European Journal of Gastroenterology & Hepatology最新文献

{"title":"Endoscopic retrograde cholangiopancreatography discharge tool combined with rapid trypsinogen-2 test to predict same-day discharge: a prospective cohort study.","authors":"Christina J Sperna Weiland, Megan M L Engels, Robbert C H Scheffer, Bas Van Balkom, Koen van Hee, Bertram J T Haarhuis, Joost P H Drenth, Jeanin E van Hooft, Peter D Siersema, Erwin J M van Geenen","doi":"10.1097/MEG.0000000000003014","DOIUrl":"10.1097/MEG.0000000000003014","url":null,"abstract":"<p><strong>Objectives: </strong>Identifying patients at high-risk for endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events (AEs) is important for postendoscopic discharge management. This study assesses two strategies, a urinary trypsinogen-2 (UT-2) dipstick combined with a risk-factor-based ERCP discharge tool, for identifying patients at increased risk of developing AEs.</p><p><strong>Methods: </strong>Between August 2018 and March 2021, 268 patients were enrolled in a multicenter prospective cohort. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the UT-2 dipstick, the discharge tool, and combined strategies were assessed for predicting ERCP-related AEs.</p><p><strong>Results: </strong>Twenty-four (10.5%) AEs occurred in the eligible 228 patients, of which 14 (6.1%) were post-ERCP pancreatitis. The discharge tool and UT-2 dipstick combination outperformed the individual strategies for all AEs with a sensitivity of 66.7% (95% CI, 44.7-84.4%), specificity of 78.5% (95% CI, 72.2-83.9%), PPV of 26.6% (95% CI, 19.8-34.8%) and NPV of 95.3% (95% CI, 91.9-97.3%). For post-ERCP pancreatitis alone, the strategies combined had a sensitivity of 64.3% (95% CI, 35.1-87.2%), specificity of 76.2% (95% CI, 69.9-81.7%), PPV of 14.9% (95% CI, 10.0-21.7%) and NPV of 97.0% (95% CI, 94.2-98.5%).</p><p><strong>Conclusion: </strong>Although the combination of UT-2 dipstick and discharge tool outperforms the two strategies separately in predicting post-ERCP AEs, we would not recommend implementation of either strategy given the low sensitivity when applied separately or combined.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1206-1212"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the efficacy and safety of endoscopic wide band resection in the treatment of colorectal polyps.","authors":"Ufuk Kutluana","doi":"10.1097/MEG.0000000000003023","DOIUrl":"10.1097/MEG.0000000000003023","url":null,"abstract":"<p><strong>Background and studys purpose: </strong>Endoscopic band ligation is commonly used in gastroenterology but limited in colorectal polyps (CRPs) treatment due to narrow cap diameters. Endoscopic mucosal resection and endoscopic submucosal dissection (ESD) are effective but carry higher bleeding risks in patients with concomitant comorbidities. Considering the narrowest part of the colon, the rectosigmoid junction measures approximately 2.5 cm, we developed a custom endoscopic wide band resection (EWBR) cap with a 24 mm external diameter for CRPs <25 mm, particularly in high-risk patients. This study evaluates the efficacy and safety of EWBR.</p><p><strong>Patients and methods: </strong>We prospectively collected and analyzed the outcomes of 32 patients with CRPs treated using EWBR and 34 matched patients treated with ESD between November 2020 and December 2024.</p><p><strong>Main results: </strong>The groups were similar in age, gender, and lesion size (all P  > 0.05). Comorbidities were significantly more common in the EWBR group (78.6 vs. 8.8%; P  < 0.001). EWBR was associated with shorter procedure time (14.2 vs. 35 min; P  < 0.001), lower rates of prolonged bleeding that extended the procedure (3.1 vs. 52.9%; P  < 0.001), smaller hemoglobin decreases (0.55 vs. 1.17 g/dl; P  = 0.002), and shorter hospital stays (1.03 vs. 2.11 days; P  = 0.001). Only one patient (3.1%) in the EWBR group developed asymptomatic minor strictures. No recurrences were observed in either group.</p><p><strong>Conclusion: </strong>EWBR is a safe and effective alternative for CRPs <25 mm, especially in high-risk patients. It reduces procedure time, bleeding, and hospital stay, making it a promising therapeutic option.