Experimental and Clinical Physiology and Biochemistry最新文献

{"title":"Functional condition of the skin in women with metabolic syndrome","authors":"N. R. Hrytsevich, V. V. Vereschaka","doi":"10.25040/ecpb2023.03.014","DOIUrl":"https://doi.org/10.25040/ecpb2023.03.014","url":null,"abstract":"It is known that in people with metabolic diseases, reparation processes are disturbed during surgical interventions. However, the functional state of the skin during the development of the metabolic syndrome has been little studied. The aim of the work was to investigate the functional state of the skin in women with metabolic syndrome. Materials and methods. The study included 60 women aged 39 to 55 who sought surgical care for cosmetic skin defects. The control group consisted of 30 practically healthy women. Signs of metabolic syndrome were registered in 30 women who were included in the main group. The rate of reproduction of basal keratinocytes was determined according to the method of P. V. Kozhevnikova. The neutralizing ability of the skin was determined by the colorimetric method according to the time of disappearance of the bright crimson color (in minutes). The elastometric indicators of the skin were studied by the vacuum aspiration method using an applied cuvette with a diameter of 20 mm at a negative pressure of 20 kPa. The results. It was found that in women with metabolic syndrome, the duration of exfoliation of the stratum corneum increased by 48.1% (p < 0.01) compared to controls. This indicates a decrease in the rate of division of basal epidermocytes in the case of the development of metabolic syndrome. In the main group, the neutralization of the irritating agent was slower by 24.1% (p < 0.01), which indicates a decrease in the reactogenic properties of the skin in people with signs of metabolic syndrome. In patients with metabolic syndrome, the elastometric index of the skin increased by 46.0% (p < 0.001), which indicates changes in the tinctorial properties of the skin associated with the metabolic destruction of collagen. Conclusion. Significant changes in the functional state of the skin were registered in women with metabolic syndrome compared to healthy women: the rate of division of basal keratinocytes decreased, the elasticity of the skin deteriorated, and the index of its reactogenicity decreased. The identified changes, to a certain extent, explain the reasons for the violation of reparative processes in the skin after surgical interventions. Key words: metabolic syndrome, exfoliation of the stratum corneum of the skin, rate of division of basal keratinocytes, skin elasticity.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139201585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State of anxiety in the military with different stress resistance","authors":"S. N. Vadzyuk, V. V. Sas","doi":"10.25040/ecpb2023.03.019","DOIUrl":"https://doi.org/10.25040/ecpb2023.03.019","url":null,"abstract":"This article analyzes the state of anxiety in military personnel with different levels of stress resistance. It was found that in servicemen with good stress resistance, a week after returning from the battlefield, a low form of situational and personal anxiety prevailed, and with medium stress resistance, high anxiety prevailed. 3 months after returning from combat, among servicemen with good stress resistance, the number of persons with low situational anxiety increased by 12%, and personal anxiety – by 4%, while high anxiety dominated with average stress resistance. High and medium positive correlations were established in persons with good and medium stress resistance and anxiety in the military. The purpose of the work is to assess the state of anxiety in military personnel with different levels of stress resistance. Materials and methods. We tested 637 servicemen who returned from the combat zone. We determined stress resistance using the test method «Stresses and stress resistance», according to which the examinees were asked to answer twenty-three questions, each of which was offered four options for answers. Anxiety (personal and situational) was examined using the Spielberger-Hanin anxiety scale (State-Trait Anxiety Inventory – STAI). The methodology consisted of 40 statements (20 to determine the level of situational anxiety and 20 – personal). The statistical processing of the obtained results was carried out by the methods of variational analysis using the licensed statistical software package «Analyst Soft Stat Plus 6» (license number 11895400) and the «Microsoft Excel» software. Results and discussion. Based on the obtained results, we can talk about the positive and reliable dynamics of reducing the level of anxiety in people with different stress resistance, however, people with good stress resistance experienced a faster and better recovery than military personnel with average stress resistance. This article analyzes the state of anxiety in military personnel with different levels of stress resistance. It was found that in servicemen with good stress resistance, a week after returning from the battlefield, a low form of situational and personal anxiety prevailed, and with medium stress resistance, high anxiety prevailed. 3 months after returning from combat, among servicemen with good stress resistance, the number of persons with low situational anxiety increased by 12%, and personal anxiety – by 4%, while high anxiety dominated with average stress resistance. High and medium positive correlations were established in persons with good and medium stress resistance and anxiety in the military.