European journal of gynaecological oncology最新文献_第7页

Interaction of Pten gene and AKT/mTOR pathway in endometrial adenocarcinoma proliferation Pten基因与AKT/mTOR通路在子宫内膜腺癌增殖中的相互作用

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-04-15 DOI: 10.31083/j.ejgo4302033

D. Tang, M. Xi, Xi Zeng

{"title":"Interaction of Pten gene and AKT/mTOR pathway in endometrial adenocarcinoma proliferation","authors":"D. Tang, M. Xi, Xi Zeng","doi":"10.31083/j.ejgo4302033","DOIUrl":"https://doi.org/10.31083/j.ejgo4302033","url":null,"abstract":"Objective : The Pten/AKT/mTOR pathway is one of the most critical pathways in tumor proliferation. The present research aimed to analyze the interaction between Pten gene and AKT/mTOR pathway in endometrial cancer cell lines. Methods : TCGA analysis was used to study the relationship between Pten expression and survival of endometrial cancer patients. Human endometrial cancer cell lines with low Pten expression (Ishikawa) and with high Pten expression (HEC-1-A) were selected. Plasmid transfection was used to regulate the Pten expression in the cell lines. QRT-PCR and Western Blot were adopted to detect Pten/AKT/mTOR expressions in tumor cells. Western blot of Ki-67 and CCK-8 were adopted to detect the activity of cells proliferation. A p < 0.05 was considered to be statistically significant. Results : The TCGA analysis showed the Pten expression was associated with survival of endometrial cancer patients significantly. Plasmid transfections elevated Pten expression in Ishikawa and decreased Pten expression in HEC-1-A cells. After the plasmid transfection, with overexpression of Pten in Ishikawa cell line, the Western Blot and QRT-PCR revealed the AKT/mTOR pathway is restrained, leading to decreased cell proliferation; with Pten decreased in HEC-1-A cells, the AKT/mTOR pathway is activated, leading to increased cell proliferation. Conclusions : A decreased expression of Pten gene in Ishikawa and HEC-1-A cell lines could activate AKT/mTOR pathway and promote tumor cells proliferation.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49547882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete blood count parameters, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in hydatidiform mole versus missed abortion 全血细胞计数参数，中性粒细胞与淋巴细胞比值，血小板与淋巴细胞比值在葡萄胎与漏产

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-04-15 DOI: 10.31083/j.ejgo4302023

Ala Aiob, Karina Naškoviča, Inna Amdur Zilberfarb, A. Sharon, J. Bornstein, L. Lowenstein

{"title":"Complete blood count parameters, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio in hydatidiform mole versus missed abortion","authors":"Ala Aiob, Karina Naškoviča, Inna Amdur Zilberfarb, A. Sharon, J. Bornstein, L. Lowenstein","doi":"10.31083/j.ejgo4302023","DOIUrl":"https://doi.org/10.31083/j.ejgo4302023","url":null,"abstract":"Objective : Molar pregnancy is the most common type of gestational trophoblastic disease. Gestational trophoblastic disease is characterized by lower absolute and relative lymphocyte levels and a lower white blood cell (WBC) count relative to normal pregnancy. However, no studies have examined the WBC count relative to missed abortion. The aim of this study was to investigate whether blood parameters, such as neutrophil and lymphocyte counts, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), WBC count and platelets can distinguish gestational trophoblastic disease from missed abortion. Methods : This retrospective study included 104 women diagnosed with molar pregnancy and 110 women with missed abortions during 2010–2020 at one institution. Sixty-nine women had partial moles (PM) and 35 had complete moles (CM). We extracted and compared maternal and pregnancy characteristics, and laboratory parameters of all the women with molar pregnancy, and separately for those with PM and CM, compared to women with missed abortion. Results : The mean neutrophil level was higher in the molar pregnancy than the missed abortion group (5.67 ± 1.92 vs. 5.02 ± 1.65, p = 0.013); the patients with PM largely drove this difference. In multivariable linear models, women with molar pregnancy were more likely to have higher neutrophil values than women with missed abortion ( p = 0.023). Platelet, WBC, NLR and PLR values did not differ significantly between women with gestational trophoblastic disease and women with missed abortion. Conclusions : A higher neutrophil level was observed among women with molar pregnancies than among women with missed abortion. This suggests that molar pregnancies may cause a higher inflammatory response due to continued trophoblastic growth. However, the magnitude of the difference was small and not useful for establishing a diagnosis.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47371475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Treatment Progress in Triple Negative Breast Cancer 三阴性乳腺癌的治疗进展

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-04-15 DOI: 10.31083/j.ejgo4302040

