Experimental Physiology最新文献_第2页

Maximal strength and voluntary activation of adductor pollicis after a single session of acute intermittent hypercapnia or acute intermittent hypoxia. 单次急性间歇高碳酸血症或急性间歇缺氧后内收肌最大强度和自主激活。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-29 DOI: 10.1113/EP093227

Anandit J Mathew, Harrison T Finn, Chiettha Prajnadewie, Simon C Gandevia, Janet L Taylor, Jane E Butler

{"title":"Maximal strength and voluntary activation of adductor pollicis after a single session of acute intermittent hypercapnia or acute intermittent hypoxia.","authors":"Anandit J Mathew, Harrison T Finn, Chiettha Prajnadewie, Simon C Gandevia, Janet L Taylor, Jane E Butler","doi":"10.1113/EP093227","DOIUrl":"https://doi.org/10.1113/EP093227","url":null,"abstract":"Acute intermittent hypoxia (AIH) can increase maximal strength of limb muscles in people with incomplete spinal cord injury (SCI), but it is mostly untested in people without SCI. Acute intermittent hypercapnia (AIC) may engage similar respiratory circuits to AIH, but the effects of AIC on human limb motor output are unknown. We examined whether single sessions of AIH or AIC improved motor output to a hand muscle in neurologically intact people. Twelve adults completed a single 30-min session of AIH (breathing alternate 1-min low oxygen air and 1-min normal air), AIC (alternate 1-min high carbon dioxide air and 1-min normal air), or SHAM (normal air). At baseline and for 80 min post-intervention, participants performed repeated isometric maximal voluntary thumb adductions. Transcranial magnetic stimulation elicited motor evoked potentials (MEPs) from first dorsal interosseous and adductor pollicis at each time point. Generalised linear mixed models were compared between conditions (AIH, AIC, SHAM). Normalised to baseline, voluntary activation was higher after AIC than SHAM (5.9%, P < 0.001) and AIH (5.5%, P < 0.001); MVC force was higher after AIC than SHAM (7.7%, P < 0.001), whereas maximal EMG was higher after AIH than SHAM (14.3%, P < 0.001). MEPs and maximal M-waves did not differ between conditions for either muscle (P > 0.25). Thus, single sessions of AIC induced small motor output improvements in people without SCI, but AIH did not. AIC increased maximal voluntary activation, but the mechanisms for this remain unclear because the MEPs provided no evidence for corticospinal facilitation.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling the effect of varying metabolic rate and cardiac output on estimated tissue and blood O₂ and CO₂ levels in an extreme deep-diver, the goose-beaked whale (Ziphius cavirostris). 模拟极端深海潜水员鹅喙鲸（Ziphius cavirostris）的不同代谢率和心输出量对估计组织和血液中O2和CO2水平的影响。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-29 DOI: 10.1113/EP093021

Andreas Fahlman, Gregory S Schorr, David A Sweeney, Brenda K Rone, Shannon N Coates, Austin S Allen, Lucia M Martín López, Susan M Jarvis, Erin A Falcone