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139202231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osmotic resistance of the erythrocyte as an indicator of the functional activity of the cell membrane","authors":"O. Y. Mazur, N. Denysenko","doi":"10.25040/ecpb2023.03.052","DOIUrl":"https://doi.org/10.25040/ecpb2023.03.052","url":null,"abstract":"The presented review describes the structure and features of the functioning of the erythrocyte membrane. Its osmotic resistance is characterized as an indicator of the functional activity of the cell membrane. Changes under the influence of various physical and chemical factors are described. The reasons for its decrease are identified and the direction of maintaining metabolic stability under the influence of various pathological factors is indicated.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"865 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139204664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and laboratory features of the course of the coronavirus disease and the level of cystatin C in hospitalized patients","authors":"S. Mahiiovych, T. Maksymets, E. Sklyarov","doi":"10.25040/ecpb2023.03.026","DOIUrl":"https://doi.org/10.25040/ecpb2023.03.026","url":null,"abstract":"The course of coronavirus disease is often accompanied by renal dysfunction, which is the result of comorbid pathology, namely diabetes mellitus, hypertension and precisely nephrological diseases. The most common and affordable way to monitor the condition of the kidneys is by determining the level of creatinine and calculating the glomerular filtration rate. However, serum cystatin C level is the «gold standard» for assessing renal function. This study aims to examine the clinical and laboratory aspects of coronavirus disease and establish the correlation between cystatin C and kidney function in hospitalized patients. 79 patients with coronavirus disease ranging from 24 to 73 years were involved in the study. The percentage of women in the group was 40,5%, while the percentage of men was 59,5%. The current protocol for the treatment of coronavirus disease, approved in Ukraine, was followed by all patients. Additionally, to assess renal dysfunction, cystatin C was determined biochemically using the SPINREACT test system (Spain). Results. Creatinine level was 123.0 (96,0; 151,0) μmol/l. Glomerular filtration rate was 52 (42,5; 71,0) ml/h/l.73m 2 , suggesting renal dysfunction. The cystatin C concentration was 1,27 (0,81; 1,87) mg/l. Cystatin C correlated with creatinine concentration (r = 0,62, p < 0,05) and negatively correlated with GFR (r = -0,65; p < 0,05), while, unlike creatinine, its level did not depend on age and gender. Increasing the concentration of cystatin C in the future could be a prognostic marker for the severe course of coronavirus disease, not just for renal dysfunction. Conclusions. Clinical manifestations and laboratory parameters during hospital admission depended on the premorbid background and were characterized by the presence of the following syndromes: systemic inflammatory response, respiratory failure, hypercoagulation and renal dysfunction. An elevated level of cystatin C is an indicator of kidney dysfunction, as well as a prognostic marker of severe coronavirus disease.","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":" 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ca2+,Mg2+-atpase activity of spermatozoa in male infertility in combination with rheumatoid arthritis","authors":"O. Melnyk, M. Z. Vorobets, Z. Fedorovych, R. Fafula, D. Vorobets","doi":"10.25040/ecpb2023.01-02.030","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.030","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80465916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newborn hearing screening: results of the first phase of a the pilot program","authors":"V. P. Bobyk, B. M. Raba, M. Cherkes, O. Semenyuk","doi":"10.25040/ecpb2023.01-02.068","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.068","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83032119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Na+,K+-atpase as a target of the antiproliferative effect of mitomycin C in the treatment of urethral stricture","authors":"D. R. Sheremeta, D. Vorobets","doi":"10.25040/ecpb2023.01-02.060","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.060","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"115 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79039749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Ceramic Veneers in Contemporary Aesthetic Dentistry","authors":"T. А. Palkov, S. Y. Leshchuk, Y. Leshchuk, M. Luka","doi":"10.25040/ecpb2023.01-02.049","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.049","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82295147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic changes in the extracellular matrix of rat liver under the conditions of chronic alcoholic hepatitis modeling","authors":"A. Mykytenko","doi":"10.25040/ecpb2023.01-02.012","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.012","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74412008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of zinc oxide nanoparticles on the prooxidant and proapoptic effects of glyphosate","authors":"YA. YU. Petrenko, M. Korda","doi":"10.25040/ecpb2023.01-02.005","DOIUrl":"https://doi.org/10.25040/ecpb2023.01-02.005","url":null,"abstract":"","PeriodicalId":12101,"journal":{"name":"Experimental and Clinical Physiology and Biochemistry","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87173552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}