European Journal of Human Genetics最新文献_第10页

Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population 日本人群中多发性系统萎缩和未确诊共济失调患者FGF14内含子GAA重复扩增的频率。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-27 DOI: 10.1038/s41431-024-01743-3

Toshiyuki Kakumoto, Kenta Orimo, Takashi Matsukawa, Jun Mitsui, Tomohiko Ishihara, Osamu Onodera, Yuta Suzuki, Shinichi Morishita, Japan Multiple System Atrophy Registry Consortium, Tatsushi Toda, Shoji Tsuji

{"title":"Frequency of FGF14 intronic GAA repeat expansion in patients with multiple system atrophy and undiagnosed ataxia in the Japanese population","authors":"Toshiyuki Kakumoto, Kenta Orimo, Takashi Matsukawa, Jun Mitsui, Tomohiko Ishihara, Osamu Onodera, Yuta Suzuki, Shinichi Morishita, Japan Multiple System Atrophy Registry Consortium, Tatsushi Toda, Shoji Tsuji","doi":"10.1038/s41431-024-01743-3","DOIUrl":"10.1038/s41431-024-01743-3","url":null,"abstract":"Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by autonomic nervous system dysfunction and cerebellar ataxia or parkinsonism. Recently, expanded GAA repeats (≥250 repeat units) in intron 1 of FGF14 have been shown to be responsible for spinocerebellar ataxia type 27B (SCA27B), a late-onset ataxia with an autosomal dominant inheritance. Patients with SCA27B may also exhibit autonomic nervous system dysfunction, potentially overlapping with the clinical presentations of MSA patients. In this study, to explore the possible involvement of expanded GAA repeats in MSA, we investigated the frequencies of expanded GAA repeats in FGF14 in 548 patients with MSA, 476 patients with undiagnosed ataxia, and 455 healthy individuals. To fully characterize the structures of the expanded GAA repeats, long-range PCR products suggesting the expansion of GAA repeats were further analyzed using a long-read sequencer. Of the 548 Japanese MSA patients, we identified one MSA patient (0.2%) carrying an expanded repeat with (GAA)≥250. Among the 476 individuals with undiagnosed ataxia, (GAA)≥250 was observed in six (1.3%); this frequency was higher than that in healthy individuals (0.2%). The clinical characteristics of the MSA patient with (GAA)≥250 were consistent with those of MSA, but not with SCA27B. Further research is warranted to explore the possibility of the potential association of expanded GAA repeats in FGF14 with MSA.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":"33 3","pages":"325-333"},"PeriodicalIF":3.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41431-024-01743-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What does a consent conversation for whole genome sequencing look like in the NHS Genomic Medicine Service? An observational study. 在英国国家医疗服务系统基因组医学服务中，全基因组测序的同意谈话是什么样的？一项观察研究。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-26 DOI: 10.1038/s41431-024-01749-x

Holly Ellard, Huda Alfardus, Saskia Sanderson, Celine Lewis

{"title":"What does a consent conversation for whole genome sequencing look like in the NHS Genomic Medicine Service? An observational study.","authors":"Holly Ellard, Huda Alfardus, Saskia Sanderson, Celine Lewis","doi":"10.1038/s41431-024-01749-x","DOIUrl":"10.1038/s41431-024-01749-x","url":null,"abstract":"Patient choice consent for whole genome sequencing (WGS) through the Genomic Medicine Service in England covers consent to diagnostic testing and an invitation to the National Genomic Research Library (NGRL). Little is known about what consent conversations for WGS look like in practice. We audio-recorded and analysed the content and structure of consent appointments (n = 26) between healthcare professionals (HCPs) and parents of children with rare disease across seven NHS Trusts. Appointments frequently covered the potential findings from testing, implications for family members, and DNA storage, but often omitted that data may be reanalysed in the future if a diagnosis is not made. Consent to the NGRL was typically sought during the same appointment; these discussions varied in content, but frequently included a background to the NGRL and data security. HCPs often tempered expectations around what WGS can achieve and asked questions to clarify parents' understanding, but less commonly elicited parents' values and concerns. Administrative tasks were time-consuming, but took less time when consent was recorded digitally. Future training should emphasise how to elicit patients' values and concerns. Digital infrastructure and hiring roles such as genomic associates to support consent may be important strategies to meet the workload demands of WGS.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular diagnoses and candidate gene identification in the congenital heart disease cohorts of the 100,000 genomes project. 十万基因组计划先天性心脏病队列中的分子诊断和候选基因鉴定。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-26 DOI: 10.1038/s41431-024-01744-2

