Epilepsy Research最新文献

{"title":"Latent renal tubular dysfunction in patients with epilepsy treated with valproic acid","authors":"Fumi Sawamura ,&nbsp;Jun Natsume ,&nbsp;Yuji Ito ,&nbsp;Takamasa Mitsumatsu ,&nbsp;Anna Shiraki ,&nbsp;Takeshi Suzuki ,&nbsp;Masahiro Kawaguchi ,&nbsp;Naoko Ishihara ,&nbsp;Toru Kato ,&nbsp;Motomasa Suzuki ,&nbsp;Tetsuo Kubota ,&nbsp;Tomoya Takeuchi ,&nbsp;Hiroyuki Yamamoto ,&nbsp;Tomohiko Nakata ,&nbsp;Hiroyuki Kidokoro","doi":"10.1016/j.eplepsyres.2025.107611","DOIUrl":"10.1016/j.eplepsyres.2025.107611","url":null,"abstract":"<div><h3>Background</h3><div>Valproic acid (VPA)-induced Fanconi’s syndrome has been reported, especially in patients with severe motor and intellectual disabilities, with carnitine deficiency identified as a possible factor. Latent renal tubular dysfunction (RTD) has also been noted in patients with epilepsy treated with VPA. We aimed to evaluate latent RTD in patients treated with and without VPA by examining urine RTD markers and their relationships with clinical variables.</div></div><div><h3>Methods</h3><div>Urine N<em>-</em>acetyl-β-D-glucosaminidase/creatinine (NAG/Cr) and β2-microglobulin/creatinine (BMG/Cr) were evaluated in 147 patients with childhood-onset epilepsy. NAG/Cr and BMG/Cr were compared between 90 patients treated with VPA (VPA group) and 57 patients treated with other anti-seizure medications (non-VPA group). Single correlations and multiple regression analyses were conducted between RTD markers and clinical variables in the VPA group.</div></div><div><h3>Results</h3><div>NAG/Cr was significantly higher in the VPA group than in the non-VPA group, whereas BMG/Cr was not significantly different. High or borderline NAG/Cr (&gt;4.0 IU/g*Cr) was seen in 85 (94 %) patients on VPA, and high NAG/Cr (≥10.0 IU/g*Cr) was seen in 21 (23 %) on VPA. In the VPA group, NAG/Cr was significantly correlated with free carnitine (FC), VPA dose adjusted for body weight, and duration of treatment with VPA. BMG/Cr was significantly correlated with the number of antiseizure medications. Multiple regression analysis showed that NAG/Cr was significantly correlated with FC.</div></div><div><h3>Conclusions</h3><div>Latent RTD was found in many patients on VPA, and elevated RTD markers were correlated with carnitine deficiency. Physicians should be aware of latent RTD in patients with childhood-onset epilepsy treated with VPA.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107611"},"PeriodicalIF":2.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and regional trends in status epilepticus-related mortality among older adults in the United States (1999–2020): A nationwide retrospective analysis","authors":"Muhammad Hassan Waseem ,&nbsp;Zain Ul Abideen ,&nbsp;Fatima Hussain ,&nbsp;Zara Jamil ,&nbsp;Eman Alamgir ,&nbsp;Areeba Shams Sarwari ,&nbsp;Farwa Naveed ,&nbsp;Abdullah ,&nbsp;Fatima Kaleem Ahmed ,&nbsp;Muhammad Fawad Tahir ,&nbsp;Sania Aimen","doi":"10.1016/j.eplepsyres.2025.107610","DOIUrl":"10.1016/j.eplepsyres.2025.107610","url":null,"abstract":"<div><h3>Background and aims</h3><div>Because mortality data related to Status Epilepticus among the elderly in the United States are lacking, demographical and regional trends from 1999 to 2020 were analyzed.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of death certificates from the Center for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC-WONDER) database using crude and age-adjusted mortality rates (AAMR), followed by Jointpoint regression models yielding annual percentage changes (APCs) stratified to age, race/ethnicity, urban-rural classification, and region.</div></div><div><h3>Results</h3><div>It was observed that from 1999 to 2020, 17,883 deaths from status epilepticus among adults 65 and above were observed with a substantial decrease from 1999 to 2005 (APC: −4.6; 95 % CI: −8.1 to −0.9). This was then reversed with an increase till 2020 (APC:7.7; 95 % CI: 7–8.4). Moreover, it was observed that Black or African American mortality rates were significantly higher from 2007 to 2020 (APC of 7.99; 95 % CI, 7.03–8.96). Both Metropolitan 2006–2018 (APC: 8.21; 95 % CI, 7.37–9.05) and non-metropolitan areas from 2006 to 2020 (APC: 8.20; 95 % CI, 6.86–9.56) showed a rise in APC trends. The highest AAMRs occurred in South Carolina (AAMR: 97.5) followed by Kentucky (AAMR: 30.4) with the Southern region exhibiting the highest AAMR at 2.2.