European annals of allergy and clinical immunology最新文献

{"title":"Provocation test on stairs: a new accessible method to cholinergic urticaria diagnosis.","authors":"G Azizi, S Dortas, A França, J Elabras, O Lupi, S Valle","doi":"10.23822/EurAnnACI.1764-1489.381","DOIUrl":"10.23822/EurAnnACI.1764-1489.381","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Cholinergic urticaria (CholU) is characterized by itching and/or stinging, painful micro wheals due to systemic heating. There are two standardized protocols to diagnose CholU using an exercise bike with heart rate or warming passive. The objective is to provide an affordable, new, low-tech test to assist the diagnostic. <b>Methods.</b> Cross-sectional study with a convenience sample; 10 with a diagnostic or high suspicion of CholU and 20 participants without suspicion of CholU, recruited in a UCARE from a developing country. After the pre-participation assessment, the provocation test through movements of going up and down a flight of stairs and with a heart rate monitor, an increasing 15 bpm every 5 min until an increase of 90 bpm above the initial level, for 30 min and/or stopped immediately, upon visualization of wheals and with body temperature measured in 3 different locations every 5 min. <b>Results.</b> The group CholU comprised eight females and two males (29.6y), and the other group had eleven females and nine males (27.2y). Data analysis demonstrated that in a positive test in a body temperature measured above 37.05ºC and with a variation of 0.35ºC above the initial value, sensitivity of 80% and specificity of 100% in the forehead region and sensitivity of 80% and specificity of 90% in tympanic region. <b>Conclusions.</b> Thus, with the feasibility of reproducing the method, it is expected that this simple and accessible method for diagnosing CholU can be a tool for application, mainly in developing countries.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the origin and educational quality of YouTube videos on adrenaline auto-injectors.","authors":"I D Toprak, P Korkmaz, Z Kılınc, D Unal, S Demir, A Gelincik","doi":"10.23822/EurAnnACI.1764-1489.333","DOIUrl":"10.23822/EurAnnACI.1764-1489.333","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Guidelines highlight the pivotal role of adrenaline auto-injector (AAI) training. However, the standards of visual training platforms have not been determined. Our aim was to evaluate the reliability and quality of the AAI related videos on YouTube. <b>Methods.</b> After a search on YouTube about AAI, all videos were categorized into groups based on their origin and the aim of the content. The quality, reliability, understandibility, and actionability of the videos were evaluated using the Global Quality Scale (GQS), Patient Education Materials Assessment Tool Audovisiual (PEMAT-A/V), Quality Criteria for Consumer Health Information (DISCERN), and a modified DISCERN. In each video, the application steps of AAI were evaluated according to a scale of correct usage. <b>Results.</b> 107 YouTube videos in English were included. No significant difference in terms of views, likes, duration and uploading time was observed between the health and non-health groups whereas the GQS (p = 0.001), DISCERN total (p = 0.02) and modified DISCERN (p = 0.001) scores were higher in the health group. It was found that scores tended to be higher in educational videos. AAI use was mentioned in 85% videos. The median number of mentioned steps was 6. <b>Conclusions.</b> YouTube is an ef-fective platform for visual learning for the use of AAIs. Although the visibility of the videos is equal independent of the origin, the ones recorded by medical professionals seem to provide the most qualified and reliable information.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"23-31"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139905332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Omega 5-gliadin allergy in patients with recurrent acute urticaria.","authors":"C M Rossi, M V Lenti, S Merli, G Achilli, A di Sabatino","doi":"10.23822/EurAnnACI.1764-1489.335","DOIUrl":"10.23822/EurAnnACI.1764-1489.335","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"45-48"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic emergencies in the prehospital setting: a 5-year retrospective study.","authors":"J Cardoso Lopes, J S da Costa Carvalho, H Pires Pereira, I F da Costa Farinha, P Botelho Alves, F da Costa Pimentel, C Ribeiro, A M P Todo-Bom Ferreira da Costa","doi":"10.23822/EurAnnACI.1764-1489.297","DOIUrl":"10.23822/EurAnnACI.1764-1489.297","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Patients with severe allergic conditions often request support from the prehospital emergency services given the rapid, unexpected and po-tentially life-threatening nature of the reactions, such as anaphylaxis. Studies regarding prehospital incidents for allergic conditions are scarce. This study aimed to characterize prehospital medical requesting assistance due to suspected hypersensitivity reactions (HSR). <b>Methods.