European Journal of Gastroenterology & Hepatology最新文献

{"title":"The 'screening funnel' and economic case: potential challenges to conclusions on colon capsule endoscopy in surveillance.","authors":"Menghui Mao, Derong Bao","doi":"10.1097/MEG.0000000000003248","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003248","url":null,"abstract":"","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"38 10","pages":"1237"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical insights on utility of colon capsule endoscopy in colorectal cancer and postpolypectomy surveillance.","authors":"Rohit Kumar, Zaina Mudassar, Shahzada Luqman, Shaista Qadir, Amina Anjum, Muhammad Owais","doi":"10.1097/MEG.0000000000003232","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003232","url":null,"abstract":"","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"38 10","pages":"1236"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Microstream capnography monitoring on adverse events during procedural sedation: retrospective analysis of a quality improvement initiative performed in five centres.","authors":"Raf Bisschops, Isabel Valbuena Gómez, Gareth Corbett, Sita J Saunders, Erica Ehrhardt, Sylwia I Kaduk, Nady Sfeir, Rhodri Saunders, Menekse Özçelik","doi":"10.1097/MEG.0000000000003207","DOIUrl":"10.1097/MEG.0000000000003207","url":null,"abstract":"<p><strong>Objectives: </strong>To quantify the safety impact of using Microstream capnography monitoring during procedural sedation for gastrointestinal procedures and bronchoscopy and to identify a risk-stratification method.</p><p><strong>Methods: </strong>A quality improvement initiative at hospitals in Belgium, Canada, Spain, Turkey, and the UK included 6734 procedures in adults undergoing procedural sedation, who received either Microstream capnography monitoring added to standard monitoring, or standard monitoring only. The primary outcome was the incidence of any intraoperative adverse event. Incidence of any severe adverse event was assessed separately. American Society of Anesthesiologists classification, sedatives, procedure time, and procedure type were used to adjust odds ratios (OR) derived from logistic regressions for adverse events and applied in risk stratification.</p><p><strong>Results: </strong>Adverse event incidence decreased from 10.8% standard monitoring to 6.7% using capnography, with a number needed to treat (NNT) of 24. The adjusted ORs were 0.54 (95% confidence interval (CI): 0.44-0.66, P  < 0.001) for any adverse event and 0.46 (95% CI: 0.26-0.83, P  = 0.01) for any severe adverse event. Procedures were stratified into low- ( N  = 1292, 25.6%), medium- ( N  = 2383, 47.2%), and high-risk ( N  = 1376, 27.2%) groups. Capnography monitoring significantly decreased adverse events in all risk groups with absolute risk reductions (NNT) of 3.8% (26), 4.6% (22), and 6.7% (15) for low- to high-risk groups, respectively. Severe adverse events significantly decreased with capnography in the high-risk group only (3.5% vs. 0.9%; OR 0.25, 95% CI: 0.10-0.60; NNT = 38). The risk stratification model should be considered exploratory and requires further validation.</p><p><strong>Conclusion: </strong>Capnography in procedural sedation significantly reduced both any and severe adverse events and should benefit patients in routine practice. We recommend considering American Society of Anesthesiologists level, sedation type, and planned procedure time in future risk stratification evaluations.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1187-1196"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sodium-glucose cotransporter-2 inhibitor use and clinical outcomes in patients with cirrhosis: a propensity-matched real-world cohort study.","authors":"Elias Helal, Elona Shehi, Ahmad Al Homaid, Migena Dervishi, Devendra K Tripathi","doi":"10.1097/MEG.0000000000003264","DOIUrl":"10.1097/MEG.0000000000003264","url":null,"abstract":"<p><strong>Background: </strong>Patients with cirrhosis frequently have metabolic comorbidities that complicate treatment. Sodium-glucose cotransporter-2 (SGLT2) inhibitors provide cardiovascular and renal benefits in type 2 diabetes, but their effects in cirrhosis remain uncertain. We evaluated the association between SGLT2 inhibitor use and clinical outcomes in patients with cirrhosis.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study using the TriNetX Research Network. Adults with cirrhosis were stratified by SGLT2 inhibitor exposure. Propensity score matching balanced demographics, comorbidities, medication use, BMI, and laboratory variables. Outcomes included all-cause mortality, hepatic decompensation, acute kidney injury/hepatorenal syndrome (AKI/HRS), and hepatocellular carcinoma (HCC).