes GIB/no hypertension (OR: 1.68, 95% CI: 1.02, 2.78, p <0.001) were each significantly positively associated with the composite outcome. The yes GIB/yes hypertension group was not significantly associated with the composite outcome. In conclusion, we found that hypertension or GIB alone were each significantly associated with increased odds for the composite outcome while having both hypertension and GIB was protective and not significantly associated with the composite outcome. We recommend that clinicians be aware of such findings when treating patients with COVID-19, as those with both hypertension and GIB may not need as aggressive treatment as compared to those with either hypertension or GIB.","PeriodicalId":12106,"journal":{"name":"Folia medica Cracoviensia","volume":"63 4","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2023-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0