European Journal of Clinical Investigation最新文献

{"title":"The role of mean platelet volume in metabolic dysfunction associated steatotic liver disease.","authors":"Papagiouvanni Ioanna, Nervas Vasileios, Gouta Chrysoula, Savvidou Savvoula","doi":"10.1111/eci.70074","DOIUrl":"https://doi.org/10.1111/eci.70074","url":null,"abstract":"<p><strong>Background: </strong>Mean platelet volume (MPV) has been reported significantly higher in patients with metabolic dysfunction associated steatotic liver disease (MASLD), suggesting a thrombogenic effect with an inconclusive link to excess risk for cardiovascular disease (CVD). The aim of this cross-sectional study was to elucidate the role of MPV in MASLD and review the literature.</p><p><strong>Methods: </strong>A cohort of consecutive biopsy-proven MASLD patients was retrospectively investigated for possible associations of MPV with histological features of the disease and, separately, with patients' estimated risk for CVD. CVD Risk was assessed with three different scores: QRISK2, HellenicSCORE II and NAFLD CV Risk. Laboratory investigation included calculation of insulin resistance with the Homeostasis Model Assessment (HOMA) and measurement of serum adiponectin in a subgroup of patients.</p><p><strong>Results: </strong>In a total of 139 MASLD patients, 56 (40.3%) with advanced fibrosis (F3/F4) steatohepatitis were included. MPV exceeded the upper limit of normal (=10 fl) in a significant proportion of study participants (n = 28.1%), with an overall mean of 9.4 ± .9 fl. Statistically significant associations of MPV with platelet count (Pearson correlation, p < .001), with fibrosis stage (one-way ANOVA, p = .040), with adiponectin (Spearman's correlation, p = .033), and all three different CVD Risk scores were found. Finally, a strong negative correlation was detected between serum adiponectin and CVD Risk scores.</p><p><strong>Conclusions: </strong>In this study's cohort of MASLD patients, high MPV was associated with higher fibrosis stages and with increased estimated risk for CVD. Correlations of serum adiponectin to MPV and CVD risk scores support its implication as a cytokine-mediator that has to be further studied.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70074"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review.","authors":"Janaina B Medina, Fábio França Vieira E Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez-Jardón, María Elena Padín-Iruegas, Mario Pérez-Sayáns, Paulo Henrique Braz-Silva, Karem L Ortega","doi":"10.1111/eci.70068","DOIUrl":"https://doi.org/10.1111/eci.70068","url":null,"abstract":"<p><strong>Background: </strong>Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.</p><p><strong>Methods: </strong>The protocol of this review was registered in PROSPERO (CRD42022331049) and performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Results: </strong>Thirty-three articles were selected and different groups of patients were assessed. In the solid organ and hematopoietic stem cell transplant groups, most studies reported that TTV viral load (VL) was highly detectable after transplantation and compared to controls, but the association with immune parameters showed conflicting results. In melanoma patients, no statistical difference in TTV VL was identified between susceptible and treatment-resistant patients. In lung cancer patients, viral load increases significantly with disease progression but decreases after chemotherapy. HIV-positive patients showed a higher VL than controls, but an inverse correlation with CD4+ was observed in half of the studies. Although 57.14% of all studies presented a low risk of bias, significant differences were observed between studies, particularly in the choice of the analyzed outcome, the parameter used to evaluate the patient's immune status, the presence of a control group, and the sample collection time points.</p><p><strong>Conclusions: </strong>Although TTV seems to have the potential to be a promising biomarker of immunosuppression, further high-quality prospective clinical studies are still needed.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70068"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal stem cell-mediated mitochondrial transfer regulates the fate of B lymphocytes.","authors":"Veronika Somova, Natalie Jaborova, Bianka Porubska, Daniel Vasek, Natalie Fikarova, Martin Prevorovsky, Zuzana Nahacka, Jiri Neuzil, Magdalena Krulova","doi":"10.1111/eci.70073","DOIUrl":"https://doi.org/10.1111/eci.70073","url":null,"abstract":"<p><strong>Background: </strong>Mitochondrial transfer is becoming recognized as an important immunomodulatory mechanism used by mesenchymal stem cells (MSCs) to influence immune cells. While effects on T cells and macrophages have been documented, the influence on B cells remains unexplored. This study investigates the modulation of B lymphocyte fate by MSC-mediated mitochondrial transfer.</p><p><strong>Methods: </strong>MSCs labelled with MitoTracker dyes or derived from mito::mKate2 transgenic mice were co-cultured with splenocytes. Flow cytometry assessed mitochondrial transfer, reactive oxygen species (ROS) levels, apoptosis and mitophagy. Glucose uptake was measured using the 2-NBDG assay. RNA sequencing analysed gene expression changes in CD19+ mitochondria recipients and nonrecipients. Pathway analysis identified affected processes. In an LPS-induced inflammation model, mito::mKate2 MSCs were administered, and B cells from different organs were analysed for mitochondrial uptake and phenotypic changes. MSC-derived mitochondria were also isolated to confirm uptake by FACS-sorted CD19+ cells.