The Pediatric Infectious Disease Journal最新文献

{"title":"Long-term Follow-up of Preterm Infants Having Been Colonized With Extended Spectrum Beta-lactamase-producing Enterobacterales Over the First 6 Years of Life.","authors":"Martin Eberhart,&nbsp;Andrea Grisold,&nbsp;Michela Lavorato,&nbsp;Elisabeth Resch,&nbsp;Andreas Trobisch,&nbsp;Bernhard Resch","doi":"10.1097/INF.0000000000003212","DOIUrl":"https://doi.org/10.1097/INF.0000000000003212","url":null,"abstract":"<p><p>We performed a retrospective case-control cohort study following 146 preterm infants (≤32 weeks of gestation) who had been colonized with extended spectrum beta-lactamase producing Enterobacterales and compared them with 1:1 matched controls regarding rates of hospitalizations and outpatient visits because of infectious and gastrointestinal diseases and developmental impairment up to school age. Preterm infants with extended spectrum beta-lactamase producing Enterobacterales colonization did have neither higher rates of gastrointestinal or infectious diseases nor higher rates of developmental impairments up to the age of 6 years.</p>","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"835-837"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39185200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Case of Meningitis in an Adolescent.","authors":"James E Stanton,&nbsp;Jeremy S Wilkes,&nbsp;Salma S Syed","doi":"10.1097/INF.0000000000003090","DOIUrl":"https://doi.org/10.1097/INF.0000000000003090","url":null,"abstract":"The Pediatric Infectious Disease Journal • Volume XX, Number XX, XXX XXX www.pidj.com | 1 ISSN: 0891-3668/21/XXXX-0000 DOI: 10.1097/INF.0000000000003090 Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. Accepted for publication January 7, 2021 From the *Department of Pediatrics and †Department of Internal Medicine/Pediatrics, East Carolina University, The Brody School of Medicine, Greenville, North Carolina. The authors have no funding or conflicts of interest to disclose. Address for correspondence: Salma S. Syed, DO, Department of Pediatrics, Pediatric Infectious Diseases and Travel Medicine, ECU Brody School of Medicine, GE 99, 600 Moye Blvd, Greenville, NC 27834. E-mail: syeds@ecu.edu.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"864-865"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25330035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rocky Mountain Spotted Fever in a Large Metropolitan Center, Mexico-United States Border, 2009-2019.","authors":"","doi":"10.1097/INF.0000000000003246","DOIUrl":"https://doi.org/10.1097/INF.0000000000003246","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"845"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39315345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Risk of Central Line-associated Bloodstream Infections in Pediatric Hematology/Oncology Patients.","authors":"Iris Kristinsdottir,&nbsp;Asgeir Haraldsson,&nbsp;Olafur Gudlaugsson,&nbsp;Valtyr Thors","doi":"10.1097/INF.0000000000003177","DOIUrl":"https://doi.org/10.1097/INF.0000000000003177","url":null,"abstract":"<p><strong>Background: </strong>Central venous lines (CVLs) are essential for standard care of pediatric hematology/oncology patients providing safe administration of cytotoxic drugs and pain-free blood sampling. Central line-associated bloodstream infections (CLABSIs) cause significant morbidity. This study describes the epidemiology, microbiology, and risk factors for CLABSI in all children with malignancies in Iceland.</p><p><strong>Methods: </strong>All children that were diagnosed with malignancy in Iceland and received a CVL during 2008-2017 were included in the study. Characteristics of CVLs and patients were registered, information on risk factors, and microbiology was collected. International standards were used for CLABSI definition.</p><p><strong>Results: </strong>One hundred forty-three CVLs were placed in 94 children. Acute lymphoblastic leukemia was the most common underlying disease (31/94). Median age was 7 years. Implantable ports were the most commonly placed CVLs (82/143, 57%), tunneled lines were 39 (27%). Overall CLABSI rate was 0.24 infections/1000 line-days (14 episodes in 58,830 line-days), with little fluctuations. No CLABSI episodes occurred for 4 consecutive years (2012-2015). Staphylococci (of which 7 Staphylococcus aureus) were the cause of 10/14 episodes. Nine CLABSI episodes led to line removal, but no deaths were linked to CLABSIs.</p><p><strong>Conclusion: </strong>We report very low CLABSI rates over a 9-year period at our hospital, with 4 consecutive CLABSI-free years. Even with the addition of episodes of possible CLABSI, rates were still very low and lower than most published reports.