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1213-1218"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to concerns about data integrity of randomized clinical trials.","authors":"Sherief Abd-Elsalam, Shaimaa Soliman, Ferial El-Kalla","doi":"10.1097/MEG.0000000000003071","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003071","url":null,"abstract":"","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"37 11","pages":"1302-1303"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triglyceride glucose index as a causal risk factor for metabolic dysfunction-associated fatty liver disease: evidence from the National Health and Nutrition Examination Survey 2017-2020 and Mendelian randomization.","authors":"Zhiwei Su, Juan Xue, Jun Sun, Yuxue Ding, Chunyan Ji","doi":"10.1097/MEG.0000000000003033","DOIUrl":"10.1097/MEG.0000000000003033","url":null,"abstract":"<p><strong>Background/aims: </strong>Metabolic dysfunction-associated fatty liver disease (MAFLD) is a global health burden increasing liver-related mortality. Existing cross-sectional studies lack causal evidence between the triglyceride glucose (TyG) index and MAFLD. Utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020 and Mendelian randomization, this study aimed to investigate the causal association between the TyG index and MAFLD.</p><p><strong>Methods: </strong>On the basis of the 2017-2020 NHANES data, baseline characteristics of MAFLD cases and the control group were comparatively analyzed. Multivariate logistic regression evaluated the association between the TyG index and MAFLD, with restricted cubic splines (RCS) employed for nonlinear relationship assessment. A two-sample Mendelian randomization analysis examined potential causal relationships, while comprehensive sensitivity analyses validated the robustness of the principal findings.</p><p><strong>Results: </strong>Cross-sectional analysis revealed a significant positive linear association between the TyG index and MAFLD risk. After multivariable adjustment, the odds ratio (OR) was 2.30 [95% confidence interval (CI) = 1.71-3.10, P  < 0.001]. RCS analysis further confirmed a monotonic linear relationship between the TyG index and MAFLD risk. The test for nonlinearity was nonsignificant ( P  = 0.07), confirming a linear dose-response. Mendelian randomization analysis indicated that a genetically predicted 1-unit increase in TyG index was associated with 64% higher MAFLD risk (OR = 1.64, 95% CI = 1.07-2.50, P  = 0.02).</p><p><strong>Conclusion: </strong>This study using cross-sectional data and Mendelian randomization confirms the TyG index as an independent causal risk factor for MAFLD, highlighting the need for early monitoring and intervention to inform precision prevention strategies.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1292-1301"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of abdominal massage on constipation and laboratory parameters in patients undergoing hemodialysis: a randomized clinical trial study.","authors":"Mahdieh Daneshfar, Mansooreh Azizzadeh Forouzi, Mohammed Faris Abdulghani, Mahlagha Dehghan, Tori Canillas-Dufau, Mohamed Alnaiem, Maryamsadat Mousavi","doi":"10.1097/MEG.0000000000003009","DOIUrl":"10.1097/MEG.0000000000003009","url":null,"abstract":"<p><strong>Background: </strong>Kidney failure is a prevalent chronic disease, and individuals undergoing hemodialysis often experience various complications, including constipation and alterations in laboratory parameters. This study, aimed to investigate the impact of abdominal massage on constipation and laboratory parameters in patients undergoing hemodialysis.</p><p><strong>Methods: </strong>In this randomized clinical trial study, convenience sampling method was used, and the participants were randomly allocated the abdominal massage group ( n  = 39) or the sham group ( n  = 38). In the intervention group, abdominal massage was administered by a trained researcher for 15 min, three times a week (1 h after the initiation of dialysis). Meanwhile, the sham group received a light abdominal touch. The Constipation Assessment Questionnaire, and a checklist of laboratory indicators were used to collect information.