{"title":"A Convolutional Framework for Forward and Back-Projection in Fan-Beam Geometry","authors":"Kai Zhang, A. Entezari","doi":"10.1109/ISBI.2019.8759285","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759285","url":null,"abstract":"We present a convolutional spline framework for highly efficient and accurate computation of forward model for image reconstruction in fan-beam geometry in X-ray computed tomography. The efficiency of computations makes this framework suitable for large-scale optimization algorithms with on-the-fly, memory-less, computations of the forward and back-projection. Our experiments demonstrate the improvements in accuracy as well as efficiency of our model, specifically for first-order box splines (i.e., pixel-basis) compared to recently developed methods for this purpose, namely Look-up Table-based Ray Integration (LTRI) and Separable Footprints (SF) in 2-D.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"388 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132963279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Curve Fitting Criteria to Determine Arterial Input Function for MR Perfusion Analysis","authors":"A. Huang, Chung-wei Lee, Hon-Man Liu","doi":"10.1109/ISBI.2019.8759307","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759307","url":null,"abstract":"The purpose of this study is to develop a fully automatic algorithm for determining a “proper” arterial input function (AIF) that is critical in the deconvolution approach for cerebral perfusion quantification. We proposed using a fast gamma variate model (GVM) fitting strategy to scout the whole brain dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) dataset for AIF candidates. Goodness-of-fit criteria such as signal to noise ratios and GVM peak shapes were first used to screen out voxels of noisy signals and non-AIF-shaped concentration-time curves respectively. Last, qualified AIF candidates were ranked by bolus peak arrival time and peak width. Our method was tested by 10 DSC-MRI datasets: 5 adults (24-52 years of age) with stenosis or occlusion, and 5 youths (9-18 years of age) with moyamoya disease. The preliminary results indicated that the proposed algorithm was able to detect AIFs robustly and efficiently under 1 minute.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133519516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yitian Zhou, L. Launay, J. Bert, R. Crevoisier, O. Acosta
{"title":"Optimized Multi-Atlas Prostate Segmentation From 3D CT Images","authors":"Yitian Zhou, L. Launay, J. Bert, R. Crevoisier, O. Acosta","doi":"10.1109/ISBI.2019.8759389","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759389","url":null,"abstract":"The purpose of this study was to evaluate and optimize the performance of a multi-atlas based method for the segmentation of prostate in CT scans improving it up to the limit of the inter-observer variability. We assessed and optimized the atlas selection, the Non-Rigid Registration (NRR) and the label fusion steps by introducing new similarity measures based on image features and a multi-scale weighted majority voting. Cross validation results on 45 CT images suggested that the similarity measure based on the local feature histogram of oriented gradients outperformed classical intensity-based metrics for atlas selection. Besides, the NiftyReg optimized in a region of interest was found to be the optimal NRR algorithm. For the label fusion, the multi-scale weighted majority voting outperformed other approaches. All those improvements led to Dice scores of $0.84 pm 0.03$, which are comparable to the inter-observer variability for manual contouring.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133357832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingru Yi, Pengxiang Wu, Qiaoying Huang, Hui Qu, D. Hoeppner, Dimitris N. Metaxas
{"title":"Context-Refined Neural Cell Instance Segmentation","authors":"Jingru Yi, Pengxiang Wu, Qiaoying Huang, Hui Qu, D. Hoeppner, Dimitris N. Metaxas","doi":"10.1109/ISBI.2019.8759204","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759204","url":null,"abstract":"Neural cell instance segmentation serves as a valuable tool for the study of neural cell behaviors. In general, the instance segmentation methods compute the region of interest (ROI) through a detection module, where the segmentation is subsequently performed. To precisely segment the neural cells, especially their tiny and slender structures, existing work employs a u-net structure to preserve the low-level details and encode the high-level semantics. However, such method is insufficient for differentiating the adjacent cells when large parts of them are included in the same cropped ROI. To solve this problem, we propose a context-refined neural cell instance segmentation model that learns to suppress the background information. In particular, we employ a light-weight context refinement module to recalibrate the deep features and focus the model exclusively on the target cell within each cropped ROI. The proposed model is efficient and accurate, and experimental results demonstrate its superiority compared to the state-of-the-arts. Code is available at https://github.com/yijingru/CRNCIS-Pytorch.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130854941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pierre-Henri Conze, C. Pons, V. Burdin, F. Sheehan, S. Brochard