S. Krämer, C. Rogmans, Dilek Saylan, D. Friedrich, C. Kraft, G. Rogmans, M. Wirtz, M. Friedrich

引用次数: 2

Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary - pulmonary type (SCOOPT): a case report and literature review 子宫腺肌症并发浆液性癌和卵巢-肺型小细胞癌(SCOOPT) 1例报告并文献复习

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-22 DOI: 10.21203/rs.3.rs-1374888/v1

Qiuyang Jing, Ying He

{"title":"Synchronous serous carcinoma arising in adenomyosis and small cell carcinoma of ovary - pulmonary type (SCOOPT): a case report and literature review","authors":"Qiuyang Jing, Ying He","doi":"10.21203/rs.3.rs-1374888/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-1374888/v1","url":null,"abstract":"\u0000 Background: Serous carcinoma arising in adenomyosis is rare, only 8 cases have been reported in the literature. Primary small cell carcinoma of ovary - pulmonary type (SCOOPT) is a rare, aggressive entity associated with poor outcomes and limited treatment options. The two malignant tumors synchronously happen at one patient has never been reported before.Case presentation: We summarized and analyzed the clinicopathological features of 1 serous carcinoma arising in adenomyosis synchronous with SCOOPT and reviewed the literature. A 60-year-old postmenopausal woman presented to our hospital with abdominal distension, abdominal pain, and constipation. Colonoscopy and computed tomography (CT) scan of pulmonary showed no abnormalities. Ultrasonography and CT scan revealed a solid-cystic mass in the pelvic cavity, slightly thickened uterine myometrium at the fundus with heterogeneous echo. A total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy were performed. The final pathology showed serous carcinoma originating from adenomyosis, while the eutopic endometrium and both fallopian epithelia were identified with no cancer. The solid-cystic mass in the right ovary is diagnosed with SCCOPT and metastasis to the myometrium of the uterus. The prognosis of previously reported cancers of adenomyosis origin and SCOOPT were both poor, while our case was alive without disease during the 6-month follow-up.Conclusion: We believe this case report will expand our recognition of the coexistence of serous carcinoma arising in adenomyosis with small cell carcinoma of the ovary–pulmonary type (SCOOPT).","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43222197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PARP inhibition in ovarian cancer: what is still missing? PARP在卵巢癌中的抑制作用:还缺少什么?

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301016

M. Morotti, E. Ghisoni

引用次数: 0

Pelvic floor dysfunction in endometrial cancer patients after treatment. A literature review 盆底功能障碍对子宫内膜癌患者治疗后的影响。文献综述

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301020

I. Theodoulidis, T. Mikos, D. Tsolakidis, L. Zepiridis, G. Grimbizis

{"title":"Pelvic floor dysfunction in endometrial cancer patients after treatment. A literature review","authors":"I. Theodoulidis, T. Mikos, D. Tsolakidis, L. Zepiridis, G. Grimbizis","doi":"10.31083/j.ejgo4301020","DOIUrl":"https://doi.org/10.31083/j.ejgo4301020","url":null,"abstract":"Endometrial cancer (EC) survivors are increasing progressively. However, treating this disorder may detrimentally affect the pelvic organs, resulting in pelvic floor disorders (PFD): urinary incontinence, pelvic organ prolapse, and bowel dysfunction. The aim of this review is to investigate the prevalence of PFD in EC survivors following both surgical and nonsurgical treatments. The authors conducted a structured search in the following databases: MEDLINE, EMBASE, Global Health, The Cochrane Library, and Web of Science from inception until August 2021. The inclusion criteria were: (1) women with EC, (2) observational studies, (3) original data, (4) PFD result evaluation, and (5) the use of verified tools for the evaluation of PFD. The initial search found 590 articles for PFD and endometrial cancer. Only 10 of the studies were finally available for further analysis, including 1849 individuals with EC. In total, the incidence of UI increased from 7.6% to 20.8% after EC therapy. The incidence of stress and urge UI after treatment ranged from 23 to 74.3% and 20.8 to 71.4%, respectively. The prevalence of POP was as high as 13.6% in 638 EC survivors. The prevalence of fecal incontinence was 21% in 732 EC survivors. In conclusion, PFDs are common after endometrial cancer treatment. The lack of comparative studies between the type of EC and the type of treatment limits further exploration of the differences in PFD frequency among EC survivors and the variety of EC treatments.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43610486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjuvant treatment in endometrial cancer: when and what to choose 子宫内膜癌的辅助治疗:何时以及选择什么

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301018

M. Paderno, T. Grassi, M. Adorni, Benedetta Zambetti, G. Di Martino, L. Bazzurini, F. Landoni, A. Lissoni

引用次数: 0

Liver surgery for advanced ovarian cancer: a systematic review of literature 晚期癌症肝手术治疗的系统文献回顾

