The Pediatric Infectious Disease Journal最新文献

{"title":"Treatment of Childhood Brucellosis: A Systematic Review.","authors":"Endi Lanza Galvão, Kathiaja Miranda Souza, Marina Gonçalves de Freitas, Marina Rocha Fonseca Souza, Moisés Willian Aparecido Gonçalves, G. Cota, Sarah Nascimento Silva","doi":"10.1097/INF.0000000000004389","DOIUrl":"https://doi.org/10.1097/INF.0000000000004389","url":null,"abstract":"BACKGROUND\u0000Proper treatment for brucellosis is crucial to eradicate the infection and prevent complications, but there is a notable gap in evidence for pediatric treatment. This study aims to address this gap by reviewing current literature, analyzing the efficacy and safety of brucellosis treatment in children, and identifying areas that require further investigation.\u0000\u0000\u0000METHODS\u0000A systematic review, following preferred reporting items for systematic reviews and meta-analyses and Cochrane Handbook guidelines, assessed antimicrobial regimens' efficacy and safety for treating human brucellosis in children. Original human studies with clinical outcomes after drug therapy intervention for children up to 10 years were included. Searches were conducted in Medline, Embase, Cochrane Library and LILACS databases for studies indexed until March 6, 2023. Study selection, data extraction, and bias risk assessment were performed by pairs of reviewers. The quality assessment used Joanna Briggs Institute tools and grading of recommendations assessment, development and evaluation system. Data were analyzed using R software.\u0000\u0000\u0000RESULTS\u0000A total of 1773 records were reviewed, yielding 11 eligible studies encompassing 1156 children. All included studies presented an observational design. The most reported treatment approaches included sulfamethoxazole-trimethoprim with rifampicin or aminoglycosides, with summarized failure rates of 2% (95% confidence interval: 0.0-0.49) and 13% (95% confidence interval: 0.06-0.29), respectively (very low certainty of evidence). Adverse events and time to defervescence were not reported.\u0000\u0000\u0000CONCLUSIONS\u0000Sulfamethoxazole-trimethoprim + rifampicin were the most prescribed antibiotics for brucellosis for pediatrics. The study highlights the need for more research with robust designs, and emphasizes uncertainty regarding the efficacy of antimicrobial regimens, emphasizing the importance of further investigations to guide specific treatment protocols for this population.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140972803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where Birth Month, Sex and Age Matters: The Burden of Severe Respiratory Disease in Danish Children <5 Years, 2016-2022.","authors":"Ebba Emilie Flach de Neergaard, Amanda Marie Egeskov-Cavling, Dorte Rytter, Caroline K Johannesen, Thea K Fischer","doi":"10.1097/INF.0000000000004399","DOIUrl":"https://doi.org/10.1097/INF.0000000000004399","url":null,"abstract":"BACKGROUND\u0000In light of the substantial impact that respiratory diseases in young children poses on healthcare systems globally, and in the wake of the recent COVID-19 pandemic, there is a growing urgency to obtain reliable estimates on the burden of respiratory disease.\u0000\u0000\u0000OBJECTIVES\u0000The aim of this study is to quantify the overall burden of respiratory disease requiring hospitalizations and explore the trends in these admissions in Danish children <5 years, January 1, 2016-October 31, 2022.\u0000\u0000\u0000METHODS\u0000The number of hospitalizations attributed to respiratory infections in children <5 years, was extracted from the Danish National Patient Register, and stratified into subgroups based on age, gender and birth month, and presented on a month-to-month basis.\u0000\u0000\u0000RESULTS\u0000A total of 48,194 children under the age of 5, were hospitalized due to respiratory infections within the study period and the annual hospitalization incidence exhibited a noteworthy variation. Risk factors associated with the highest hospitalization incidence were young age, male gender and in children under 1-year-old, birth months falling in the period of November to January. Younger age and admission during the winter months were linked to longer hospital stays. The seasonal pattern of hospitalizations and the distribution of hospitalizations across various subgroups were greatly influenced by the COVID-19 pandemic.\u0000\u0000\u0000CONCLUSION\u0000This study describes and quantifies the importance of factoring in specific child demographics and seasonal variations in hospitalizations when devising preventive healthcare strategies such as the use of monoclonal antibody therapy and vaccines.