European Journal of Gastroenterology & Hepatology最新文献

{"title":"The role of chest X-ray in detecting latent tuberculosis among patients with low-risk inflammatory bowel disease before advanced therapy.","authors":"Yvette Gatt, Daniela Chatlani, Clive Camilleri, Martina Sciberras, Lisa Micallef Grimaud, Pierre Ellul","doi":"10.1097/MEG.0000000000002975","DOIUrl":"10.1097/MEG.0000000000002975","url":null,"abstract":"<p><strong>Background: </strong>Patients treated with biologics or Janus kinase (JAK) inhibitors have an increased risk of reactivating latent tuberculosis infection (LTBI). ECCO guidance recommends screening for LTBI by using clinical data, epidemiological factors, chest X-ray (CXR), and either a tuberculin skin test or interferon-gamma release assay (IGRA). The evidence supporting CXR use is categorised at level 5. We aimed to determine the relation between CXR and IGRA test results in adults with inflammatory bowel disease (IBD) before starting immunosuppressive therapy in a low-risk population.</p><p><strong>Methods: </strong>This retrospective analysis identified adult patients with IBD on biologics or JAK inhibitors and their epidemiological data, CXR, and IGRA results were evaluated.</p><p><strong>Results: </strong>356 patients diagnosed with IBD were included, 58.7% ( n  = 209) being male. Most patients had Crohn's disease (66.6%, n  = 237), 30.6% ( n  = 109) had ulcerative colitis, and the remaining 2.8% were classified as IBD-unclassified. The mean age of IBD diagnosis was 30.3 years (SD ± 15.7). None of the patients had any clinical suggestion or exposure to tuberculosis (TB); 93.8% ( n  = 334) of the IGRA results were negative and 4.2% ( n  = 15) were indeterminate. Among those with indeterminate results, 66.7% ( n  = 10) were undergoing corticosteroid treatment. The remaining 2.0% ( n  = 7) had a positive IGRA test result. None of the CXRs performed revealed any radiological signs of TB disease. None of these patients had TB reactivation after immunosuppresion.</p><p><strong>Conclusion: </strong>Routinely performing a CXR in individuals with a negative IGRA offers limited benefits, and submits patients to unnecessary radiation.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"728-732"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between coronary heart disease and risk of advanced liver fibrosis: results of the 2017-2018 national health and nutrition examination survey.","authors":"Hao Pei, Yue-Qiao Chen, Feng-Lan Wu, Yan-Yan Zhang, Xue Zhang, Jian-Yu Li, Li-Yi Pan, Yu Chen, Yu-Wen Huang","doi":"10.1097/MEG.0000000000002956","DOIUrl":"10.1097/MEG.0000000000002956","url":null,"abstract":"<p><strong>Background: </strong>Studies have shown that advanced liver fibrosis is strongly associated with cardiovascular risk factors (including age and smoking status). Nevertheless, the exact mechanism is not yet clear. Hence, this study aimed to investigate the relationship between coronary heart disease (CHD) and advanced liver fibrosis and to reveal the developmental processes.</p><p><strong>Methods: </strong>In this study, we included 9254 participant data from the National Health and Nutrition Examination Surveydatabases in 2017-2018 to explore the association between risk factors and advanced liver fibrosis. First, the baseline characteristics of the participants were examined using Student's t -test and chi-squared test. Moreover, the association between CHD and advanced liver fibrosis was assessed using logistic regression analysis. Thereafter, the receiver operating characteristic curve was used to further evaluate the diagnostic performance of model 3 for advanced liver fibrosis.</p><p><strong>Results: </strong>In total, 3624 participants were included in this study after removing samples with missing information. Baseline statistics showed that CHD, age, sex, BMI, alcohol consumption, smoking, diabetes, and physical activity were all remarkably discrepancies between nonadvanced and advanced liver fibrosis groups ( P  < 0.05). Of these, CHD was shown to have a strong association with advanced liver fibrosis (95% confidence interval (CI), 1.84-7.27, P  = 0.0063, odds ratio (OR) = 3.6587). Moreover, the effect of CHD on advanced liver fibrosis was not confounded by other confounders in model 3, in which confounders were corrected. Eventually, with an area under the curve greater than 0.7, the receiver operating characteristic curve confirmed the good diagnostic performance of Model 3 for advanced liver fibrosis.</p><p><strong>Conclusion: </strong>This study suggested that having CHD was a risk factor for patients with advanced liver fibrosis, which provides a basis for the study of advanced liver fibrosis.