Experimental Physiology最新文献

{"title":"Physiology of lived experience: The struggles of my first experience of sleep at 3810 m.","authors":"Julian C Bommarito","doi":"10.1113/EP093948","DOIUrl":"10.1113/EP093948","url":null,"abstract":"","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The physiology of lived experiences: A hole in the heart and the dive that found it.","authors":"James E Clark","doi":"10.1113/EP092420","DOIUrl":"10.1113/EP092420","url":null,"abstract":"","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal venular constriction during hypercapnia in highlanders: The potential roles of oxygenation and occupational exposure.","authors":"Faisal Ahsaan, Bakhtawar Latif, Aliza Akhtar","doi":"10.1113/EP094340","DOIUrl":"https://doi.org/10.1113/EP094340","url":null,"abstract":"","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agomelatine ameliorates abortion-related alterations in rats: Insights from behavioural, biochemical and histological analyses.","authors":"Mehtap Pervin, Zeynep Dila Oz, Ahmed Sait Bozyil, Orhan Sayin, Husna Batmaz, Serhat Hancer, Salih Burcin Kavak, Nevin Kocaman, Haluk Kelestimur, Emine Kacar","doi":"10.1113/EP093951","DOIUrl":"https://doi.org/10.1113/EP093951","url":null,"abstract":"<p><p>Abortion aetiology is critically linked to increased myometrial contractions and maternal psychological stress. Given the limited efficacy of current therapies such as progesterone, investigating novel therapeutic interventions is essential. Melatonin exerts reproductive benefits. Agomelatine stands out as an agent that exerts antidepressant effects through serotonin receptor (5-HT_2C) antagonism in addition to its potent melatonergic activity. Furthermore, agomelatine inhibits myometrial contractions. In this context, this study investigates agomelatine's therapeutic potential in an abortion model across behavioural, biochemical and histological parameters. Eighty female Sprague-Dawley rats were randomized into eight groups: control, sham, abortion, melatonin (M), agomelatine (A), progesterone (P) and combinations (MP, AP). Following pregnancy (Day 0), oral treatments were administered daily for 14 days. Abortion was induced via mifepristone on Day 11. Depressive-like behaviours were assessed using a forced swimming test on Day 13. The next day, rats were sacrificed for serum hormone analysis and uterine histological evaluation. The forced swimming test showed shorter immobility time in the AP group compared to the abortion group. An enzyme-linked immunosorbent Assay revealed lower serum prostaglandin F_2α level in the AP group and lower serum oxytocin levels in the M, A, MP and AP groups versus the abortion group. Histologically, M, A, P, MP and AP groups exhibited higher scores for complete fetus, decidual congestion, decidual inflammation and cytotrophoblast-syncytiotrophoblast cells compared to the abortion group. Additionally, the abortion group showed higher decidual necrosis than controls. In conclusion, agomelatine-containing protocols demonstrated restorative effects in abortion across behavioural, biochemical and histological parameters. These effects of agomelatine provide a new perspective on the currently limited options for treatment of abortion.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary amino acid patterns and epilepsy among the PERSIAN cohort population: A cross-sectional study.","authors":"Hamid Abbasi, Ali Jafari, Saeid Doaei, Akram Kooshki, Raul Zamora-Ros","doi":"10.1113/EP093525","DOIUrl":"https://doi.org/10.1113/EP093525","url":null,"abstract":"<p><p>Epilepsy is characterized by the occurrence of at least two unprovoked seizures occurring more than 24 h apart, reflecting a predisposition to recurrent epileptic events. The role of dietary amino acids (AAs) in epilepsy is not clearly understood. To the best of our knowledge, this study is the first to investigate the link between the odds of developing epilepsy and dietary AA patterns. This cross-sectional study, derived from the Prospective Epidemiologic Research Studies in Iran (PERSIAN) Sabzevar Cohort Study, included 112 individuals diagnosed with prevalent epilepsy and 3951 participants without epilepsy. Dietary intake was estimated using a validated semi-quantitative food frequency questionnaire. Principal component analysis was applied to identify two distinct dietary AA patterns: one predominantly derived from animal sources and the other from plant food sources. Participants with epilepsy were more likely to be male, have lower levels of education, be married, be unemployed and also to exhibit lower intakes of all assessed AAs. In the fully adjusted model, no significant association was observed between the animal AA pattern and the odds of having epilepsy (odds ratio (OR) (Q4 vs. Q1): 0.62, 95% CI: 0.35-1.08, P = 0.094), although the P-value for trend across quartiles was statistically significant (P_trend= 0.002). By contrast, higher adherence to the plant AA pattern was associated with 63% lower odds of having epilepsy (OR (Q4 vs. Q1): 0.37, 95% CI: 0.20-0.67, P = 0.001). The P-value for trend across quartiles was significant (P_trend= 0.001). In conclusion, greater adherence to the plant-based AA pattern was associated with lower odds of having epilepsy. These findings may inform dietary strategies, but prospective studies are needed to determine whether these associations reflect a causal relationship.