European Heart Journal - Cardiovascular Pharmacotherapy最新文献

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Impact of ethnicity on antiplatelet treatment regimens for bleeding reduction in acute coronary syndromes: a systematic review and pre-specified subgroup meta-analysis. 种族对急性冠脉综合征患者减少出血的抗血小板治疗方案的影响:一项系统综述和预先指定的亚组荟萃分析。
IF 5.3 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad085
Mattia Galli, Renzo Laborante, Giovanni Occhipinti, Andea Zito, Luigi Spadafora, Giuseppe Biondi-Zoccai, Roberto Nerla, Fausto Castriota, Domenico D'Amario, Davide Capodanno, Young-Hoon Jeong, Takeshi Kimura, Roxana Mehran, Dominick J Angiolillo
{"title":"Impact of ethnicity on antiplatelet treatment regimens for bleeding reduction in acute coronary syndromes: a systematic review and pre-specified subgroup meta-analysis.","authors":"Mattia Galli, Renzo Laborante, Giovanni Occhipinti, Andea Zito, Luigi Spadafora, Giuseppe Biondi-Zoccai, Roberto Nerla, Fausto Castriota, Domenico D'Amario, Davide Capodanno, Young-Hoon Jeong, Takeshi Kimura, Roxana Mehran, Dominick J Angiolillo","doi":"10.1093/ehjcvp/pvad085","DOIUrl":"10.1093/ehjcvp/pvad085","url":null,"abstract":"<p><strong>Aims: </strong>Randomized controlled trials (RCTs) testing bleeding reduction strategies using antiplatelet treatment regimens (BRATs) in acute coronary syndromes (ACS) have shown promising results, but the generalizability of these findings may be significantly influenced by the ethnicity of the patients enrolled, given that East Asian (EA) patients show different ischaemic-bleeding risk profile compared to non-EA patients.</p><p><strong>Methods and results: </strong>RCTs comparing a BRAT vs. standard 12-month dual antiplatelet therapy (DAPT) in patients with ACS undergoing percutaneous coronary intervention (PCI) were selected. The primary efficacy endpoint was major adverse cardiovascular events (MACE) as defined in each trial and the primary safety endpoint was minor or major bleeding. Twenty-six RCTs testing seven different BRATs were included. The only strategy associated with a trade-off in MACE was 'upfront unguided de-escalation' in the subgroup of non-EAs (risk ratio 1.16, 95% confidence interval 1.09-1.24). All but aspirin monotherapy-based strategies (i.e. 'short and very short DAPT followed by aspirin') were associated with reduced bleeding compared with standard DAPT in both EA and non-EA patients. There were no significant differences between subgroups, but the lack of RCTs in some of the included strategies and the difference in the certainty of evidence between EA and non-EA patients revealed that the evidence in support of different BRATs in ACS undergoing PCI is influenced by ethnicity. Moreover, absolute risk reduction estimation revealed that some BRATs might be more effective than others in reducing bleeding according to ethnicity.</p><p><strong>Conclusion: </strong>The majority of BRATs are associated with reduced bleeding without any trade-off in hard ischaemic endpoints regardless of ethnicity. However, the supporting evidence and relative safety profiles of different BRATs might be significantly affected by ethnicity, which should be taken into account in clinical practice.</p><p><strong>Study registration: </strong>This study is registered in PROSPERO (CRD42023416710).</p>","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":5.3,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92153353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of omega-3 fatty acids vs. fenofibrate with adverse cardiovascular outcomes in people with metabolic syndrome: propensity matched cohort study. 代谢综合征患者中omega-3脂肪酸与非诺贝特不良心血管结局的相关性:倾向匹配队列研究
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad090
Nam Hoon Kim, Ji Yoon Kim, Jimi Choi, Sin Gon Kim
{"title":"Associations of omega-3 fatty acids vs. fenofibrate with adverse cardiovascular outcomes in people with metabolic syndrome: propensity matched cohort study.","authors":"Nam Hoon Kim, Ji Yoon Kim, Jimi Choi, Sin Gon Kim","doi":"10.1093/ehjcvp/pvad090","DOIUrl":"10.1093/ehjcvp/pvad090","url":null,"abstract":"<p><strong>Aims: </strong>Omega-3 fatty acids and fenofibrates have shown some beneficial cardiovascular effects; however, their efficacy has not been compared. This study aimed to compare the effectiveness of currently available omega-3 fatty acids and fenofibrate for reducing major adverse cardiovascular events (MACE).