European journal of gynaecological oncology最新文献_第10页

Exploration on correlation of high DLX2 expression with poor prognosis and cellular proliferation in epithelial ovarian cancers 上皮性卵巢癌DLX2高表达与不良预后及细胞增殖的相关性探讨

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2093

Menghui Huang, Yu-Wen Han, Qinghua Xi, Yunfeng Jin, Ying-lei Liu, Yunhe Han, Hai-Li Kai, Qian Zhang, Yan-Li Zheng

{"title":"Exploration on correlation of high DLX2 expression with poor prognosis and cellular proliferation in epithelial ovarian cancers","authors":"Menghui Huang, Yu-Wen Han, Qinghua Xi, Yunfeng Jin, Ying-lei Liu, Yunhe Han, Hai-Li Kai, Qian Zhang, Yan-Li Zheng","doi":"10.31083/J.EJGO.2021.03.2093","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2093","url":null,"abstract":"Objective: It has been found that overexpression of distal-less homeobox 2 (DLX2) is closely correlated with multiple cancers. However, the role of DLX2 in the pathogenesis of ovarian cancers is not known. This study was designed to explore the mechanism of action of DLX2 on cellular proliferation and apoptosis in epithelial ovarian cancers (EOCs). Methods: A total of 119 EOC tissue specimens were analyzed immunohistochemically, and the correlation between DLX2 expressional level and clinicopathological characteristics was determined. Moreover, western blot method was used to measure DLX2 protein in EOC specimen of different grades and EOC cell lines and explore its molecular mechanism of action. Kaplan-Meier survival analysis revealed that overexpression of DLX2 was obviously correlated with an adverse clinical outcome in EOCs (P < 0.01*). Results: DLX2 expressional level had an obvious association with histopathological grade, FIGO stage, ascites and ki-67 expressional level in EOC patients and DLX2 exerted a crucial effect in regulating cellular proliferation in EOCs. Knocking down DLX2 using shRNA-DLX2 reduced the proliferation and enhanced the apoptosis in EOC cells. Conclusion: DLX2 might act as a new prognostic indicator and have an important value for molecular targeted therapeutic drugs in EOCs.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"521-529"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42122038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bevacizumab for malignant pleural effusion in ovarian clear cell carcinoma: a case report 贝伐单抗治疗卵巢透明细胞癌恶性胸腔积液1例

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2338

Di Wu, Yanqin Zhang, Jinwei Miao

引用次数: 1

BRCA-guided therapy of ovarian cancer BRCA引导下治疗癌症

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2210

P. Economopoulou, I. Kotsantis, A. Bamias

{"title":"BRCA-guided therapy of ovarian cancer","authors":"P. Economopoulou, I. Kotsantis, A. Bamias","doi":"10.31083/J.EJGO.2021.03.2210","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2210","url":null,"abstract":"Advanced (FIGO stages III and IV) epithelial ovarian cancer (aEOC) accounts for the majority of deaths from gynecological cancers in western countries. Although the prognosis of this disease has been considerably improved in the last two decades, the majority of women will still die from progression of EOC. Optimal cytoreductive surgery and cytotoxic chemotherapy remains the mainstay of treatment in the front-line setting. Approximately 18% of EOCs harbor germline mutations of the tumor suppressor genes Breast Cancer Susceptibility Gene 1 (BRCA1) and 2 (BRCA2), while another 3–6% of these tumors have somatic mutations of these genes. These mutations lead to increased predisposition of multiple cancers. In addition, BRCA1 and BRCA2 genes encode proteins that are implicated in the Homologous Recombination (HR) mechanism, which is responsible for the repair of DNA Double Strand Breaks (DSBs), which is a common mechanism of action of chemotherapy. The incorporation of BRCA-targeted therapies, such as poly ADP ribose polymerase (PARP) inhibitors in the treatment algorithm of advanced EOC has further improved outcomes and represents a successful strategy of individualization of treatment in EOC. In this review, we summarize current treatment recommendations for patients with EOC and a BRCA1/2 mutation.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"405-413"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44570525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The prognostic significance of microsatellite status and its relationship with tumor-infiltrating lymphocyte in endometrial cancer 子宫内膜癌症微卫星状态及其与肿瘤浸润淋巴细胞关系的预后意义

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2287

S. Lacin, G. E. Tasar, A. Usubutun, Z. Arık, D. Yuce, M. Salman, A. Kars

引用次数: 0

Incidence and predictors of venous thromboembolism after surgery for gynecologic cancer 妇科肿瘤术后静脉血栓栓塞的发生率及预测因素