</div></div><div><h3>Conclusion</h3><div>The study reveals a significant increase in mortality rates from status epilepticus among the elderly, particularly within Black or African American communities and the Southern United States. These findings underscore the urgent need for targeted public health strategies to address and mitigate these growing disparities.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107610"},"PeriodicalIF":2.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation for epilepsy: A systematic review and meta-analysis of randomized and non-randomized studies of thalamic targeting","authors":"Jasneet Kaur Dhaliwal ,&nbsp;Michelle Ruiz-Perez ,&nbsp;Aswin Chari ,&nbsp;Rory J. Piper ,&nbsp;Martin M. Tisdall ,&nbsp;Michael Hart","doi":"10.1016/j.eplepsyres.2025.107607","DOIUrl":"10.1016/j.eplepsyres.2025.107607","url":null,"abstract":"<div><h3>Introduction</h3><div>Deep Brain Stimulation (DBS) of the thalamus for drug-resistant epilepsy (DRE) is an emerging treatment modality. This systematic review and meta-analysis sought to evaluate the efficacy of stimulating different targets within the thalamus.</div></div><div><h3>Methods</h3><div>A systematic search of four databases was conducted. Rates for overall seizure reduction (SR), responder rate (RR ≥50 % SR), and seizure freedom (SF) were evaluated at a minimum time point of 12 months post-stimulation commencement in the anterior (ANT) and centro-median (CMN) thalamic nuclei. Subgroup analyses for a minimum 24 months follow up, sensitivity analyses, and funnel plots to assess for publication bias were also performed. Risk of bias was assessed using the ROBINS-I tool.</div></div><div><h3>Results</h3><div>Fourty-nine articles met the inclusion criteria. The mean seizure reduction (SR) across 21 studies was 62.31 % (95 % CI: 55.99–68.62, p &lt; 0.01). Specifically, SR was 64.28 % for ANT (95 % CI: 57.55–71.01, p &lt; 0.01) and 69.11 % for CMN (95 % CI: 58.14–80.09, p &lt; 0.01). Meta-analyses of 41 ANT studies and 12 CMN studies reported a response rate (RR) of 61.51 % (95 % CI: 54.11–68.9, p &lt; 0.01) and 69.09 % (95 % CI: 54.01–84.16, p &lt; 0.01), respectively. Overall seizure freedom (SF) was 3.57 % % for ANT (95 % CI: 1.86–5.28, p = 0.45) and 1.32 % for CMN(95 % CI: 0–4.45, p = 0.81). For ANT, RR was 67.63 % (95 % CI: 61.04–74.23) for follow-up periods longer than 24 months, and 44.05 % (95 % CI: 26.73–61.38) for periods shorter than 24 months. The SF rate for ANT was 3 % (95 % CI: 1–4 %) for follow-up under 12 months. For CMN, RR was 70 % (95 % CI: 53–87 %) for periods over 24 months, and 68 % (95 % CI: 31–100 %) for periods under 24 months. The SF rate for CMN was 1 % (95 % CI: 0–4 %) for periods under 12 months. There was no strong evidence of publication bias based on funnel plot analysis, and results were consistent across sensitivity analyses. Insufficient data precluded meta-analysis for other nuclei.</div></div><div><h3>Conclusion</h3><div>These findings demonstrate efficacy of ANT and CMN DBS for patients with DRE, defined by responder rate and seizure reduction. Further research is required to optimize patient selection, predict individual response, and assess non-seizure related outcomes.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107607"},"PeriodicalIF":2.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple and reliable electroencephalogram montage for detecting and managing electrographic seizures in children with acute encephalitis and encephalopathy","authors":"Naohiro Yamamoto ,&nbsp;Ichiro Kuki ,&nbsp;Naoki Yamada ,&nbsp;Shizuka Nagase-Oikawa ,&nbsp;Masataka Fukuoka ,&nbsp;Kiyohiro Kim ,&nbsp;Takeshi Inoue ,&nbsp;Megumi Nukui ,&nbsp;Junichi Ishikawa ,&nbsp;Kiyoko Amo ,&nbsp;Masao Togawa ,&nbsp;Yasunori Otsuka ,&nbsp;Shin Okazaki","doi":"10.1016/j.eplepsyres.2025.107609","DOIUrl":"10.1016/j.eplepsyres.2025.107609","url":null,"abstract":"<div><h3>Background</h3><div>Continuous electroencephalogram (EEG) monitoring (C-EEG) is crucial for the early diagnosis and treatment of electrographic seizures (ESz) in children with acute encephalitis and encephalopathy. However, in Japan, like many other countries, C-EEG is not widely accessible due to reliance on specialized physicians and technicians to apply the international 10–20 system for full-electrode EEG (FE-EEG). Therefore, this study aimed to evaluate a simple and reliable reduced EEG montage.