European Heart Journal - Quality of Care and Clinical Outcomes最新文献

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Prognostic significance of the estimated pulse wave velocity in critically ill patients with coronary heart disease: analysis from the MIMIC‑IV database. 冠心病重症患者估计脉搏波速度的预后意义:MIMIC-IV 数据库分析。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-14 DOI: 10.1093/ehjqcco/qcae076
Yingzhen Gu, Xiaorong Han, Jinxing Liu, Yifan Li, Zuozhi Li, Wei Zhang, Naqiang Lv, Aimin Dang
{"title":"Prognostic significance of the estimated pulse wave velocity in critically ill patients with coronary heart disease: analysis from the MIMIC‑IV database.","authors":"Yingzhen Gu, Xiaorong Han, Jinxing Liu, Yifan Li, Zuozhi Li, Wei Zhang, Naqiang Lv, Aimin Dang","doi":"10.1093/ehjqcco/qcae076","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae076","url":null,"abstract":"<p><strong>Background: </strong>There are currently no specialized risk-scoring systems for critically ill patients with coronary heart disease (CHD). Arterial stiffness, as measured by estimated pulse wave velocity (ePWV), has emerged as a potential indicator of mortality or adverse cardiovascular events in individuals with CHD. This study aimed to evaluate the association between ePWV and all-cause mortality among critically ill patients with CHD beyond traditional risk scores.</p><p><strong>Methods: </strong>This study included 11 001 participants with CHD from the Medical Information Mart for Intensive Care IV, with a one-year follow-up. The primary endpoint was one-year all-cause mortality, and the secondary endpoint was in-hospital mortality.</p><p><strong>Results: </strong>Elevated ePWV was significantly associated with higher risks of in-hospital (OR 1.15, 95% CI 1.12-1.17, p < 0.001) and one-year (HR 1.21, 95% CI 1.20-1.23, p < 0.001) mortality. These associations remained consistent when adjusted for traditional risk scores and potential confounders. When ePWV was integrated into traditional risk scoring models (OASIS, SOFA score, APSIII, SIRS score, SAPS II, and LODS score), the predictive accuracy (area under the curve: 64.55 to 70.56, 64.32 to 72.51, 72.35 to 75.80, 55.58 to 67.68, 71.27 to 73.53, 67.24 to 73.40, p < 0.001) and reclassification (net reclassification index: 0.230, 0.268, 0.257, 0.255, 0.221, 0.254; integrated discrimination improvement: 0.049, 0.072, 0.054, 0.068, 0.037, 0.061, p < 0.001) of these models significantly improved for one-year mortality. Similar results were also found for in-hospital mortality.</p><p><strong>Conclusions: </strong>ePWV is a strong independent predictor of both short- and long-term mortality in critically ill patients with CHD. Importantly, integrating ePWV into traditional risk scores significantly boosts the predictive accuracy for one-year and in-hospital all-cause mortality.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bacteremia and infective endocarditis following left-sided heart valve surgery. 左侧心脏瓣膜手术后的菌血症和感染性心内膜炎。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-14 DOI: 10.1093/ehjqcco/qcae080
Christine Holgersson, Lauge Østergaard, Eva Havers-Borgersen, Anna Stahl, Katra Hadji-Turdeghal, Amna Alhakak, Marianne Voldstedlund, Morten Smerup, Christian Torp-Pedersen, L Køber, E Fosbøl
{"title":"Bacteremia and infective endocarditis following left-sided heart valve surgery.","authors":"Christine Holgersson, Lauge Østergaard, Eva Havers-Borgersen, Anna Stahl, Katra Hadji-Turdeghal, Amna Alhakak, Marianne Voldstedlund, Morten Smerup, Christian Torp-Pedersen, L Køber, E Fosbøl","doi":"10.1093/ehjqcco/qcae080","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae080","url":null,"abstract":"<p><strong>Background and aims: </strong>In patients undergoing heart valve surgery, subsequent bacteremia and infective endocarditis are feared events. Data on the incidence and bacterial microbiological etiology following left-sided heart valve surgery are sparse.