PD-L1 expression pattern as predictive factor of biological behaviour in intracranial meningiomas: A single-center retrospective study.

IF 3.6 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2025-09-24 DOI:10.1111/eci.70124

Gabriele Gaggero, Alessandro Pesaresi, Debora Giunti, Andrea Bianconi, Monica Truffelli, Massimiliano Grassi, Luca Valle, Sharon Duzioni, Paolo Nozza, Mariella Dono, Giorgia Anselmi, Gianluigi Zona, Valerio Vellone, Pietro Fiaschi

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引用次数: 0

Abstract

Background: Molecular expression of meningiomas has become increasingly important for predicting their biological behaviour. However, the factors influencing tumour recurrence and progression after surgery remain unclear. Recent studies suggest that programmed death-ligand 1 (PD-L1) could be a key predictive and therapeutic factor in these tumours.

Methods: This single-center retrospective study included 96 patients who underwent Simpson Grade I resection of intracranial meningiomas between 2001 and 2022. PD-L1 expression was assessed immunohistochemically (clone SP142) and categorized as overall (OE), membranous (mb), granular cytoplasmic (gr) and perinuclear dot-like. Associations with WHO grade, recurrence, mitotic count and Ki-67 index were analysed using univariate and multivariate statistics.

Results: 118 samples were analysed. Grade 2 meningiomas showed significantly higher mitotic count (4.0 ± 5.5 vs. 1.0 ± 1.0 n/mm², p < .001) and Ki-67 index (7.6 ± 2.1% vs. 3.5 ± .2%, p < .001) than Grade 1. PD-L1 OE (2.0 ± 5.0% vs. .0 ± 1.0%, p < .001), gr (1.0 ± 2.5% vs. .0 ± 1.0%, p < .001) and mb (1.0 ± 1.0% vs. .0 ± .0%, p = .003) expressions were also higher in Grade 2. At recurrence, Grade 1 tumours progressing to Grade 2 showed increased PD-L1 OE (p = .025), gr (p = .024) and mb (p = .037). Multivariate analysis confirmed PD-L1 gr and mb as independent markers of high-grade tumours.

Conclusions: Granular cytoplasmic and membranous PD-L1 expression patterns are significantly associated with tumour grade, recurrence and progression, suggesting their potential role as prognostic biomarkers in meningiomas.

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PD-L1表达模式作为颅内脑膜瘤生物学行为的预测因素：一项单中心回顾性研究。

背景：脑膜瘤的分子表达在预测其生物学行为方面变得越来越重要。然而，影响术后肿瘤复发和进展的因素仍不清楚。最近的研究表明，程序性死亡配体1 （PD-L1）可能是这些肿瘤的关键预测和治疗因素。方法：这项单中心回顾性研究纳入了2001年至2022年间96例接受Simpson I级颅内脑膜瘤切除术的患者。免疫组织化学检测PD-L1的表达（克隆SP142），并将其分为整体（OE）、膜状（mb）、颗粒状细胞质（gr）和核周点状。采用单因素和多因素统计分析与WHO分级、复发率、有丝分裂计数和Ki-67指数的关系。结果：对118份样品进行了分析。2级脑膜瘤有丝分裂计数（4.0±5.5 vs. 1.0±1.0 n/mm2）显著高于2级脑膜瘤（4.0±5.5 vs. 1.0±1.0 n/mm2）。结论：颗粒状细胞质和膜质PD-L1表达模式与肿瘤分级、复发和进展显著相关，提示其作为脑膜瘤预后生物标志物的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.