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"761-766"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori promotes YTHDF2-mediated SRA1 m 6 A modification and promotes the occurrence and development of gastric cancer.","authors":"Di Wang, Tong-Yan An, Quan-Man Hu, Yan-Qiao Hua, Peng Ni, Bin Jia, Guang-Cai Duan, Shuai-Yin Chen","doi":"10.1097/MEG.0000000000002972","DOIUrl":"10.1097/MEG.0000000000002972","url":null,"abstract":"<p><strong>Background: </strong>Helicobacter pylori ( H. pylori ) is known to be linked to gastric cancer development, but its precise carcinogenic mechanisms are not fully understood. This study aims to investigate the function and mechanism of N 6 -methyladenosine (m 6 A) modification in H. pylori -associated gastric cancer, and to elucidate its regulatory network, offering novel insights and potential therapeutic targets for gastric cancer management.</p><p><strong>Methods: </strong>Western blotting and quantitative PCR (q-PCR) will be used to assess the expression of YTH N 6 -methyladenosine RNA binding protein 2 (YTHDF2) and Steroid Receptor RNA Activator 1 (SRA1), and the impact of YTHDF2 overexpression/knockdown on SRA1 expression. The m 6 A MAZF enzyme digestion method, luciferase reporter assay, and RNA stability assay will be used to assess YTHDF2's role in H. pylori -mediated SRA1 upregulation through m 6 A modification.</p><p><strong>Results: </strong>After H. pylori infection, SRA1 expression rises in mRNA and protein, boosting gastric mucosal and gastric cancer cell proliferation and migration, while YTHDF2 has an opposing impact. We demonstrate that H. pylori increases the m 6 A level of the SRA1 mRNA 3' untranslated regions by inhibiting the m 6 A reader protein YTHDF2, upregulates SRA1 expression, and activates the nuclear factor (NF)-κB pathway, thereby inducing malignant transformation in gastric mucosal epithelial cells and gastric cancer cells.</p><p><strong>Conclusion: </strong>Our findings confirm that H. pylori upregulates SRA1 via m 6 A modification to enhance the malignant progression of gastric cancer, and provide important insights into the activation of the NF-κB pathway, which triggers the onset and progression of gastric cancer. This implies that SRA1 could be a promising therapeutic target for preventing gastric cancer.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"717-727"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil gelatinase-associated lipocalin for predicting acute kidney injury in orthotopic liver transplantation: a systematic review and meta-analysis.","authors":"Fangran Yan, Zenghua Zhou, Xueke Du, Sheng He, Linghui Pan","doi":"10.1097/MEG.0000000000002935","DOIUrl":"10.1097/MEG.0000000000002935","url":null,"abstract":"<p><p>Acute kidney injury (AKI) is associated with poor prognosis. New biomarkers, like neutrophil gelatinase-associated lipocalin (NGAL), are helpful for early warning of AKI. This study aims to investigate the accuracy of NGAL in evaluating the perioperative AKI of liver transplantation. The four databases, PubMed, Web of Science, Embase, and Cochrane Library, were searched for relevant studies published from database inception to August 2023. Results were pooled using random-effects models, and heterogeneity was examined. A total of 16 case-control studies with 1271 patients were included. The results showed that both preoperative [standardized mean difference (SMD) = 0.53; 95% confidence interval (CI): 0.15, 0.91; P  < 0.001] and postoperative NGAL levels (SMD = 0.63; 95% CI: 0.24, 1.03; P  < 0.001) were higher in the AKI group compared with the non-AKI group. Subgroup analysis by continents showed higher preoperative NGAL levels in AKI patients in the European population (SMD = 1.63; 95% CI: 0.55, 0.27; P  = 0.003), but no differences in Asian, African, North American, and South American. Subgroup analysis by continents revealed higher postoperative NGAL levels in the European (SMD = 1.63; 95% CI: 0.55, 0.27; P  = 0.002) and Asian populations (SMD = 0.42; 95% CI: 0.04, 0.81; P  = 0.039). Higher postoperative NGAL levels in plasma and urine were observed in AKI patients compared with non-AKI patients [plasma (SMD = 1.29; 95% CI: 0.21, 2.38; P  = 0.011), urine (SMD = 0.88; 95% CI: 0.18, 1.59; P  = 0.035)], while there was no difference in African, North American, South American, and serum NGAL. NGAL level may be an important biomarker for early detection of AKI in the perioperative period of liver transplantation.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"683-690"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paper Alert.","authors":"","doi":"10.1097/MEG.0000000000002992","DOIUrl":"https://doi.org/10.1097/MEG.0000000000002992","url":null,"abstract":"<p><p>A selection of interesting papers that were published in the month before our press date in major journals likely to report important results in gastroenterology and hepatology. Peter Hayes and John Plevris The Royal Infirmary, Edinburgh EH3 9YW, UK.