腋窝淋巴结阴性(pN−)乳腺癌的预后因素

S. Aaltomaa , P. Lipponen , M. Eskelinen , V.-M. Kosma , S. Marin , E. Alhava , K. Syrjänen
{"title":"腋窝淋巴结阴性(pN−)乳腺癌的预后因素","authors":"S. Aaltomaa ,&nbsp;P. Lipponen ,&nbsp;M. Eskelinen ,&nbsp;V.-M. Kosma ,&nbsp;S. Marin ,&nbsp;E. Alhava ,&nbsp;K. Syrjänen","doi":"10.1016/0277-5379(91)90414-9","DOIUrl":null,"url":null,"abstract":"<div><p>Axillary lymph node-negative (pN−) breast carcinomas (<em>n</em> = 281) were analysed histoquantitatively for two mitotic indexes (MAI, mitotic activity index; M/V, volume corrected mitotic index) and nine nuclear factors with special emphasis on disclosing prognostic factors during a follow-up of 12 years. The M/V index (<em>P</em> = 0.0018), tumour size (<em>P</em> = 0.0052), MAI (<em>P</em> = 0.0115) and histological grade (<em>P</em> = 0.0565) predicted the recurrence-free survival. MAI (<em>P</em> = 0.0007), M/V index (<em>P</em> = 0.0046), tumour size (<em>P</em> = 0.0133), histological grade (<em>P</em> = 0.0528) and S.D. of the nuclear perimetry (<em>P</em> = 0.07) predicted the disease-related survival. In Cox's analysis, MAI (<em>P</em> = 0.004), adjuvant therapy (<em>P</em> = 0.03) and tumour size (<em>P</em> = 0.09) predicted survival independently. Recurrence-free survival was related independently to nuclear perimetry (<em>P</em> &lt; 0.001), SD of nuclear area (<em>P</em> = 0.01) and MAI (<em>P</em> = 0.019) in Cox's analysis. In small (diameter ≤ 20 mm) tumours, S.D. of nuclear perimetry predicted recurrence-free survival (<em>P</em> = 0.03) in Cox's analysis. The results advocate the use of mitotic indexes and nuclear factors in place or in combination with conventional histological grading in predicting the survival and tumour recurrence in axillary lymph node-negative breast carcinomas.</p></div>","PeriodicalId":11925,"journal":{"name":"European Journal of Cancer and Clinical Oncology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1991-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0277-5379(91)90414-9","citationCount":"17","resultStr":"{\"title\":\"Prognostic factors in axillary lymph node-negative (pN−) breast carcinomas\",\"authors\":\"S. Aaltomaa ,&nbsp;P. Lipponen ,&nbsp;M. Eskelinen ,&nbsp;V.-M. Kosma ,&nbsp;S. Marin ,&nbsp;E. Alhava ,&nbsp;K. Syrjänen\",\"doi\":\"10.1016/0277-5379(91)90414-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Axillary lymph node-negative (pN−) breast carcinomas (<em>n</em> = 281) were analysed histoquantitatively for two mitotic indexes (MAI, mitotic activity index; M/V, volume corrected mitotic index) and nine nuclear factors with special emphasis on disclosing prognostic factors during a follow-up of 12 years. The M/V index (<em>P</em> = 0.0018), tumour size (<em>P</em> = 0.0052), MAI (<em>P</em> = 0.0115) and histological grade (<em>P</em> = 0.0565) predicted the recurrence-free survival. MAI (<em>P</em> = 0.0007), M/V index (<em>P</em> = 0.0046), tumour size (<em>P</em> = 0.0133), histological grade (<em>P</em> = 0.0528) and S.D. of the nuclear perimetry (<em>P</em> = 0.07) predicted the disease-related survival. In Cox's analysis, MAI (<em>P</em> = 0.004), adjuvant therapy (<em>P</em> = 0.03) and tumour size (<em>P</em> = 0.09) predicted survival independently. Recurrence-free survival was related independently to nuclear perimetry (<em>P</em> &lt; 0.001), SD of nuclear area (<em>P</em> = 0.01) and MAI (<em>P</em> = 0.019) in Cox's analysis. In small (diameter ≤ 20 mm) tumours, S.D. of nuclear perimetry predicted recurrence-free survival (<em>P</em> = 0.03) in Cox's analysis. The results advocate the use of mitotic indexes and nuclear factors in place or in combination with conventional histological grading in predicting the survival and tumour recurrence in axillary lymph node-negative breast carcinomas.</p></div>\",\"PeriodicalId\":11925,\"journal\":{\"name\":\"European Journal of Cancer and Clinical Oncology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0277-5379(91)90414-9\",\"citationCount\":\"17\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Cancer and Clinical Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/0277537991904149\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Cancer and Clinical Oncology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0277537991904149","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 17

摘要

腋窝淋巴结阴性(pN−)乳腺癌(n = 281)组织定量分析两项有丝分裂指数(MAI,有丝分裂活性指数;M/V(体积校正有丝分裂指数)和9个核因子,特别强调在随访12年期间披露预后因素。M/V指数(P = 0.0018)、肿瘤大小(P = 0.0052)、MAI (P = 0.0115)和组织学分级(P = 0.0565)预测无复发生存期。MAI (P = 0.0007)、M/V指数(P = 0.0046)、肿瘤大小(P = 0.0133)、组织学分级(P = 0.0528)和核周镜sd (P = 0.07)预测疾病相关生存。在Cox分析中,MAI (P = 0.004)、辅助治疗(P = 0.03)和肿瘤大小(P = 0.09)独立预测生存。无复发生存期与核周长独立相关(P <Cox分析中核面积SD (P = 0.01)、MAI (P = 0.019)。在小肿瘤(直径≤20mm)中,核周检查的sd预测无复发生存(P = 0.03)。结果表明,有丝分裂指数和核因子在预测腋窝淋巴结阴性乳腺癌的生存和肿瘤复发时可用原位或联合常规组织学分级。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic factors in axillary lymph node-negative (pN−) breast carcinomas

Axillary lymph node-negative (pN−) breast carcinomas (n = 281) were analysed histoquantitatively for two mitotic indexes (MAI, mitotic activity index; M/V, volume corrected mitotic index) and nine nuclear factors with special emphasis on disclosing prognostic factors during a follow-up of 12 years. The M/V index (P = 0.0018), tumour size (P = 0.0052), MAI (P = 0.0115) and histological grade (P = 0.0565) predicted the recurrence-free survival. MAI (P = 0.0007), M/V index (P = 0.0046), tumour size (P = 0.0133), histological grade (P = 0.0528) and S.D. of the nuclear perimetry (P = 0.07) predicted the disease-related survival. In Cox's analysis, MAI (P = 0.004), adjuvant therapy (P = 0.03) and tumour size (P = 0.09) predicted survival independently. Recurrence-free survival was related independently to nuclear perimetry (P < 0.001), SD of nuclear area (P = 0.01) and MAI (P = 0.019) in Cox's analysis. In small (diameter ≤ 20 mm) tumours, S.D. of nuclear perimetry predicted recurrence-free survival (P = 0.03) in Cox's analysis. The results advocate the use of mitotic indexes and nuclear factors in place or in combination with conventional histological grading in predicting the survival and tumour recurrence in axillary lymph node-negative breast carcinomas.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信