</p><p><strong>Methods: </strong>Between 2010-2021, all patients undergoing left-sided valve surgery were identified using Danish nationwide registries. Incidence and type bacteremia within one-year post-surgery was analyzed. Secondary outcome of interest was infective endocarditis. Cumulative incidence curves were stratified for bacterial species and for subgroups of interest: type of valve surgery, age, and sex.</p><p><strong>Results: </strong>A total of 14 935 patients were included, of which 69% were male and the median age was 70.4 years (25th-75th percentile 62.4-76.2 years). The one-year cumulative incidence of bacteremia was 6.1% (95% CI 5.7-6.5%), and the most frequent bacteremia was coagulase-negative staphylococci (27%). More than half of the bacteremia with coagulase-negative staphylococci occurred within 30 days of follow-up. Patients developing bacteremia had a significantly higher Charlson comorbidity score at baseline, more often underwent CABG concomitant to valve surgery, and more often had surgery on both valves. The one-year cumulative incidence of infective endocarditis was 1.5% (95% CI 1.3-1.7), of which 23% were caused by Enterococci, and 22% were blood culture negative. The median time from surgery to infective endocarditis was 109 days.</p><p><strong>Conclusions: </strong>Bacteremia and infective endocarditis following left-sided heart valve surgery occurred in 6.1% and 1.5% of patients, respectively. The most frequent bacteremia was coagulase-negative staphylococci, and more than half of these occurred within 30 days of surgery. Optimization of prophylactic strategies are warranted.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behavioural digital biomarkers enable real-time monitoring of patient-reported outcomes: a substudy of the multicentre, prospective observational SafeHeart study. 行为数字生物标志物能够实时监测患者报告的结果:多中心前瞻性观察性SafeHeart研究的一个子研究。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcad069
Maarten Z H Kolk, Diana M Frodi, Joss Langford, Caroline J Meskers, Tariq O Andersen, Peter Karl Jacobsen, Niels Risum, Hanno L Tan, Jesper H Svendsen, Reinoud E Knops, Søren Z Diederichsen, Fleur V Y Tjong
{"title":"Behavioural digital biomarkers enable real-time monitoring of patient-reported outcomes: a substudy of the multicentre, prospective observational SafeHeart study.","authors":"Maarten Z H Kolk, Diana M Frodi, Joss Langford, Caroline J Meskers, Tariq O Andersen, Peter Karl Jacobsen, Niels Risum, Hanno L Tan, Jesper H Svendsen, Reinoud E Knops, Søren Z Diederichsen, Fleur V Y Tjong","doi":"10.1093/ehjqcco/qcad069","DOIUrl":"10.1093/ehjqcco/qcad069","url":null,"abstract":"<p><strong>Aims: </strong>Patient-reported outcome measures (PROMs) serve multiple purposes, including shared decision-making and patient communication, treatment monitoring, and health technology assessment. Patient monitoring using PROMs is constrained by recall and non-response bias, respondent burden, and missing data. We evaluated the potential of behavioural digital biomarkers obtained from a wearable accelerometer to achieve personalized predictions of PROMs.</p><p><strong>Methods and results: </strong>Data from the multicentre, prospective SafeHeart study conducted at Amsterdam University Medical Center in the Netherlands and Copenhagen University Hospital, Rigshospitalet in Copenhagen, Denmark, were used. The study enrolled patients with an implantable cardioverter defibrillator between May 2021 and September 2022 who then wore wearable devices with raw acceleration output to capture digital biomarkers reflecting physical behaviour. To collect PROMs, patients received the Kansas City Cardiomyopathy Questionnaire (KCCQ) and EuroQoL 5-Dimensions 5-Level (EQ5D-5L) questionnaire at two instances: baseline and after six months. Multivariable Tobit regression models were used to explore associations between digital biomarkers and PROMs, specifically whether digital biomarkers could enable PROM prediction. The study population consisted of 303 patients (mean age 62.9 ± 10.9 years, 81.2% male). Digital biomarkers showed significant correlations to patient-reported physical and social limitations, severity and frequency of symptoms, and quality of life. Prospective validation of the Tobit models indicated moderate correlations between the observed and predicted scores for KCCQ [concordance correlation coefficient (CCC) = 0.49, mean difference: 1.07 points] and EQ5D-5L (CCC = 0.38, mean difference: 0.02 points).