Experimental and clinical endocrinology最新文献_第7页

A case of lipoatrophy with human insulin-therapy. 人胰岛素治疗脂肪萎缩1例。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211231

E Chantelau, M Reuter, S Schotes, A A Starke

引用次数: 7

Characterization of five monoclonal antibodies raised against domain E of the porcine estradiol receptor. 5种抗猪雌二醇受体E结构域单克隆抗体的鉴定。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211216

H H Thole, F Jakob

引用次数: 14

Myocardial atrial natriuretic factor gene expression after coronary ligation in rats. 冠脉结扎后大鼠心肌房利钠因子基因表达。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211226

T Kanda, M Nakano, M Arai, A Yamamoto, T Suzuki, K Murata

引用次数: 6

Increased serum neopterin levels in patients with Graves' disease. 巴塞杜氏病患者血清蝶呤水平升高。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211240

R Wagner, S Hayatghebi, M Rosenkranz, D Reinwein

{"title":"Increased serum neopterin levels in patients with Graves' disease.","authors":"R Wagner, S Hayatghebi, M Rosenkranz, D Reinwein","doi":"10.1055/s-0029-1211240","DOIUrl":"10.1055/s-0029-1211240","url":null,"abstract":"Neopterin (NPT) a marker of activation of the T-lymphocyte/monocyte axis has been measured in serum of 89 patients with autoimmune thyroid disease (72 patients with Graves' disease and 17 patients with autoimmune thyroiditis) and compared to a group of 24 normal controls and 24 patients with nontoxic goitre. There was a significant correlation between NPT levels and age in the patients with nontoxic goitre (r = 0.447, p < 0.001) but not in patients with autoimmune thyroid disease. Significantly higher NPT levels were found in all patients with Graves' disease (GD) compared to age and sex matched healthy controls, and patients with nontoxic goitre (5.7 +/- 2.4 vs 4.1 +/- 1.7, and 4.0 +/- 1.5, p < 0.01). However, there was no difference in NPT levels between each group of patients with GD when subdivided in: hyperthyroid newly diagnosed GD, treated GD, GD in remission and relapse. Patients with autoimmune thyroiditis did not have abnormal NPT levels compared to age and sex matched normal controls. Neopterin serum levels were not influenced by hyperthyroidism as no significant differences in NPT levels could be found in 24 patients with hyperthyroid Graves' disease and 13 patients with toxic goitre or toxic adenoma when compared to age and sex matched euthyroid patients with Graves' disease or normal controls. Moreover, there was no significant difference in mean NPT levels 1. before and after restoration of euthyroidism in 10 patients with hyperthyroid Graves' disease and 2. before and under T3 supplementation in 18 patients with Graves' disease in remission who underwent a T3 thyroid suppression test.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":12104,"journal":{"name":"Experimental and clinical endocrinology","volume":"101 4","pages":"249-54"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0029-1211240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19295490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Leydig cell neoplasia in a patient with Reifenstein syndrome. 赖芬斯坦综合征患者间质细胞瘤1例。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211259

Jockenhövel, J K Rutgers, J S Mason, J E Griffin, R S Swerdloff

{"title":"Leydig cell neoplasia in a patient with Reifenstein syndrome.","authors":"Jockenhövel, J K Rutgers, J S Mason, J E Griffin, R S Swerdloff","doi":"10.1055/s-0029-1211259","DOIUrl":"https://doi.org/10.1055/s-0029-1211259","url":null,"abstract":"We present the rare coincidence of a Leydig cell tumor in both testicles of a patient with partial androgen insensitivity syndrome (PAIS). The clinical picture with perineoscrotal hypospadia, micropenis, gynecomastia and delayed puberty and the serum hormone levels with elevated concentrations of testosterone, luteinising hormone (LH) and follicle-stimulating hormone were entirely consistent with PAIS. Ultimately, the diagnosis was confirmed by determination of genital skin fibroblast androgen receptor binding capacity for 5 beta-dihydrotestosterone, which demonstrated a qualitatively abnormal androgen receptor. At 44 years of age, a nodule in the left testis led to orchidectomy. At that time, the right testis was inconspicuous sonographically. But 3 years later the right testis developed nodules and was removed. Review of testicular histology revealed the presence of Leydig cell hyperplasia (LCH), multifocal nodular hyperplasia and Leydig cell neoplasia (LCN) in both testes. Many micronodules of Leydig cells in transition from hyperplasia to neoplasia were also identified. The simultaneous development of histologically identical nodes of LCN independently from each other and a different sites of both tests indicates the presence of a tumorigenic factor acting on the Leydig cells. Furthermore, the observation of multiple foci of cells in all stages of transition from hyperplasia to neoplasia demonstrates the persistent process of transformation. We speculate, that in this patient the grossly elevated LH levels present over 30 years have enhanced, if not provoked, the formation of LCN. In addition, the defective androgen receptor might have prevented suppressive effects of androgens on the Leydig cells.","PeriodicalId":12104,"journal":{"name":"Experimental and clinical endocrinology","volume":"101 6","pages":"365-70"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0029-1211259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19148393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

37th Symposium of the German Society of Endocrinology. Berlin, March 3-6, 1993. Abstracts. 第37届德国内分泌学会研讨会。柏林，1993年3月3日至6日。摘要。

