European journal of respiratory diseases. Supplement最新文献_第2页

Cell culture approaches to the investigation of human airway ion transport. 细胞培养方法研究人体气道离子运输。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

R C Boucher, J R Yankaskas, C U Cotton, M R Knowles, M J Stutts

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View of the Central Union of Agricultural Producers on research and development of health services for the farming population of Finland. 农业生产者中央联盟关于研究和发展芬兰农业人口保健服务的意见。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

E Lindstedt

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Intermediate filament expression in small cell lung cancer; poor correlation to in vitro data. 小细胞肺癌中纤维的中间表达与体外数据相关性较差。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

H H Berendsen, L de Ley, S Poppema, P E Postmus, H J Sluiter, T H The

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Small cell lung cancer. 小细胞肺癌。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

L de Leij, H Berendsen, H The

{"title":"Small cell lung cancer.","authors":"L de Leij, H Berendsen, H The","doi":"","DOIUrl":"","url":null,"abstract":"It can be stated that, depending on the type of lung cancer, the best opportunity for curative treatment is in the early stage of disease, when cancer is limited to the lung and surgical intervention can be indicated. Especially in the case of SCLC, the number of patients presenting with such a limited disease is very low. In SCLC, chemo- and/or radiotherapy can induce initial good responses, which, although not curative in most cases, can elongate life for an average of 10 months. Although changes and refinements in treatment are continuously introduced, further progresses in the outcome have not achieved for the last decennium. Therefore, more fundamental research is needed to indicate new treatment avenues. A number of findings appear promising in this field. Firstly, the development of tissue culture techniques has enabled a better study of the biological properties of both SCLC and non-SCLC. Secondly, the development of monoclonal antibodies has refined the possibilities to type lung cancer. Particularly if monoclonal antibodies could be identified which occurrence turns out to be relevant to prognosis, immunohistopathology could become an important additional tool for the assessment of a pathological diagnosis in lung cancer. In addition, monoclonal antibodies which are specific for lung cancer could be used for an immunotherapeutical approach in the near future. Such a treatment might complement currently available treatment modalities.","PeriodicalId":12048,"journal":{"name":"European journal of respiratory diseases. Supplement","volume":"149 ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14167309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of mucus hypersecretion. 粘液分泌过多的处理。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

S W Clarke

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Mucociliary clearance in early simple chronic bronchitis. 早期单纯性慢性支气管炎的纤毛粘液清除率。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

H Dirksen, F Hermansen, S Groth, F Mølgaard

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The relative permeabilities of human conducting and terminal airways to 99mTcDTPA. 人体传导和末端气道相对渗透率为99mTcDTPA。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

M P Barrowcliffe, J G Jones, J E Agnew, R A Francis, S W Clarke

引用次数: 0

Airborne moulds and actinomycetes in work environment of farmers. 农民工作环境中的空气传播霉菌和放线菌。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

M H Kotimaa, E O Terho, K Husman

{"title":"Airborne moulds and actinomycetes in work environment of farmers.","authors":"M H Kotimaa, E O Terho, K Husman","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this series of studies was to investigate the quality and quantity of farmers' exposure to airborne spores during the handling of hay or grain. In the beginning, the Petri dish method and later a six-stage Andersen sampler were used to collect the samples. The number of spores of mesophilic fungi, thermotolerant fungi, thermophilic actinomycetes and fungi of the Aspergillus glaucus group were determined in order to find possible causative agents of farmer's lung disease. The level of exposure varied from 10(4) cfu/m3 to 10(7) cfu/m3 (cfu = colony forming unit). In hay, fungi of the A. glaucus group usually dominated. In grain the most common moulds were Cladosporium spp. and Penicillium spp. In both hay and grain the most common thermophilic actinomycete was Thermoactinomyces vulgaris; Micropolyspora faeni was found less frequently. Silaging was found to be the best method to prevent moulding of hay. Chemicals added during baling did not satisfactorily prevent moulding of hay. For stored grain, however, the best results were obtained with propionic acid treatment. The quality and quantity of airborne spores found suggests that farm work exposes farmers to a high risk of becoming sensitized, which leads to the development of asthma or farmer's lung. Few of the methods presently available for making or storing hay and grain can satisfactorily prevent moulding. So far, use of personal dust respirators with a type P2 (previously II b) filter seems to be the only way to effectively diminish exposure to spores.","PeriodicalId":12048,"journal":{"name":"European journal of respiratory diseases. Supplement","volume":"152 ","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14602653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Respiratory tract secretions. Proceedings of an international workshop. Killarney, Eire, 10-12 April 1985. 呼吸道分泌物。国际研讨会论文集。基拉尼，爱尔兰，1985年4月10日至12日。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

引用次数: 0

Rôle of surfactant free fatty acids in antimicrobial defenses. Rôle表面活性剂游离脂肪酸在抗菌防御中的作用。

European journal of respiratory diseases. Supplement Pub Date : 1987-01-01

J D Coonrod

{"title":"Rôle of surfactant free fatty acids in antimicrobial defenses.","authors":"J D Coonrod","doi":"","DOIUrl":"","url":null,"abstract":"Previous studies of the mechanisms of killing of inhaled bacteria have been confined to the demonstration that alveolar macrophages phagocytose and kill inhaled staphylococcus intracellularly. We have found recently th at the surfactant-containing fraction of rat bronchoalveolar lavage fluid is bactericidal for pneumococci and some other gram-positive bacteria, excluding staphylococci. In studies reviewed herein, we show that these antibacterial factors in rat surfactant are long-chain free fatty acids (FFA). Polyunsaturated FFA appear to be particularly active. Because inhaled pneumococci are cleared very rapidly in vivo in the absence of conventional opsonins, we speculate that FFA may have a rôle in pneumococcal killing. All species tested to date, including humans, dogs, and guinea pigs have detectable FFA in their surfactant, although the level of FFA in these species is lower than in rats. Human and guinea pig surfactant, in fact, have too little FFA in their pulmonary surfactant to give detectable antipneumococcal activity in vitro. Nonetheless, inhaled pneumococci are killed rapidly by guinea pigs, suggesting that the level of FFA in bronchoalveolar lavage is not a good indication of the amount of FFA on alveolar surfaces, or, alternatively that FFA may not play a rôle in pneumococcal clearance in vivo. We have recently completed histological studies which demonstrate that inhaled pneumococci are, in fact, killed extracellularly in rats. This observation adds credence to the concept that mechanisms exist in the alveoli for extracellular killing of some bacteria and indicates that further studies of FFA in this process are worthwhile.","PeriodicalId":12048,"journal":{"name":"European journal of respiratory diseases. Supplement","volume":"153 ","pages":"209-14"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14605703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0