Expert Review of Cardiovascular Therapy最新文献_第2页

Working toward the future of transcatheter aortic valve replacement: integrating computational modeling with patient-specific clinical care. 面向经导管主动脉瓣置换术的未来：将计算模型与患者特异性临床护理相结合。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-23 DOI: 10.1080/14779072.2026.2735939

Courtney Ream, Imran Shah, Luis René Mata Quiñonez, Srujana Joshi, Thangam Natarajan, Sanchita S Bhat, Lakshmi Prasad Dasi

{"title":"Working toward the future of transcatheter aortic valve replacement: integrating computational modeling with patient-specific clinical care.","authors":"Courtney Ream, Imran Shah, Luis René Mata Quiñonez, Srujana Joshi, Thangam Natarajan, Sanchita S Bhat, Lakshmi Prasad Dasi","doi":"10.1080/14779072.2026.2735939","DOIUrl":"10.1080/14779072.2026.2735939","url":null,"abstract":"Introduction: Transcatheter aortic valve replacement (TAVR) is rapidly evolving to become the standard of care for aortic stenosis (AS) patients, as opposed to open-heart surgery. The emergence of new commercial TAVR devices, as well as technological advancements in AS diagnosis and procedural planning, combat post-TAVR complications but pose new challenges with patient selection and optimal timing of valve replacement. Computational modeling is a powerful tool that may help streamline solutions for heart teams facing these complexities.Areas covered: This narrative review outlines the evolving landscape of TAVR patients - with a primary focus on AS - and examines the paradigm shift toward computational modeling in diagnostics, procedural planning, and intraoperative guidance. Mechanistic and AI-accelerated modeling studies were identified via PubMed, with publication dates ranging from January 2016-April 2026, while additional sources were identified without a publication date constraint.Expert opinion: TAVR indications and available devices will continue to increase. Improved device durability is increasingly necessary as the mean age of TAVR patients decreases and life expectancy increases. Emerging computational techniques, such as radiomics and AI/ML tools to enhance standard imaging modalities, hold promise in identifying who and when to treat for AS or AR. Digital twins may facilitate TAVR planning and optimal treatment pathways for individual patients.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"1-18"},"PeriodicalIF":2.5,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic inertia in children with heterozygous familial hypercholesterolemia: challenges of guideline-recommended goals. 杂合子家族性高胆固醇血症儿童的治疗惰性：指南推荐目标的挑战

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-20 DOI: 10.1080/14779072.2026.2735935

Cristina Pederiva, Giuseppe Banderali

引用次数: 0

Lactation as a targeted intervention for hypertensive disorders in pregnancy: understanding the cardioprotective relationship. 哺乳期作为妊娠期高血压疾病的针对性干预：了解其与心脏保护的关系。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-09-17 DOI: 10.1080/14779072.2026.2733418

Adrienne Hoyt-Austin, Eleanor B Schwarz

{"title":"Lactation as a targeted intervention for hypertensive disorders in pregnancy: understanding the cardioprotective relationship.","authors":"Adrienne Hoyt-Austin, Eleanor B Schwarz","doi":"10.1080/14779072.2026.2733418","DOIUrl":"10.1080/14779072.2026.2733418","url":null,"abstract":"Introduction: Hypertensive disorders of pregnancy portend future cardiovascular risk and warrant implementation of evidence-based, preventive strategies. Lactation is an underrecognized, time-sensitive health behavior that improves cardiovascular outcomes across the life course.Areas covered: This narrative review covers the relationships between maternal cardiovascular disease and lactation, including recent epidemiologic, translational, and clinical literature. We reviewed published studies linking breastfeeding, lactation and cardiometabolic risk factors (including hypertension, hyperlipidemia, and diabetes), and cardiovascular disease, presenting evidence from large cohort studies and randomized trials. We also review mechanistic pathways, including endocrine regulation, metabolic adaptations, and anti-inflammatory effects mediated by key lactation-related hormones. The literature search was conducted in April and May of 2026 using PubMed and Open Evidence searches.Expert opinion: Breastfeeding is an important health-related behavior with meaningful cardioprotective benefits, especially for mothers facing elevated cardiovascular risk after a hypertensive disorder of pregnancy. Evidence-based, multidisciplinary care for patients with hypertensive disorders of pregnancy, should include prompt lactation support, guideline‑concordant maternity care, and early postpartum interventions designed to improve maternal health across the life course. Recognizing lactation as a component of preventive cardiology offers an important opportunity to reduce the long-term burden of hypertension and cardiovascular disease among women.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"755-762"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining patient history and plasma lipoprotein (a) for improving atherosclerotic cardiovascular disease risk assessment. 结合患者病史和血浆lp(a)改善动脉粥样硬化性心血管疾病的风险评估。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-08-20 DOI: 10.1080/14779072.2026.2718197