</b> Retrospective study of allergic-re-lated requesting assistances between 2017 and 2022 of a Portuguese emergency dispatch center ‒ Emergency and Resuscitation Medical Vehicle (VMER) ‒ in Coimbra University Hospital. Demographic and clinical variables were analyzed, including clinical manifestations, anaphylaxis severity grading, therapeutic interventions, and post-incident allergic work-up. Regarding anaphylactic events, three diagnosis timings were compared: on-site, hospital emergency department and investigator-diagnosis based on data reviewed. <b>Results.</b> Out of 12,689 VMER requesting assistances, 210 (1.7%) were classified as suspected HSR reactions. After on-site medical evaluation, 127 (60.5%) cases maintained the HSR classification (median age 53 years; 56% males) and the main diag-noses included HSR to Hymenoptera venom (29.9%), food allergy (29.1%), and pharmaceutical drugs (25.5%). Anaphylaxis was assumed on-site in 44 (34.7%) cases, in the hospital emergency department in 53 cases (41.7%) and by investigators in 76 (59.8%) cases. Regarding management, epinephrine was administered on-site in 50 cases (39.4%). <b>Conclusions.</b> The main reason for prehospital requesting assistance was HSR to Hymenoptera venom. A high proportion of incidents met the criteria for anaphylaxis and despite the inher-ent difficulties of the prehospital setting, many of the on-site diagnoses agreed with the criteria. Regarding management, epinephrine was underused in this setting. After pre-hospital events, a proper referral to a specialized consultation is crucial for a full diagnostic work-up and disease management.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"32-40"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9833887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of the diagnosis of hypersensitivity reactions to antineoplastic and biological agents: experience with drug provocation test.","authors":"J Queirós Gomes, L P Pereira Dias, P Barreira, J Barradas Lopes, M J Sousa, S Cadinha, D Malheiro","doi":"10.23822/EurAnnACI.1764-1489.296","DOIUrl":"10.23822/EurAnnACI.1764-1489.296","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Evidence regarding drug provocation test (DPT) with chemo-therapeutic agents is scarce. The aim of our study is to describe the experience of DPT in patients with a history of hypersensitivity reactions (HSRs) to antineoplastic and biological agents. <b>Methods.</b> Eight-year retrospective, observational, descriptive study of patients with a history of HSRs to chemo-therapy who were submitted to DPT. Anamnesis, skin tests (ST) and DPT were analyzed. Patients with a negative DPT were submitted to at least one regular supervised administration (RSA). Patients with positive DPT or HSR during RSA were offered rapid drug desensitization (RDD). <b>Results.</b> A total of 54 patients were submitted to DPT. The most common suspected drugs were platins (n = 36), followed by taxanes (n = 11). Most of the initial reactions were classified as grade II (n = 39) according to Brown's grading system. ST with platinum (n = 35), taxanes (n = 10) and biological agents (n = 4) were negative, except for one intradermal test with paclitaxel, which was positive. A total of 64 DPTs were performed. Eleven percent of all DPTs were positive [platins (n = 6), doxorubicin (n = 1)]. Of the 57 RSA with the culprit drugs, 2 were positive (platins). The diagnosis of hypersensitivity was confirmed by DPT/RSA in 9 patients. All patients with positive DPT/RSA presented HSRs of equal or less severity than the initial one. <b>Conclusions.</b> DPT followed by RSA allowed to exclude HSRs in 45 patients (55 culprit drugs). DPT before desensitization prevents non-hypersensitivity patients from undergoing RDD. In our study DPT was safe, all reactions were managed by an allergist.