</p><p><strong>Results: </strong>MSCs transferred mitochondria to CD19+ cells, though less than to other immune cells. Transfer correlated with ROS levels and mitophagy induction. Mitochondria were preferentially acquired by activated B cells, as indicated by increased CD69 expression and glycolytic activity. Bidirectional transfer occurred, with immune cells exchanging dysfunctional mitochondria for functional ones. CD19+ recipients exhibited increased viability, proliferation and altered gene expression, with upregulated cell division genes and downregulated antigen presentation genes. In vivo, mitochondrial acquisition reduced B cell activation and inflammatory cytokine production. Pre-sorted B cells also acquired isolated mitochondria, exhibiting a similar anti-inflammatory phenotype.</p><p><strong>Conclusions: </strong>These findings highlight mitochondrial trafficking as a key MSC-immune cell interaction mechanism with immunomodulatory therapeutic potential.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70073"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation.","authors":"Federico Carbone, Jean-Pierre Després, John P A Ioannidis, Ian J Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz-Esquiroz, Javier Gómez-Ambrosi, Emma Chávez-Manzanera, Verónica Vázquez-Velázquez, Jean-Michel Oppert, Dimitrios N Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco","doi":"10.1111/eci.70059","DOIUrl":"https://doi.org/10.1111/eci.70059","url":null,"abstract":"<p><strong>Background: </strong>Most forms of obesity are associated with chronic diseases that remain a global public health challenge.</p><p><strong>Aims: </strong>Despite significant advancements in understanding its pathophysiology, effective management of obesity is hindered by the persistence of knowledge gaps in epidemiology, phenotypic heterogeneity and policy implementation.</p><p><strong>Materials and methods: </strong>This consensus statement by the European Society for Clinical Investigation identifies eight critical areas requiring urgent attention. Key gaps include insufficient long-term data on obesity trends, the inadequacy of body mass index (BMI) as a sole diagnostic measure, and insufficient recognition of phenotypic diversity in obesity-related cardiometabolic risks. Moreover, the socio-economic drivers of obesity and its transition across phenotypes remain poorly understood.</p><p><strong>Results: </strong>The syndemic nature of obesity, exacerbated by globalization and environmental changes, necessitates a holistic approach integrating global frameworks and community-level interventions. This statement advocates for leveraging emerging technologies, such as artificial intelligence, to refine predictive models and address phenotypic variability. It underscores the importance of collaborative efforts among scientists, policymakers, and stakeholders to create tailored interventions and enduring policies.</p><p><strong>Discussion: </strong>The consensus highlights the need for harmonizing anthropometric and biochemical markers, fostering inclusive public health narratives and combating stigma associated with obesity. By addressing these gaps, this initiative aims to advance research, improve prevention strategies and optimize care delivery for people living with obesity.</p><p><strong>Conclusion: </strong>This collaborative effort marks a decisive step towards mitigating the obesity epidemic and its profound impact on global health systems. Ultimately, obesity should be considered as being largely the consequence of a socio-economic model not compatible with optimal human health.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70059"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergency department glucose cut-off for 2-year mortality: A multicentre, prospective, cohort study.","authors":"Carmen Barbero Linares, José Luis Martín-Conty, Begoña Polonio-López, Cristina Rivera Picón, Juan J Bernal-Jiménez, Francisca Torres Falguera, Joseba Rabanales Sotos, Miguel Antonio Sampedro-Nuñez, Fernando Sebastián-Valles, Miguel Ángel Castro Villamor, Carlos Del Pozo Vegas, Marta Pérez González, Raúl López-Izquierdo, Francisco Martín-Rodríguez, Ancor Sanz-García","doi":"10.1111/eci.70066","DOIUrl":"https://doi.org/10.1111/eci.70066","url":null,"abstract":"<p><strong>Introduction: </strong>Admission glucose levels in acute illnesses are critical prognostic biomarkers; yet their impact on long-term outcomes has not been sufficiently studied, particularly in emergency medical services (EMS). This study aims to establish specific glucose cut-off points to predict 2-year mortality in patients treated in emergency departments (ED), stratified by diabetes status (Nondiabetic, Uncomplicated diabetes and Complicated diabetes).</p><p><strong>Methods: </strong>A multicentre, prospective cohort study was conducted, including 5632 adult patients with acute illnesses managed by EMS and admitted to EDs in three Spanish provinces. Patients were classified as nondiabetic, with uncomplicated diabetes, or with diabetes with complications. Multivariable analyses were used to identify predictors of 2-year mortality and determine specific glucose cut-off points.