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"37 6","pages":"785-788"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The mediating role of BMI in alcohol-linked liver enzyme elevation among adults at a tertiary care hospital in South India.","authors":"Arivarasan Barathi, Yuvaraj Krishnamoorthy, Suthanthira Kannan, Dhanajayan Govindhan, Venmathi Elangovan, Padmavathi Subbiah, Deivasigamani Kuberan","doi":"10.1097/MEG.0000000000002949","DOIUrl":"10.1097/MEG.0000000000002949","url":null,"abstract":"<p><strong>Background: </strong>Excessive alcohol consumption is a major risk factor for liver disease, with significant variations in its impact across populations. BMI has been identified as a potential mediator in alcohol-related liver damage. This study aimed to examine the association between alcohol consumption and liver function and to explore the mediating role of BMI in a population from India, where both are rising public health concerns.</p><p><strong>Materials and methods: </strong>A cross-sectional study was conducted using data from adult participants. Liver function was assessed using serum levels of gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP). Alcohol consumption was self-reported, and BMI was calculated AST from height and weight measurements. Multiple linear regression models were used to evaluate the relationship between alcohol consumption and liver enzymes while adjusting for BMI as a mediator. Statistical significance was set at P  < 0.05.</p><p><strong>Results: </strong>The results indicated that higher alcohol consumption was significantly associated with elevated levels of GGT, ALT, and AST. BMI was found to mediate this relationship, with individuals having higher BMI showing a greater increase in liver enzyme levels in response to alcohol consumption. However, no significant association was observed for ALP. BMI also independently correlated with higher levels of GGT, ALT, and AST.</p><p><strong>Conclusion: </strong>This study highlights the mediating role of BMI in alcohol-induced liver dysfunction in the Indian population. Public health interventions focusing on both reducing alcohol intake and managing obesity may help mitigate the risk of liver disease in this high-risk population.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"745-752"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between the Bowel Ultrasound Score and International Bowel Ultrasound Segmental Activity Score based on ileocolonoscopy in patients with Crohn's disease.","authors":"Ilhami Yuksel, Yavuz Cagir, Muhammed Bahaddin Durak, Ali Atay, Mucahit Ergul, Oguz Ozturk, Emir Tugrul Keskin, Ahmet Burak Fedai, Muhammed Mustafa Ince, Erdogan Deniz, Zeki Mesut Yalin Kilic","doi":"10.1097/MEG.0000000000002969","DOIUrl":"10.1097/MEG.0000000000002969","url":null,"abstract":"<p><strong>Background and aim: </strong>We aimed to compare two main existing scores, the Bowel Ultrasound Score (BUSS) and the International Bowel Ultrasound Segmental Activity Score (IBUS-SAS) to predict simplified endoscopic activity score for Crohn's disease (SES-CD).</p><p><strong>Methods: </strong>A cross-sectional study was conducted to evaluate the disease activity in Crohn's disease (CD) patients with ileal involvement between November 2019 and February 2024. Endoscopic remission for CD was accepted as SES-CD ≤2.</p><p><strong>Results: </strong>A total of 56 adult patients with CD (male: 38, 68%, median age: 40.5 years) were included in the study, the median duration of the disease was 8.4 years. The cutoff value for BUSS to determine endoscopic remission was 3.9, whereas the cutoff value for IBUS-SAS to establish endoscopic remission was 24.4. BUSS and SES-CD had a strong positive correlation ( P  < 0.001), BUSS and IBUS-SAS had a high positive correlation ( P  < 0.001), and BUSS and C-reactive protein had a slightly positive correlation ( P  < 0.001).</p><p><strong>Conclusion: </strong>This study revealed that the cutoff values for BUSS and IBUS-SAS in CD patients with endoscopic remission were 3.9 and 24.4, respectively. Furthermore, it was demonstrated that BUSS and IBUS-SAS highly correlate with endoscopic activity in the real-world cohort.