{"title":"Deep convolutional encoder-decoders for deltoid segmentation using healthy versus pathological learning transferability","authors":"Pierre-Henri Conze, C. Pons, V. Burdin, F. Sheehan, S. Brochard","doi":"10.1109/ISBI.2019.8759378","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759378","url":null,"abstract":"Shoulder muscle segmentation in patients with obstetrical brachial plexus palsy is a challenging task from magnetic resonance images. A reliable fully-automated method could greatly help clinicians to plan therapeutic interventions. Among various structures, shoulders comprise a rounded and triangular-shaped muscle located on top: the deltoid. The purpose of this work consists in investigating the feasibility of pathological deltoid segmentation using deep convolutional encoder-decoders. Given a limited amount of available annotated images, we study learning transferability from healthy to pathological data by comparing different learning schemes in terms of model generalizability. Extended versions of convolutional encoder-decoder architectures using an encoder pre-trained on non-medical data are proposed to improve the delineation accuracy. Promising results obtained on a dataset of 24 shoulder examinations offer new insights for force inference in musculo-skeletal disorder management.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123889207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Saliency-Aware Hybrid Dense Network for Bleeding Detection in Wireless Capsule Endoscopy Images","authors":"Xiaohan Xing, Yixuan Yuan, Xiao Jia, M. Meng","doi":"10.1109/ISBI.2019.8759401","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759401","url":null,"abstract":"Wireless Capsule Endoscopy (WCE) has been widely used for the screening of Gastrointestinal (GI) diseases. However, manually reviewing the huge number of WCE images is time-consuming and error-prone, thus a computer-aided diagnosis (CAD) system is highly demanded in clinical practice. In this paper, we propose a novel Saliency-aware Hybrid Network (SHNet) for automatic GI bleeding detection. Specifically, the SHNet consists of two densely connected convolutional networks (DenseNets) that are respectively considered as global image stream and saliency-aware stream. Moreover, we introduce polar transformation to reduce the noise from the background and highlight the image information. Finally, we employ the ensemble learning strategy to jointly optimize the final diagnosis result. Extensive experiments on the clinical WCE dataset illustrate that our proposed method outperforms the-state-of-the-art algorithms in GI bleeding detection with the F1 score of 0.959.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"93 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126140095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fanglin Huang, A. El-Azab, Le Ou-Yang, Joseph Tan, Tianfu Wang, Baiying Lei
{"title":"Sparse Low-rank Constrained Adaptive Structure Learning using Multi-template for Autism Spectrum Disorder Diagnosis","authors":"Fanglin Huang, A. El-Azab, Le Ou-Yang, Joseph Tan, Tianfu Wang, Baiying Lei","doi":"10.1109/ISBI.2019.8759487","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759487","url":null,"abstract":"Autism spectrum disorder (ASD) is a developmental disability that causes severe social, communication and behavioral challenges. Up to now, many imaging-based approaches for ASD diagnosis have been proposed. However most of them limited to single template. In this paper, we propose a novel sparse low-rank constrained multi-templates data based method for ASD diagnosis, which performs feature selection and adaptive local structure learning simultaneously. Specifically, we encode modularity prior while constructing functional connectivity (FC) brain networks from different templates for each subject. After extracting features from FC networks, feature selection is applied. Meanwhile, the local structure is learnt via an adaptive process. Extensive experiments are conducted to demonstrate the effectiveness of our proposed method on the Autism Brain Imaging Data Exchange (ABIDE) database. Experimental results verify our proposed method can enhance the diagnosis performances and outperform the commonly used and state-of-the-art methods.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115638329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Burlina, Neil J. Joshi, Seth D. Billings, I-J. Wang, J. Albayda