</p><p><strong>Results: </strong>In nondiabetic patients, admission glucose levels showed a U-shaped relationship with 2-year mortality, with key cut-off points at 76.1 and 143 mg/dL. Conversely, no significant association between glucose levels and mortality was observed in diabetic patients. Predictors of mortality included advanced age, high aCCI scores and organ dysfunction in nondiabetics, while diabetic patients exhibited additional alterations related to chronic inflammation and coagulation.</p><p><strong>Conclusion: </strong>Admission glucose levels are a key biomarker for predicting 2-year mortality in nondiabetic patients treated in EDs, emphasizing the importance of maintaining glucose within optimal ranges. These findings support the development of personalised management strategies based on the metabolic and clinical status of patients, optimising resources and outcomes in EMS and EDs.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70066"},"PeriodicalIF":4.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing the heat: Thermostable analogs of Bst polymerase allow high-temperature LAMP.","authors":"Rita Silva Ramos Madureira Simões, João Paulo Soeiro Terra Teodoro, Pedro Miguel Bule Gomes, Carlos Mendes Godinho de Andrade Fontes","doi":"10.1111/eci.70071","DOIUrl":"https://doi.org/10.1111/eci.70071","url":null,"abstract":"<p><strong>Background: </strong>Loop-mediated isothermal amplification (LAMP) is a nucleic acid amplification method that gained prominence during the early months of the COVID-19 pandemic due to its simplicity, sensitivity and robustness. However, this technique is susceptible to non-specific amplifications, raising concerns about false-positive results and reduced diagnostic accuracy. A primary contributor to false-positive testing is primer dimerization, which can theoretically be mitigated by performing reactions at higher temperatures. Unfortunately, the strand-displacing DNA polymerases typically used in LAMP, such as Bst, exhibit reduced efficiency at elevated temperatures. To address this limitation, we hypothesised that naturally occurring thermophilic analogs of Bst may be capable of supporting LAMP at higher temperatures, thereby improving reaction specificity.</p><p><strong>Methods: </strong>Bioinformatics and recombinant enzyme production allowed the identification and synthesis of several Bst analogs. These were tested in real-time LAMP assays to detect diverse targets, in a wide range of reaction temperatures (63°C-75°C) and in the presence of typical qPCR inhibitors.</p><p><strong>Results: </strong>Three polymerases-Bst_7, Bst_8 and Bst_15-demonstrated exceptional activity and robust stability at higher temperature conditions (up to 72.5°C), while displaying considerable resistance to common qPCR inhibitors.</p><p><strong>Conclusions: </strong>The identified thermophilic Bst analogs represent a potential solution for the mitigation of non-specific amplification in LAMP, further boosting the application of this technique in molecular diagnostic settings.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70071"},"PeriodicalIF":4.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-house editorials and journalistic pieces comprise a massive corpus in the scientific literature that can be improved.","authors":"John P A Ioannidis, Michaéla C Schippers","doi":"10.1111/eci.70061","DOIUrl":"https://doi.org/10.1111/eci.70061","url":null,"abstract":"<p><p>In-house editorials and journalistic pieces are massively published in peer-reviewed scientific journals. This corpus has remained outside the efforts of evidence-based medicine and research reform, and it can be imbued with unchecked biases. High-impact journals publish such pieces massively and may generate strong support for specific narratives and perspectives. Pieces with a political slant are also a major issue. Besides high-impact journals, across the entire scientific corpus, such pieces may be (mis)used to boost impact factors, create implausibly prolific CVs (occasionally even fraudulent) and can be powerful instruments of opinion making favouring some sponsors. Here we propose how this influential literature corpus may be strengthened to maximize its benefits and diminish its potential harms. Helpful measures to consider may include bolstering transparency (on authorship, financial compensation, disclosures of publication-specific and generic conflicts of interest, handling of political issues, peer-review, commissioning and timing); self-regulation with limits per author, improvement of subject matter expertise (with experts, meta-researchers and methodologists); balance of perspectives (with debates and for choice of topics); and post-publication review, audit, correction and potential retraction, as needed. A systematic research agenda is needed to study better this phenomenon and also the effectiveness of proposed interventions.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70061"},"PeriodicalIF":4.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of smoking in MINOCA patients.","authors":"Hersh Osman, Clara Schlettert, Daniel Materzok, Muharrem Akin, Mohammad Abumayyaleh, Ibrahim Akin, Andreas Mügge, Assem Aweimer, Nazha Hamdani, Ibrahim El-Battrawy","doi":"10.1111/eci.70054","DOIUrl":"https://doi.org/10.1111/eci.70054","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Considerable research has been conducted in recent years on patients afflicted with myocardial infarction with nonobstructive coronary disease (MINOCA), focussing on its prognosis, prevalence and predisposing risk factors. Nevertheless, there remains a dearth of information regarding the baseline characteristics and outcomes of MINOCA patients with a history of smoking. This study endeavours to examine the in-hospital complications and baseline characteristics of a presumed MINOCA cohort comprising individuals with a history of smoking.