Matheus Augusto de Oliveira Amorim, José Moreira Kffuri Filho, Viviane Zorzanelli Rocha

引用次数: 0

Personalizing myocardial revascularization strategies in the setting of acute myocardial infarction. 急性心肌梗死的个体化心肌血运重建策略。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-09-07 DOI: 10.1080/14779072.2026.2726771

Abhyuday Mandala, Lavinia Gabara, Nick Curzen, Richard J Jabbour

{"title":"Personalizing myocardial revascularization strategies in the setting of acute myocardial infarction.","authors":"Abhyuday Mandala, Lavinia Gabara, Nick Curzen, Richard J Jabbour","doi":"10.1080/14779072.2026.2726771","DOIUrl":"10.1080/14779072.2026.2726771","url":null,"abstract":"Introduction: Revascularization post myocardial infarction is a complex interplay of patient and anatomical factors. There is a growing number of interventional tools providing both physiological and anatomical delineation of disease burden which can help determine the method and extent of revascularization. A tailored approach is required taking into consideration shared decision making, co-morbidities, and evolving treatment options.Areas covered: This review article explores the wide array of revascularization techniques of both the culprit lesion and non-culprit lesions in the setting of acute myocardial infarction. A scoping literature review was undertaken of the PubMed database using keywordshighlighted below.Expert opinion: Prompt and durable revascularization of the infarct-related coronary artery remains the cornerstone of treatment for acute myocardial infarction. Specifically, timely restoration of normal flow and implantation of a DES during the index procedure remains the gold standard; however, deferred treatment and novel devices such as DCB may have an emerging role. Despite much evidence, complete revascularization of non-culprit coronary artery disease in acute myocardial infarction is still the subject of contention.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"763-777"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TAVI in low‑risk severe aortic stenosis: evidence, controversies, and lifetime treatment strategy. TAVI治疗低风险重度主动脉瓣狭窄：证据、争议和终身治疗策略

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-09-06 DOI: 10.1080/14779072.2026.2729316

Kelly Wright, Arafat Rahman, Georgia Penny, Maneesha Mohanarajan, Angela Sara Philip, Amer Harky

{"title":"TAVI in low‑risk severe aortic stenosis: evidence, controversies, and lifetime treatment strategy.","authors":"Kelly Wright, Arafat Rahman, Georgia Penny, Maneesha Mohanarajan, Angela Sara Philip, Amer Harky","doi":"10.1080/14779072.2026.2729316","DOIUrl":"10.1080/14779072.2026.2729316","url":null,"abstract":"Transcatheter aortic valve implantation (TAVI) has expanded from a treatment for inoperable and high-risk aortic stenosis to an established therapeutic option for selected patients at low surgical risk. This review focuses on the outcomes of major trials comparing TAVI to traditional surgical aortic valve replacement (SAVR), highlighting outcomes and potential complications when considering lifetime valve management as we move into the younger population. A literature search of PubMed using terms such as 'transcatheter aortic valve replacement' and 'low surgical risk' was used to identify relevant publications from within the last 10 years. Recent randomized trials and follow-up studies suggest that, in appropriately selected low-risk patients, TAVI and SAVR provide broadly comparable mid-term outcomes for cardiovascular mortality, stroke, and valve re-intervention. However, important differences remain. TAVI is consistently associated with lower rates of new-onset atrial fibrillation but higher rates of permanent pacemaker implantation and paravalvular aortic regurgitation. As TAVI moves into younger and asymptomatic populations, unresolved questions remain around valve durability, coronary access, redo strategies, and lifetime valve management, highlighting the central role of multidisciplinary heart-team assessment in selecting the optimal lifetime therapeutic strategy.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"805-816"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying patients at risk of Takotsubo syndrome during cancer treatment: a sex-based cardio-oncology review. 在癌症治疗期间识别有Takotsubo综合征风险的患者：基于性别的心脏肿瘤学综述

