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Establishment of validated stability indicating purity method based on the stress degradation behavior of gonadotropin-releasing hormone antagonist (ganirelix) in an injectable formulation using HPLC and LC-MS-QTOF. 基于促性腺激素释放激素拮抗剂(ganirelix)在注射制剂中的应激降解行为，采用HPLC和LC-MS-QTOF建立了经过验证的稳定性指示纯度方法。
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-04-01 Epub Date: 2021-04-07 DOI: 10.1177/14690667211005335
Kumarswamy Ummiti, J V Shanmukha Kumar
{"title":"Establishment of validated stability indicating purity method based on the stress degradation behavior of gonadotropin-releasing hormone antagonist (ganirelix) in an injectable formulation using HPLC and LC-MS-QTOF.","authors":"Kumarswamy Ummiti,&nbsp;J V Shanmukha Kumar","doi":"10.1177/14690667211005335","DOIUrl":"https://doi.org/10.1177/14690667211005335","url":null,"abstract":"<p><p>Stress study of a drug substance or pharmaceutical drug product provides a vision into degradation pathways and degradation products of the active pharmaceutical ingredient and helps in interpretation of the chemical structure of the degradation impurities. In the current study, Ganirelix active ingredient presented in the Orgalutran® was stressed with acidic and alkali hydrolysis, photolysis, thermal and oxidation conditions as per the guidelines of International Conference on Harmonization (ICH) Q1A (R2). Ganirelix was found to be labile under thermal and alkali hydrolytic stress conditions, while it was stable to acid hydrolytic, oxidative and photolytic stress. All degradation products were separated with a resolution > 1.5 on a C18 column (2.6 µm, 25 cm×4.6 mm) using a hydrophilic ion pair such as sodium perchlorate, at a concentration <0.04 M. In total, four major degradant impurities were found during stress study. These impurities were fractionated and desalted by flash chromatography for identification of chemical structures. LC-MS-QTOF analysis revealed that two degradation products are diastereomers of Ganirelix, one degradation product is a deamination compound and other degradation product result from the insertion of a new amino acid residue in the Ganirelix peptide sequence. The developed method is sensitive enough to quantify the related substances of Ganirelix at the 0.04% level with that of Ganirelix test concentration.</p>","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"27 2-4","pages":"126-140"},"PeriodicalIF":1.3,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14690667211005335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25564730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Silicon surface assisted laser desorption ionization mass spectrometry for quantitative analysis. 硅表面辅助激光解吸电离质谱法定量分析。
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-04-01 Epub Date: 2021-04-04 DOI: 10.1177/14690667211006017
Alexander A Grechnikov, Alexey S Borodkov, Yaroslav O Simanovsky, Sergey M Nikiforov
{"title":"Silicon surface assisted laser desorption ionization mass spectrometry for quantitative analysis.","authors":"Alexander A Grechnikov,&nbsp;Alexey S Borodkov,&nbsp;Yaroslav O Simanovsky,&nbsp;Sergey M Nikiforov","doi":"10.1177/14690667211006017","DOIUrl":"https://doi.org/10.1177/14690667211006017","url":null,"abstract":"<p><p>The approach to quantitative analysis by silicon Surface Assisted Laser Desorption Ionization Mass Spectrometry (Si-SALDI) is proposed. The approach is based on the new method for forming an active surface layer on a silicon substrate by exposing to laser radiation directly in the ion source of a mass spectrometer. The method can be used repeatedly on the same substrate, providing high reproducibility of its surface ionization properties and high ionization efficiency of organic compounds. Within the proposed approach, the methods of improvement of signal reproducibility are also considered, including continuous monitoring of the silicon surface ionization properties using a Knudsen effusion cell; scanning the surface of a silicon substrate with a laser beam; selecting the optimal value of laser fluence and using a reproducible sample introduction technique. It is demonstrated that this approach can be successfully applied to quantify clinically relevant concentrations of pharmaceutical drugs in extracts of blood.</p>","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"27 2-4","pages":"84-93"},"PeriodicalIF":1.3,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14690667211006017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25561984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A simulation study of excitation contour of a linear trap with spatial harmonics. 具有空间谐波的线性阱激励轮廓的仿真研究。
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-04-01 Epub Date: 2021-05-26 DOI: 10.1177/14690667211020153
N V Konenkov
