Orbitrap质谱法鉴定电子烟气溶胶中新形成的有毒化学物质及其对电子烟控制的影响。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Accounts of Chemical Research Pub Date : 2021-04-01 Epub Date: 2021-08-27 DOI:10.1177/14690667211040207
Beizhan Yan, Dimitri Zagorevski, Vesna Ilievski, Norman J Kleiman, Diane B Re, Ana Navas-Acien, Markus Hilpert
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引用次数: 6

摘要

电子尼古丁传递系统(ENDS)的使用越来越多,由于多种新出现的不良健康影响而引起关注。大多数对ENDS有害化学物质的分析都以金属或丙二醇等载体液体热分解产生的羰基为目标。然而,可能会形成新的复杂化合物,不能常规识别,对健康的影响未知。采用直接气溶胶液滴沉积法采集ENDS气溶胶样品。采用高质量精度的Orbitrap质谱法进行非靶向分析。我们在气溶胶中发现了30多个“特征”,这些特征是由化合物的质量电荷比“m/z”和保留时间对表征的。我们发现了几种含有尼古丁和丙二醇(NIC-PG)的化合物,它们相对于尼古丁的丰度随着电子烟的使用而增加。根据环境保护署毒性评估软件工具的预测,这些化合物具有发育毒性。此外,根据分子量确定了一种含氮化合物,可能是三丁基胺(一种已知的肺刺激物)。这种化合物以前未在ENDS电子液体和气溶胶中发现。ENDS不仅产生小的有毒化合物如醛,也产生大的复杂的有毒化合物如NIC-PG。NIC-PG的预测发育毒性与使用ENDS的孕妇、接触二手或三手ENDS气溶胶的儿童以及大脑仍在发育的青少年使用ENDS的胎儿发育有关。NIC-PG水平与终端功率输出之间的强正相关,支持调节高功率终端。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification of newly formed toxic chemicals in E-cigarette aerosols with Orbitrap mass spectrometry and implications on E-cigarette control.

The increasing use of electronic nicotine delivery systems (ENDS) is of concern due to multiple emerging adverse health effects. Most analyses of the harmful chemicals of ENDS have targeted metals or carbonyls generated by thermal decomposition of carrier liquids such as propylene glycol. However, new complex compounds not routinely identified and with unknown health consequences could be formed. ENDS aerosol samples were collected by the direct aerosol droplet deposition method. Untargeted analysis was performed using Orbitrap mass spectrometry with high mass accuracy. We identified more than 30 "features" in the aerosol characterized by pairs of the mass-to-charge ratio "m/z" of the compound and the retention time. We identified several compounds containing nicotine and propylene glycol (NIC-PG), whose abundance relative to nicotine increased along with vaping power used. On the basis of the prediction by the Environmental Protection Agency Toxicity Estimation Software Tool, these compounds exert developmental toxicity. In addition, a nitrogen-containing compound, likely tributylamine (a known lung irritant), was identified based on the molecular weight. This compound has not been previously identified in ENDS e-liquids and aerosols. ENDS produce not only small toxic compounds such as aldehydes, but also large complex toxic compounds such as NIC-PG. Predicted development toxicity for NIC-PG is concerning for fetal development in pregnant women who use ENDS, children exposed to secondhand or thirdhand ENDS aerosols, and teenage ENDS users whose brains are still developing. The strong positive association between NIC-PG levels and ENDS power output supports regulating high-powered ENDS.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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