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/j.ejgo.2021.03.2240

Xiao-juan Wang, K. Hua

{"title":"Incidence and predictors of venous thromboembolism after surgery for gynecologic cancer","authors":"Xiao-juan Wang, K. Hua","doi":"10.31083/j.ejgo.2021.03.2240","DOIUrl":"https://doi.org/10.31083/j.ejgo.2021.03.2240","url":null,"abstract":"Objective: To describe the incidence, timing, and risk factors of venous thromboembolism (VTE) after surgery for gynecological cancer and to evaluate its effects of these events on survival. Methods: This was a retrospective analysis from January 2008 through December 2016 at a single center. Data were recorded on surgical procedures, patient demographic characteristics, type of malignancy and VTE, and mortality outcomes within 30 days after surgery. Significant variables related to VTE were evaluated using bivariate analysis, and Logistic regression models were used to assess risk factors for VTE. Results: The overall rate of postoperative VTE was 0.899% (36/4005) within 30 days after surgery. Of these rates, the rate in abdominal surgery was 1.56% (19/1220), and the rate in minimally invasive surgery (MIS) was 0.6% (17/2785). The median time from surgery to diagnosis was 8.5 days. In univariate analysis, VTE was statistically significantly associated with ovarian and fallopian cancer (P < 0.05), older age (P = 0.001), and blood transfusion (P < 0.001). A multivariate logistic regression model was used to adjust for variables with P < 0.2 in univariate analysis and found that except for age, the other variables continued to have a significant association with VTE. Conclusion: The second week after surgery might be high-risk period of VTE occuring, and ovarian and fallopian tube cancer, abdominal surgery, and blood transfusion might be significant risk factors for developing VTE.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42032478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Methylated p16 gene is associated with negative expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in breast cancer 甲基化p16基因与乳腺癌症雌激素受体、孕激素受体和人表皮生长因子受体2的负表达相关

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2173

Shun Zhang, Ya-Qin Wang, Jing-hua Zhang, Jiwei Hu, Jie Ma, Z. Gu, Yu Wang, Jingjing Chen

{"title":"Methylated p16 gene is associated with negative expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in breast cancer","authors":"Shun Zhang, Ya-Qin Wang, Jing-hua Zhang, Jiwei Hu, Jie Ma, Z. Gu, Yu Wang, Jingjing Chen","doi":"10.31083/J.EJGO.2021.03.2173","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2173","url":null,"abstract":"Objective: This study was conducted to determine the relationship between p16 gene methylation and expression of relevant receptors in breast cancer (BC) for subtyping the disease. Methods: Methylationspecific PCR (MSP) was carried out to detect the methylation status of p16 gene in 240 tissue samples and 205 serum samples from BC patients treated at our hospital. Immunohistochemistry was used to determine the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Receiver operating characteristics (ROC) curve was analyzed for diagnostic value based on methylation status for triple-negative (TN) BC. Results: The overall methylation rates of the p16 gene were 36.7% (88/240) and 35.1% (72/205) in the tissue and serum samples, respectively. In patients with ER, PR and HER2-TNBC, the methylation rate of the p16 gene was significantly higher than that in non-triple negative patients (84.9%, 62/73) vs (25.9%, 35/135, P<0.01). The methylation of p16 gene was negatively associated with the expression of ER, PR and HER2 (r = -0.661, -0.694 and -0.765, respectively, P < 0.05), but it was not correlated with the pathological characteristics of BC, such as tumor grade and lymph-node metastasis. Receiver operator characteristic (ROC) curve analysis showed that p16 gene methylation had a significant diagnostic value for TNBC with an AUC of 0.815. Therefore, p16 gene methylation is associated with the subtype of TNBC and can be used as an easy and non-invasive approach to screen patients for TNBC.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"530-536"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46112395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prophylactic mastectomy and ovariectomy—a religious perspective 预防性乳房切除术和卵巢切除术——宗教观点

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2253

B. Kasprzak, Przemysław Zgórecki

引用次数: 0

Proceedings of Asociación Aragonesa de Ginecología y Obstetricia (AGOA) 2021 congress 阿拉贡妇产科协会会议录（AGOA）2021年大会

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2021

L. B. Mainar

{"title":"Proceedings of Asociación Aragonesa de Ginecología y Obstetricia (AGOA) 2021 congress","authors":"L. B. Mainar","doi":"10.31083/J.EJGO.2021.03.2021","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2021","url":null,"abstract":"Marta Lamarca Ballestero*, Leticia Álvarez Sarrado, Javier Navarro Sierra, Yasmina José Gutiérrez, Isabel Negredo Quintana, Miguel Angel Ruiz Conde Department of Gynecology, Miguel Servet University Hospital, Paseo Isabel la Católica 1-3, 50009 Zaragoza, Spain. * m.lamarca@yahoo.es Objectives: To describe the clinical findings, treatment, and outcome of borderline ovarian tumors in 32 premenopausal patients admitted to the Miguel Servet University Hospital over a 17-year period. Methods: Thirty-two premenopausal patients diagnosed and treated from 2003 to 2020 for borderline ovarian tumors were retrospectively evaluated. Results: The 32 borderline included 12 serous, 19 mucinous, and 1 endometrioid tumors, 2 of them were of stage more than I. The average age of the patients was 34.5 years (14–45), 22 were symptomatic, pain being the most frequent symptom (68.8%). 8 patients were operated on primarily by laparoscopy and 24 by laparotomy. In the laparoscopy group, median tumor diameter was smaller (7.5 versus 14.7 cm, p = 0.019) and surgeries were less extensive, without hysterectomy, as compared to the laparotomy group. There were 21 fertility-sparing surgeries, 7 patients attempted a subsequent pregnancy and in 6 cases a pregnancy with a healthy child was obtained (2 using assisted reproductive techniques). During the 7–108 months follow-up time, there were 3 relapses: 2 borderline tumors (treated surgically and desease free) and 1 carcinoma treated with surgery and chemotherapy that ended in death due to cancer. Discussion: In our study, only 6.25% of the borderline tumors were of stage more than I, whereas other studies report a higher proportion of more advanced stages (7.5–18.5%). As borderline ovarian tumors more often arise in young women, in whom malignancy is less common and who wish to preserve their fertility, their initial surgery is often laparoscopy. Conclusions: Borderline ovarian tumors have an excellent prognosis. Good results are provided in young patients wishing to preserve fertility.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"605-609"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46566576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor proximity to serosal surface as an independent prognostic factor in FIGO stage 1 endometrial cancer 肿瘤靠近浆膜表面是FIGO 1期癌症的独立预后因素