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"12-22"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenalin use in Kounis syndrome: a well-unknown entity.","authors":"Ö Özdemir","doi":"10.23822/EurAnnACI.1764-1489.346","DOIUrl":"10.23822/EurAnnACI.1764-1489.346","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"41-42"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Adrenalin use in Kounis syndrome: a wellunknown entity\".","authors":"G Zisa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":"57 1","pages":"43-44"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Adrenalin use in Kounis syndrome: a wellunknown entity\".","authors":"G Zisa","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":"57 1","pages":"43-44"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of asthma on severe food-induced allergic reactions: a systematic review and meta-analysis.","authors":"M B Cilona, G A Ramirez, C Asperti, A Ferlito, G Benanti, S Nannipieri, R M Abdul Hadi, C Capellini, L Dagna, M Cottini, M-R Yacoub","doi":"10.23822/EurAnnACI.1764-1489.351","DOIUrl":"10.23822/EurAnnACI.1764-1489.351","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> Food allergy can range from mild to severe, life-threatening reactions with various symptoms and organ involvement. The impact of asthma on severe food-induced allergic reactions is not completely understood. In the hypothesis that asthma increases the risk of severe food-induced allergic reactions, the aim of this study is to compare the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. <b>Methods.</b> We performed a systematic research on electronic databases, including PubMed, Scopus and Web of Science. Observational studies, studies reporting medical characteristics of patients diagnosed with food allergy and studies reporting medical history of patients with allergic reactions were included. The primary outcome was the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. <b>Results.</b> Eight studies with a total of 90,367 patients met the inclusion criteria and were included, with a total population of 28,166 of patients with food allergy. The incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma was increased (OR 1.28; 95%CI 1.03-1.59; p = 0.03; I2 = 59%). <b>Conclusions.</b> Individuals with both food allergy and asthma are at high risk of severe, potentially fatal allergic reactions. Healthcare professionals should prioritize prevention and management strategies for these subjects. Patients with asthma and food allergy are at increased risk of potentially fatal food-induced allergic reactions. Optimal management of both diseases is nec-essary to prevent potentially life-threatening events. <b>Study registration.</b> The protocol of this review was registered in PROSPERO (CRD42023448293).</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":"4-11"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between baseline IgE level and urticaria control at six months of omalizumab treatment in chronic urticaria.","authors":"G Tuncay, E Damadoglu, G Karakaya, A Fuat Kalyoncu","doi":"10.23822/EurAnnACI.1764-1489.379","DOIUrl":"https://doi.org/10.23822/EurAnnACI.1764-1489.379","url":null,"abstract":"<p><strong>Summary: </strong><b>Background.</b> There is limited data on the use of baseline IgE level as a predictor of omalizumab response in chronic urticaria (CU). The aim of the present study was to determine if baseline serum total IgE level is associated with response at six months of standard-dose omalizumab. <b>Methods.</b> The study was designed as a retrospective, single-center, cohort survey. This observational real-life study included CU patients receiving omalizumab from September 1, 2014, to July 31, 2022 at a tertiary care allergy center. The control of urticaria was determined by the urticaria control test in the sixth month. <b>Results.</b> A total of 159 patients were enrolled in the study. All patients had received standard-dose omalizumab for six months. At the end of the treatment period, 126 (80%) patients were under control. The median of baseline IgE level was similar in controlled and uncontrolled patients. The baseline D-dimer level and regular antihistamine use during omalizumab treatment use were significantly higher, and CU duration at baseline was shorter in the uncontrolled group (p = 0.03, p = 0.02, p = 0.003, respectively). ROC analysis revealed that CU duration at baseline was related to urticaria control (AUC:0.665, 95%CI [0.586-0.738]). <b>Conclusions.</b> The results of the present study showed that urticaria control at six months of omalizumab treatment in CU was not associated with baseline IgE level but was associated with CU duration at baseline. The shorter CU duration was associated with poorer urticaria control in the sixth month of omalizumab.</p>","PeriodicalId":11890,"journal":{"name":"European annals of allergy and clinical immunology","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}