Verity Hartill, Mitra Kabir, Sunayna Best, Wasay Mohiuddin Shaikh Qureshi, Stephanie L Baross, Jenny Lord, Jing Yu, Erina Sasaki, Hazel Needham, Deborah Shears, Matthew Roche, Elizabeth Wall, Nicola Cooper, Gavin Ryan, Jacqueline Eason, Robert Johnson, Bernard Keavney, Kathryn E Hentges, Colin A Johnson

{"title":"Molecular diagnoses and candidate gene identification in the congenital heart disease cohorts of the 100,000 genomes project.","authors":"Verity Hartill, Mitra Kabir, Sunayna Best, Wasay Mohiuddin Shaikh Qureshi, Stephanie L Baross, Jenny Lord, Jing Yu, Erina Sasaki, Hazel Needham, Deborah Shears, Matthew Roche, Elizabeth Wall, Nicola Cooper, Gavin Ryan, Jacqueline Eason, Robert Johnson, Bernard Keavney, Kathryn E Hentges, Colin A Johnson","doi":"10.1038/s41431-024-01744-2","DOIUrl":"10.1038/s41431-024-01744-2","url":null,"abstract":"Congenital heart disease (CHD) describes a structural cardiac defect present from birth. A cohort of participants recruited to the 100,000 Genomes Project (100 kGP) with syndromic CHD (286 probands) and familial CHD (262 probands) were identified. \"Tiering\" following genome sequencing data analysis prioritised variants in gene panels linked to participant phenotype. To improve diagnostic rates in the CHD cohorts, we implemented an agnostic de novo Gene Discovery Pipeline (GDP). We assessed de novo variants (DNV) for unsolved CHD participants following filtering to select variants of interest in OMIM-morbid genes, as well as novel candidate genes. The 100kGP CHD cohorts had low rates of pathogenic diagnoses reported (combined CHD \"solved\" 5.11% (n = 28/548)). Our GDP provided diagnostic uplift of nearly one third (1.28% uplift; 5.11% vs. 6.39%), with a new or potential diagnosis for 9 additional participants with CHD. When a filtered DNV occurred within a non-morbid gene, our GDP prioritised biologically-plausible candidate CHD genes (n = 79). Candidate variants occurred in both genes linked to cardiac development (e.g. AKAP13 and BCAR1) and those currently without a known role (e.g. TFAP2C and SETDB1). Sanger sequencing of a cohort of patients with CHD did not identify a second de novo variant in the candidate dataset. However, literature review identified rare variants in HMCN1, previously reported as causative for pulmonary atresia, confirming the approach utility. As well as diagnostic uplift for unsolved participants of the 100 kGP, our GDP created a dataset of candidate CHD genes, which forms an important resource for further evaluation.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considering severity in the design of reproductive genetic carrier screening programs: screening for severe conditions 在设计生殖遗传携带者筛查计划时考虑严重程度：筛查严重病症。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-25 DOI: 10.1038/s41431-024-01738-0

Lucinda Freeman, Alison D. Archibald, Lisa Dive, Martin B. Delatycki, Edwin P. Kirk, Nigel Laing, Ainsley J. Newson