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Context-dependent effects of whole-body vibration on reproductive function and penile tissue integrity in sedentary male rats.","authors":"Mujdat Ayva, Senay Akin, Irem Gungor Orhan, Neslihan Coskun Akcay, Berkay Ozerklig, Kemal Kosemehmetoglu, Mesut Altan, Haydar A Demirel, Fazil Tuncay Aki","doi":"10.1113/EP094086","DOIUrl":"https://doi.org/10.1113/EP094086","url":null,"abstract":"<p><p>Sedentary behaviour is increasingly recognized as a risk factor for systemic disorders; however, its effects on male reproductive health and penile tissue integrity remain insufficiently understood. Furthermore, the therapeutic role of whole-body vibration (WBV) has not been investigated. This study evaluated the effects of sedentary behaviour on testicular and penile tissues and examined whether WBV could attenuate these alterations. We hypothesized that sedentary behaviour would impair spermatogenesis and penile tissue integrity, whereas WBV would attenuate these effects. Thirty-two male Wistar rats were randomized into four groups (n = 8/group): Control, Sedentary, Sedentary+WBV and WBV. Sedentary conditions were induced for 28 days via a reduced-cage model, with daily WBV application (45 Hz, 3 mm). Serum testosterone, sperm parameters, testicular histology and penile smooth muscle-to-collagen ratio were assessed. Sedentary behaviour impaired spermatogenesis, with lower Johnsen scores (P = 0.008), reduced sperm concentration (P = 0.006) and motility (P < 0.001), and increased morphological abnormalities (P < 0.001). It also reduced the penile smooth muscle-to-collagen ratio (P < 0.001), indicating adverse structural remodelling in erectile tissue. In sedentary animals, WBV attenuated several alterations, preserving sperm quality and cavernosal smooth muscle content. However, WBV alone impaired spermatogenesis and increased sperm morphological abnormalities in non-sedentary animals. Serum testosterone levels did not differ significantly. In conclusion, prolonged sedentary behaviour impaired male reproductive indices and induced adverse structural remodelling of penile tissue in male rats. WBV showed context-dependent effects, attenuating alterations under sedentary conditions while showing adverse associations in non-sedentary animals. These findings warrant further translational investigation into the context-dependent effects of WBV on male reproductive and penile tissues.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13632662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RETRACTION: Surgery in Space: The Ultimate Frontier.","authors":"","doi":"10.1113/eph.70449","DOIUrl":"10.1113/eph.70449","url":null,"abstract":"<p><strong>Retraction: </strong>M. Bashir, A. Murtada, M. Jubouri, A. Bashir, I. Williams, and D. Bailey, \"Surgery in Space: The Ultimate Frontier,\" Experimental Physiology (2025): EP092765, 10.1113/EP092765. The above article, published online on 10 June 2025 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by the Physiological Society and John Wiley & Sons Ltd., with the agreement of all authors. Following publication, concerns were raised by a third party that one of the references in the article could not be verified. A subsequent investigation by the editors found that 12 out of 23 citations could not be substantiated as they were presented in the published article. As a result, The Physiological Society and John Wiley & Sons Ltd no longer have confidence in the article as a properly supported scholarly contribution and therefore agree that the article must be retracted.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":"4942"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-frequency characteristics of scalp high-frequency oscillations provide complementary biomarkers in infantile epileptic spasms syndrome.","authors":"Shunta Yamaguchi, Keisuke Maeda, Naoko Ishihara, Gen Furukawa, Himari Tsuboi, Keisuke Osakabe, Keiko Sugimoto, Naohiro Ichino","doi":"10.1113/EP094250","DOIUrl":"10.1113/EP094250","url":null,"abstract":"<p><p>Infantile epileptic spasms syndrome (IESS) is characterized by epileptic spasms (ES) in infants and hypsarrhythmia on EEG. High-frequency oscillations (HFOs), defined as oscillatory events at >80 Hz, reflect rapid spatiotemporal dynamics of cortical activity and might serve as novel biomarkers for epilepsy. In this study, we investigated the association among hypsarrhythmia, ES and scalp HFOs in IESS, focusing on their spatiotemporal and morphological characteristics. We analysed scalp EEG recordings from 22 paediatric patients with IESS (12 males; age range, 0-12 years), classified into four groups: hypsarrhythmia with ES; hypsarrhythmia without ES; multifocal interictal epileptiform discharges (IED); and non-multifocal IED. The proportions of EEG recordings with at least one detected scalp HFO differed significantly among the groups, being 100.0% in hypsarrhythmia with ES, 90.9% in hypsarrhythmia without ES, 36.0% in multifocal IED and 29.4% in non-multifocal