Association between diabetes duration and risk of pancreatic cancer: a meta-analysis of observational studies.

IF 1.8 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

European Journal of Gastroenterology & Hepatology Pub Date : 2025-09-01 DOI:10.1097/MEG.0000000000003041

Xuefeng Hua, Rongdang Fu, Ziwei Yin, Hui Gong

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Abstract

Background: Prior studies have implicated diabetes as a risk factor for pancreatic cancer, yet the impact of diabetes progression on pancreatic cancer incidence remains unclear. We aim to assess pancreatic cancer risk across different stages of diabetes.

Methods: Employing a predefined search strategy, we conducted a literature review of electronic databases up to 29 February 2024. Extracting odds ratios (OR) and 95% confidence intervals (CIs) relevant to diabetes, we aimed to evaluate pancreatic cancer risk among diabetic patients and conduct subgroup analyses.

Results: Our systematic review comprised 29 observational cohort studies with 25 million participants. We observed a 2.13-fold higher likelihood of pancreatic cancer among diabetic individuals compared with nondiabetic counterparts. Specifically, males with diabetes exhibited a greater pancreatic cancer risk than females; however, regional disparities in pancreatic cancer risk among diabetic patients were NS. Regarding diabetes duration, pooled ORs (95% CI) for pancreatic cancer risk were 2.41 (2.07-2.81) for 1-4 years, 1.67 (1.50-1.85) for 4-10 years, and 2.01 (1.81-2.22) for over 10 years.

Conclusion: The results of this study confirm a significant association between diabetes and pancreatic cancer. Although there was no statistically significant difference in risk between different diabetes duration groups, diabetic patients overall face a higher risk of pancreatic cancer. Therefore, diabetic patients should undergo regular pancreatic cancer screening and take appropriate management measures to detect potential pancreatic cancer at an early stage.

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糖尿病病程与胰腺癌风险之间的关系：一项观察性研究的荟萃分析

背景：先前的研究表明糖尿病是胰腺癌的危险因素，但糖尿病进展对胰腺癌发病率的影响尚不清楚。我们的目标是评估不同阶段糖尿病的胰腺癌风险。方法：采用预定义的检索策略，对截至2024年2月29日的电子数据库进行文献综述。提取与糖尿病相关的比值比（OR）和95%置信区间（CIs），我们旨在评估糖尿病患者的胰腺癌风险并进行亚组分析。结果：我们的系统综述包括29项观察性队列研究，涉及2500万参与者。我们观察到糖尿病患者患胰腺癌的可能性比非糖尿病患者高2.13倍。具体来说，男性糖尿病患者患胰腺癌的风险高于女性；然而，糖尿病患者胰腺癌风险的地区差异不明显。关于糖尿病病程，1-4年胰腺癌风险的合并or （95% CI）为2.41(2.07-2.81)，4-10年为1.67(1.50-1.85)，10年以上为2.01（1.81-2.22）。结论：本研究结果证实糖尿病与胰腺癌之间存在显著相关性。虽然不同糖尿病病程组之间的风险无统计学差异，但糖尿病患者总体上面临更高的胰腺癌风险。因此，糖尿病患者应定期进行胰腺癌筛查，并采取相应的管理措施，及早发现潜在的胰腺癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Gastroenterology & Hepatology 医学-胃肠肝病学

CiteScore

4.40

自引率

4.80%

发文量

269

审稿时长

1 months

期刊介绍： European Journal of Gastroenterology & Hepatology publishes papers reporting original clinical and scientific research which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The journal publishes three types of manuscript: in-depth reviews (by invitation only), full papers and case reports. Manuscripts submitted to the journal will be accepted on the understanding that the author has not previously submitted the paper to another journal or had the material published elsewhere. Authors are asked to disclose any affiliations, including financial, consultant, or institutional associations, that might lead to bias or a conflict of interest.