</p><p><strong>Results: </strong>In the abdominal massage group, the mean constipation score was 6.62 before the intervention, indicating a moderate level of constipation; however, after the intervention, there was a significant decrease in the score to 4.77, indicating a mild level of constipation. Similarly, in the sham group, the constipation score significantly decreased from 6.42 before the intervention to 4.66 at the end of the study. The mean scores of laboratory indicators, including sodium, potassium, phosphorus, calcium, and dialysis adequacy, did not differ significantly between the intervention and sham groups after the intervention ( P  < 0.05).</p><p><strong>Conclusion: </strong>Both abdominal massage and light touch have shown to be effective in reducing the severity of constipation in patients undergoing hemodialysis; however, these interventions did not have any significant impact on the laboratory indicators.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1198-1205"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis on the efficacy of fecal microbiome transplantation in patients with severe alcohol-associated hepatitis.","authors":"Evance Pakuwal, Jin Lin Tan, Richard J Woodman, Amanda J Page, Andrea M Stringer, Mohamed Asif Chinnaratha","doi":"10.1097/MEG.0000000000003003","DOIUrl":"10.1097/MEG.0000000000003003","url":null,"abstract":"<p><strong>Background: </strong>Severe alcohol-associated hepatitis (sAH) has a high short-term mortality, with limited treatment options. Fecal microbiota transplantation (FMT) has shown benefits in small, uncontrolled studies.</p><p><strong>Aim: </strong>Perform a systematic review and meta-analysis to provide updated evidence on the efficacy and safety of FMT in sAH patients.</p><p><strong>Method: </strong>Electronic databases were searched till 4 December 2023 for studies comparing FMT with standard of care (SOC) in sAH patients. Sensitivity analysis (leave-one-out method) and subgroup analyses were performed. Pooled risk ratio (RR) was used to compare the survival outcomes.</p><p><strong>Results: </strong>Eight studies with 444 patients (FMT: 218; SOC: 226) met the eligibility criteria and were included in this meta-analysis. The 28- and 90-day survival range was higher in the FMT group (75-100% and 53-87%) compared to the SOC group (48-80% and 25-56%). The random-effects model showed a statistically significant increase in survival in the FMT arm at 28 days [RR (95% confidence interval) 2.30 (1.24-4.28), P  = 0.01] and 90 days [2.53 (1.34-4.77), P  < 0.001]. However, there was no statistically significant change in survival at the 6-month [1.89 (0.89-4.05), P  = 0.10] and the 12-month time [1.86 (0.68-5.08), P  = 0.23]. Sensitivity analysis showed no major changes in the overall effect sizes, and subgroup analysis showed that the survival benefit was restricted only to the retrospective studies. No serious treatment-related adverse events were reported.</p><p><strong>Conclusion: </strong>FMT is a safe and efficacious treatment option that improves short-term survival in sAH patients, without major adverse events. A multicentre randomized controlled trial with an adequate sample size is required to confirm these findings.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1260-1268"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the epidemiology of gastric cancer: a review and case-only analysis from Italy.","authors":"Giulia Collatuzzo, Giulia Fiorini, Tommaso Renieri, Matteo Pavoni, Stefania Boccia, Antonietta D'Errico, Dino Vaira, Paolo Boffetta","doi":"10.1097/MEG.0000000000003064","DOIUrl":"10.1097/MEG.0000000000003064","url":null,"abstract":"<p><strong>Background: </strong>Gastric cancer epidemiology evolved rapidly in the last century, shifting from being one of the main causes of cancer-related death to the sixth in high-income countries.</p><p><strong>Methods: </strong>We conducted a narrative review on gastric cancer epidemiology. Our review focused on trends of gastric cancer and its relationship with Helicobacter pylori infection; cardia and noncardia gastric cancer risk factors; early onset gastric cancer; second primary cancers in patients with gastric cancer; and implementation of gastric cancer prevention strategies. In addition, we provided results of a case-only analysis of recently diagnosed gastric cancer from a middle-risk population.