{"title":"Considering severity in the design of reproductive genetic carrier screening programs: screening for severe conditions","authors":"Lucinda Freeman, Alison D. Archibald, Lisa Dive, Martin B. Delatycki, Edwin P. Kirk, Nigel Laing, Ainsley J. Newson","doi":"10.1038/s41431-024-01738-0","DOIUrl":"10.1038/s41431-024-01738-0","url":null,"abstract":"Reproductive genetic carrier screening (RGCS) provides information about people’s chance of having children with certain genetic conditions, to inform reproductive decision making. RGCS at population scale requires a robust and streamlined program that is purposively designed and formally implemented to ensure equity and consistency. There are many considerations in selecting conditions, genes and variants for inclusion in RGCS, with severity of the genetic condition a key criterion. However, the concept of severity is complex and often underspecified in available guidelines. Severity is often determined in relation to other contextual features and can be experienced differently by individuals who all have the same condition. While some genetic conditions are unambiguously considered severe, there are many factors that contribute to how severe a condition is perceived to be (and by whom), and perspectives will vary. In this paper, we analyse why severity is an important criterion when selecting conditions, genes or variants to be included in RGCS. We suggest that screening programs should be oriented more towards variants and genes associated with severe conditions. We discuss the importance of taking a practical approach to gene selection in a carrier screening program when presenting the offer at population scale.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":"33 2","pages":"194-198"},"PeriodicalIF":3.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41431-024-01738-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Slowly progressive autosomal dominant Alport Syndrome due to COL4A3 splicing variant. 更正：由 COL4A3 剪接变异导致的缓慢进展型常染色体显性阿尔波特综合征。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-25 DOI: 10.1038/s41431-024-01736-2

Sergio Daga, Lorenzo Loberti, Giulia Rollo, Loredaria Adamo, Olga Lorenza Colavecchio, Giulia Brunelli, Kristina Zguro, Sergio Antonio Tripodi, Andrea Guarnieri, Guido Garosi, Romina D'Aurizio, Francesca Ariani, Rossella Tita, Alessandra Renieri, Anna Maria Pinto

引用次数: 0

Polygenic risk scores in the clinic: a systematic review of stakeholders’ perspectives, attitudes, and experiences 临床中的多基因风险评分：对利益相关者的观点、态度和经验的系统回顾。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-23 DOI: 10.1038/s41431-024-01747-z

Lara Andreoli, Hilde Peeters, Kristel Van Steen, Kris Dierickx

{"title":"Polygenic risk scores in the clinic: a systematic review of stakeholders’ perspectives, attitudes, and experiences","authors":"Lara Andreoli, Hilde Peeters, Kristel Van Steen, Kris Dierickx","doi":"10.1038/s41431-024-01747-z","DOIUrl":"10.1038/s41431-024-01747-z","url":null,"abstract":"Polygenic Risk Scores (PRS) are statistical methods estimating part of an individual’s genetic susceptibility to various disease phenotypes. Their potential clinical applications to enhance the prediction, prevention, and risk management of complex conditions motivate current research efforts worldwide. While a growing body of literature has highlighted the scientific and ethical limitations of PRS, the technology’s clinical translation will present both opportunities and challenges for the stakeholders involved. Here, a mixed-method systematic review of empirical studies was performed to gather evidence on the perspectives, attitudes, and experiences of healthcare providers, patients, and the public regarding the use of PRS in healthcare settings. The PRISMA reporting protocol was followed and 24 articles were included. Three major themes were identified. First, we reported on participants’ familiarity with the test, including their knowledge, understanding, and education on PRS’ clinical use. The second theme collects stakeholders’ motivations for taking the test and their perspectives on sensitive issues related to the return of results. Participants’ normative stances regarding the appropriate use of PRS, their benefits, and harms were presented in the third theme. The findings underscore significant knowledge gaps and challenges in the clinical interpretation of PRS among healthcare providers. On the other hand, the provision of genetic counseling benefitted patients’ understanding of PRS results and in most cases, no psychosocial burden was reported. Finally, the review highlights that stakeholders’ perspectives on the clinical use of PRS are highly context-dependent, shaped by population characteristics, disease type, and social factors, emphasizing the need for tailored approaches across diverse healthcare settings.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":"33 3","pages":"266-280"},"PeriodicalIF":3.7,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-22 DOI: 10.1038/s41431-024-01745-1