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301015

S. Forte, F. Ferrari, G. Valenti, V. Capozzi, B. Navarro Santana, G. Babin, F. Guyon

{"title":"Liver surgery for advanced ovarian cancer: a systematic review of literature","authors":"S. Forte, F. Ferrari, G. Valenti, V. Capozzi, B. Navarro Santana, G. Babin, F. Guyon","doi":"10.31083/j.ejgo4301015","DOIUrl":"https://doi.org/10.31083/j.ejgo4301015","url":null,"abstract":"Objective: To analyze the surgical treatment of liver metastases from advanced ovarian cancer (AOC) during either primary or interval debulking surgery (PDS or IDS). Data sources, methods of study selection: A systematic research of the literature was conducted in Scopus, PubMed/MEDLINE, ScienceDirect and the Cochrane Library, including observational prospective, retrospective studies, case series and case reports. Tabulation, integration and results: We collected data regarding study features, characteristics of the patients and of liver metastasis, the type of surgical treatment and postoperative morbidity. The type of liver surgery was described according to the terminology of Brisbane 2000 (TB2000). Ten articles were selected, and 61 patients were included, even though data was not complete for all of them. The weighted average age was 57 years old, and most women underwent PDS (n = 21/32 [66%]). The number of liver metastases was available only for 17 patients including 3 (18%) and 14 (82%) with multiple and single lesions, respectively. Metastasis from peritoneal seeding (peritoneal metastasis) was the most common type of lesion (n = 27/42 [64%]). Only in one study the authors declared the specialty of the surgeon performing the procedures (hepatobiliary). Two studies (n = 15) adopted the TB2000 and reported as follow: 47% wedge resections, 33% segmentectomies, 13% hemi-hepatectomies and 7% right-trisegmentectomy. ClavienDindo grade III or greater complications was 13% (n = 2/15). Conclusions: Liver resection is feasible during either PDS or IDS. Single lesion and peritoneal metastasis represent the most common conditions. Wedge liver resection is the most frequent procedure. Prognostic advantage is suggested after liver surgery especially for peritoneal metastasis.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46694859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Growing teratoma syndrome after surgery for ovarian immature teratoma 卵巢未成熟畸胎瘤术后生长性畸胎瘤综合征

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301017

Soichiro Suzuki, Y. Ota, Rikiya Sano, Yumiko Morimoto, T. Moriya, M. Shiota

{"title":"Growing teratoma syndrome after surgery for ovarian immature teratoma","authors":"Soichiro Suzuki, Y. Ota, Rikiya Sano, Yumiko Morimoto, T. Moriya, M. Shiota","doi":"10.31083/j.ejgo4301017","DOIUrl":"https://doi.org/10.31083/j.ejgo4301017","url":null,"abstract":"Growing teratoma syndrome (GTS) is a condition characterized by tumor growth during or after chemotherapy for a germ cell tumor, albeit with normal tumor marker levels in the absence of histopathological evidence of immature teratoma components. We encountered a 10-cm large GTS lesion in the para-aorti nodes after fertility-preserving surgery for a grade 3 ovarian immature teratoma. The patient was a 20 year old woman who presented to the hospital with complaints of abdominal pain and swelling. Imaging examination revealed an ovarian tumor mass measuring 24 cm in the abdominal cavity, suspected to be composed of a mixture of fat and other components. The α-fetoprotein (AFP) levels were elevated at 853 ng/mL. We elected to perform fertility-preserving surgery. The surgical findings included a tumor in the right ovary, which was excised without rupture with adnexectomy. The histopathological diagnosis was grade 3 immature teratoma. Palpation of the pelvic and para-aortic lymph node areas did not reveal significant lymphadenopathy. Subsequently, a para-aortic node metastasis (major axis: 8 cm) was discovered before chemotherapy (19 days after surgery). We confirmed that there was no swelling before surgery and assumed that the immature teratoma had recurred. Chemotherapy was initiated, and the serum AFP levels normalized after 4 courses of bleomycin, etoposide, and cisplatin (BEP) therapy. However, the para-aortic node metastasis had grown further (major axis: 10 cm). Another open surgery was performed. The nodal mass was completely excised and pathology revealed only mature teratoma. Growing teratoma syndrome should be considered in the setting of a recurrent mass with negative tumor markers.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46360711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cervical cancer elimination in the era of COVID-19: the potential role of Artificial Intelligence (AI)-guided digital colposcope cloud platform COVID-19时代的宫颈癌消除:人工智能(AI)引导的数字阴道镜云平台的潜在作用

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2022-02-15 DOI: 10.31083/j.ejgo4301019

M. J. Mendez, P. Xue, Youlin Qiao

引用次数: 3