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 83 patients presenting with fever and status epilepticus or fever and impaired consciousness who underwent C-EEG using FE-EEG between 2015 and 2020. After excluding 41 patients diagnosed with febrile status epilepticus, 42 diagnosed with acute encephalitis or encephalopathy were included. Of these, two patients were excluded because their EEGs demonstrated an ictal-interictal continuum, precluding accurate seizure counting. Finally, 15 patients who had more than five ESz were included in this retrospective study. We re-formatted the EEG data recorded with FE-EEG into three reduced montages: double-distance reduced EEG (RE-EEG), Hairline, and amplitude-integrated EEG (aEEG), comprises 4, 3, and 1 EEG channel(s) on each hemisphere, respectively. The ESz detection rates of these reduced montages were compared using Poisson regression analysis.</div></div><div><h3>Results</h3><div>Among 42 patients with acute encephalitis or encephalopathy, 15 exhibited ESz more than five times. RE-EEG detected ESz with no significant difference compared to FE-EEG. Furthermore, RE-EEG demonstrated a significantly higher ESz detection rate than the Hairline and aEEG montages.</div></div><div><h3>Conclusion</h3><div>RE-EEG offered a reliable seizure detection rate exceeding 90 %, except for one case. Beyond detecting ESz, RE-EEG could serve as a quick, convenient, and temporary monitor for brain function, offering significant potential for implementation in resource-limited healthcare settings.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107609"},"PeriodicalIF":2.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical satisfaction and influencing factors in patients with epilepsy in China","authors":"Qun Yu ,&nbsp;Si-xuan Jiang ,&nbsp;Mei-juan Lan ,&nbsp;Zheng-Yan-Ran Xu ,&nbsp;Yi Guo","doi":"10.1016/j.eplepsyres.2025.107608","DOIUrl":"10.1016/j.eplepsyres.2025.107608","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to evaluate the level of surgical satisfaction among patients with epilepsy (PWEs) in China and to identify factors influencing their satisfaction.</div></div><div><h3>Methods</h3><div>PWEs who underwent surgical intervention at least three months prior were included. Data on demographics and medical history were collected, and their satisfaction with surgery was assessed using the Chinese version of the 19-item Epilepsy Surgery Satisfaction Questionnaire (C-ESSQ-19). Based on a median satisfaction score of 88.1, patients were categorized into a \"high satisfaction group\" and a \"low satisfaction group\". Factors influencing satisfaction were identified through univariate analysis and logistic regression.</div></div><div><h3>Results</h3><div>A total of 234 PWEs participated, with a median C-ESSQ-19 score of 88.1. Univariate analysis identified nine potential influencing factors: employment status, duration of epilepsy, type of surgery, Seizure control, use of anti-seizure medications (ASMs), severity of epilepsy, seizure-related disability, depression, and quality of life. In the final logistic regression model, good seizure control (odds ratio: 9.367–10.343; P &lt; 0.05) and quality of life (odds ratio: 1.100; P &lt; 0.001) emerged as significant independent factors associated with satisfaction.</div></div><div><h3>Conclusions</h3><div>PWEs in China reported high levels of satisfaction with surgical outcomes. Improved postoperative quality of life and good seizure control were strongly linked to greater satisfaction.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107608"},"PeriodicalIF":2.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144272005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of migraine in individuals with functional seizures: A systematic review and meta-analysis","authors":"Gaziz Kyrgyzbay ,&nbsp;Dina Kalinina ,&nbsp;Ruslan Akhmedullin ,&nbsp;Zhassulan Utebekov ,&nbsp;Asemgul Kasenova ,&nbsp;Raffaele Ornello ,&nbsp;Darkhan Kimadiev ,&nbsp;Guldana Zhumabayeva","doi":"10.1016/j.eplepsyres.2025.107596","DOIUrl":"10.1016/j.eplepsyres.2025.107596","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to understand the prevalence of migraine in patients with functional seizures in general, as well as compared to patients with epileptic seizures.</div></div><div><h3>Methods</h3><div>We conducted a literature search of the PubMed, Scopus, and Web of Science databases from database inception until July, 2024. We identified studies using an observational design and performed a meta-analysis to evaluate the association between migraines and functional seizures. We assessed the quality of the studies with the Newcastle-Ottawa Scale, and identified the pooled odds ratios (OR) and mean differences. Heterogeneity was investigated using the I² statistic, significance was determined using Cochran's test, and a post-hoc Begg's test was performed. This study was registered with PROSPERO (CRD42024558536).