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/j.ejgo.2021.03.2310

L. Harbin, L. Berry, A. Wahlquist, J. Richmond, W. Graybill, M. Kohler, W. Creasman

{"title":"Tumor proximity to serosal surface as an independent prognostic factor in FIGO stage 1 endometrial cancer","authors":"L. Harbin, L. Berry, A. Wahlquist, J. Richmond, W. Graybill, M. Kohler, W. Creasman","doi":"10.31083/j.ejgo.2021.03.2310","DOIUrl":"https://doi.org/10.31083/j.ejgo.2021.03.2310","url":null,"abstract":"Objective: Determine if tumor distance from serosal surface is an independent prognostic factor for disease recurrence and survival in stage 1 endometrial cancer. Methods: 747 patients diagnosed with stage 1 endometrial cancer between 1984 and 2015 were identified from an institutional database. This retrospective cohort was evaluated to assess di ferences in tumor distance from the serosal surface, histologic subtype, histologic grade, use of adjuvant treatment, recurrence rates and overall survival. Cox proportional hazard models were used to determine if variables of interest were related to recurrence and overall survival. Concordance correlation coe ficients were used to compare our model to the 2009 International Federation of Gynecology andObstetrics (FIGO) staging. Results: Tumor distance from serosal surface ranged from 0mm–21mm. 47 (8.7%) patients experienced recurrence. Patients with tumors located 5mmor less from the serosal surface were 2.24 times more likely to experience recurrent disease (HR 2.24, 95% CI: 1.16 to 4.31, p = 0.02). Concordance rates for disease recurrence were 0.573 and 0.583 for our tumor distance model compared to the 2009 FIGO staging (95% CI: 0.568 to 0.579 and 95% CI: 0.577 to 0.589). Conclusions: Our study demonstrates that patients with tumors located 5 mm or less from the serosal surface have a two-fold increased risk of recurrence. Concordance ratesarevery similarbetweenourmodelandthe2009FIGO staging suggesting comparable predictability; these rates suggest there is roomfor improvement inbothmethods topredict disease recurrence and survival.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":" ","pages":""},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42378467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing cosmetic outcome of breast-conserving treatment in breast cancer: a narrative review 影响乳腺癌保乳治疗美容效果的因素:综述

IF 0.4 4区医学

European journal of gynaecological oncology Pub Date : 2021-06-15 DOI: 10.31083/J.EJGO.2021.03.2285

A. Brands-Appeldoorn, S. Maaskant-Braat, L. Janssen, V. Tjan-Heijnen, R. Roumen

{"title":"Factors influencing cosmetic outcome of breast-conserving treatment in breast cancer: a narrative review","authors":"A. Brands-Appeldoorn, S. Maaskant-Braat, L. Janssen, V. Tjan-Heijnen, R. Roumen","doi":"10.31083/J.EJGO.2021.03.2285","DOIUrl":"https://doi.org/10.31083/J.EJGO.2021.03.2285","url":null,"abstract":"Background: A deformed breast following Breast-Conserving Treatment (BCT) is influenced by an array of factors encompassing final cosmesis. This overview examines the factors that may influence cosmetic outcome for BCT patients. Methods: Literature search was performed using PubMed and EMBASE databases. Research articles published in English (1990–2018) pertaining to patients that had previously undergone unilateral BCT for breast cancer were included. Results: 42 articles were used for our final analysis that utilized subjective and objective tools to assess cosmetic outcome. Factors can be allocated as patient, tumor, surgery, radiotherapy or systemic therapy associated. Based on significance in both univariable as well as multivariable analysis and frequency of reporting, extensiveness of primary tumor resection, tumor size, tumor location, adjuvant radiotherapy and adjuvant chemotherapy, were the factors affecting cosmetic outcome the most. Conclusions: In this study, we reviewed and discussed several patient-, tumorand treatment related factors affecting cosmetic outcome. Many different tools, either subjective or objective, are observed worldwide.","PeriodicalId":11903,"journal":{"name":"European journal of gynaecological oncology","volume":"42 1","pages":"425-433"},"PeriodicalIF":0.4,"publicationDate":"2021-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46167014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0