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this study, a total of 373 patients (85 current smokers and 283 non-smokers), who exhibited elevated troponin levels but had no evidence of obstructive coronary artery disease, were enrolled between 2010 and 2021. MINOCA patients had to fulfil the modified criteria for acute myocardial infarction (AMI) based on the 'Fourth Universal Definition of Myocardial Infarction', including an up- or downregulated troponin level with at least one value exceeding the 99th percentile, along with clinical evidence of infarction (e.g. ischaemic ECG changes, myocardial damage or coronary thrombus). Additionally, patients with less than 50% stenosis of a major epicardial vessel without intervention and those with alternative diagnoses mimicking troponin-positive nonobstructive coronary disease were excluded. It should be noted that there were five patients for whom data regarding smoking status were not available. The primary objective of this investigation was to evaluate the occurrence of various in-hospital events, including pulmonary oedema, invasive ventilation, cardiogenic shock, stroke, cardiopulmonary resuscitation, malignant cardiac arrhythmias, supraventricular arrhythmias, left ventricular thrombus, thromboembolic events and in-hospital mortality. Additionally, long-term cardiovascular events were assessed over an 11-year follow-up period.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Baseline demographics in smokers and non-smokers showed notable differences in the prevalence of supraventricular arrhythmia, particularly atrial fibrillation (5.8% vs. 17.4%; p = .020), diabetes mellitus (DM) (10.5% vs. 19.7%; p = .051), kidney disease (9.3% vs. 15.9%; p = .075) and chronic obstructive pulmonary disease (COPD) (18.6% vs. 10.8%; p = .057). The occurrence of in-hospital cardiovascular events and mortality rates was found to be comparable between smokers and non-smokers. However, non-smokers experienced a higher incidence of long-term cardiovascular events compared to smokers. A multivariable Cox analysis for long-term outcomes indicated that individuals under the age of 50 who were smokers had a more favourable outcome. Nonetheless, the presence of DM, supraventricular tachycardia, pulmonary disease and neurological disease were all associated with a diminished long-term prognosis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Although the long-term health outcomes for smokers are c","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70054"},"PeriodicalIF":4.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biases and debiasing in policy decision-making.","authors":"Michaéla C Schippers, Kasper P Kepp, John P A Ioannidis","doi":"10.1111/eci.70064","DOIUrl":"https://doi.org/10.1111/eci.70064","url":null,"abstract":"<p><p>Policy decision-making should use the best evidence obtained with the most rigorous and reproducible science and should be applied with minimal bias to maximize positive outcomes. This is particularly important in public health and other major decisions. Reality, however, is usually far from this ideal. The quality and use of scientific evidence to address wicked problems and sticky crises have been the focus of intense debate. Policymakers often succumb to fallacies, leading to suboptimal decision-making and maladaptive practices. We map the key biases involved at three different, but communicating, domains: the scientific evidence itself, the policymakers and the citizens. Biases may be classified along two axes pertaining to the perception of the risk and the perception of the effectiveness of the intervention: minimizing risk (e.g. crisis denial), maximizing risk (e.g. moral panic), minimizing intervention effectiveness (e.g. anti-medicine, anti-government) and maximizing effectiveness (e.g. drug lobbyism). We discuss common cognitive biases, including normalcy bias, ostrich effect, negativity bias, Just World Fallacy, false consensus effect, action bias and death spiral effect. Furthermore, we present an overview of potential debiasing processes and tools. Debiasing may help enhance the quality of implementations and trust in institutions, to the benefit of both science and society at large.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70064"},"PeriodicalIF":4.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-specific glycoprotein 1 promotes wound closure in animal models.","authors":"Tom Moore, John M Williams, Kathy Barriscale Walsh, Derek Whelan, James Clover","doi":"10.1111/eci.70056","DOIUrl":"https://doi.org/10.1111/eci.70056","url":null,"abstract":"<p><p>Recombinant human PSG1 administered intradermally at wound margins enhances skin wound healing in the mouse and pig, including in an acute diabetic mouse model. A highly significant effect on wound re-epithelialisation was observed in the pig, and PSG1 treatment of the human HaCaT keratinocyte cell line regulated wound healing-associated genes and enhanced scratch wound closure in cell monolayers in vitro. Clinical use of PSG1 might enhance closure of incisional and traumatic wounds and enhance re-epithelialisation of burn injuries.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":" ","pages":"e70056"},"PeriodicalIF":4.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}