European Journal of Cancer and Clinical Oncology最新文献

{"title":"Preclinical evaluation of polymer-bound doxorubicin","authors":"R. Duncan, L. Seymour, K. Ulbrich, F. Spreafico, M. Grandi, M. Ripamonti, M. Farao, A. Suarato","doi":"10.1016/0277-5379(91)91369-T","DOIUrl":"https://doi.org/10.1016/0277-5379(91)91369-T","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83488800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular events in B-cell activation and growth: Sensitivity to alpha interferon","authors":"Erik Lundgren , Håkan Hedman , Göran Landberg , Fanyi Chiang, Göran Roos , Rhiannon Sanders","doi":"10.1016/0277-5379(91)90584-Z","DOIUrl":"10.1016/0277-5379(91)90584-Z","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90584-Z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicentre study of a randomized therapeutic protocol in previously untreated patients with Ph1-positive chronic myelogenous leukaemia: Interferon alfa-2b and hydroxyurea with or without cytosine arabinoside, preliminary results","authors":"François Guilhot, Jean-Pierre Lamagnère, Jean Luc Harousseau, Hervé Tilly, Philippe Casassus, Norbert Ifrah, Henri Rochant, Francis Bauters, Gerard Dine, Joseph Tanzer","doi":"10.1016/0277-5379(91)90561-Q","DOIUrl":"10.1016/0277-5379(91)90561-Q","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90561-Q","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha interferon maintenance therapy in patients with low-grade non-Hodgkin's lymphomas after cytoreductive chemotherapy with prednimustine and mitoxantrone","authors":"Wolfgang Hiddemann ,&nbsp;Michael Unterhalt ,&nbsp;Peter Koch ,&nbsp;Martina Nahler ,&nbsp;Richard Herrmann ,&nbsp;Jürgen van de Loo","doi":"10.1016/0277-5379(91)90568-X","DOIUrl":"10.1016/0277-5379(91)90568-X","url":null,"abstract":"<div><p>A combination of prednimustine 100 mg/m²/day orally, days 1–5, and mitoxantrone 8 mg/m²/day intravenously, days 1 and 2, was administered to 19 patients with advanced low-grade non-Hodgkin's lymphoma after failure on or relapse after standard chemotherapy. The prednimustine and mitoxantrone (PmM) regimen was repeated every 4–6 weeks to a maximum of six cycles. Thirteen patients, achieving a complete (4) or partial (9) remission (CR or PR), received two additional courses for consolidation followed by interferon alfa-2b 5 million units (MU) subcutaneously (s.c.) three times weekly until progression or relapse. At the present time, remission duration ranges from 4.5+ to 17.5+ months, with a median of 14.5 months. In a historical comparison to unmaintained first remission preceding the PmM/interferon trial, a tendency towards a longer period of freedom from progression was apparent in the 13 patients receiving interferon maintenance treatment during their second PR or CR. These data provided the basis for a currently ongoing multicentre study randomly comparing initial chemotherapy with PmM versus cyclophosphamide/vincristine (Oncovin)/prednisone (COP) in patients with advanced centroblastic-centrocytic and centrocytic non-Hodgkin's lymphomas, followed by a second randomization in CR and PR patients for maintenance with alpha interferon versus observation only.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90568-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should surgery remain the initial treatment of “operable” breast cancer?","authors":"John M. Kurtz","doi":"10.1016/0277-5379(91)90408-6","DOIUrl":"10.1016/0277-5379(91)90408-6","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90408-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12943908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors in axillary lymph node-negative (pN−) breast carcinomas","authors":"S. Aaltomaa ,&nbsp;P. Lipponen ,&nbsp;M. Eskelinen ,&nbsp;V.-M. Kosma ,&nbsp;S. Marin ,&nbsp;E. Alhava ,&nbsp;K. Syrjänen","doi":"10.1016/0277-5379(91)90414-9","DOIUrl":"10.1016/0277-5379(91)90414-9","url":null,"abstract":"<div><p>Axillary lymph node-negative (pN−) breast carcinomas (<em>n</em> = 281) were analysed histoquantitatively for two mitotic indexes (MAI, mitotic activity index; M/V, volume corrected mitotic index) and nine nuclear factors with special emphasis on disclosing prognostic factors during a follow-up of 12 years. The M/V index (<em>P</em> = 0.0018), tumour size (<em>P</em> = 0.0052), MAI (<em>P</em> = 0.0115) and histological grade (<em>P</em> = 0.0565) predicted the recurrence-free survival. MAI (<em>P</em> = 0.0007), M/V index (<em>P</em> = 0.0046), tumour size (<em>P</em> = 0.0133), histological grade (<em>P</em> = 0.0528) and S.D. of the nuclear perimetry (<em>P</em> = 0.07) predicted the disease-related survival. In Cox's analysis, MAI (<em>P</em> = 0.004), adjuvant therapy (<em>P</em> = 0.03) and tumour size (<em>P</em> = 0.09) predicted survival independently. Recurrence-free survival was related independently to nuclear perimetry (<em>P</em> &lt; 0.001), SD of nuclear area (<em>P</em> = 0.01) and MAI (<em>P</em> = 0.019) in Cox's analysis. In small (diameter ≤ 20 mm) tumours, S.D. of nuclear perimetry predicted recurrence-free survival (<em>P</em> = 0.03) in Cox's analysis. The results advocate the use of mitotic indexes and nuclear factors in place or in combination with conventional histological grading in predicting the survival and tumour recurrence in axillary lymph node-negative breast carcinomas.