干扰素治疗多发性骨髓瘤平台期:瑞典研究的最新进展

Jan Westin , Agostino Cortelezzi , Martin Hjorth , Stig Rödjer , Ingemar Turesson , Göran Zador , Cooperative study group
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引用次数: 14

摘要

为了评估干扰素(IFN)在多发性骨髓瘤患者中的作用,进行了一项多中心临床试验。对传统间歇性melphalan-强的松诱导治疗有反应并达到平台期的患者(n = 120)在该点随机接受干扰素α -2b,剂量为500万单位(MU),每周3次或不接受治疗。本报告介绍了一项中期分析的结果,对患者进行了中位数为20个月的随访。与无治疗组(26周)相比,IFN组的平台期持续时间明显更长(59周)。总共发生了34例死亡,其中13例在干扰素组,21例在无治疗组。尽管研究患者的中位年龄较高(70岁),但大多数患者能够耐受全部或仅轻微减少的IFN剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interferon therapy during the plateau phase of multiple myeloma: An update of the Swedish study

A multicentre clinical trial was carried out in order to evaluate the effect of interferon (IFN) in patients with multiple myeloma. Patients (n = 120) who had shown response to conventional intermittent melphalan-prednisone induction therapy, and achieved a plateau phase, were randomized at that point to receive either interferon alfa-2b in a dose of 5 million units (MU) three times per week or no therapy. This report presents the results of an interim analysis, performed when the patients had been followed for a median of 20 months. The duration of the plateau phase was significantly longer in the IFN arm (59 weeks), compared to the no therapy arm (26 weeks). A total of 34 deaths have occurred, 13 in the IFN arm and 21 in the no therapy arm. In spite of the high median age of the patients studied (70 years), most patients were able to tolerate a full or only slightly reduced IFN dose.

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