</p><p><strong>Results: </strong>After matching, 34 590 patients remained in each cohort. SGLT2 inhibitor use was associated with lower all-cause mortality [15.0 vs. 24.2%; hazard ratio: 0.67, 95% confidence interval (CI): 0.64-0.69, P < 0.001] and composite hepatic decompensation (28.6 vs. 36.3%; hazard ratio: 0.78, 95% CI: 0.76-0.80, P < 0.001). AKI/HRS was not increased on time-to-event analysis (hazard ratio: 0.99, 95% CI: 0.96-1.02, P = 0.346). HCC incidence was lower among SGLT2 inhibitor users (hazard ratio: 0.57, 95% CI: 0.39-0.86, P = 0.006).</p><p><strong>Conclusion: </strong>SGLT2 inhibitor use in patients with cirrhosis was associated with lower mortality, hepatic decompensation, and HCC incidence without increased AKI/HRS. These findings support prospective evaluation in selected patients with cirrhosis.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"38 10","pages":"1224-1228"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic mucosal resection with precutting vs. anchoring technique using snare tip for 10-25 mm nonpedunculated colorectal polyps: a randomized controlled trial.","authors":"Jong Yoon Lee, Hee Yoon Noh, Yang Hyun Baek, Myung Hwan Noh, Minkook Son, Mee Sook Roh, Jong Hoon Lee","doi":"10.1097/MEG.0000000000003200","DOIUrl":"10.1097/MEG.0000000000003200","url":null,"abstract":"<p><strong>Background and aims: </strong>Modified endoscopic mucosal resection (EMR) techniques using a snare tip, precutting EMR (P-EMR) and anchoring EMR (A-EMR), have been developed for the effective resection of nonpedunculated colorectal polyps measuring 10-25 mm. Although previous studies have compared either P-EMR or A-EMR with conventional EMR, no study has directly compared these two snare tip-assisted techniques within modified EMR. This study aimed to evaluate P-EMR and A-EMR in terms of the R0 resection rate and procedure duration.</p><p><strong>Methods: </strong>This prospective randomized controlled trial enrolled patients with nonpedunculated colorectal polyps measuring 10-25 mm. The patients were randomly assigned to the P-EMR or A-EMR groups. The primary outcome was R0 resection rate, defined as en bloc resection with histologically tumor-free margins. Secondary outcomes included the injection-to-snaring time, total procedure time, and adverse events.</p><p><strong>Results: </strong>Each group included 63 polyps, of which 126 were analyzed in the final evaluation. Both groups achieved high R0 resection rates (93.7% for P-EMR and 88.9% for A-EMR), with no significant difference ( P  = 0.344). However, the A-EMR group demonstrated significantly shorter injection-to-snaring time (181.8 ± 81.9 vs. 320.9 ± 143.5 s, P  < 0.001) and total procedure time (259.7 ± 139.7 vs. 479.8 ± 249.0 s, P  < 0.001). Adverse events, including intraprocedural and delayed bleeding, were comparable between the groups.</p><p><strong>Conclusion: </strong>Both P-EMR and A-EMR demonstrated high R0 resection rates for nonpedunculated polyps measuring 10-25 mm. However, A-EMR achieved these outcomes with a shorter procedure time than P-EMR.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1180-1186"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allostatic load, unhealthy behaviors, and mortality risk among participants with and without metabolic dysfunction-associated steatotic liver disease.","authors":"Dongzhi Hong, Bin Xi, Zuopei Lv, Nannan Li, Xinyu He, Xinyi Zhu, Jianan Zhang, Chenxing Wang, Zhenzhai Cai, Hao Wu, Beilei Fu","doi":"10.1097/MEG.0000000000003290","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003290","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress and unhealthy behaviors are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). However, whether and to what extent they are associated with mortality across different stages of MASLD remains unclear. This study aimed to examine the associations of allostatic load and unhealthy behaviors with mortality according to MASLD stage.</p><p><strong>Methods: </strong>The study included 9761 participants from the National Health and Nutrition Examination Survey (2005-2018). MASLD was defined as hepatic steatosis with at least one cardiometabolic criterion. Allostatic load, an indicator of chronic stress, was assessed using 10 biomarkers. Health behaviors included diet, nicotine exposure, physical activity, and sleep duration. Cox proportional hazards models estimated the associations of allostatic load and health behavior score (HBS) with mortality.</p><p><strong>Results: </strong>Among 9761 participants, 3158 (32.4%) were classified as having MASLD. During a median follow-up of 7.42 years, 922 participants died, including 268 cardiovascular deaths. Allostatic load and HBS were associated with all-cause and cardiovascular mortality among participants with and without MASLD. The combination of high allostatic load and poor HBS was associated with higher risks of all-cause and cardiovascular mortality, particularly among participants with MASLD [hazard ratio = 3.33, 95% confidence interval (CI) = 1.97-5.65 for all-cause mortality; hazard ratio = 3.66, 95% CI = 1.31-10.23 for cardiovascular mortality].