The association between HIC1 methylation and ovarian cancer: a meta-analysis

IF 0.5 4区医学 Q4 OBSTETRICS & GYNECOLOGY

European journal of gynaecological oncology Pub Date : 2022-04-15 DOI:10.31083/j.ejgo4302037

Jiayi Guo, Lifang Sun, Qingqing Lv

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引用次数: 0

Abstract

Objective : HIC1 is a tumor suppressor gene (TSG) located in the 17p13.3 region that encodes a transcriptional repressor. Research published over the past few years indicates that HIC1 methylation is a critical factor in the oncogenesis of ovarian cancer (OC). However, previous studies had only small sample sizes and thus were unable to reach firm conclusions. Data Sources : Therefore, we performed a meta-analysis to further investigate the association between HIC1 methylation and OC. Studies related to HIC1 methylation and OC were identified from searches of PubMed, EMBASE, Medline and CNKI. Methods of Study Selection : Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between the two factors. Subgroup analysis and Begg’s test were used to evaluate heterogeneity and publication bias. From 591 studies, 7 were selected for meta-analysis and these comprised 455 cases and 278 controls. Tabulation, Integration and Results : A significant association between HIC1 methylation and OC was found under the fixed-effects model (OR = 4.306, 95% CI = 2.846 to 6.515). Subgroup analysis of the control type yielded a less tight association (OR = 4.143, p = 0.147, I 2 = 41.1%). Finally, we conducted analysis of the Cancer Genome Atlas (TCGA) data and found higher HIC1 methylation levels in OC compared to adjacent non-tumor tissue. Conclusion : In conclusion, this meta-analysis found that HIC1 methylation was strongly associated with OC.

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HIC1甲基化与卵巢癌的关系:一项荟萃分析

目的：HIC1是一个位于17p13.3区的肿瘤抑制基因，编码一个转录抑制因子。过去几年发表的研究表明，HIC1甲基化是卵巢癌症（OC）发生的关键因素。然而，以前的研究样本量很小，因此无法得出确切的结论。数据来源：因此，我们进行了一项荟萃分析，以进一步研究HIC1甲基化与OC之间的关系。从PubMed、EMBASE、Medline和CNKI的搜索中确定了与HIC1甲基化和OC相关的研究。研究选择方法：使用比值比（OR）和95%置信区间（CI）来评估这两个因素之间的相关性。亚组分析和Begg检验用于评估异质性和发表偏倚。从591项研究中，选择7项进行荟萃分析，其中包括455例病例和278例对照。制表、积分和结果：在固定效应模型下，HIC1甲基化和OC之间存在显著相关性（OR=4.306，95%CI=2.846至6.515）。对照组的亚组分析显示相关性较低（OR=4.143，p=0.147，I2=41.1%）。最后，我们对癌症基因组图谱（TCGA）数据进行了分析，发现OC中的HIC1甲基化水平高于邻近的非肿瘤组织。结论：总之，本荟萃分析发现HIC1甲基化与OC密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of gynaecological oncology 医学-妇产科学

自引率

25.00%

发文量

审稿时长

1 months

期刊介绍： EJGO is dedicated to publishing editorial articles in the Distinguished Expert Series and original research papers, case reports, letters to the Editor, book reviews, and newsletters. The Journal was founded in 1980 the second gynaecologic oncology hyperspecialization Journal in the world. Its aim is the diffusion of scientific, clinical and practical progress, and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists, and so on.