{"title":"Modelling the effect of varying metabolic rate and cardiac output on estimated tissue and blood O2 and CO2 levels in an extreme deep-diver, the goose-beaked whale (Ziphius cavirostris).","authors":"Andreas Fahlman, Gregory S Schorr, David A Sweeney, Brenda K Rone, Shannon N Coates, Austin S Allen, Lucia M Martín López, Susan M Jarvis, Erin A Falcone","doi":"10.1113/EP093021","DOIUrl":"https://doi.org/10.1113/EP093021","url":null,"abstract":"High-resolution movement data from Cuvier's beaked, or goose-beaked whale (Ziphius cavirostris, hereafter Ziphius, n = 8) tag deployments (4.1-19.2 days) were used to estimate blood and tissue O2 and CO2 levels. Acceleration and magnetometry data were used to estimate the locomotion cost (LC) from the relationship between activity and the O2 consumption rate. We estimated that the diving metabolic rate (DMR) decreased with increasing dive duration, ranging from 6.18 mL O2 min-1 kg-1 for very short dives (<1.0 min) to 1.65 mL O2 min-1 kg-1 and 2.06 mL O2 min-1 kg-1 for intermediate (>17.5 and ≤33.3 min) and long dives (>33.3 min), respectively. The calculated aerobic dive limit (cADL), average behavioural ADL (bADL) and dynamic ADL (dADL) were 62.4, 61.3 (44.3-75.4) and 41.7 (2.0-102.5) min, respectively. Despite the physiological and metabolic adjustments assumed by the model, the muscle O2 ran out for many of the stereotypical long, deep dives exhibited by these animals. Based on the model results, we speculate that a large portion of the foraging dives in Ziphius are fuelled by alternative metabolic pathways, for example, phosphocreatine or glycolysis. A reliance on these alternative metabolic pathways during foraging may require long recovery periods, including primarily aerobic dives. Disturbing this normal dive pattern may disrupt this normal dive pattern, leading to behavioural and physiological changes that could cause trauma.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of internal and external cooling on high-intensity intermittent cycling performance and cognitive function in the heat. 内外冷却对高温下高强度间歇循环性能和认知功能的影响。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-27 DOI: 10.1113/EP092679

Stacey Cowe, Simon B Cooper, Rachel Malcolm, Caroline Sunderland

{"title":"Effect of internal and external cooling on high-intensity intermittent cycling performance and cognitive function in the heat.","authors":"Stacey Cowe, Simon B Cooper, Rachel Malcolm, Caroline Sunderland","doi":"10.1113/EP092679","DOIUrl":"https://doi.org/10.1113/EP092679","url":null,"abstract":"We investigated the effect of internal and external cooling on high-intensity intermittent cycling performance and cognitive function in the heat. Twenty-nine males completed a control trial (CON) and a cooling trial (ice slurry and ice collar; COOL) in the heat (33°C, 50% relative humidity) involving a 40 min intermittent cycling protocol (two sets of ten 2 min stages, each consisting of 5 s sprint, 105 s active recovery and 10 s rest). A battery of cognitive tests was completed pre- and postexercise, with physiological and perceptual responses recorded throughout. No differences in peak or mean power output were found between conditions (all p > 0.05). Average trial rectal (COOL: 37.39°C ± 0.59°C; CON: 37.59°C ± 0.56°C, p < 0.001) and neck (COOL: 28.87°C ± 4.87°C; CON: 32.82°C ± 1.43°C, P < 0.001) temperatures were found to be lower in COOL. Participants reported feeling better and reported lower ratings of thermal sensation and improved comfort in COOL (all p < 0.05). Response times on the Stroop task complex level were quicker over time in COOL (COOL: -48 ± 23 ms; CON: -11 ± 18 ms, p = 0.002) and quicker overall on the number level of Sternberg during COOL (COOL: 434 ± 77 ms; CON: 437 ± 84 ms, p = 0.046). However, over time, the improvement in response times on the number level of Sternberg was greater in CON (COOL: -6 ± 3 ms; CON: -26 ± 2 ms, p = 0.015). Response times became quicker over time to a greater extent in CON on the visual search complex level (COOL: -15 ± 1 ms; CON: -119 ± 31 ms, p = 0.009). The combined cooling intervention did not influence sprint performance and had only a minimal influence on some domains of cognitive function but did lead to improvements in physiological and perceptual responses. These findings provide information on a practical combined cooling method that can be implemented in elite sport.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sildenafil helps the beat go on. 西地那非有助于保持心跳。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-27 DOI: 10.1113/EP093206

Jules C Hancox

引用次数: 0

A multi-omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data. 肌少症和虚弱的多组学研究：整合基因组、表观基因组和端粒长度数据。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-27 DOI: 10.1113/EP092853

Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I Ahmetov, Vidmantas Alekna

{"title":"A multi-omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data.","authors":"Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I Ahmetov, Vidmantas Alekna","doi":"10.1113/EP092853","DOIUrl":"https://doi.org/10.1113/EP092853","url":null,"abstract":"Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age-related diseases and might contribute to the development of both sarcopenia and frailty. In this study, we investigated the contribution of multi-omics data to sarcopenia, frailty, lean mass index (LMI) and handgrip strength in an elderly Lithuanian population. A total of 204 participants (age 82.2 ± 7.6 years) were included, comprising 122 individuals diagnosed with sarcopenia and/or frailty and 82 healthy, community-dwelling older adults. The results showed that LMI was associated with various health and lifestyle factors. Two genetic variants, CLIC5 rs75652203 and GHITM rs17102732, were found to be significantly associated with handgrip strength at the genome-wide level. Additionally, 12 polymorphisms previously linked to sarcopenia were replicated in relationship to LMI: BOK rs76993203, VAMP5 rs1374370, TMEM18 rs12714414, SFMBT1 rs36033494, BANK1 rs13136118, TET2 rs2647239, FOXO3 rs9384679, L3MBTL3 rs13209574, ZFAT rs13267329, CEP57 rs35793328, PCGF2 rs1985352 and MC4R rs66922415. Furthermore, several genes, many of which are involved in immune system processes, were significantly enriched with differentially methylated sites associated with LMI. Shorter telomeres were also associated with both sarcopenia and frailty. Notably, a significant relationship was observed between telomere length and methylation levels in genes related to lifestyle traits and the risk of developing these conditions. These findings provide new insights into the biological mechanisms underlying sarcopenia and frailty, underscoring the important roles of genetic and epigenetic factors in their pathogenesis among older adults.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stroke and motor outcomes are associated with regional and age-specific changes in periodic and aperiodic cortical activity. 中风和运动结果与周期性和非周期性皮层活动的区域和年龄特异性变化有关。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-24 DOI: 10.1113/EP093171

Asher J Albertson, Eric C Landsness, Margaret Eisfelder, Brittany M Young, Bradley Judge, Matthew R Brier, Matthew J Euler, Steven C Cramer, Jin-Moo Lee, Keith R Lohse

{"title":"Stroke and motor outcomes are associated with regional and age-specific changes in periodic and aperiodic cortical activity.","authors":"Asher J Albertson, Eric C Landsness, Margaret Eisfelder, Brittany M Young, Bradley Judge, Matthew R Brier, Matthew J Euler, Steven C Cramer, Jin-Moo Lee, Keith R Lohse","doi":"10.1113/EP093171","DOIUrl":"https://doi.org/10.1113/EP093171","url":null,"abstract":"Historically, stroke and ageing have been associated with changes in narrow-band periodic neuronal activity, but recent work has highlighted the importance of broad-band aperiodic activity. Aperiodic activity is represented by the 1/f slope of power spectral density generated by cortical activity. Here we explored changes in both periodic and aperiodic cortical activity in neurologically intact individuals and individuals with stroke, across the lifespan. We compared 'resting state' electroencephalograms from all participants after applying the specparam algorithm, which decomposes the power spectrum into aperiodic and periodic components. We also correlated motor outcomes to average whole cortex spectral slopes within the stroke group. We found a significant flattening (decrease in exponent) of power spectral slope with normal ageing. We found that both ageing and stroke were associated with fewer periodic peaks. Interestingly, we found that stroke was associated with a significant increase in spectral slope, but age moderated this effect. Younger stroke patients showed minimal difference in slope while older stroke patients had significantly steeper slopes (opposite to the direction in normal ageing). We next investigated the lesion locations most associated with changes in slope. Deep lesions were observed to have the greatest influence on cortical spectral slope. Finally, the slope in the stroke group was associated with performance on a test of manual dexterity, but this association was stronger in older individuals, and varied by scalp region. Our data suggest that stroke in the aged brain has unique effects on aperiodic activity possibly reflecting unique influence of injury on cerebral excitation/inhibition balance in aged individuals.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-24 DOI: 10.1113/EP092811

Ayechew A Getu, Melissa Ilardo, Joshua C Tremblay, Jay M J R Carr, Vitalie Faoro, Philip N Ainslie