{"title":"A simulation study of excitation contour of a linear trap with spatial harmonics.","authors":"N V Konenkov","doi":"10.1177/14690667211020153","DOIUrl":"https://doi.org/10.1177/14690667211020153","url":null,"abstract":"<p><p>The process of nonlinear resonant excitation of ion oscillations in a linear trap is studied. There is still no detailed simulation of the resonance peak in the literature. We propose to use the excitation contour to describe the collective ion resonance. The excitation contour is a resonant mass peak obtained by the trajectory method with the Gaussian distribution of the initial coordinates and velocities. The following factors are considered: excitation time, low order hexapole and octopole harmonics with amplitudes A<sub>3</sub> and A<sub>4</sub>, the depth of the initial ion cloud position. These multipoles are used for selective ion ejection from linear ion trap. All these factors affect the ion yield and the shape of the contours. Obtained data can be useful for control of such processes as ion fragmentation, ion isolation, ion activation, and ion ejection. Simulated resonance peaks are important for the theoretical description of the ion collective nonlinear resonances.</p>","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"27 2-4","pages":"94-100"},"PeriodicalIF":1.3,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14690667211020153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38952117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Theoretical fractional formulation of a three-dimensional radio frequency ion trap (Paul-trap) for optimum mass separation. 用于最佳质量分离的三维射频离子阱(保罗阱)的理论分数公式。
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-04-01 Epub Date: 2021-07-04 DOI: 10.1177/14690667211026790
Sarkhosh Seddighi Chaharborj, Shahriar Seddighi Chaharborj, Zahra Seddighi Chaharborj, Pei See Phang
{"title":"Theoretical fractional formulation of a three-dimensional radio frequency ion trap (Paul-trap) for optimum mass separation.","authors":"Sarkhosh Seddighi Chaharborj,&nbsp;Shahriar Seddighi Chaharborj,&nbsp;Zahra Seddighi Chaharborj,&nbsp;Pei See Phang","doi":"10.1177/14690667211026790","DOIUrl":"https://doi.org/10.1177/14690667211026790","url":null,"abstract":"<p><p>We investigate the dynamics of an ion confined in a Paul-trap supplied by a fractional periodic impulsional potential. The Cantor-type cylindrical coordinate method is a powerful tool to convert differential equations on Cantor sets from cantorian-coordinate systems to Cantor-type cylindrical coordinate systems. By applying this method to the classical Laplace equation, a fractional Laplace equation in the Cantor-type cylindrical coordinate is obtained. The fractional Laplace equation is solved in the Cantor-type cylindrical coordinate, then the ions is modelled and studied for confined ions inside a Paul-trap characterized by a fractional potential. In addition, the effect of the fractional parameter on the stability regions, ion trajectories, phase space, maximum trapping voltage, spacing between two signals and fractional resolution is investigated and discussed.</p>","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"27 2-4","pages":"73-83"},"PeriodicalIF":1.3,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14690667211026790","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39147654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of anthocyanin from red sorghum (Sorghum bicolor) bran by liquid chromatography-electron spray ionization mass spectrometry analysis. 液相色谱-电子喷雾质谱分析表征红高粱(高粱双色)麸皮中花青素的含量。
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-04-01 Epub Date: 2021-07-29 DOI: 10.1177/14690667211035720
P Suganyadevi, M Saravanakumar, S Mohandas
{"title":"Characterization of anthocyanin from red sorghum (<i>Sorghum bicolor</i>) bran by liquid chromatography-electron spray ionization mass spectrometry analysis.","authors":"P Suganyadevi,&nbsp;M Saravanakumar,&nbsp;S Mohandas","doi":"10.1177/14690667211035720","DOIUrl":"https://doi.org/10.1177/14690667211035720","url":null,"abstract":"<p><p>In the present study, anthocyanin pigments from red sorghum (<i>Sorghum bicolor</i>) bran were identified and characterized by Liquid Chromatography-Electron Spray Ionization Mass Spectrometry. The individual anthocyanins were identified by comparing their mass spectrometric data and retention times, published data. 3-deoxyanthocyanidins and methyl 3-deoxyanthocyanidins were identified in red sorghum bran. This paper presents complete LCMS profile and MS spectrometric data of red sorghum bran.</p>","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"27 2-4","pages":"107-114"},"PeriodicalIF":1.3,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/14690667211035720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39257485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Applications of Beta Negative Binomial Distribution Series on Holomorphic Functions 负二项分布级数在全纯函数上的应用
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-03-23 DOI: 10.34198/EJMS.6221.271292
A. Wanas, Najah Ali Jiben Al-Ziadi
{"title":"Applications of Beta Negative Binomial Distribution Series on Holomorphic Functions","authors":"A. Wanas, Najah Ali Jiben Al-Ziadi","doi":"10.34198/EJMS.6221.271292","DOIUrl":"https://doi.org/10.34198/EJMS.6221.271292","url":null,"abstract":"The purpose of this article is to derive the necessary and sufficient conditions for the power series ℘ג, whose coefficients are probabilities of the beta negative binomial distribution to be in the family F , , , , , ג, of holomorphic functions which are defined in the open unit disk. We establish a number of important geometric properties, such as, coefficient estimates, extreme points, neighborhood property, integral representation, radii of starlikeness and convexity and Hadamard product properties for functions belongs to this family. Also we determinate some differential subordination properties of the power series ℘ג, .","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"1 1","pages":"271-292"},"PeriodicalIF":1.3,"publicationDate":"2021-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42505033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Coupled Anti Q-Fuzzy Subgroups using t-Conorms 利用t-正则的耦合反q -模糊子群