Giulia Ferrera, Kevork Derderian, Rossella Izzo, Barbara Gnutti, Andrea Legati, Giovanna Zorzi, Eleonora Lamantea, Arcangela Iuso, Anna Ardissone

{"title":"WDR45-related encephalopathy mimicking Leigh syndrome associated with complex I deficiency: a case report","authors":"Giulia Ferrera, Kevork Derderian, Rossella Izzo, Barbara Gnutti, Andrea Legati, Giovanna Zorzi, Eleonora Lamantea, Arcangela Iuso, Anna Ardissone","doi":"10.1038/s41431-024-01745-1","DOIUrl":"10.1038/s41431-024-01745-1","url":null,"abstract":"Pathogenic WDR45 variants cause neurodevelopmental disorders (NDDs) including β-propeller protein-associated neurodegeneration (BPAN), characterized by developmental delay (DD), ataxia and extrapyramidal signs. Our patient, initially presenting at 22 months with DD, now, aged 7, shows intellectual disability, ataxia and rigidity. MRI findings were suggestive of Leigh syndrome, a mitochondrial disorder (MD) phenotype, with no brain iron accumulation. Reduced activity of respiratory chain complex I (cI) and complex II (cII) was identified in muscle and fibroblasts, and a cII reduction in muscle only; however, a primary MD was excluded. Exome sequencing revealed a de novo pathogenic WDR45 variant. Autophagic flux analysis showed a mildly reduced p62 response, with normal autophagy progression. This is the first report linking WDR45 to cI assembly and activity, indicating mitochondrial dysfunction as a potential pathophysiological BPAN mechanism. We recommend considering WDR45-related NDDs when diagnosing early-onset NDDs, particularly Leigh-like encephalopathies with cI deficiency, even without brain iron accumulation.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":"33 2","pages":"248-251"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Huntingtin CAG repeat size variations below the Huntington's disease threshold: associations with depression, anxiety and basal ganglia structure. 低于亨廷顿病阈值的亨廷廷蛋白 CAG 重复大小变异：与抑郁、焦虑和基底神经节结构的关联。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-21 DOI: 10.1038/s41431-024-01737-1

Magdalena Vater, Nicolas Rost, Gertrud Eckstein, Susann Sauer, Alina Tontsch, Angelika Erhardt, Susanne Lucae, Tanja Brückl, Thomas Klopstock, Philipp G Sämann, Elisabeth B Binder

{"title":"Huntingtin CAG repeat size variations below the Huntington's disease threshold: associations with depression, anxiety and basal ganglia structure.","authors":"Magdalena Vater, Nicolas Rost, Gertrud Eckstein, Susann Sauer, Alina Tontsch, Angelika Erhardt, Susanne Lucae, Tanja Brückl, Thomas Klopstock, Philipp G Sämann, Elisabeth B Binder","doi":"10.1038/s41431-024-01737-1","DOIUrl":"https://doi.org/10.1038/s41431-024-01737-1","url":null,"abstract":"Huntington's disease (HD) is strongly associated with psychiatric symptoms, yet, associations between huntingtin gene (HTT) CAG repeat size variations and psychiatric phenotypes outside the HD complex are still under-investigated. In this genetic case-control study we compared the distribution of HTT CAG repeat sizes in predefined ranges between patients with major depressive disorder (MDD) (n = 2136) and anxiety disorders (ANX) (n = 493), and healthy controls (CON) (n = 1566). We used regression models to study interactions between the alleles and associations with fine-granular clinical phenotypes and basal ganglia structure. HD mutations in the range of incomplete penetrance (36-39 repeats) were not overrepresented in patients. In participants older than 48 years, 13-20 repeats on both HTT alleles were associated with a reduced ANX risk whereas a 13-20 | 21-26 combination was associated with an increased ANX risk. Post-hoc analyses confirmed a turning point around 21 repeats and trends in the same direction were detected for MDD. The joint patient | CON analysis of the full spectrum of allele combinations confirmed interaction effects and age-dependent allele | risk profiles. A short-by-long interaction effect and an age-dependent negative correlation of the short allele on the nucleus accumbens volume was detected, independently of the diagnostic group. In conclusion, we revealed that HTT CAG repeat sizes of both alleles in the non-HD range are associated with a risk modulation for common psychiatric disorders as well as basal ganglia structure differences in an age-dependent way, possibly implying that normal variation of the functionally diverse wildtype huntingtin protein may impact brain function.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