</p><p><strong>Conclusion: </strong>Wearable digital biomarkers correlate with PROMs, and may be leveraged for real-time prediction. These findings hold promise for monitoring of PROMs through wearable accelerometers.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138498144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of the method of calculating 30-day readmission rate after hospitalization for heart failure. Data from the VancOuver CoastAL Acute Heart Failure (VOCAL-AHF) registry. 心衰住院后 30 天再入院率计算方法的影响。数据来自 VancOuver CoastAL 急性心力衰竭(VOCAL-AHF)登记处。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcae026
Samaneh Salimian, Sean A Virani, Thomas M Roston, Ren Jie Robert Yao, Ricky D Turgeon, Justin Ezekowitz, Nathaniel M Hawkins
{"title":"Impact of the method of calculating 30-day readmission rate after hospitalization for heart failure. Data from the VancOuver CoastAL Acute Heart Failure (VOCAL-AHF) registry.","authors":"Samaneh Salimian, Sean A Virani, Thomas M Roston, Ren Jie Robert Yao, Ricky D Turgeon, Justin Ezekowitz, Nathaniel M Hawkins","doi":"10.1093/ehjqcco/qcae026","DOIUrl":"10.1093/ehjqcco/qcae026","url":null,"abstract":"<p><strong>Background: </strong>Thirty-day readmission rate after heart failure (HF) hospitalization is widely used to evaluate healthcare quality. Methodology may substantially influence estimated rates. We assessed the impact of different definitions on HF and all-cause readmission rates.</p><p><strong>Methods: </strong>Readmission rates were examined in 1835 patients discharged following HF hospitalization using 64 unique definitions derived from five methodological factors: (1) International Classification of Diseases-10 codes (broad vs. narrow), (2) index admission selection (single admission only first-in-year vs. random sample; or multiple admissions in year with vs. without 30-day blanking period), (3) variable denominator (number alive at discharge vs. number alive at 30 days), (4) follow-up period start (discharge date vs. day following discharge), and (5) annual reference period (calendar vs. fiscal). The impact of different factors was assessed using linear regression.</p><p><strong>Results: </strong>The calculated 30-day readmission rate for HF varied more than two-fold depending solely on the methodological approach (6.5-15.0%). All-cause admission rates exhibited similar variation (18.8-29.9%). The highest rates included all consecutive index admissions (HF 11.1-15.0%, all-cause 24.0-29.9%), and the lowest only one index admission per patient per year (HF 6.5-11.3%, all-cause 18.8-22.7%). When including multiple index admissions and compared with blanking the 30-day post-discharge, not blanking was associated with 2.3% higher readmission rates. Selecting a single admission per year with a first-in-year approach lowered readmission rates by 1.5%, while random-sampling admissions lowered estimates further by 5.2% (P < 0.001).</p><p><strong>Conclusion: </strong>Calculated 30-day readmission rates varied more than two-fold by altering methods. Transparent and consistent methods are needed to ensure reproducible and comparable reporting.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management and outcome in foreign-born vs native-born patients with myocardial infarction in Sweden. 瑞典心肌梗塞患者中外国出生者与本地出生者的管理和预后。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcae020
Sammy Zwackman, Jenny Häggström, Emil Hagström, Tomas Jernberg, Jan-Erik Karlsson, Sofia Sederholm Lawesson, Margret Leosdottir, Annica Ravn-Fischer, Marie Eriksson, Joakim Alfredsson