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-08-05 DOI: 10.1080/14779072.2026.2714263

Nicole Tesoro, Jennifer Marsidi, Jonathan Spaan, Henry Okoroike, Joanne Sutter, Rebecca Jonas, Marie Altenburg, Tochi Okwuosa, Annabelle Santos Volgman

{"title":"Identifying patients at risk of Takotsubo syndrome during cancer treatment: a sex-based cardio-oncology review.","authors":"Nicole Tesoro, Jennifer Marsidi, Jonathan Spaan, Henry Okoroike, Joanne Sutter, Rebecca Jonas, Marie Altenburg, Tochi Okwuosa, Annabelle Santos Volgman","doi":"10.1080/14779072.2026.2714263","DOIUrl":"10.1080/14779072.2026.2714263","url":null,"abstract":"Introduction: Takotsubo syndrome is an acute, transient ventricular dysfunction that frequently mimics acute coronary syndrome. Patients with cancer may be particularly vulnerable because malignancy-related stress and cancer therapies converge with cardiovascular susceptibility.Areas covered: This narrative review examines sex-related susceptibility and acuity, cancer-related stressors, implicated therapy classes, diagnostic differentiation, management, and treatment rechallenge. PubMed/MEDLINE was searched from January 2000 through June 2026 using combinations of terms for Takotsubo syndrome, cancer, cardio-oncology, sex, specific antineoplastic agents, imaging, outcomes, and rechallenge; reference lists of relevant consensus statements and reviews were also screened. Evidence is predominantly derived from registries, retrospective cohorts, case series, and case reports.Expert opinion: Sex should be treated as a risk modifier rather than a stand-alone determinant. A cumulative vulnerability framework integrating patient susceptibility, cancer-related stress burden, and treatment exposure may support earlier recognition and multidisciplinary decisions, but prospective validation and standardized sex-stratified reporting are required.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"793-804"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-based differences in acute coronary syndrome: mechanisms, management, and outcomes. 急性冠状动脉综合征的性别差异：机制、管理和结果。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-09-10 DOI: 10.1080/14779072.2026.2729313

Kamil Bujak, Costanza Agata Bordonaro, Maria Sara Mauro, Davide Capodanno

{"title":"Sex-based differences in acute coronary syndrome: mechanisms, management, and outcomes.","authors":"Kamil Bujak, Costanza Agata Bordonaro, Maria Sara Mauro, Davide Capodanno","doi":"10.1080/14779072.2026.2729313","DOIUrl":"10.1080/14779072.2026.2729313","url":null,"abstract":"Introduction: Acute coronary syndrome (ACS) remains a leading cause of morbidity and mortality worldwide. Sex- and gender-related differences in ACS persist and encompass risk profiles, clinical presentation, management, and outcomes.Areas covered: PubMed was searched from database inception through May 2026 for relevant literature on sex- and gender-based differences in ACS. This review examines these differences across the entire continuum of ACS, including cardiovascular risk factors, symptom presentation, underlying pathophysiological mechanisms, in-hospital management, secondary prevention, and long-term outcomes.Expert opinion: Sex-related disparities in ACS reflect a complex interplay between biological factors, comorbidities, and modifiable gaps in care. However, adjusted outcomes are not uniformly worse in women and vary across cohorts, with some registry data suggesting less favorable outcomes in older men. Improved recognition of sex-related differences and more consistent implementation of evidence-based care are needed across the ACS continuum. Such efforts are essential to improve outcomes for both women and men.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"817-832"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensuring durable pulmonary vein isolation for atrial fibrillation: prevention of collateral thermal injury and lesion inconsistency. 确保房颤持久肺静脉隔离：预防侧支热损伤和病变不一致。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-09-01 Epub Date: 2026-08-07 DOI: 10.1080/14779072.2026.2714259

Cristian Martignani, Alberto Spadotto, Maria Carelli, Lorenzo Bartoli, Andrea Angeletti, Igor Diemberger, Giulia Massaro

