Experientia最新文献_第3页

Importance of the Bcl-2 family in cell death regulation. Bcl-2家族在细胞死亡调控中的重要性。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920110

T J McDonnell, A Beham, M Sarkiss, M M Andersen, P Lo

{"title":"Importance of the Bcl-2 family in cell death regulation.","authors":"T J McDonnell, A Beham, M Sarkiss, M M Andersen, P Lo","doi":"10.1007/BF01920110","DOIUrl":"https://doi.org/10.1007/BF01920110","url":null,"abstract":"Bcl-2 was first identified as a novel transcript associated with the t(14;18) chromosomal breakpoint which occurs in most follicular lymphomas. The deregulated expression of bcl-2 was found to contribute to multistep neoplasia through the suppression of cell death, or apoptosis, in transgenic mouse models. Bcl-2 was subsequently shown to be normally expressed in a variety of tissues and to significantly inhibit the induction of apoptosis in many experimental systems. Bcl-2 is now known to be structurally similar to other proteins, in particular within the domains referred to as BH1 and BH2. This multigene family of cell death regulators includes members which enhance rates of apoptosis, including bcl-xs and bax, and those which inhibit apoptosis, including MCL-1 and bcl-xL. Members of the bcl-2 family physically interact with other proteins, including other family members and these interactions appear to modulate their function. The mechanism(s) by which bcl-2 family members regulate cell death remain in large part unknown, although recent evidence suggests that bcl-2 may interfere with cellular signalling events involved in apoptosis induction.","PeriodicalId":12087,"journal":{"name":"Experientia","volume":"52 10-11","pages":"1008-17"},"PeriodicalIF":0.0,"publicationDate":"1996-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01920110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19881438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Transglutaminase induction by various cell death and apoptosis pathways. 转谷氨酰胺酶诱导多种细胞死亡和凋亡途径。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920102

L Fesus, A Madi, Z Balajthy, Z Nemes, Z Szondy

引用次数: 50

Recognition of apoptotic cells by phagocytes. 吞噬细胞对凋亡细胞的识别。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920103

S P Hart, C Haslett, I Dransfield

引用次数: 41

Cellular catabolism in apoptosis: DNA degradation and endonuclease activation. 细胞凋亡中的细胞分解代谢:DNA降解和内切酶激活。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920104

J W Montague, J A Cidlowski

引用次数: 21

Proteases in apoptosis. 凋亡中的蛋白酶。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920106

B Zhivotovsky, D H Burgess, S Orrenius

引用次数: 18

dNTP pools imbalance as a signal to initiate apoptosis. dNTP池失衡作为启动细胞凋亡的信号。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920108

F J Oliver, M K Collins, A López-Rivas

引用次数: 30

Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis. 分歧走向死胡同?细胞凋亡中核糖体RNA不同结构域的分裂。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920105

G Houge, S O Døskeland

{"title":"Divergence towards a dead end? Cleavage of the divergent domains of ribosomal RNA in apoptosis.","authors":"G Houge, S O Døskeland","doi":"10.1007/BF01920105","DOIUrl":"https://doi.org/10.1007/BF01920105","url":null,"abstract":"In several cases of apoptotic death the large ribosomal subunit 28S rRNA is specifically cleaved. The cleavages appear at specific sites within those domains of the rRNA molecule that have shown exceptional high divergence in evolution (D domains). The cleavages accompany rather than precede apoptosis, and there is a positive, but not complete, correlation between rRNA cleavage and internucleosomal DNA fragmentation. Most cell types studied so far show two alternative cleavage pathways that are mutually exclusive. Cleavage can either start in the D8 domain with secondary cuts within a subdomain of D2 (D2c), or in the D2 domain with subsequent excision of the D2c subdomain. The latter pathway is of particular interest since D2 (unlike D8) is normally inaccessible for RNase attack. That apoptosis specifically affects the ribosomal divergent domains suggests that these domains, which make up roughly 25% of total cellular RNA, might have evolved to serve functions related to apoptosis. Future studies will be directed to test the hypothesis that rRNA fragmentation may be part of an apoptotic program directed against the elimination of illegitimate (viral?) polynucleotides.","PeriodicalId":12087,"journal":{"name":"Experientia","volume":"52 10-11","pages":"963-7"},"PeriodicalIF":0.0,"publicationDate":"1996-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01920105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19882145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis. p53肿瘤抑制基因:G1生长阻滞和细胞凋亡的中介。

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920109

E Yonish-Rouach

引用次数: 21

Apoptosis -- the story so far.... 细胞凋亡——到目前为止的故事....

Experientia Pub Date : 1996-10-31 DOI: 10.1007/BF01920101

A Samali, A M Gorman, T G Cotter

引用次数: 60

Novel diterpenoid diacylglycerols from marine molluscs: potent morphogens and protein kinase C activators. 来自海洋软体动物的新型二萜二酰基甘油:有效的形态形成因子和蛋白激酶C激活剂。

Experientia Pub Date : 1996-09-15 DOI: 10.1007/BF01938873

L De Petrocellis, P Orlando, M Gavagnin, M Ventriglia, G Cimino, V Di Marzo

引用次数: 7