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140976233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Pain in a Seventeen-year-old Girl.","authors":"Joana Baptista de Lima, Bárbara Barros, Isabel Mota Pinheiro, José Paulo Souto, Marta Cerqueira Silva, Joana Pires Borges, Leonilde Machado, Joana Pereira, Joaquim Cunha","doi":"10.1097/INF.0000000000004303","DOIUrl":"https://doi.org/10.1097/INF.0000000000004303","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"48 12","pages":"606-608"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Meningococcal Meningitis Revealing a Novel Form of Properdin Deficiency in a Previously Healthy 13-year-old Child.","authors":"Martina Bevacqua, P. Bastard, Yael Pinhas, M. Aubart, Charles-Joris Roux, Muhamed-Kheir Taha, Jérémie F. Cohen","doi":"10.1097/INF.0000000000004397","DOIUrl":"https://doi.org/10.1097/INF.0000000000004397","url":null,"abstract":"A 13-year-old boy was admitted with severe meningococcal meningitis. Immunologic workup revealed a properdin deficiency, and genetic sequencing of CFP identified a novel, private and predicted pathogenic variant in exon 8. The patient received broad immunizations and penicillin prophylaxis. Children with invasive meningococcal disease should be tested for complement deficiency.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140992564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized, Double-blind, Active-controlled Phase III Trial of a Cell Culture-derived Quadrivalent Inactivated Influenza Vaccine in Healthy South Korean Children and Adolescents 6 Months to 18 Years of Age.","authors":"B. Eun, T. Lee, Jina Lee, Ki Hwan Kim, Dong Ho Kim, D. Jo, S. Shin, Hun Kim, Kyung-Ho Kim, Y. Kim","doi":"10.1097/INF.0000000000002406","DOIUrl":"https://doi.org/10.1097/INF.0000000000002406","url":null,"abstract":"BACKGROUND\u0000Cell culture-derived influenza vaccines have several important advantages over egg-based influenza vaccines. The quadrivalent influenza vaccine may offer broader protection against seasonal influenza than trivalent influenza vaccine by containing 1 more B strain. The purpose of this study was to evaluate the immunogenicity and safety of NBP607-QIV, a novel cell culture-derived inactivated quadrivalent influenza vaccine (cIIV4), in children and adolescents.\u0000\u0000\u0000METHODS\u0000This phase III, randomized, double-blind, multicenter trial in children/adolescents (6 mo to 18 yr) was conducted in South Korea during 2014-2015 season. Subjects were randomized 4:1 to receive either NBP607-QIV or control inactivated trivalent influenza vaccine. Hemagglutination inhibition antibody titers were assessed in prevaccination and 28 days postvaccination sera. Safety data were collected for up to 6 months postvaccination.\u0000\u0000\u0000RESULTS\u0000A total of 454 participants completed the study. Three-hundred sixty-six subjects received cIIV4 and 88 subjects received inactivated trivalent influenza vaccine. Overall, NBP607-QIV met the immunogenicity criteria of Committee for Medicinal Products for Human Use for each of the 4 strains. Between the NBP607-QIV and control groups, immunogenicity endpoints were comparable. Participants younger than 3 years of age had lower immunologic responses to 2 influenza B strains in both NBP607-QIV and control group. No deaths, vaccine-related serious adverse events (AEs) or withdrawals because of AEs were reported. The solicited AEs reported were generally of mild intensity.\u0000\u0000\u0000CONCLUSIONS\u0000NBP607-QIV, a novel cIIV4, showed good immunogenicity to all 4 influenza strains and had tolerable safety profiles in children and adolescents. Moreover, NBP607-QIV was more immunogenic against influenza B compared to the control, an egg-based subunit vaccine.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124669956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Human Granulocytic Anaplasmosis is Rare in Europe.","authors":"M. Pokorn, T. A. Županc, F. Strle","doi":"10.1097/INF.0000000000001004","DOIUrl":"https://doi.org/10.1097/INF.0000000000001004","url":null,"abstract":"6 358 | www.pidj.com The Pediatric Infectious Disease Journal • Volume 35, Number 3, March 2016 fever up to 39.7°C accompanied by chills, headache, neck and lumbar pain and passing of dark urine. The patient lived in a rural area and reported being bitten by numerous ticks in the preceding month. He had no underlying illnesses and at the age of 12 had completed a 3-dose basic tick-borne encephalitis (TBE) vaccination. On admission, he was afebrile with jaundice and a discrete maculopapular rash on the trunk and neck. A systolic murmur was heard in the precordium, and the abdomen was tender to palpation below the right costal margin and in the right flank region. Elevated C-reactive protein (10.1 mg/dL), normal white blood cells count (4300/mm) with 19% band forms, thrombocytopenia (91,000/mm), elevated transaminases (aspartate aminotransferase, 1.96; alanine aminotransferase, 1.47; gamma-glutamyltransferase, 1.96 μkat/L; normal