</p><p><strong>Methods and results: </strong>From a nationwide population-based cohort in South Korea (2008-2019), individuals with metabolic syndrome (≥30 years) who received statin with omega-3 fatty acids and those receiving statin with fenofibrate were matched by propensity score (n = 39 165 in both groups). The primary outcome was MACE, including ischaemic heart disease (IHD), ischaemic stroke (IS), and death from cardiovascular causes. The risk of MACE was lower [hazard ratio (HR), 0.79; 95% confidence interval (CI), 0.74-0.83] in the fenofibrate group than in the omega-3 fatty acid group. Fenofibrate was associated with a lower incidence of IHD (HR, 0.72; 95% CI, 0.67-0.77) and hospitalization for heart failure (HR, 0.90; 95% CI, 0.82-0.97), but not IS (HR, 0.90; 95% CI, 0.81-1.00) nor death from cardiovascular causes (HR, 1.07; 95% CI, 0.97-1.17). The beneficial effect of fenofibrate compared to omega-3 fatty acids was prominent in patients with preexisting atherosclerotic cardiovascular disease and those receiving lower doses of omega-3 fatty acids (≤2 g per day).</p><p><strong>Conclusion: </strong>In a real-world setting, fenofibrate use was associated with a lower risk of MACE compared with low-dose omega-3 fatty acids when added to statins in people with metabolic syndrome.</p>","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138451203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New data on NOVEL ORAL ANTICOAGULANT, SGLT2i, lipid treatment and genetics. 关于新型口服抗凝剂、SGLT2i、血脂治疗和遗传学的新数据。
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvae005
Stefan Agewall
{"title":"New data on NOVEL ORAL ANTICOAGULANT, SGLT2i, lipid treatment and genetics.","authors":"Stefan Agewall","doi":"10.1093/ehjcvp/pvae005","DOIUrl":"10.1093/ehjcvp/pvae005","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential future role of extensive lipid lowering in ACS patients with the use of PCSK9 inhibitors: early bird catches the worm. 使用PCSK9抑制剂在ACS患者中广泛降脂的潜在未来作用:早起的鸟儿有虫吃
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad089
Kyriakos Dimitriadis, Nikolaos Pyrpyris, Konstantinos Tsioufis
{"title":"The potential future role of extensive lipid lowering in ACS patients with the use of PCSK9 inhibitors: early bird catches the worm.","authors":"Kyriakos Dimitriadis, Nikolaos Pyrpyris, Konstantinos Tsioufis","doi":"10.1093/ehjcvp/pvad089","DOIUrl":"10.1093/ehjcvp/pvad089","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136396935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First-in-human trial of PCSK9 gene editing therapy for lowering cholesterol: a new frontier in cardiovascular pharmacotherapy? News from AHA. PCSK9基因编辑治疗降胆固醇的首次人体试验:心血管药物治疗的新前沿?来自美国心脏协会的新闻。
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad095
Basil S Lewis
{"title":"First-in-human trial of PCSK9 gene editing therapy for lowering cholesterol: a new frontier in cardiovascular pharmacotherapy? News from AHA.","authors":"Basil S Lewis","doi":"10.1093/ehjcvp/pvad095","DOIUrl":"10.1093/ehjcvp/pvad095","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138458768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of inotropes in cardiogenic shock: to help, to harm or do nothing at all? 肌注在心源性休克中的作用:帮助、伤害还是什么都不做?
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad098
Melissa Fay Lepage-Ratte, Benjamin Hibbert, Rebecca Mathew
{"title":"The role of inotropes in cardiogenic shock: to help, to harm or do nothing at all?","authors":"Melissa Fay Lepage-Ratte, Benjamin Hibbert, Rebecca Mathew","doi":"10.1093/ehjcvp/pvad098","DOIUrl":"10.1093/ehjcvp/pvad098","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium glucose co-transporter 2 inhibitors and quality of life in patients with heart failure: a comprehensive systematic review and meta-analysis of randomized controlled trials. 钠葡萄糖共转运蛋白2抑制剂与心衰患者的生活质量:随机对照试验的综合系统评价和荟萃分析
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-02-23 DOI: 10.1093/ehjcvp/pvad088
Chiara Oriecuia, Daniela Tomasoni, Isabella Sala, Giovanni Battista Bonfioli, Marianna Adamo, Cristina Gussago, Carlo Mario Lombardi, Matteo Pagnesi, Gianluigi Savarese, Marco Metra, Claudia Specchia
{"title":"Sodium glucose co-transporter 2 inhibitors and quality of life in patients with heart failure: a comprehensive systematic review and meta-analysis of randomized controlled trials.","authors":"Chiara Oriecuia, Daniela Tomasoni, Isabella Sala, Giovanni Battista Bonfioli, Marianna Adamo, Cristina Gussago, Carlo Mario Lombardi, Matteo Pagnesi, Gianluigi Savarese, Marco Metra, Claudia Specchia","doi":"10.1093/ehjcvp/pvad088","DOIUrl":"10.1093/ehjcvp/pvad088","url":null,"abstract":"<p><strong>Background: </strong>Sodium glucose co-transporter 2 inhibitors (SGLT2i) are one of the cornerstones of heart failure (HF) therapy. While benefits in terms of HF hospitalizations and death are well established, their impact on quality-of-life (QoL) has not been systematically investigated.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aims to evaluate the impact of SGLT2i treatment on QoL in patients with HF, by analysing data from randomized clinical trials (RCTs).