</p>","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"827-831"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38913668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Manifestations of Multisystem Inflammatory Syndrome in Children with COVID-19.","authors":"İmran Arkan,&nbsp;Semra Tiryaki Demir,&nbsp;Elif Hazal Livan,&nbsp;Mustafa Nuri Elçioğlu","doi":"10.1097/INF.0000000000003216","DOIUrl":"https://doi.org/10.1097/INF.0000000000003216","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"e356-e358"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39103928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Limitations of Cytomegalovirus DNA Detection in Cerebrospinal Fluid of Newborn Infants With Congenital CMV Infection: A Tertiary Care Neonatal Center Experience.","authors":"Justyna Czech-Kowalska,&nbsp;Dominika Jedlińska-Pijanowska,&nbsp;Beata Kasztelewicz,&nbsp;Magdalena Kłodzińska,&nbsp;Aleksandra Pietrzyk,&nbsp;Eliza Sarkaria,&nbsp;Dorota Dunin-Wąsowicz,&nbsp;Kinga Gradowska,&nbsp;Anna Niezgoda,&nbsp;Dariusz Gruszfeld,&nbsp;Anna Dobrzańska","doi":"10.1097/INF.0000000000003205","DOIUrl":"https://doi.org/10.1097/INF.0000000000003205","url":null,"abstract":"<p><strong>Background: </strong>Congenital cytomegalovirus (cCMV) infection of the central nervous system (CNS) can cause ventriculomegaly, gliosis, calcifications and cortical defects. Detection of CMV DNA in cerebrospinal fluid by PCR (CSF-CMV-PCR) is a marker of CNS involvement.</p><p><strong>Objective: </strong>To evaluate a diagnostic value of the positive CSF-CMV-PCR in cCMV.</p><p><strong>Methods: </strong>Analysis of clinical, laboratory, neuroimaging and single-nucleotide polymorphisms (SNPs) data according to the results of CSF-CMV-PCR were performed in infants with cCMV.</p><p><strong>Results: </strong>A total of 168 infants were included; 145 (86.3%) had negative and 23 (13.7%) had positive CSF-CMV-PCR results. Associations between the positive CSF-CMV-PCR results and prematurity (odds ratio [OR] = 3.24; 95% confidence interval [CI]: 1.30-8.07), microcephaly (OR = 5.67; 95% CI: 2.08-15.41), seizures (OR = 4.15; 95% CI: 1.10-15.67), sensorineural hearing loss (OR = 6.6; 95% CI: 2.49-17.46), splenomegaly (OR = 8.13; 95% CI: 3.12-21.16), hepatitis (OR = 10.51; 95% CI: 3.31-33.35), petechiae (OR = 10.21; 95% CI: 3.78-27.57) and heterozygous T/C genotype at TLR4rs4986791 (OR = 7.88; 95% CI: 1.55-40.12) were observed. When using a multivariate logistic regression analysis, only the presence of severe sensorineural hearing loss (OR = 7.18; 95% CI: 1.75-29.34, P = 0.006), cystic lesions on MRI (OR 5.29; 95% CI: 1.31-21.36, P = 0.02), and calcifications on MRI (OR = 7.19; 95% CI: 1.67-30.97, P = 0.008) remained as the significant independent predictors of the positive CSF-CMV-PCR results.</p><p><strong>Conclusions: </strong>The detection of CMV DNA in CSF is associated with a higher rate of CNS damage including abnormal MRI neuroimaging and severe hearing loss. Therefore, detection of CMV DNA in CSF may be considered as a marker of severe CNS injury in cCMV infection. However, the very low prevalence of the positive CSF-CMV-PCR results, even in infants with proven CNS involvement, may imply its limited role in clinical practice.</p>","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"838-845"},"PeriodicalIF":3.6,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39202687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Tuberculosis and Progress Toward Meeting Global Targets: Worldwide, 2019.","authors":"","doi":"10.1097/INF.0000000000003241","DOIUrl":"https://doi.org/10.1097/INF.0000000000003241","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"752"},"PeriodicalIF":3.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39176458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated Cystic Echinococcosis Cured With Lengthy Albendazole and Praziquantel Oral Therapy.","authors":"Elpis Mantadakis,&nbsp;George Totikidis,&nbsp;Savas Deftereos","doi":"10.1097/INF.0000000000003163","DOIUrl":"https://doi.org/10.1097/INF.0000000000003163","url":null,"abstract":"Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. The authors have no conflicts of interest to disclose. All authors had access to the patient’s medical and imaging data and significantly contributed to the preparation of this article. Address for correspondence: Elpis Mantadakis, MD, PhD, Pediatric Hematology/Oncology, Democritus University of Thrace Faculty of Medicine, 6th Kilometer AlexandroupolisMakris, 68100 Alexandroupolis, Thrace, Greece. E-mail: emantada@med.duth.gr. Disseminated Cystic Echinococcosis Cured With Lengthy Albendazole and Praziquantel Oral Therapy","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"e319"},"PeriodicalIF":3.