November in EJHG: looking at genetic counsellor training in Europe, novel clinical guidelines and ancestral impact on variant interpretation EJHG 杂志 11 月刊：关注欧洲遗传咨询师培训、新临床指南和祖先对变异解释的影响

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-19 DOI: 10.1038/s41431-024-01713-9

Alisdair McNeill

引用次数: 0

Using a behaviour-change approach to support uptake of population genomic screening and management options for breast or prostate cancer 采用改变行为的方法，支持人群接受乳腺癌或前列腺癌基因组筛查和管理方案。

IF 3.7 2区生物学

European Journal of Human Genetics Pub Date : 2024-11-12 DOI: 10.1038/s41431-024-01729-1

Zoe Fehlberg, Louise Fisher, Cun Liu, Nathasha Kugenthiran, Roger L. Milne, Mary-Anne Young, Amanda Willis, Melissa C. Southey, Ilias Goranitis, Stephanie Best

{"title":"Using a behaviour-change approach to support uptake of population genomic screening and management options for breast or prostate cancer","authors":"Zoe Fehlberg, Louise Fisher, Cun Liu, Nathasha Kugenthiran, Roger L. Milne, Mary-Anne Young, Amanda Willis, Melissa C. Southey, Ilias Goranitis, Stephanie Best","doi":"10.1038/s41431-024-01729-1","DOIUrl":"10.1038/s41431-024-01729-1","url":null,"abstract":"As the possibility of implementing population genomic screening programs for the risk of developing hereditary cancers in health systems increases, understanding how to support individuals who wish to have genomic screening is essential. This qualitative study aimed to link public perceived barriers to a) taking up the offer of population genomic screening for breast or prostate cancer risk and b) taking up risk-management options following their result, with possible theory-informed behaviour-change approaches that may support implementation. Ten focus groups were conducted with a total of 25 members of the Australian public to identify and then categorise barriers within the behaviour-change Capability, Opportunity, Motivation - Behaviour (COM-B) model. Ten COM-B categorised barriers were identified as perceived influences on an individual’s intentions to take-up the offer, including Capability (e.g., low public awareness), Opportunity (e.g., inconvenient sample collection procedure) and Motivation (e.g., genomic screening not perceived as relevant to an individual). Ten barriers for taking up risk-management options included Motivation (e.g., concerns about adverse health impact) and Opportunity (e.g., social opportunity and cost incurred to the individual). Our findings demonstrate that a nuanced approach is required to support people to take-up the offer of population genomic screening and, where appropriate, to adopt risk-management options. Even amongst participants who were enthusiastic about a population genomic screening program, needs were varied, demanding a range of implementation strategies. Promulgating equitable uptake of genomic screening and management options for breast and prostate cancer risk will require a needs-based approach.","PeriodicalId":12016,"journal":{"name":"European Journal of Human Genetics","volume":"33 1","pages":"108-120"},"PeriodicalIF":3.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0