{"title":"Human adaptation to high-altitude: A contemporary comparison of the oxygen cascade in Andean, Tibetan and Ethiopian highlanders.","authors":"Ayechew A Getu, Melissa Ilardo, Joshua C Tremblay, Jay M J R Carr, Vitalie Faoro, Philip N Ainslie","doi":"10.1113/EP092811","DOIUrl":"https://doi.org/10.1113/EP092811","url":null,"abstract":"Human populations native to high altitude have evolved distinct physiological adaptations to chronic hypoxia. This adaptation is evident in the O2 transport cascade. In this review, with brief inclusion of the related genetic adaptations, we compare the O2 cascade across three well-characterized high-altitude populations: Andeans (Aymara and Quechua), Tibetans/Sherpa and Ethiopians (Amhara and Oromo). We contrast the steps of the O2 cascade: (1) ventilation; (2) pulmonary O2 diffusion; (3) cardiac output and circulation; (4) haematological traits; and (5) tissue O2 utilization. Tibetans exhibit a robust hypoxic ventilatory response and efficient pulmonary diffusion capacity. They maintain preserved cardiac function with optimized muscle energetics. These adaptations are supported by enhanced tissue blood flow and greater muscle capillary density. Andeans demonstrate a blunted ventilatory response and marked remodelling of the pulmonary circulation, resulting in elevated pulmonary arterial pressure and mild but persistent right ventricular hypertrophy along with lifelong sympathetic overactivity. They also show strong haematological adaptations, with increased haemoglobin concentration. Ethiopians, particularly Amhara highlanders, show ventilatory status close to sea-level values, with limited pulmonary and cerebral vasoreactivity to hypoxia. Although data remain limited, the Amhara highlanders exhibit higher oxygen saturation and enhanced tissue blood flow in comparison to Oromo counterparts. In conclusion, these physiological (i.e., O2 cascade) differences provide evidence of the diverse patterns of evolutionarily adaptive responses to the stresses of high-altitude hypoxia. Further research comparing the O2 cascade across these Indigenous populations will enhance our understanding of the genetic and physiological adaptations to life at high altitude.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise prehabilitation for brain health and sensory-cognitive function: Mechanistic insights into brain-body interactions. 运动康复对大脑健康和感觉-认知功能的影响：脑-体相互作用的机制见解。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-23 DOI: 10.1113/EP092907

Helen E Nuttall, Daren Subar, Christopher J Gaffney

{"title":"Exercise prehabilitation for brain health and sensory-cognitive function: Mechanistic insights into brain-body interactions.","authors":"Helen E Nuttall, Daren Subar, Christopher J Gaffney","doi":"10.1113/EP092907","DOIUrl":"https://doi.org/10.1113/EP092907","url":null,"abstract":"This mini review article presents a novel hypothesis for extending exercise prehabilitation into the domains of brain health and cognition. Whilst prehabilitation has been gaining popularity in cancer treatment, conferring significant positive benefits to numerous physiological indicators, including post-operative infection and hospital length of stay, the benefits to patients' brain health and cognition are underexplored. There lies a timely and exciting opportunity in expanding prehabilitation to target neural and sensory dysfunction in cancer patients. We review data from healthy adults on the benefits of exercise to brain structure and function, and cognitive and sensory domains. Finally, we review how exercise could improve brain health, as well as sensory systems of the body, which are often negatively affected by cancer and associated treatment. We also outline further physiological contexts outside of cancer in which prehabilitation could also benefit brain health. Through this synthesis, we seek to inspire novel research into prehabilitation and brain health to further improve patient health and wellbeing.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury. 丹酚对羊革兰氏阴性脓毒性急性肾损伤模型肾髓组织缺氧的影响。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-22 DOI: 10.1113/EP092396

Rachel Peiris, Anton Trask-Marino, Alemayehu Jufar, Ashenafi H Betrie, Adam Southon, Sally G Hood, Rinaldo Bellomo, Abraham H Hulst, Clive N May, Connie P C Ow, Yugeesh R Lankadeva