{"title":"Management and outcome in foreign-born vs native-born patients with myocardial infarction in Sweden.","authors":"Sammy Zwackman, Jenny Häggström, Emil Hagström, Tomas Jernberg, Jan-Erik Karlsson, Sofia Sederholm Lawesson, Margret Leosdottir, Annica Ravn-Fischer, Marie Eriksson, Joakim Alfredsson","doi":"10.1093/ehjqcco/qcae020","DOIUrl":"10.1093/ehjqcco/qcae020","url":null,"abstract":"<p><strong>Aims: </strong>Previous studies on disparities in healthcare and outcomes have shown conflicting results. The aim of this study was to assess differences in baseline characteristics, management, and outcomes in myocardial infarction (MI) patients, by country of birth.</p><p><strong>Methods and results: </strong>In total, 194 259 MI patients (64% male, 15% foreign-born) from the nationwide SWEDEHEART (The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) registry were included and compared by geographic region of birth. The primary outcome was 1-year major adverse cardiovascular events (MACEs) including all-cause death, MI, and stroke. Secondary outcomes were long-term MACE (up to 12 years), the individual components of MACE, 30-day mortality, management, and risk factors. Logistic regression, Cox proportional hazard models, and propensity score match (PSM), accounting for baseline differences, were used. Foreign-born patients were younger, often male, and had a higher cardiovascular (CV) risk factor burden, including smoking, diabetes, and hypertension. In PSM analyses, Asia-born patients had higher likelihood of revascularization [odds ratio 1.16, 95% confidence interval (CI) 1.04-1.30], statins and beta-blocker prescription at discharge, and a 34% lower risk of 30-day mortality. Furthermore, no statistically significant differences were found in primary outcomes except for Asia-born patients having lower risk of 1-year MACE [hazard ratio (HR) 0.85, 95% CI 0.73-0.98], driven by lower mortality (HR 0.72, 95% CI 0.57-0.91). The results persisted over the long-term follow-up.</p><p><strong>Conclusion: </strong>This study shows that in a system with universal healthcare coverage in which acute and secondary preventive treatments do not differ by country of birth, foreign-born patients, despite higher CV risk factor burden, will do at least as well as native-born patients.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140058977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remnant cholesterol and risk of premature mortality: an analysis from a nationwide prospective cohort study. 残留胆固醇与过早死亡风险:一项全国性前瞻性队列研究的分析。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcad071
Likang Li, Jun Lai, Jingyi Zhang, Harriette G C Van Spall, Lehana Thabane, Gregory Y H Lip, Guowei Li
{"title":"Remnant cholesterol and risk of premature mortality: an analysis from a nationwide prospective cohort study.","authors":"Likang Li, Jun Lai, Jingyi Zhang, Harriette G C Van Spall, Lehana Thabane, Gregory Y H Lip, Guowei Li","doi":"10.1093/ehjqcco/qcad071","DOIUrl":"10.1093/ehjqcco/qcad071","url":null,"abstract":"<p><strong>Aims: </strong>To explore the relationship between remnant cholesterol (RC) and the risk of premature mortality as well as life expectancy in the general population.</p><p><strong>Methods: </strong>We included a total of 428 804 participants from the UK Biobank for analyses. Equivalent population percentiles approach based on the low-density lipoprotein cholesterol cut-off points was performed to categorize participants into three RC groups: low (with a mean RC of 0.34 mmol/L), moderate (0.53 mmol/L), and high (1.02 mmol/L). We used multivariable Cox proportional hazards models to evaluate the relationship between RC groups and the risk of premature mortality (defined as death before age 75 years). Life table methods were used to estimate life expectancy by RC groups.</p><p><strong>Results: </strong>During a median follow-up of 12.1 years (Q1-Q3 11.0-13.0), there were 23 693 all-cause premature deaths documented, with an incidence of 4.83 events per 1000 person-years [95% confidence interval (CI): 4.77-4.89]. Compared with the low RC group, the moderate RC group was associated with a 9% increased risk of all-cause premature mortality [hazard ratio (HR) = 1.09, 95% CI: 1.05-1.14], while the high RC group had an 11% higher risk (HR = 1.11, 95% CI: 1.07-1.16). At the age of 50 years, high RC group was associated with an average 2.2 lower years of life expectancy for females, and an average 0.1 lower years of life expectancy for males when compared with their counterparts in the low RC group.