</div></div><div><h3>Results</h3><div>Of the 3248 studies identified, 13 studies (N = 2415) were eligible for inclusion. Out of 2415 patients with functional seizures, 763 (31.5 %) patients had comorbid migraine. The pooled OR for prevalence of migraine in individuals with functional seizures compared with those with epileptic seizures was 2.77 (95 % CI: 2.36–3.27), with a corresponding mean difference of 18 % ((95 % CI: 9 %-27 %). Quality assessment revealed moderate-to-high quality in all the included studies.</div></div><div><h3>Conclusion</h3><div>This study revealed a high prevalence of migraine in patients with functional seizures. However, existing evidence is limited to a handful of observational studies. More studies are needed to evaluate the direction of the association and the clinical and therapeutic impact of migraine on functional seizures.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107596"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification of epilepsy seizure types in pediatrics based on Turkish EEG reports","authors":"Özkan Aslan ,&nbsp;Naim Karasekreter ,&nbsp;Caner Balım ,&nbsp;Süleyman Yaman ,&nbsp;Süleyman Şahin","doi":"10.1016/j.eplepsyres.2025.107593","DOIUrl":"10.1016/j.eplepsyres.2025.107593","url":null,"abstract":"<div><div>This study focuses on the binary classification of pediatric epilepsy seizure types as focal or generalized using Turkish electroencephalography (EEG) reports, leveraging natural language processing (NLP) and machine learning methodologies. A novel dataset comprising 130 Turkish EEG reports was developed and publicly released, addressing the scarcity of resources in this domain. The study employed various text representation models, including TF-IDF, FastText, ElectraTR, XLM, and BERTurk, along with classifiers such as Logistic Regression, Support Vector Machines, and CatBoost. The highest classification performance was achieved using BERTurk embeddings combined with Logistic Regression, yielding an accuracy of 96.6 %. This work is significant for being the first to explore focal versus generalized seizure classification from text-based EEG reports in Turkish. It underscores the critical role of contextual embeddings in handling morphologically rich languages and demonstrates the potential of NLP techniques in advancing pediatric epilepsy diagnostics. The findings pave the way for automating diagnostic processes and improving efficiency in clinical settings. Future research aims to expand the dataset, incorporate EEG signal data, and refine the models for broader applicability.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"215 ","pages":"Article 107593"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health and healthcare utilization in veterans with post-traumatic epilepsy","authors":"Richard Zhou ,&nbsp;Erin Sullivan-Baca ,&nbsp;Thomas Bart ,&nbsp;Mary Jo Pugh ,&nbsp;Alan Towne ,&nbsp;Zulfi Haneef","doi":"10.1016/j.eplepsyres.2025.107594","DOIUrl":"10.1016/j.eplepsyres.2025.107594","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with post-traumatic epilepsy (PTE) are at an increased risk of adverse outcomes, and utilization of specialty care is important to manage symptoms. We examined the relationship between social determinants of health (SDoH) and healthcare utilization in Veterans with PTE (VWPTE).</div></div><div><h3>Methods</h3><div>Data were collected from the Veterans Affairs (VA) Corporate Data Warehouse administrative data. SDoH data were derived from ICD-10-CM codes, and area deprivation index (ADI) was based on patient zip code. Utilization measures included neurology encounters, comprehensive epilepsy care, neuroimaging, and seizure-related emergency care. Logistic and Poisson regressions were used to model the effect of demographics, epilepsy characteristics, patient comorbidities, and SDoH on utilization measures.</div></div><div><h3>Results</h3><div>There were 6732 VWPTE who met inclusion criteria. Increased ADI quartile (i.e. higher area deprivation) relative to the first quartile was strongly predictive of decreased utilization, including fewer VA general neurology clinic visits (second quartile IRR=0.926, 95 % CI 0.866, 0.990, p = 0.024; third quartile IRR=0.866, 95 % CI 0.812, 0.925, p &lt; 0.001; fourth quartile IRR=0.745, 95 % CI 0.690, 0.804, p &lt; 0.001), epilepsy specialty care (third quartile OR=0.594, 95 % CI 0.485, 0.729, p &lt; 0.001; fourth quartile OR=0.306, 95 % CI 0.235, 0.395, p &lt; 0.001), MRI studies (fourth quartile OR=0.761, 95 % CI 0.610, 0.946, p = 0.014) and lower EEG usage (fourth quartile OR=0.665, 95 % CI 0.532, 0.830, p &lt; 0.001). Additional SDoH were inconsistently correlated to utilization.