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"710-716"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding 'Adjuvant non-opioid analgesics decrease in-hospital mortality in targeted patients with acute pancreatitis receiving opioids'.","authors":"Osman Cagin Buldukoglu, Serkan Ocal, Ayhan Hilmi Cekin","doi":"10.1097/MEG.0000000000002983","DOIUrl":"https://doi.org/10.1097/MEG.0000000000002983","url":null,"abstract":"","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"37 6","pages":"784"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping training programs for endoscopy nurses in gastroenterology: a scoping review.","authors":"Arianna Parrella, Daniele Rusconi, Arianna Povoli, Alessandra Guarini, Nazario Munno, Giulio Petrocelli, Ilaria Basile, Flavia Rampichini, Letteria Consolo","doi":"10.1097/MEG.0000000000002951","DOIUrl":"10.1097/MEG.0000000000002951","url":null,"abstract":"<p><strong>Objective: </strong>Given the significant differences in the scope of practice for endoscopy nurses across various countries and due to the heterogeneity in training required to become an endoscopy nurse, this study aims to map the existing training programs designed for endoscopy nurse in gastroenterology and examine the influence of such educational programs on clinical practice and patient care outcomes.</p><p><strong>Methods: </strong>A scoping review was conducted using the Arksey and O'Malley framework. We identified studies relevant to endoscopy nurse training across databases including PubMed, Embase, Web of Science, SCOPUS, and CINAHL. Eligible studies focused on training programs for endoscopy nurses and were subjected to a two-stage screening process. Data extraction focused on program characteristics, skill development, and clinical outcomes.</p><p><strong>Results: </strong>Of 4834 records, 12 studies were included in the final analysis. These studies detailed diverse training programs ranging from 1-day workshops to 2-year extensive programs. Key skills developed included sedation administration, airway management, handling endoscopy equipment, and interpreting capsule endoscopy images. Nontechnical skills, such as communication, teamwork, and crisis management, were also emphasized. Training programs demonstrated a positive impact on clinical and organizational outcomes, reducing adverse events and improving procedural efficiency. Endoscopy nurses also reported higher job satisfaction following training.</p><p><strong>Conclusion: </strong>Training programs for endoscopy nurses play a vital role in improving both technical and nontechnical competencies, enhancing clinical practice and patient safety. However, significant variability exists in the content and duration of these programs. Standardizing training practices could further optimize nurse performance and patient outcomes in gastroenterology endoscopy.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"702-709"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of serum HBV RNA on HBeAg seroconversion in treated chronic hepatitis B patients.","authors":"Ting Liu, Yuru Shi, Jing Wu, Linghan Qin, Yingjie Qi","doi":"10.1097/MEG.0000000000002946","DOIUrl":"10.1097/MEG.0000000000002946","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the predictive value of serum hepatitis B virus (HBV) RNA on HBeAg seroconversion in treated chronic hepatitis B (CHB) patients.</p><p><strong>Methods: </strong>Sixty-four HBeAg-positive CHB patients were selected. They were divided into HBeAg seroconversion group including 11 cases and HBeAg non-seroconversion group including 53 cases. HBV RNA levels and other laboratory results were measured at baseline and week 12, 24, 48, 72 during treatment in both groups. The predictive value of HBV RNA level for the seroconversion of HBeAg in patients treated for hepatitis B was analyzed.</p><p><strong>Results: </strong>Significant differences existed in serum HBV DNA and HBV RNA levels between the two groups at baseline while there was no significant difference in HBsAg. The correlation between HBV RNA and HBV DNA was significantly high ( r  = 0.707, P  < 0.05), while the correlation between HBV DNA and HBsAg ( r  = 0.474, P  < 0.05) or HBV RNA and HBsAg was poor ( r  = 0.372, P  < 0.05). Patients with younger age and higher HBV RNA levels at baseline and week 24 were less likely to have HBeAg seroconversion. HBV RNA was better than HBV DNA and HBsAg in predicting HBeAg seroconversion whether at baseline or week 12 and week 24. The area under the curve of HBV RNA level at 24th week was the highest, which was 0.942, and the cutoff value was 4.145 log 10 copies/ml.</p><p><strong>Conclusion: </strong>HBV RNA level may be a suitable serum marker to predict whether HBeAg seroconversion can occur. CHB patients with serum HBV RNA level lower than 4.145 log 10 copies/ml at week 24 were more likely to achieve HBeAg seroconversion.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"738-744"},"PeriodicalIF":2.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}