values, <0.58, <0.74 and <0.92 μkat/L, respectively), lactate dehydrogenase (8.67 μkat/L; normal level < 4.13) and bilirubin (total, 64 μmol/L; direct, 18 μmol/L; upper normal values, 17 and 5 μmol/L, respectively) as well as prolonged prothrombin time (0.63, international normalized ratio, 1.32) were found. Serum electrolytes, urea and creatinine were normal. The patient was given cefotaxime and flucloxacillin for suspected sepsis but remained febrile. Because blood, urine and stool cultures were negative, white blood cells (nadir 1600/mm) and platelet (53,000/mm) counts further decreased and transaminase levels increased (maximum values aspartate aminotransferase, 3.59; alanine aminotransferase, 3.05 and γ-GT, 3.80 μkat/L) and tests for A. phagocytophilum infection [demonstration of morulae in peripheral blood smear, detection of A. phagocytophilum genome in blood with polymerase chain reaction (PCR) and immunofluorescence assay for detection of A. phagocytophilum antibodies] were performed on day 3 of hospital stay. Based on a positive specific PCR result, treatment with doxycycline 100 mg/12 hours was accompanied by prompt defervescence and normalization of laboratory values. Differential diagnoses included tests for hantavirus infection (serology) and infection with Leptospira sp. (PCR in urine) that were negative, whereas serology for TBE was compatible with postvaccination levels (positive IgG and negative IgM). The patient made an uneventful recovery after 10 days of doxycycline treatment. The test results for A. phagocytophilum and Ehrlichia chaffeensis infection are shown in Table 1. HGA is rare in Europe and affects predominately adults with only 2 cases described in children. In a prospective Pediatric Human Granulocytic Anaplasmosis is Rare in Europe Letters to the editor","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"64 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121645100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rotavirus: Evidence for Vaccination","authors":"P. Lepage","doi":"10.1097/INF.0b013e31815eedea","DOIUrl":"https://doi.org/10.1097/INF.0b013e31815eedea","url":null,"abstract":"Rotavirus (RV) is the most common cause of severe acute gastroenteritis in children in developing as well as in industrialized nations. Annually more than 25 million outpatient visits and 2 million hospitalizations are attributable to RV infection in subjects less than 5 years of age. In developing nations about 600000 deaths are caused by RV each year. RV infection is responsible for 21-58% of hospital admission for acute gastroenteritis in Europe. Recently 2 new live orally administered vaccines - Rotarix and RotaTeq - that provide wide protection against RV infections have been developed. These 2 vaccines have recently undergone extensive testing for safety and efficacy. Indeed 2 recent large clinical trials have demonstrated their excellent efficacy and safety including absence of vaccine-associated intussusception in young infants. (excerpt)","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133094590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccines and autism.","authors":"Frank DeStefano","doi":"10.1097/00006454-200109000-00013","DOIUrl":"https://doi.org/10.1097/00006454-200109000-00013","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"187 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116601455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic mucocutaneous candidiasis.","authors":"CHARLES H. Kirkpatrick","doi":"10.1097/00006454-200102000-00017","DOIUrl":"https://doi.org/10.1097/00006454-200102000-00017","url":null,"abstract":"Chronic mucocutaneous candidiasis should be viewed as a spectrum of disorders in which the patients have persistent and/or recurrent candidiasis of the skin, nails and mucous membranes. Some of the conditions have genetic predispositions. A common immunologic abnormality is failure of the patient's T lymphocytes to produce cytokines that are essential for expression of cell-mediated immunity to Candida. Antifungal drugs are effective in clearing the infections, and treatments that restore cellular immunity have produced long term remissions.","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2001-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117292860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPIDEMIOLOGY AND CLINICAL MANIFESTATIONS OF LYME BORELIOSIS IN CHILDHOOD: A PROSPECTIVE MULTI‐CENTRE STUDY WITH SPECIAL REGARD TO NEUROBORRELIOSIS","authors":"H. Christen","doi":"10.1097/00006454-199310000-00028","DOIUrl":"https://doi.org/10.1097/00006454-199310000-00028","url":null,"abstract":"","PeriodicalId":118937,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1993-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126186608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}