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90414-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12943913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of interferon alfa-2b in the management of patients with advanced cutaneous T-cell lymphoma","authors":"Tariq I. Mughal","doi":"10.1016/0277-5379(91)90569-Y","DOIUrl":"10.1016/0277-5379(91)90569-Y","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90569-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferon and dexamethasone in multiple myeloma patients refractory to chemotherapy","authors":"Jesús F. San Miguel ,&nbsp;Maria Moro ,&nbsp;Juan Bladé ,&nbsp;Luciano Guerras ,&nbsp;Jose Hernandez ,&nbsp;Ramiro Jimenez-Galindo ,&nbsp;Fernando Ortega ,&nbsp;Marcos Gonzalez","doi":"10.1016/0277-5379(91)90572-U","DOIUrl":"10.1016/0277-5379(91)90572-U","url":null,"abstract":"","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90572-U","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interferon therapy during the plateau phase of multiple myeloma: An update of the Swedish study","authors":"Jan Westin ,&nbsp;Agostino Cortelezzi ,&nbsp;Martin Hjorth ,&nbsp;Stig Rödjer ,&nbsp;Ingemar Turesson ,&nbsp;Göran Zador ,&nbsp;Cooperative study group","doi":"10.1016/0277-5379(91)90571-T","DOIUrl":"10.1016/0277-5379(91)90571-T","url":null,"abstract":"<div><p>A multicentre clinical trial was carried out in order to evaluate the effect of interferon (IFN) in patients with multiple myeloma. Patients (<em>n</em> = 120) who had shown response to conventional intermittent melphalan-prednisone induction therapy, and achieved a plateau phase, were randomized at that point to receive either interferon alfa-2b in a dose of 5 million units (MU) three times per week or no therapy. This report presents the results of an interim analysis, performed when the patients had been followed for a median of 20 months. The duration of the plateau phase was significantly longer in the IFN arm (59 weeks), compared to the no therapy arm (26 weeks). A total of 34 deaths have occurred, 13 in the IFN arm and 21 in the no therapy arm. In spite of the high median age of the patients studied (70 years), most patients were able to tolerate a full or only slightly reduced IFN dose.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90571-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12961608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolving modalities of treatment with interferon alfa-2b for Ph1-positive chronic myelogenous leukaemia","authors":"Enrica Morra ,&nbsp;Giuliana Alimena ,&nbsp;Mario Lazzarino ,&nbsp;Anna Marina Liberati ,&nbsp;Enrico Montefusco ,&nbsp;Paolo Bernasconi ,&nbsp;Marco Mancini ,&nbsp;Emilio Donti ,&nbsp;Serena Merante ,&nbsp;Ferdinando Dianzani ,&nbsp;Fausto Grignani ,&nbsp;Carlo Bernasconi ,&nbsp;Franco Mandelli","doi":"10.1016/0277-5379(91)90557-T","DOIUrl":"10.1016/0277-5379(91)90557-T","url":null,"abstract":"<div><p>We have administered interferon alfa-2b, alone or in combination with chemotherapy, to 126 Ph¹-positive chronic myelogenous leukaemia patients. Of 71 early chronic phase (CP) patients (&lt; 12 months from diagnosis), 41 (58%) obtained a complete haematological response (CHR). Daily interferon was more effective than intermittent administration. In previously untreated patients, the response was significantly influenced by risk status at diagnosis. Thirty-four out of 71 (48%) patients improved cytogenetically, the median of Ph¹+ mitoses declining from 100% to 66% with complete Ph¹-suppression in one case. Of 46 late CP patients (&gt; 12 months from diagnosis), 32 (70%) achieved CHR with interferon alone or combined with chemotherapy. All 10 patients with disease well controlled by chemotherapy obtained stable CHR with interferon alone. Of 36 partial responders to conventional chemotherapy, 22 (61%) obtained CHR on interferon plus low-dose hydroxyurea. Ph¹ mosaicism was reached by 16 (35%) late CP patients (median Ph¹+ cells 75%). Of nine accelerated phase patients on interferon plus chemotherapy, one attained CHR, and two responded partially. At a median follow up of 36 months, of 41 CHR patients in early CP, 15 are controlled on interferon, 12 have had autologous bone marrow transplantation (BMT), and two allogeneic BMT. Blastic transformation (BT) has occurred in eight of 41 CHR patients (19%) versus 17 of 30 (57%) non-responders and partial responders to interferon. At a median follow up of 22 months, of 32 late CP patients obtaining CHR, 26 remain on interferon, one had allogeneic BMT, one had autologous BMT, and one developed BT (versus five out of 14 with less than CHR). These studies confirm the haematological and cytogenetic efficacy of interferon in CML and indicate that the disease status at the start of treatment is critical in determining the success of therapy.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90557-T","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12962474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}