{"title":"Reply to: \"Vessels Are Not Independent Observations in a Sex-Interaction Analysis\".","authors":"Yipu Ding, Jeroen J Bax, Alexander van Rosendael","doi":"10.1093/ehjci/jeag262","DOIUrl":"10.1093/ehjci/jeag262","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":""},"PeriodicalIF":6.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julio I Farjat-Pasos, Juan H Del Portillo, Laurent Biertho, Simon Marceau, Benoît M Labbé, David Belzile, Kim O'Connor, Jonathan Beaudoin, Mathieu Bernier, Jean-Michel Paradis, Stephan Langevin, Erwan Salaun, Josep Rodés-Cabau
{"title":"Usefulness of oesophageal irrigation during transoesophageal echocardiographic guidance for structural heart interventions.","authors":"Julio I Farjat-Pasos, Juan H Del Portillo, Laurent Biertho, Simon Marceau, Benoît M Labbé, David Belzile, Kim O'Connor, Jonathan Beaudoin, Mathieu Bernier, Jean-Michel Paradis, Stephan Langevin, Erwan Salaun, Josep Rodés-Cabau","doi":"10.1093/ehjci/jeag167","DOIUrl":"10.1093/ehjci/jeag167","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1890-1892"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Anderton, Bradley Chambers, Maryum Farooq, Chin Yit Soo, Mehak Asad, Michelle Gibbs, Peter Harrison, Osama Tariq, Wasim Javed, Erica Dall'Armellina, Peter Kellman, Sven Plein, Peter P Swoboda, Masafumi Takafuji
{"title":"Impact of rate-pressure product correction of myocardial blood flow on the prognostic relevance in patients with heart failure.","authors":"Thomas Anderton, Bradley Chambers, Maryum Farooq, Chin Yit Soo, Mehak Asad, Michelle Gibbs, Peter Harrison, Osama Tariq, Wasim Javed, Erica Dall'Armellina, Peter Kellman, Sven Plein, Peter P Swoboda, Masafumi Takafuji","doi":"10.1093/ehjci/jeag193","DOIUrl":"10.1093/ehjci/jeag193","url":null,"abstract":"<p><strong>Aims: </strong>Quantitative perfusion cardiac magnetic resonance (QP-CMR) allows estimation of myocardial blood flow (MBF) and myocardial perfusion reserve (MPR). Resting MBF values are often corrected for the rate-pressure product (RPP). We aimed to assess the effect of RPP correction on MBF values and the prognostic value of QP-CMR in patients with heart failure (HF).</p><p><strong>Methods and results: </strong>QP-CMR data from 641 prospectively recruited patients with HF and 184 healthy volunteers were analysed. Rest MBF was corrected for RPP (MBFcorr = rest MBFuncorr×10 000/RPP). Corrected MPR was defined as uncorrected stress MBF/rest MBFcorr. The primary endpoint was a composite of heart failure hospitalization (HFH) and all-cause mortality. RPP correction increased rest MBF and decreased MPR to a greater extent in healthy volunteers than in patients. During median follow-up of 3.5 years, 101 events occurred (55 deaths and 46 HFH). Patients who reached the primary endpoint had significantly higher rest MBFuncorr and lower MPRuncorr. Rest MBFuncorr (adjusted hazard ratio per 1 mL/g/min increase, 3.97, 95% confidence interval [CI] 1.93-8.16, P < 0.001) and MPRuncorr (adjusted hazard ratio per 1-unit increase, 0.74, 95% CI 0.57-0.95, P = 0.024) were significantly associated with the primary endpoint in univariate and multivariate models. After RPP correction, these associations were no longer significant. Kaplan-Meier analysis revealed significant differences in event-free survival for rest MBFuncorr (P = 0.005), MPRuncorr (P < 0.001), and MPRcorr (P = 0.044), but not for rest MBFcorr (P = 0.076).</p><p><strong>Conclusion: </strong>Uncorrected rest MBF and MPR by QP-CMR are independently predictive of adverse outcomes in patients with HF. RPP correction changes MBF and MPR values and attenuates their predictive value.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1817-1826"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148583832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katsuji Inoue, Lars-Egil R Hammersboen, Otto A Smiseth