</p><p><strong>Conclusion: </strong>Higher allostatic load and poorer health behaviors were independently and jointly associated with higher risks of all-cause and cardiovascular mortality among participants with and without MASLD. These findings highlight the importance of chronic stress and poor health behaviors in MASLD management and prognosis.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underwater versus conventional polypectomy for colorectal polyps 10 mm or smaller: a systematic review and meta-analysis of randomized controlled trials.","authors":"Gedion Yilma Amdetsion, Chun-Wei Pan, Pius Ojemolon, Fnu Vikash, Hiwot Gebeyehu Tebeje, Ayokunle T Abegunde","doi":"10.1097/MEG.0000000000003288","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003288","url":null,"abstract":"<p><p>Underwater polypectomy has emerged as an alternative to conventional polypectomy for the removal of colorectal polyps. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to evaluate the comparative efficacy and safety of underwater polypectomy and conventional polypectomy. We systematically searched PubMed, Embase, Cochrane Library, and Web of Science for RCTs comparing underwater polypectomy and conventional polypectomy for colorectal polyps. We restricted the analysis to polyps 10 mm or smaller. The primary outcome was en bloc resection rate. Secondary outcomes included incomplete resection, piecemeal resection, R0 resection, intraprocedural bleeding, and resection time. Risk ratios with 95% confidence intervals (CI) were calculated for binary outcomes, and standardized mean differences for continuous outcomes using random-effects models. Four RCTs contributed 1166 polyps 10 mm or smaller (598 underwater polypectomy, 568 conventional polypectomy). Underwater polypectomy and conventional polypectomy showed comparable en-bloc resection rates (risk ratio: 1.01, 95% CI: 0.97-1.05; I2 = 68.9%). Underwater polypectomy was associated with significantly lower incomplete resection rates (risk ratio: 0.38, 95% CI: 0.25-0.56; I2 = 0%). R0 resection favored underwater polypectomy (risk ratio: 1.16, 95% CI: 1.00-1.34; I2 = 85.8), although substantial heterogeneity limits interpretation. Intraprocedural bleeding and resection time did not differ between techniques. Underwater polypectomy demonstrates a significant advantage over conventional polypectomy in reducing incomplete resection rates while maintaining comparable en bloc resection rates and safety profiles. These findings support underwater polypectomy as a reasonable and, in specific settings, preferable alternative to conventional cold snare polypectomy.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality controlling in capsule gastroduodenoscopy with less annotation via self-supervised learning.","authors":"Yaqiong Zhang, Kai Zhang, Meijia Wang, Peng Bai, Shengqiang Wang, Xuanye Hu, Ting Ma, Feng Hu, Peng Li, Guisheng Liu","doi":"10.1097/MEG.0000000000003286","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003286","url":null,"abstract":"<p><strong>Background: </strong>It is possible to control the quality of capsule endoscopic images using artificial intelligence, but it requires a great deal of time for labeling. Verifying the performance of self-supervised learning for quality control for capsule endoscopic images.</p><p><strong>Methods: </strong>A simple framework for contrastive learning of visual representations (SimCLR), is capable of acquiring the inherent image representation with minimal annotation, but the feasibility is not studied. A total of 62 840 images were collected to train models in internal cross-validation (more training data and less testing data) and reversed cross-validation (less training data and more testing data). Random forest and eXtreme Gradient Boosting (XGBoost) were used to complete the quality control after SimCLR extracted the features from images.</p><p><strong>Results: </strong>Random forest and XGBoost reported that the mean area under the receiver operating characteristic (AUROC) curve exceeded 0.98 and 0.97 using SimCLR-derived features. Moreover, XGBoost surpassed supervised convolutional neural network (CNN). Extra 12 032 images were gathered for prospective validation and the AUROC of SimCLR surpassed 0.93 (95% confidence interval = 0.9271-0.9548), which is close to supervised CNN (0.9645) in cross-validation. Moreover, the AUROC of random forest and XGBoost (trained with SimCLR-derived features) surpasses 0.96, which is better than supervised CNN (0.8374) in reversed cross validation.</p><p><strong>Conclusion: </strong>Our results demonstrate that the SimCLR framework enables high-performance quality control in capsule endoscopy, achieving accuracy comparable to - or even surpassing - supervised learning methods, while requiring substantially fewer annotated images.