{"title":"Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram-negative septic acute kidney injury.","authors":"Rachel Peiris, Anton Trask-Marino, Alemayehu Jufar, Ashenafi H Betrie, Adam Southon, Sally G Hood, Rinaldo Bellomo, Abraham H Hulst, Clive N May, Connie P C Ow, Yugeesh R Lankadeva","doi":"10.1113/EP092396","DOIUrl":"https://doi.org/10.1113/EP092396","url":null,"abstract":"Renal arterial infusion of tempol (RAT) at the onset of Gram-negative sepsis can prevent sepsis-induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary tissue hypoxia after ovine Gram-negative septic AKI. Following right unilateral nephrectomy, the left kidney was instrumented with a renal arterial catheter and oxygen-sensing fibre-optic probes into the renal medulla. After 23 h of Escherichia coli infusion, conscious sheep were fluid resuscitated with Hartmann's solution (30 mL/kg over 0.5 h) and randomized to intravenous tempol (IVT; n = 7) at 30 mg/kg/h, RAT (3 mg/kg/h; n = 6) or vehicle (n = 5) from 24 to 31 h of sepsis. At 31 h, E. coli infusion ceased, and sheep received ceftriaxone (1 g) and were allowed a 48 h recovery period. At 23 h of E. coli infusion, septic sheep developed a 2.2 ± 0.8-fold increase in plasma creatinine and a 57% ± 6% decrease in urine output, and the renal medulla was ischaemic and hypoxic. Neither RAT nor IVT attenuated the sepsis-induced renal medullary tissue hypoxia during the 7 h intervention period. Renal medullary tissue partial pressure of O2 returned to the pre-morbid levels in all groups by 16 h after treatment cessation, and sepsis was resolved with antibiotics. In conclusion, in sheep with established septic AKI, treatment with RAT or IVT did not improve renal medullary oxygenation or kidney function, in contrast to the effectiveness we have shown in early sepsis. These findings emphasize the dramatically different response to a treatment in early compared with late stages of sepsis.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency responses of human magnetophosphene perception thresholds during dark adaptation point to rod modulation. 暗适应过程中人类磁膦感知阈值的频率响应指向棒调制。

IF 2.8 4区医学

Experimental Physiology Pub Date : 2025-09-19 DOI: 10.1113/EP092852

Nicolas Bouisset, Andres Carvallo, Sebastien Villard, Ilkka Laakso, Alexandre Legros

{"title":"Frequency responses of human magnetophosphene perception thresholds during dark adaptation point to rod modulation.","authors":"Nicolas Bouisset, Andres Carvallo, Sebastien Villard, Ilkka Laakso, Alexandre Legros","doi":"10.1113/EP092852","DOIUrl":"https://doi.org/10.1113/EP092852","url":null,"abstract":"Magnetophosphenes are flickering lights perceived when an extremely low frequency magnetic field generates a sufficiently strong electric field in the head. Understanding how phosphenes are produced is crucial, as they form the basis for international safety standards and guidelines for both workers and the general population. However, there is still ongoing debate about whether this phenomenon originates in the retina, the cortex, or involves both. Investigating magnetophosphenes at various frequencies during dark adaptation provides deeper physiological insights into this process. Forty-one participants were exposed to varying levels of magnetic stimulation using a custom global transcranial alternative magnetic stimulation system that provided full-head exposure. Participants were divided into four groups: one light-exposed group and three dark-adapted groups, each assigned a different frequency (20, 50 and 60 Hz). Every 3 min during a 42-min dark adaptation period, participants reported their threshold for magnetophosphene perception. Flux density thresholds were then compared across groups using repeated measures ANOVAs. The data acquired showed a significant (F(15, 270) = 3.637, P < 0.001) increase in the magnetophosphene threshold throughout the 42-min darkness adaptation period. An inversed exponential decay regression was used to model the time course of the magnetophosphene threshold for each frequency. The rising magnetophosphene threshold during dark adaptation is likely linked to retinal phototransduction mechanisms, suggesting that magnetophosphene perception originates from rod cells in the retina. In addition to their significance for establishing new international guidelines and safety standards for workers and the public, our findings could also pave the way for new research into non-invasive assessments of retinal dysfunction.","PeriodicalId":12092,"journal":{"name":"Experimental Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0