{"title":"Unsupervised Deep Novelty Detection: Application To Muscle Ultrasound And Myositis Screening","authors":"P. Burlina, Neil J. Joshi, Seth D. Billings, I-J. Wang, J. Albayda","doi":"10.1109/ISBI.2019.8759565","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759565","url":null,"abstract":"This study investigates unsupervised novelty detection (ND) for screening of rare myopathies and specifically myositis. To support this study we developed from the ground up a novel and fully annotated dataset consisting of 3586 images taken of eighty nine individuals obtained under informed consent during 2016–2017. We developed and compared performance for several ND methods leveraging deep feature embeddings, utilizing generative as well as discriminative deep learning approaches for embeddings, and using various novelty scores. We carried out several performance comparisons including with a clinician, supervised binary classification approaches, and a generative method, demonstrating that our best performing approach is competitive with human performance and other best of breed algorithms.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116873851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Diamantis, P. Dalgarno, T. Anderson, J. Jensen, V. Sboros
{"title":"A comparison between image and signal sharpness-based axial localization of ultrasound scatterers","authors":"K. Diamantis, P. Dalgarno, T. Anderson, J. Jensen, V. Sboros","doi":"10.1109/ISBI.2019.8759225","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759225","url":null,"abstract":"Super-resolution ultrasound imaging deploys contrast microbubble (MB) tracking to delineate micro-vessels. The potential application spans to a large number of diseases which cause compromised vascular networks. Current super-resolution methods are mainly based on image processing. Sharpness-based localization is an alternative to such methods for scatterer localization in the axial direction, and can be implemented using both image and signal data. A 7-MHz, linear ultrasound transducer $(lambda = 212 mu mathrm{m})$ and the Synthetic Aperture Real-time Ultrasound System (SARUS) were used to image a wire-target (point scatterer) at different depth positions. The method predicts a depth estimate and its difference from the true scatterer position demonstrates its accuracy. This average difference can be as low as $27.41 mu mathrm{m}($ or $approx lambda /8)$ for the image-derived sharpness and drops to $2.84 mu mathrm{m}($ or $approx quad lambda /75)$ when the signals are used. These figures were calculated for a 8 mm depth range, which can be extended subject to further processing. The process of image formation involves interpolation and logarithmic compression that reduce the overall performance of the method when using image data. Such details may be significant when reconstructing micro-vessels of the order of tens of micrometres in diameter.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117242710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Mancini, Shauna Crampsie, David L. Thomas, Z. Jaunmuktane, J. Holton, J. E. Iglesias
{"title":"Hierarchical Joint Registration of Tissue Blocks With Soft Shape Constraints For Large-Scale Histology of The Human Brain","authors":"M. Mancini, Shauna Crampsie, David L. Thomas, Z. Jaunmuktane, J. Holton, J. E. Iglesias","doi":"10.1109/ISBI.2019.8759396","DOIUrl":"https://doi.org/10.1109/ISBI.2019.8759396","url":null,"abstract":"Large-scale 3D histology reconstruction of the human brain with MRI as volumetric reference generally requires reassembling the tissue blocks into the MRI space, prior to any further reconstruction of the histology of the individual blocks. This is a challenging registration problem, particularly in the frequent case that blockface photographs of paraffin embedded tissue are used as intermediate modality, as their contrast between white and gray matter is rather low. Here we propose a registration framework to address this problem, relying on two key components. First, blocks are simultaneously aligned to the MRI while exploiting the spatial constraints that they impose on each other, by means of a customized soft shape constraint (similarly to a jigsaw puzzle). And second, we adopt a hierarchical optimization strategy that capitalizes on our prior knowledge on the slicing and blocking procedure. Our framework is validated quantitatively on synthetic data, and qualitatively on the histology of a whole human hemisphere.","PeriodicalId":119935,"journal":{"name":"2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI 2019)","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121254093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}