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid ammonia normalization and long-term efficacy of rifaximin in patients with cirrhosis: a multicenter retrospective study.","authors":"Joji Tani, Tetsu Tomonari, Akira Hirose, Akio Moriya, Chikara Ogawa, Akemi Tsutsui, Asahiro Morishita, Teppei Sakamoto, Hiroki Tai, Rie Yano, Naoya Tada, Mai Nakahara, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Shima Mimura, Takashi Himoto, Hironori Tanaka, Ryosuke Imado, Takushi Manabe, Kei Takuma, Takuya Nagano, Koichi Takaguchi, Hideki Kobara","doi":"10.1097/MEG.0000000000003285","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003285","url":null,"abstract":"<p><strong>Objective: </strong>Hyperammonemia drives the pathogenesis of hepatic encephalopathy and independently predicts poor outcomes in cirrhosis. Despite the widespread use of rifaximin, data on ammonia normalization kinetics and long-term effects on hepatic functional reserve remain limited. We aimed to evaluate the efficacy and safety of long-term rifaximin therapy for hyperammonemia in patients with cirrhosis.</p><p><strong>Methods: </strong>This multicenter retrospective study analyzed 247 cirrhotic patients with hyperammonemia treated with rifaximin at six institutions in Japan (2016-2022). Ammonia normalization kinetics and predictors, hepatic functional reserve, and safety were assessed over a median follow-up of 377 days.</p><p><strong>Results: </strong>Blood ammonia concentrations (BACs) decreased by 34.7% at 1 week, and 74.5% of patients achieved normalization at a median of 63 days. Lower serum albumin was independently associated with delayed normalization. Serum albumin, prothrombin time, and the Child-Pugh score showed small but statistically significant improvements at 12 months, whereas the MELD and ALBI scores remained stable. Hepatic encephalopathy-related hospitalizations decreased by 60.2% compared with the preceding 2 years. Adverse events occurred in 2.0% of patients, all grade 1.</p><p><strong>Conclusion: </strong>Rifaximin rapidly normalized BACs, and this effect was sustained during long-term therapy. Long-term rifaximin administration was associated with a mild improvement in some indicators of hepatic functional reserve, suggesting that it may contribute to the maintenance or improvement of hepatic functional reserve. Lower baseline albumin is associated with delayed normalization, highlighting the importance of hepatic functional reserve in treatment response.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of serum osmolarity in patients with acute pancreatitis.","authors":"Fatma Balci, Altug Senol, Ismail Selimoglu, Baris Afsar","doi":"10.1097/MEG.0000000000003279","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003279","url":null,"abstract":"<p><strong>Background: </strong>Approximately 15-25% of cases of acute pancreatitis follow a severe clinical course. Early identification of severe acute pancreatitis is crucial for predicting potential morbidity and mortality. This study aimed to evaluate the association between serum osmolarity and in-hospital mortality in acute pancreatitis patients.</p><p><strong>Methods: </strong>Patients hospitalized with a diagnosis of acute pancreatitis between 1 January 2015 and 1 August 2019 in the Gastroenterology Service and Internal Medicine ICU in a tertiary center were analyzed retrospectively. A total of 311 patients were enrolled in the study. Demographic, clinical, laboratory, and radiological data, including calculated serum osmolarity values and their components, were analyzed based on acute pancreatitis morphological type, disease severity, in-hospital mortality, and ICU admission.</p><p><strong>Results: </strong>Admission serum osmolarity was significantly higher in patients with severe acute pancreatitis and those who required intensive care (P < 0.001 and P = 0.003, respectively). Admission osmolarity showed positive correlations with the Ranson score, length of stay, and high-sensitive C-reactive protein. The area under the curve (AUC) for serum osmolarity at 24 h was [AUC: 0.822, 95% confidence interval (CI): 0.728-0.921, P = 0.001], with a cut-off value of 295.69 mOsm/L (sensitivity: 60% and specificity: 90.4%). The AUC for serum osmolarity at 48 h (OSM48) was (AUC: 0.932, 95% CI: 0.815-0.976, P < 0.001), with a cut-off value of 296.67 mOsm/L (sensitivity: 70% and specificity: 94%). Each 1 mOsm/L increase in (OSM48) was associated with a 15.1% increase in the odds of in-hospital mortality.</p><p><strong>Conclusion: </strong>Elevated serum osmolarity, measured at 48 h after admission, is a valuable and easily obtainable parameter and is related to in-hospital mortality in patients with acute pancreatitis.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}