{"title":"Diastolic function and HFpEF: are classifications and probability scores enough?","authors":"Katsuji Inoue, Lars-Egil R Hammersboen, Otto A Smiseth","doi":"10.1093/ehjci/jeag201","DOIUrl":"10.1093/ehjci/jeag201","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1885-1886"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gal Tsaban, Giovanni Benfari, Benjamin A Essayagh, Eunjung Lee, Manuel A Montoya Hernandez, Prabin Thapa, Vuyisile T Nkomo, Sorin V Pislaru, Hector I Michelena, Maurice Enriquez-Sarano
{"title":"Decoding the complexity of tricuspid regurgitation prognostic drivers using explainable artificial intelligence.","authors":"Gal Tsaban, Giovanni Benfari, Benjamin A Essayagh, Eunjung Lee, Manuel A Montoya Hernandez, Prabin Thapa, Vuyisile T Nkomo, Sorin V Pislaru, Hector I Michelena, Maurice Enriquez-Sarano","doi":"10.1093/ehjci/jeag168","DOIUrl":"10.1093/ehjci/jeag168","url":null,"abstract":"<p><strong>Aims: </strong>Prognosis in tricuspid regurgitation (TR) is shaped by complex clinical and haemodynamic interactions, complicating risk stratification. We aimed to use explainable artificial intelligence (EAI) to model these relationships and identify key predictors of outcomes.</p><p><strong>Methods and results: </strong>We analysed long-term all-cause mortality in a large prospective registry of patients with native TR across the full severity spectrum. Patients underwent detailed clinical evaluation and quantitative Doppler-echocardiography. Supervised EAI models were applied to identify and rank predictors of mortality under medical therapy, capturing non-linear associations and interactions among baseline characteristics.Among 9761 patients [mean age 73 ± 15 years; 56.9% women; effective regurgitant orifice area (EROA) 40 (30-56) mm2; regurgitant volume 39 (29-53) mL/beat; 42% severe TR], 2676 deaths occurred during 3.8 ± 4.6 years of follow-up. EAI identified and ranked 20 prognostic determinants of survival. Haemodynamic measures, led by elevated pulmonary-artery systolic and right-atrial pressures, were strongest, followed by age and comorbidity. TR-related variables ranked next, led by right ventricular dysfunction and EROA, which outperformed integrative TR grade and TRIScore. Left-ventricular parameters were less influential. Non-linear effects, including those involving ejection fraction, and interactions such as higher EROA-related risk with elevated pulmonary pressures or lower TRIScore (both P < 0.03) were observed. Proportional hazards models confirmed EROA as the strongest TR severity marker (P < 0.0001), with excess mortality beginning at 40 mm2 and increasing further at 60 mm2.</p><p><strong>Conclusion: </strong>EAI ranked mortality predictors in TR, highlighting patient factors, haemodynamics, TR-specific measures, and left-ventricular function. Among TR-specific measures, EROA and TRIScore were most prognostic. Recognizing their impact can refine risk stratification, guide intervention timing, and inform long-term management.</p>","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1830-1841"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to: Achieved LDL-C strata do not establish NIRS as a treatment-benefit marker.","authors":"Yu Kataoka, Stephen J Nicholls, Teruo Noguchi","doi":"10.1093/ehjci/jeag217","DOIUrl":"10.1093/ehjci/jeag217","url":null,"abstract":"","PeriodicalId":12026,"journal":{"name":"European Heart Journal - Cardiovascular Imaging","volume":" ","pages":"1897-1898"},"PeriodicalIF":6.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148860313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}