Experimental and clinical endocrinology Pub Date : 1993-01-01

引用次数: 0

Effect of L-thyroxine and carbimazole on blood levels of biogenic amines in rat. l -甲状腺素和卡咪唑对大鼠血中生物胺水平的影响。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211249

L Upadhyaya, J K Agrawal, G P Dubey

引用次数: 12

Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy. 胰岛素瘤患者胰岛素作用受药物和手术治疗的影响。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211258

J Skrha, J Hilgertová, V Justová

{"title":"Insulin action in patients with insulinoma influenced by pharmacological and surgical therapy.","authors":"J Skrha, J Hilgertová, V Justová","doi":"10.1055/s-0029-1211258","DOIUrl":"https://doi.org/10.1055/s-0029-1211258","url":null,"abstract":"Organic hyperinsulinism due to insulinoma is accompanied by changes of insulin action on receptor and postreceptor levels. The influence of conservative and surgical treatment on insulin sensitivity was examined by euglycaemic hyperinsulinaemic clamps in ten patients with insulinoma. The \"responders\" (n = 5) and \"non-responders\" (n = 5) to diazoxide treatment were distinguished by using fasting plasma glucose and insulin concentrations. The index of insulin sensitivity was significantly decreased in pretreated \"responders\" as compared to healthy persons (19 +/- 3 vs 39 +/- 6 and 20 +/- 3 vs 37 +/- 5 mumol.kg-1.min-1 per mU.l-1 x 100, p < 0.01) and it was improved during diazoxide administration (27 +/- 4 vs 19 +/- 3 and 35 +/- 12 vs 20 +/- 3 mumol.kg-1.min-1 per mU.l-1 x 100, p < 0.05). Significantly decreased insulin sensitivity in pretreated \"non-responders\" (25 +/- 5 vs 39 +/- 6 and 28 +/- 6 vs 37 +/- 5 mumol.kg-1.min-1 per mU.l-1 x 100, p < 0.05) was not improved by diazoxide administration. Metabolic clearance rate of glucose was significantly higher in \"non-responders\" as compared to \"responders\" and healthy persons (12.7 +/- 3.4 vs 7.9 +/- 2.7 and 7.4 +/- 2.4 ml.min-1.kg-1, p < 0.05) already in pretreated state. An inverse relationship was found between metabolic clearance rate of glucose and of insulin (r = 0.72, p < 0.001). Plasma glucose, insulin concentration, index of insulin sensitivity, and metabolic clearance rate of glucose and of insulin were normalized after surgical removal of an insulinoma in all patients.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":12104,"journal":{"name":"Experimental and clinical endocrinology","volume":"101 6","pages":"360-4"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0029-1211258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19148392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Measurement of insulin-like growth factor I (IGF-I) in normal adults, patients with liver cirrhosis and acromegaly: experience with a new competitive enzyme immunoassay. 胰岛素样生长因子I (IGF-I)在正常成人、肝硬化和肢端肥大症患者中的测量:一种新的竞争性酶免疫分析法的经验

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211221

J Kratzsch, W F Blum, E Schenker, E Keller, G Jahreis, B Haustein, M Ventz, W Rotzsch

{"title":"Measurement of insulin-like growth factor I (IGF-I) in normal adults, patients with liver cirrhosis and acromegaly: experience with a new competitive enzyme immunoassay.","authors":"J Kratzsch, W F Blum, E Schenker, E Keller, G Jahreis, B Haustein, M Ventz, W Rotzsch","doi":"10.1055/s-0029-1211221","DOIUrl":"https://doi.org/10.1055/s-0029-1211221","url":null,"abstract":"A competitive enzyme immunoassay for the determination of human insulin-like growth factor I in microtiter plates was established. Using a polyclonal antiserum raised in rabbits against hIGF-I ovalbumin conjugate the assay system was able to detect IGF-I at a range of 12-800 pg/well with a sensitivity of 10 pg/well. It showed a low (< 0.5%) cross reactivity with hIGF-II. The serum concentrations of IGF-I found by EIA agreed well with those found in a conventional RIA (r = 0.965, p < 0.001). Effects of age and sex on IGF-I levels were studied in 260 normal adults. There was no evidence for sex differences but a steep decline of values from the third to the fourth and from the eight to the ninth decade, respectively. To asses the diagnostic capability of the IGF-I determination in liver cirrhosis, 71 sera of patients classified according to Child classes (A-C) were measured. Although significantly diminished concentrations were found in class B vs A and in class C vs B, the diagnostic sensitivity in cross-sectional examinations proved to be low (class A: 0.33, class B: 0.67). Only in the case of extensively destroyed liver parenchyma (Child C: 0.94) IGF-I was a good indicator of impaired hepatocellular capacity. In 29 patients with acromegaly serum IGF-I levels were investigated. All patients with active acromegaly showed increased IGF-I levels. In contrast, in inactive or weakly active acromegaly values were considerably lower.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":12104,"journal":{"name":"Experimental and clinical endocrinology","volume":"101 3","pages":"144-9"},"PeriodicalIF":0.0,"publicationDate":"1993-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0029-1211221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19213035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Aspartate-aminopeptidase activity during the estrous cycle and the pregnancy in rat brain and pituitary gland. 大鼠脑和脑垂体发情周期与妊娠期天冬氨酸氨基肽酶活性的关系。

Experimental and clinical endocrinology Pub Date : 1993-01-01 DOI: 10.1055/s-0029-1211223

J M de Gandarias, J Irazusta, E Echevarria, L Casis

引用次数: 1