腋窝淋巴结阴性(pN−)乳腺癌的预后因素

S. Aaltomaa , P. Lipponen , M. Eskelinen , V.-M. Kosma , S. Marin , E. Alhava , K. Syrjänen
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引用次数: 17

摘要

腋窝淋巴结阴性(pN−)乳腺癌(n = 281)组织定量分析两项有丝分裂指数(MAI,有丝分裂活性指数;M/V(体积校正有丝分裂指数)和9个核因子,特别强调在随访12年期间披露预后因素。M/V指数(P = 0.0018)、肿瘤大小(P = 0.0052)、MAI (P = 0.0115)和组织学分级(P = 0.0565)预测无复发生存期。MAI (P = 0.0007)、M/V指数(P = 0.0046)、肿瘤大小(P = 0.0133)、组织学分级(P = 0.0528)和核周镜sd (P = 0.07)预测疾病相关生存。在Cox分析中,MAI (P = 0.004)、辅助治疗(P = 0.03)和肿瘤大小(P = 0.09)独立预测生存。无复发生存期与核周长独立相关(P <Cox分析中核面积SD (P = 0.01)、MAI (P = 0.019)。在小肿瘤(直径≤20mm)中,核周检查的sd预测无复发生存(P = 0.03)。结果表明,有丝分裂指数和核因子在预测腋窝淋巴结阴性乳腺癌的生存和肿瘤复发时可用原位或联合常规组织学分级。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prognostic factors in axillary lymph node-negative (pN−) breast carcinomas

Axillary lymph node-negative (pN−) breast carcinomas (n = 281) were analysed histoquantitatively for two mitotic indexes (MAI, mitotic activity index; M/V, volume corrected mitotic index) and nine nuclear factors with special emphasis on disclosing prognostic factors during a follow-up of 12 years. The M/V index (P = 0.0018), tumour size (P = 0.0052), MAI (P = 0.0115) and histological grade (P = 0.0565) predicted the recurrence-free survival. MAI (P = 0.0007), M/V index (P = 0.0046), tumour size (P = 0.0133), histological grade (P = 0.0528) and S.D. of the nuclear perimetry (P = 0.07) predicted the disease-related survival. In Cox's analysis, MAI (P = 0.004), adjuvant therapy (P = 0.03) and tumour size (P = 0.09) predicted survival independently. Recurrence-free survival was related independently to nuclear perimetry (P < 0.001), SD of nuclear area (P = 0.01) and MAI (P = 0.019) in Cox's analysis. In small (diameter ≤ 20 mm) tumours, S.D. of nuclear perimetry predicted recurrence-free survival (P = 0.03) in Cox's analysis. The results advocate the use of mitotic indexes and nuclear factors in place or in combination with conventional histological grading in predicting the survival and tumour recurrence in axillary lymph node-negative breast carcinomas.

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