</p><p><strong>Methods: </strong>We identified a total of 23 RCTs that investigated the role of SGLT2i on quality of life in patients with HF, irrespective of their left ventricular ejection fraction (LVEF). RCTs that used Kansas City Cardiomyopathy Questionnaire overall summary score (KCCQ-OSS) to assess QoL and had a minimum follow-up of 3 months were included. The difference in mean change of the KCCQ-OSS between the SGLT2i group and the standard of care (SOC) group at 3 and 6 months from baseline was considered as the outcome measure.</p><p><strong>Findings: </strong>Fourteen RCTs (21 737 patients) were included in the analysis. A significant improvement in KCCQ-OSS over time (p < 0.001) was observed in both patients receiving SOC and those receiving SGLT2i in addition. The pooled estimate showed a significant improvement of 1.94 points [95% confidence interval (CI), 1.41-2.46] in KCCQ-OSS mean change at 3 months and of 2.18 points (95% CI, 1.13-3.24) at 6 months from baseline, with SGLT2i compared to SOC alone, irrespective of LVEF. A greater improvement in KCCQ-OSS was observed among patients with a recent episode of worsening HF compared to those with chronic stable HF.</p><p><strong>Conclusions: </strong>Among patients with HF, irrespective of their LVEF and clinical status, the addition of SGLT2i to SOC demonstrated a significant improvement in quality of life as early as at 3-month follow-up.</p>","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138175970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FLOW trial stopped early due to evidence of renal protection with semaglutide. 由于有证据表明赛马鲁肽具有肾脏保护作用,FLOW试验提前停止。
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-01-05 DOI: 10.1093/ehjcvp/pvad080
Felice Gragnano, Vincenzo De Sio, Paolo Calabrò
{"title":"FLOW trial stopped early due to evidence of renal protection with semaglutide.","authors":"Felice Gragnano, Vincenzo De Sio, Paolo Calabrò","doi":"10.1093/ehjcvp/pvad080","DOIUrl":"10.1093/ehjcvp/pvad080","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71479662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular prevention and risk factors. 心血管疾病的预防和危险因素。
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-01-05 DOI: 10.1093/ehjcvp/pvad087
Stefan Agewall
{"title":"Cardiovascular prevention and risk factors.","authors":"Stefan Agewall","doi":"10.1093/ehjcvp/pvad087","DOIUrl":"10.1093/ehjcvp/pvad087","url":null,"abstract":"","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138433592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation at low risk of stroke in japan: a retrospective cohort study. 非维生素K拮抗剂口服抗凝剂治疗日本低卒中风险心房颤动患者的有效性和安全性:一项回顾性队列研究。
IF 7.1 1区 医学
European Heart Journal - Cardiovascular Pharmacotherapy Pub Date : 2024-01-05 DOI: 10.1093/ehjcvp/pvad077
Masato Uchida, Taisuke Jo, Akira Okada, Hiroki Matsui, Hideo Yasunaga
{"title":"Effectiveness and safety of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation at low risk of stroke in japan: a retrospective cohort study.","authors":"Masato Uchida, Taisuke Jo, Akira Okada, Hiroki Matsui, Hideo Yasunaga","doi":"10.1093/ehjcvp/pvad077","DOIUrl":"10.1093/ehjcvp/pvad077","url":null,"abstract":"<p><strong>Aims: </strong>Contemporary guidelines differ in their recommendations regarding initiating non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) at low risk of stroke. This study aimed to examine the effectiveness and safety of NOACs for low-risk AF in a Japanese cohort.</p><p><strong>Methods and results: </strong>In this retrospective cohort study based on the JMDC Claims Database extracted between April 2011 and November 2022, we identified 13 291 patients with AF at low risk of stroke. We performed inverse probability of treatment weighting Cox regression analyses to compare the embolization and bleeding risks between the nontreatment and NOAC groups. Net clinical benefit was defined as the annual incidence of ischaemic stroke events prevented by NOACs after subtracting intracranial haemorrhage (ICH) events attributable to NOACs, multiplied by a weighting factor. The incidences of stroke and ICH in the nontreatment group were 0.47 and 0.15 per 100 person-years, respectively. The NOAC group had higher incidences of ICH (hazard ratio [HR]: 1.73, 95% confidence interval [CI]: 0.75-4.00) and stroke (HR: 1.41, 95% CI: 0.84-2.36). The net clinical benefit of NOAC treatment was -0.35% per year (95% CI: -0.99-0.29%).</p><p><strong>Conclusion: </strong>Non-vitamin K antagonist oral anticoagulants treatment may be associated with a slightly high risk of ICH, and it yielded a neutral clinical benefit in the present Japanese population, which provides reassurance concerning the role of ethnicity in NOAC treatment for patients with AF and suggests a need to assess comprehensive weighting of the respective risk factors.</p>","PeriodicalId":11982,"journal":{"name":"European Heart Journal - Cardiovascular Pharmacotherapy","volume":null,"pages":null},"PeriodicalIF":7.1,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49675750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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