</p><p><strong>Results: </strong>Literature consistently describes the ongoing declining trend of gastric cancer rates and the overall increase in in absolute number of incident cases because of a change in population. The evolving distribution of risk factor prevalence impacts the epidemiology of gastric cancer, with an increase in early onset and in cardia gastric cancer. A negative correlation was observed between H. pylori prevalence and the proportion of cardia gastric cancer. The analysis of 117 gastric cancer cases observed between 2016 and 2020 in Bologna, Italy, showed that smoking and epigastric pain were significantly associated with increased risk of early-onset gastric cancer after accounting for confounders.</p><p><strong>Conclusion: </strong>Multifaceted strategies are needed to address challenges in gastric cancer control, early diagnosis, and clinical management in a changing epidemiological landscape. Prevention remains the cornerstone to reduce the gastric cancer burden.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1249-1259"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of nonceliac wheat sensitivity in refractory irritable bowel syndrome and functional dyspepsia: results from a randomized double-blind placebo-controlled study.","authors":"Omesh Goyal, Manjeet Kumar Goyal, Abhinav Gupta, Arshia Bharadwaj, Akshay Mehta, Paraag Kumar, Prerna Goyal, Ajit Sood","doi":"10.1097/MEG.0000000000003046","DOIUrl":"https://doi.org/10.1097/MEG.0000000000003046","url":null,"abstract":"<p><strong>Background and aims: </strong>Nonceliac wheat sensitivity (NCWS) is characterized by gastrointestinal and extraintestinal symptoms triggered by gluten ingestion. Its symptomatology overlaps substantially with irritable bowel syndrome (IBS) and functional dyspepsia (FD), leading to diagnostic challenges. Data on the prevalence and predictors of NCWS among patients with IBS or FD, especially those with refractory symptoms, are limited. We aimed to determine the prevalence, clinical predictors, and impact of a gluten-free diet (GFD) in this population using the Salerno Experts' Criteria.</p><p><strong>Methods: </strong>In this prospective, multicenter trial, adults (18-65 years) with Rome IV-defined IBS or FD, refractory to standard therapy, were enrolled. Participants underwent a 6-week GFD; gluten responders subsequently underwent a double-blind placebo-controlled gluten challenge (DBPCGC) with crossover. Symptom trajectories, health-related quality of life (HRQOL), anxiety, and depression were assessed. Multivariable logistic regression identified predictors of NCWS. Trial registration number- CTRI/2021/10/037323.</p><p><strong>Results: </strong>Of 252 screened patients, 177 were enrolled for a 6-week GFD (step I), and 154 patients completed this phase (mean age 41.9 ± 14.2 years, 53.2% males). Eighty-two (52.3%) patients responded to GFD, of whom 77 entered step II (DBPCGC). Thirty-one (20.1%) patients had significant symptom worsening on blinded gluten ingestion, suggesting the presence of NCWS. Female sex, FD-IBS overlap, headache, fatigue, and anxiety independently predicted NCWS. GFD was associated with significant HRQOL improvement.</p><p><strong>Conclusion: </strong>Approximately one-fifth of the patients with refractory IBS/FD fulfill the NCWS criteria. Therefore, screening for NCWS in patients with refractory IBS or FD is extremely important to limit unnecessary pharmacotherapy and enhance patient outcomes.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":"37 11","pages":"1238-1248"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of care in inflammatory bowel disease from patient's perspective using QUOTE-IBD: a Greek multicenter prospective study.","authors":"Aikaterini Mantaka, Ioannis Apostolakis, Phillippe-Richard Domeyer, Pavlos Sarafis, Antreas Psistakis, Evangelia Anagnostopoulou, Konstantinos Karmiris, Angeliki Theodoropoulou, Ioannis E Koutroubakis","doi":"10.1097/MEG.0000000000003031","DOIUrl":"10.1097/MEG.0000000000003031","url":null,"abstract":"<p><strong>Objective: </strong>Most of the existing instruments assessing quality of care (QoC) are based on the perception of healthcare providers that may differ from that of healthcare users. We aimed to measure QoC through the patient's eyes in a Greek cohort of patients with inflammatory bowel disease (GR QUOTE-IBD) and to investigate putative sociodemographic and disease-related QoC predictors.