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-03-13 DOI: 10.34198/EJMS.6221.239251
C. Ampadu
{"title":"Coupled Anti Q-Fuzzy Subgroups using t-Conorms","authors":"C. Ampadu","doi":"10.34198/EJMS.6221.239251","DOIUrl":"https://doi.org/10.34198/EJMS.6221.239251","url":null,"abstract":"In this paper we study coupled anti Q-fuzzy subgroups of G with respect to t-conorm C. We also discuss the union, normal and direct product of them. Moreover, the homomorphic image and pre-image of them is investigated under group homomorphisms and anti homomorphisms. 1 Some Old and New Notions and Notations Remark 1.1. (a) In this paper we assume G is a group as defined in [1]. (b) We assume the notions of homomorphism and anti-homomorphism as defined in [1]. (c) We assume C : [0, 1]× [0, 1] 7→ [0, 1] is a t-conorm as defined in [1]. (d) By idempotent, we refer to t-conorm C as defined in [1]. Definition 1.2. Let G be an arbitrary group with multiplicative binary operation and identity e. By a fuzzy subset of G×G we mean a function from G×G into [0, 1]. The set of all fuzzy subsets of G×G will be called the [0, 1]-power set of G×G, and will be denoted by [0, 1]G×G. Received: February 1, 2021; Accepted: March 7, 2021 2010 Mathematics Subject Classification: 08A72, 20-XX, 47A30, 20N25, 20K27, 20K30.","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"1 1","pages":"239-251"},"PeriodicalIF":1.3,"publicationDate":"2021-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46883360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special Subfamilies of Holomorphic and Bi-univalent Functions related to Quasi-subordination 与拟隶属相关的全纯函数和双单价函数的特殊子族
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-03-11 DOI: 10.34198/EJMS.6221.225237
S. R. Swamy, Y. Sailaja
{"title":"Special Subfamilies of Holomorphic and Bi-univalent Functions related to Quasi-subordination","authors":"S. R. Swamy, Y. Sailaja","doi":"10.34198/EJMS.6221.225237","DOIUrl":"https://doi.org/10.34198/EJMS.6221.225237","url":null,"abstract":"In the current work, special subfamilies of holomorphic bi-univalent functions based on quasi-subordination are introduced. Initial coefficient estimates for functions belonging to these subfamilies are established. Several consequences of our results and connections to known families are indicated. 1 Preliminaries Let A be the set of normalized holomorphic functions that have the form","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"1 1","pages":"225-237"},"PeriodicalIF":1.3,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69827211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coefficient Estimates for Certain Subclasses of m-Fold Symmetric Bi-univalent Functions Associated with Pseudo-Starlike Functions 与拟星形函数相关的m重对称双单价函数的某些子类的系数估计
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-03-07 DOI: 10.34198/EJMS.6221.209223
T. G. Shaba, A. Patil
{"title":"Coefficient Estimates for Certain Subclasses of m-Fold Symmetric Bi-univalent Functions Associated with Pseudo-Starlike Functions","authors":"T. G. Shaba, A. Patil","doi":"10.34198/EJMS.6221.209223","DOIUrl":"https://doi.org/10.34198/EJMS.6221.209223","url":null,"abstract":"In the present investigation, we introduce the subclasses ΛΣ (η,h, φ) and ΛΣ (η,h, δ) of m-fold symmetric bi-univalent function class Σm, which are associated with the pseudo-starlike functions and defined in the open unit disk U. Moreover, we obtain estimates on the initial coefficients |bm+1| and |b2m+1| for the functions belong to these subclasses and identified correlations with some of the earlier known classes.","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"1 1","pages":"209-223"},"PeriodicalIF":1.3,"publicationDate":"2021-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46974343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Anticommutativity and n-schemes 反交换性和n格式
IF 1.3 4区 化学
European Journal of Mass Spectrometry Pub Date : 2021-02-26 DOI: 10.34198/EJMS.6121.175186
Brice Réné Amougou Mbarga
{"title":"Anticommutativity and n-schemes","authors":"Brice Réné Amougou Mbarga","doi":"10.34198/EJMS.6121.175186","DOIUrl":"https://doi.org/10.34198/EJMS.6121.175186","url":null,"abstract":"Abstract The purpose of this paper is two-fold. A first and more concrete aim is to give new characterizations of equivalence distributive Goursat categories (which extend 3-permutable varieties) through variations of the little Pappian Theorem involving reflexive and positive relations. A second and more abstract aim is to show that every finitely complete category E satisfying the n-scheme is locally anticommutative.","PeriodicalId":12007,"journal":{"name":"European Journal of Mass Spectrometry","volume":"1 1","pages":"175-186"},"PeriodicalIF":1.3,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41403273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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