S100A7 promotes endometrial carcinoma progression by activating the MAPK signaling pathway

IF 0.5 4区医学 Q4 OBSTETRICS & GYNECOLOGY

European journal of gynaecological oncology Pub Date : 2023-01-01 DOI:10.22514/10.22514/ejgo.2023.028

Xiaojing Sun, Xinyue Zhang, Lanhui Yuan, Yu-Qin Fu, N Concin, X Matias-Guiu, I Vergote, D Cibula, M Mirza, S Marnitz, V Makker, M Taylor, C Aghajanian, A Oaknin, J Mier, A Cohn, J Perera, P Hoskin, X Liang, H Zeng, S Chen, M Jiang, S Liu, Fan, Y Zhang, W Zhao, Z Chen, X Zhao, P Ren, M Zhu, J Guo, X Cui, X Zhang, H Qian, H Duan, Y Zhang, F D'amico, E Skarmoutsou, M Libra, G Luo, M Tang, Q Zhao, L Lu, Y Xie, Y Li, Z Lu, S Zheng, C Liu, X Wang, G Zhang, F Wang, K Dey, R Bharti, G Dey, I Pal, Y Rajesh, S Chavan, E Asl, M Amini, S Najafi, B Mansoori, A Mokhtarzadeh, A Mohammadi, H Park, K Baek, J Wang, P Xu, X Yang, Q Yu, X Xu, G Zou, L Gonzalez, K Garrie, M Turner, P Singh, S Ali, S Doi, N Fujioka, S Ohtsuka, R Kondo, M Yamamoto, M Denda, C Allgwer, A Kretz, Von Karstedt, S Wittau, M Henne-Bruns, D Lemke, J, D Dowarha, R Chou, C Yu, D Meng, R Sun, G Liu, L Peng, L Zheng, P Xie, G Huang, J Zhang, G Qing, D Liu, X Wang, Y Chen, H Xu, H Song, Q Zhou, P Huang, J Xue, Y Cong, Y Cui, S Wang, L Jiang, J Cao, S Zhu, Q Sun, Y Cao, Y Lan, L Lei, B Zhang, S Wang, G Peng, S Tsukamoto, K Okumura, H Ogawa, S Ikeda, F Niyonsaba, M Muoio, M Talia, R Lappano, A Sims, V Vella, F Cirillo, S Mishra, M Charan, R Shukla, P Agarwal, S Misri, A Verma, J Anjum, S Mitra, R Das, R Alam, A Mojumder, T Emran, G Bora, A Yaba, Jin, Jin Li, G Zheng, J, Y Wang, L Pan, Y Liu, Y Ding, Y Nie, M Yang, M Song, B Zhou, B Li, L Tian, Q Jiang, C Xiong, Y Lv, X Zhang, G Qi, X Zhang, L Wang, F Li, J Guo, T Tang, J Li, Y Yang, L Zhang, Y Quan

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引用次数: 0

Abstract

S100 calcium binding protein A7 (S100A7) has been proofed to play a carcinogenic role in several cancers. However, its role and the regulatory mechanism in Endometrial carcinoma (EC) was unknown. Western blot was applied to determine the expression of S100A7 and Mitogen-activated protein kinase (MAPK) pathway-related protein in EC cells. Functional in vitro experiments were conducted to explore the effects of S100A7 on cell proliferation, apoptosis, migration, invasion and angiogenesis in EC. As a result, S100A7 expression was dramatically up-regulated in EC cells. Overexpression of S100A7 enhanced EC cells proliferation, migration, invasion and angiogenesis, and suppressed cell apoptosis, as well as activated MAPK signaling pathway. Whereas, knockdown of S100A7 exerted the opposite effects. Our finding suggested that S100A7 may promote the malignant progression of EC by activating MAPK pathway, implying S100A7 has significant potential to be used as an emerging therapeutic target for EC treatment.

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S100A7通过激活MAPK信号通路促进子宫内膜癌进展

S100钙结合蛋白A7 （S100A7）已被证实在几种癌症中起致癌作用。然而，其在子宫内膜癌（EC）中的作用和调控机制尚不清楚。Western blot检测EC细胞中S100A7及丝裂原活化蛋白激酶（MAPK）通路相关蛋白的表达。通过体外功能实验探讨S100A7对EC细胞增殖、凋亡、迁移、侵袭及血管生成的影响。结果，S100A7在EC细胞中的表达显著上调。过表达S100A7可增强EC细胞的增殖、迁移、侵袭和血管生成，抑制细胞凋亡，激活MAPK信号通路。而敲低S100A7则产生相反的效果。我们的研究结果表明，S100A7可能通过激活MAPK通路促进EC的恶性进展，这意味着S100A7具有作为EC治疗新靶点的巨大潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European journal of gynaecological oncology 医学-妇产科学

自引率

25.00%

发文量

审稿时长

1 months

期刊介绍： EJGO is dedicated to publishing editorial articles in the Distinguished Expert Series and original research papers, case reports, letters to the Editor, book reviews, and newsletters. The Journal was founded in 1980 the second gynaecologic oncology hyperspecialization Journal in the world. Its aim is the diffusion of scientific, clinical and practical progress, and knowledge in female neoplastic diseases in an interdisciplinary approach among gynaecologists, oncologists, radiotherapists, surgeons, chemotherapists, pathologists, epidemiologists, and so on.