{"title":"Ensuring durable pulmonary vein isolation for atrial fibrillation: prevention of collateral thermal injury and lesion inconsistency.","authors":"Cristian Martignani, Alberto Spadotto, Maria Carelli, Lorenzo Bartoli, Andrea Angeletti, Igor Diemberger, Giulia Massaro","doi":"10.1080/14779072.2026.2714259","DOIUrl":"10.1080/14779072.2026.2714259","url":null,"abstract":"Introduction: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation for atrial fibrillation (AF). Despite major technological advances, arrhythmia recurrence remains common because of pulmonary vein reconnection caused by non-durable lesions. Achieving durable PVI requires balancing effective lesion formation with the prevention of collateral injury.Areas covered: This review examines the biophysical determinants of lesion formation, mechanisms responsible for lesion inconsistency, and strategies to improve lesion durability while minimizing collateral injury. The literature was identified through a structured review of major clinical trials, observational studies, mechanistic investigations, and contemporary guideline documents focusing on radiofrequency, cryoballoon, laser balloon, and pulsed field ablation technologies, together with emerging approaches for lesion assessment and procedural optimization.Expert opinion: Durable PVI depends not only on the energy source but also on precise control of catheter-tissue interaction, lesion contiguity, and individualized energy delivery. Pulsed field ablation has substantially improved procedural safety by reducing collateral thermal injury; however, durable lesion formation remains dependent on adequate tissue contact and appropriate energy delivery. Future progress will be driven less by the development of new energy sources than by technologies capable of providing real-time lesion verification and patient-specific ablation strategies.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"779-791"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suitability of sedative usage in patients undergoing cardiovascular surgery. 心血管手术患者使用镇静剂的适宜性。

IF 2.5

Expert Review of Cardiovascular Therapy Pub Date : 2026-08-01 Epub Date: 2026-07-13 DOI: 10.1080/14779072.2026.2703069

Nathaniel J Martin, Hannah M Brinkman, Sarah Ellis, Christoph G S Nabzdyk, Jamel P Ortoleva, Erica D Wittwer, Jacopo D'Andria Ursoleo, Patrick M Wieruszewski, Fabrizio Monaco

{"title":"Suitability of sedative usage in patients undergoing cardiovascular surgery.","authors":"Nathaniel J Martin, Hannah M Brinkman, Sarah Ellis, Christoph G S Nabzdyk, Jamel P Ortoleva, Erica D Wittwer, Jacopo D'Andria Ursoleo, Patrick M Wieruszewski, Fabrizio Monaco","doi":"10.1080/14779072.2026.2703069","DOIUrl":"10.1080/14779072.2026.2703069","url":null,"abstract":"Introduction: The provision of optimal anesthesia care is essential to the safe conduct of cardiac surgery. Nevertheless, evidence regarding ideal choices for anesthetic induction and maintenance remain conflicting. Individualized regimens balancing the patient's cardiac pathology and the expected hemodynamic perturbations from the anesthetics are likely optimal, underscoring the rationale for this review of contemporary anesthetic strategies in cardiac surgery.Areas covered: Descriptions of cardiac surgery trends and advancements that necessitate concomitant anesthesia, including the challenges with the provision of anesthesia in these patients were introduced. Induction and maintenance anesthesia considerations are discussed next, along with individual medication-specific commentary on volatile anesthetics, propofol, benzodiazepines, barbiturates, ketamine, etomidate, opioids, dexmedetomidine, and remimazolam. PubMed/MEDLINE, EMBASE, and Google Scholar were searched without date restriction through April 2026.Expert opinion: An optimal blanket anesthetic strategy for patients undergoing cardiac surgery remains elusive. Thoughtful combinations of multiple agents considering the patient's physiology, anticipated hemodynamic perturbations, and type and length of surgery are likely to continue to dominate practice. Novel agents, like remimazolam, may prove especially fruitful for patients given their unique properties, but more evidence is needed to prove impact on patient outcomes for this, and other agents in combination.","PeriodicalId":12098,"journal":{"name":"Expert Review of Cardiovascular Therapy","volume":" ","pages":"715-727"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148419918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0