</p><p><strong>Methods: </strong>GR QUOTE-IBD questionnaire was delivered to patients at their regular follow-up visit, and adequate time was offered to fill it in. The outcome of the analysis was associated with epidemiological and disease-related characteristics. Statistical analysis was performed with SPSS (version 29, SPSS Inc., Chicago, Illinois, USA).</p><p><strong>Results: </strong>GR QUOTE-IBD questionnaire was completed by 150 patients from three IBD clinics, 93 with Crohn's disease (CD), with a median disease duration of 10 years (range 0.6-43 years). Quality Index (QI) for total care was >9 in all three hospitals. Quality deficit QI <9 was found only for accessibility to IBD care in two of three clinics. Autonomy in decision-making was rated as the least important dimension of QoC from the patients' perspective. A positive association was found between CD diagnosis and QI scores for total care ( P  = 0.013). Steroid treatment over two times in lifetime was negatively associated with QI scores for total care ( P  = 0.019).</p><p><strong>Conclusion: </strong>Total QoC from patients' perspective is high in Crete. CD and disease severity seem to affect patients' perceptions of IBD care. Gastroenterologists in Crete should improve accessibility to IBD care and empower patients' involvement in shared decision-making.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1230-1227"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to clinical and endoscopic standards of quality in inflammatory bowel disease: a nationwide survey from the Italian Association of Hospital Gastroenterologists and Endoscopists.","authors":"Maria Carla Di Paolo, Andrea Cassinotti, Cristiano Pagnini, Linda Ceccarelli, Giammarco Mocci, Ileana Luppino, Rossella Pumpo, Elisabetta Antonelli, Maria Cappello, Roberto Vassallo, Michele Comberlato, Sergio Segato, Massimo Bellini, Marco Soncini","doi":"10.1097/MEG.0000000000003025","DOIUrl":"10.1097/MEG.0000000000003025","url":null,"abstract":"<p><strong>Objective: </strong>Quality of care in inflammatory bowel disease (IBD) patients is a major priority as it is associated with better outcomes. We assessed the adherence of Italian gastroenterologists to current international recommendations regarding quality performance measures for clinical and endoscopic IBD activities.</p><p><strong>Methods: </strong>From March to July 2023, 179 Italian specialists participated in an online questionnaire-based survey concerning their demographic details, affiliations, clinical, and endoscopic practice. Data on the characteristics of the specialists' centres were also collected. Recommendations from European Crohn's and Colitis Organisation, Building Resources and Research in IBD Globally group, and European Society of Gastrointestinal Endoscopy for clinical and endoscopic standards were used as reference standards.</p><p><strong>Results: </strong>Deviations from guidelines' recommendations included suboptimal availability of all specialties required for multidisciplinary teams, underuse of maintenance treatment with oral mesalamine in ulcerative colitis but still frequent use in Crohn's disease, suboptimal dosages of topical therapy, low attention to performing ileal biopsies in suspected IBD and to Paris and mucosal pattern classifications for lesion characterisation. No significant regional differences were observed, while significantly lower performances were reported for many responses coming from small centres or doctors less dedicated to IBD care.</p><p><strong>Conclusion: </strong>In Italy, adherence to current standards of care for IBD is generally good, with some practices to be improved. There is a need to support small centres and doctors less engaged in IBD within integrated clinical care networks.</p>","PeriodicalId":11999,"journal":{"name":"European Journal of Gastroenterology & Hepatology","volume":" ","pages":"1219-1229"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}