</div></div><div><h3>Conclusion</h3><div>Higher area deprivation predicted lower healthcare utilization in VWPTE across several metrics of specialized epilepsy care and neuroimaging, though individual SDoH based on ICD-10-CM codes were inconsistently correlated to utilization.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107594"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of cognitive impairment due to epilepsy on quality of life: What do we know?","authors":"Theodore S. Aliyianis ,&nbsp;Gavin P. Winston","doi":"10.1016/j.eplepsyres.2025.107592","DOIUrl":"10.1016/j.eplepsyres.2025.107592","url":null,"abstract":"<div><div>People with epilepsy (PWE) often experience cognitive impairment that negatively affects their quality of life (QOL). However, the relationship between patterns of cognitive impairment and QOL is not well established either overall or within different epilepsy subtypes. Our understanding is limited by the heterogeneity of the tools used to measure QOL across studies and subtypes of epilepsy and the lack of standardization between cognitive assessment batteries. This narrative review explores the current approaches used to investigate this relationship and identifies key findings from the literature. We highlight the need to standardize approaches to measuring QOL and cognition with studies focusing on specific epilepsy subtypes. We suggest expanding cognitive assessments to include social cognition, which correlates with QOL in PWE. Both researchers and clinicians can use this narrative review as another step toward characterizing the unique effects of cognitive impairment in the treatment of epilepsy.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"215 ","pages":"Article 107592"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-pregnancy changes in seizure frequency and antiseizure medication treatment","authors":"Revital Gandelman-Marton ,&nbsp;Jacques Theitler","doi":"10.1016/j.eplepsyres.2025.107595","DOIUrl":"10.1016/j.eplepsyres.2025.107595","url":null,"abstract":"<div><h3>Background</h3><div>Maternal seizures during the post-pregnancy period are associated with severe morbidity and increased risk of mortality, and pose a risk of injury to their babies, that may be sometimes life threatening.</div></div><div><h3>Objectives</h3><div>To evaluate whether seizure frequency during post-pregnancy is higher compared to the pre-pregnancy period and to nonpregnant women with epilepsy.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed the computerized database and the medical records of all the women with epilepsy who were followed-up in our adult epilepsy clinic during an 8-year period (2012–2020), and identified 42 pregnancies in 34 women. The control group included 42 nonpregnant women with epilepsy, matched for age and epilepsy type.</div></div><div><h3>Results</h3><div>Mean monthly seizure frequency, seizure freedom rates and changes of seizure frequency during pregnancy and post-pregnancy did not significantly differ between pregnant women and controls. Among pregnant women there was a trend towards decreased seizure frequency during post-pregnancy (p = 0.076). Pregnant women received fewer antiseizure medications (ASMs) during pregnancy (1.3 vs 2) (p = 0.004) and post-pregnancy (1.4 vs 1.9) (p = 0.023) compared to controls, with a trend towards fewer ASMs during pre-pregnancy (p = 0.051). Compared to controls, changes of ASM treatment were more common in pregnant women during post-pregnancy (57.1 % vs 33.3 %) (p = 0.048), with a trend towards more common ASM changes during pregnancy (p = 0.073).</div></div><div><h3>Conclusions</h3><div>Seizure frequency during post-pregnancy in women with epilepsy who are managed according to the guidelines did not significantly differ in this cohort from that during pre-pregnancy and during the same epoch in nonpregnant women with epilepsy.</div></div>","PeriodicalId":11914,"journal":{"name":"Epilepsy Research","volume":"216 ","pages":"Article 107595"},"PeriodicalIF":2.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144203249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}