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39175473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying Clinical, Biologic and Echocardiography Criteria to Predict a Resistant Kawasaki Disease in Children.","authors":"Anne-Cécile Robert,&nbsp;Anne-Laure Parmentier,&nbsp;Olivier Schulze,&nbsp;Cindy Verney,&nbsp;Frédéric Huet,&nbsp;Gérard Thiriez,&nbsp;Raphaël Anxionnat","doi":"10.1097/INF.0000000000003144","DOIUrl":"https://doi.org/10.1097/INF.0000000000003144","url":null,"abstract":"<p><strong>Background: </strong>Resistant Kawasaki disease (KD) represents 10%-15% of KD patients and increases risk of coronary artery abnormalities (CAAs). Different scores exist to predict resistant KD but only in Japanese population, although a French team has recently proposed a new scoring system. The principal objective of this study is to establish criteria to predict resistant KD in our representative French population. The second objective is an attempt to develop a predictive score of resistant KD.</p><p><strong>Methods: </strong>We conducted a retrospective multicenter study including 2 universities and five secondary hospitals in Eastern France. Patients were included over a period from January 1, 2010 through December 31, 2019. Diagnosis of KD was recorded to the European Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) initiative criteria.</p><p><strong>Results: </strong>Two hundred two eligible patients had KD and 194 patients were analyzed: 160 sensitive KD and 34 (17.5%) resistant KD. In univariate model, serum sodium <133 mmol/L (odds ratio [OR] 2.97 [1.40-6.45]), hemoglobin level <110 g/L (OR 3.17 [1.46-7.34]), neutrophils >80% (OR 2.36 [1.03-5.25]), C reactive protein level >150 mg/L (OR 4.47 [2.07-10.19]), CAA (OR 3.85 [1.67-8.79]) or myocarditis (OR 6.98 [1.47-36.95]) at the diagnosis were statistically significant, but only serum sodium was an independent factor of resistant KD.</p><p><strong>Conclusion: </strong>This study shows an association between resistant KD and biologic and echocardiography criteria, but only serum sodium is an independent predictive factor. A score to predict resistant KD could not yet be established.</p>","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"710-714"},"PeriodicalIF":3.6,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39176457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics of Patients With Kawasaki Disease Whose Siblings Had the Same Disease.","authors":"Kanako Hayashida,&nbsp;Ryusuke Ae,&nbsp;Hiroya Masuda,&nbsp;Koki Kosami,&nbsp;Masami Matsumura,&nbsp;Nobuko Makino,&nbsp;Yuri Matsubara,&nbsp;Teppei Sasahara,&nbsp;Yosikazu Nakamura","doi":"10.1097/INF.0000000000003074","DOIUrl":"https://doi.org/10.1097/INF.0000000000003074","url":null,"abstract":"<p><strong>Background: </strong>Some patients with Kawasaki disease (KD) have siblings who developed the same disease. Using a large-scale epidemiologic dataset, the present study aimed to determine the clinical characteristics of this population.</p><p><strong>Methods: </strong>We analyzed 89,725 patients diagnosed with KD during 2011-2018 who were registered in the nationwide Japanese KD survey database. Multivariable logistic regression analyses were performed to determine factors associated with sibling history of KD.</p><p><strong>Results: </strong>Of the 89,725 patients, 1777 (2%) had sibling history of KD. Annual prevalence ranged from 1.5% to 2.3% during the study period and showed a tendency toward an increasing trend. Patients with recurrent KD and parental history of KD were significantly associated with sibling history of KD (adjusted odds ratio [95% confidence interval] = 2.15 [1.82-2.54] and 2.64 [2.02-3.47], respectively). Although patients with a sibling history of KD were significantly associated with initial intravenous immunoglobulin treatment resistance (1.14 [1.02-1.28]), no significant association was found between sibling history and coronary artery abnormality development. Among patients with a sibling history of KD, male patients were less likely to have recurrent KD than female patients (0.68 [0.49-0.96]).</p><p><strong>Conclusions: </strong>The significant association between sibling history and parental history may indicate genetic susceptibility to KD onset. Among those with a sibling history, recurrent KD was more likely to occur in female patients. Further studies focusing on this population may contribute toward identification of the cause of KD onset.</p>","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" ","pages":"531-536"},"PeriodicalIF":3.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38910938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}