IED (P < 0.001). Age-adjusted odds ratios [95% confidence intervals] for high HFO detection rates were significantly greater in the hypsarrhythmia groups than in the IED groups (with ES, 24.66 [4.86-125.10], P < 0.001; and without ES, 8.38 [1.94-36.20], P = 0.004). Receiver operating characteristic analysis showed that scalp HFO detection rates discriminated ES activity with an area under the curve of 0.92, 100% sensitivity and 77.4% specificity. Compared with the IED groups, the hypsarrhythmia groups exhibited lower-frequency HFOs, with the lowest HFO frequencies being observed in the hypsarrhythmia with ES group. These findings suggest that the spatiotemporal and morphological characteristics of scalp HFOs might provide complementary multidimensional biomarkers for hypsarrhythmia and assessing ictal states in IESS.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":"4852-4875"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148790050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes.","authors":"Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay","doi":"10.1113/EP094062","DOIUrl":"10.1113/EP094062","url":null,"abstract":"<p><p>Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca²⁺ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined. Here, we investigated whether sirtuin signalling coordinates intracellular Ca²⁺ homeostasis and mitochondrial function in a high-sucrose diet-induced mouse model of MetS. Male BALB/c mice were exposed to 32% sucrose for 24 weeks, followed by isolation of ventricular cardiomyocytes. MetS cardiomyocytes exhibited mitochondrial depolarization, increased reactive oxygen species production, elevated basal cytosolic Ca²⁺ levels, reduced Ca²⁺ transient amplitude and decreased sarcoplasmic reticulum Ca²⁺ content. These alterations were associated with reduced phospholamban phosphorylation, increased CaMKII and ryanodine receptor phosphorylation and activation of pro-apoptotic signalling. Notably, pharmacological inhibition of SIRT1 with EX527 in control cardiomyocytes recapitulated key features of the MetS phenotype, whereas SIRT1 activation with SRT1720 restored mitochondrial membrane potential, reduced reactive oxygen species production, improved Ca²⁺ handling, normalized aberrant phosphorylation of Ca²⁺-handling proteins and attenuated apoptotic signalling. Collectively, these findings identify SIRT1 as a critical integrator of mitochondrial function and Ca²⁺ homeostasis during metabolic stress, highlighting sirtuin-dependent pathways as promising therapeutic targets in metabolic cardiomyopathy.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":"4646-4658"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13433892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevation of body temperature during exercise enhances protection against dexamethasone‑induced skeletal muscle atrophy.","authors":"Berkay Ozerklig, Senay Akin, Seda Olgaz Bingol, Bulent Okan Yildiz, Scott K Powers, Ibrahim Turkel, Haydar A Demirel","doi":"10.1113/EP093744","DOIUrl":"10.1113/EP093744","url":null,"abstract":"<p><p>Prolonged glucocorticoid exposure induces skeletal muscle atrophy through suppression of protein synthesis and activation of catabolic signalling pathways. Although exercise attenuates glucocorticoid-induced muscle loss, whether exercise-induced increases in body temperature contribute remains unclear. In this study, we examined whether exercise in different thermal conditions modulates skeletal muscle atrophy and intracellular signalling during glucocorticoid exposure. Female Sprague-Dawley rats (n = 48) were assigned to six groups: control (CON), dexamethasone-treated (DEX), cold exercise (∼5°C; CE), cold exercise with dexamethasone (CED), warm exercise (25°C; WE) and warm exercise with dexamethasone. Exercise protocols were matched, and dexamethasone was administered for 5 days. Dexamethasone reduced plantaris muscle mass (by 17%, P < 0.0001) and fibre cross-sectional area (27%, P < 0.0001). During dexamethasone treatment, exercise in a cold environment provided partial protection, with muscle mass higher than DEX (P = 0.0476), but both muscle mass and fibre CSA remained lower than CON (P = 0.0096 and P = 0.0215, respectively). In contrast, exercise in a warm environment preserved muscle mass and fibre CSA (no difference vs. CON) and resulted in higher muscle mass (P = 0.0070) and fibre CSA (P < 0.0001) than DEX. Exercise-induced increases in rectal temperature were associated with higher Hsp72 and Hsp25 expression, partial preservation of Akt-FoxO3a signalling and reduced MuRF1 expression, whereas exercise in a cold environment showed minimal heat shock protein response and limited suppression of catabolic signalling. These findings indicate that exercise-induced elevation of body temperature enhances protection against glucocorticoid-induced skeletal muscle atrophy and support a role for heat-associated cellular stress responses in modulating muscle protein turnover during glucocorticoid exposure.</p>","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":"4781-4792"},"PeriodicalIF":3.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13524206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}