</p><p><strong>Conclusions: </strong>Elevated RC was significantly related to an increased risk of premature mortality and a reduced life expectancy. Premature death in the general population would benefit from measurement to aid risk stratification and proactive management of RC to improve cardiovascular risk prevention efforts.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138797997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric morbidity and work participation in patients with congenital ventricular septal defects: a case-controlled study. 先天性室间隔缺损患者的精神病发病率和工作参与:病例对照研究。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcad072
Filip Eckerström, Vibeke Elisabeth Hjortdal, Charlotte Ulrikka Rask, Camilla Nyboe
{"title":"Psychiatric morbidity and work participation in patients with congenital ventricular septal defects: a case-controlled study.","authors":"Filip Eckerström, Vibeke Elisabeth Hjortdal, Charlotte Ulrikka Rask, Camilla Nyboe","doi":"10.1093/ehjqcco/qcad072","DOIUrl":"10.1093/ehjqcco/qcad072","url":null,"abstract":"<p><strong>Background: </strong>The burden of psychiatric morbidity, level of education, and work participation are currently unknown in patients with congenital ventricular septal defects (VSD).</p><p><strong>Methods and results: </strong>In a Danish population-based cohort study using nationwide medical registries, the burden of psychiatric disorders, use of psychotropic agents, level of education, and work participation were examined in patients with isolated congenital VSD and controls from the general population matched by age and sex. Subjects with known chromosomal abnormalities were excluded. To compute estimates, Cox proportional regression model, Fine and Gray's competing risk regression, and Kaplan-Meier failure function were used. We included 8006 patients and 79 568 controls born before 2018. Median follow-up was 23 years. Compared with controls, patients with VSD displayed a hazard ratio (HR) of 1.24 [95% confidence interval (CI): 1.17-1.32] for any psychiatric disorder where the hazard for intellectual disabilities was most pronounced [HR of 3.66 (95% CI: 2.98-4.50)]. The use of psychotropic agents was higher in patients compared with controls [HR 1.14 (95% CI: 1.09-1.20)]. The work participation was lower in patients with VSD compared with controls (P < 0.001) and was lower in patients with VSD with a psychiatric disorder compared with those without (P < 0.001). The 40-year cumulative incidence of permanent social security benefits was 29% in patients with psychiatric disorders (vs. 21% in controls with psychiatric disorders) and 8% in patients without psychiatric disorders (vs. 4% in controls).</p><p><strong>Conclusion: </strong>Patients with isolated VSD suffer from a higher burden of psychiatric disorders and display lower work participation compared with matched controls from the general Danish population. It is important to consider longer-term impacts on mental health, education, and subsequent employment in patients with VSD, in addition to cardiovascular effects, as these factors severely affect quality of life and have direct socioeconomic implications on an individual and societal level.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11398907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139097624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of pharmacist-led interventions on the appropriateness and clinical outcomes of anticoagulant therapy: a systematic review and meta-analysis. 药剂师主导的干预对抗凝剂治疗的适当性和临床结果的影响:系统回顾和荟萃分析。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcae045
Belayneh Kefale, Gregory M Peterson, Corinne Mirkazemi, Woldesellassie M Bezabhe
{"title":"The effect of pharmacist-led interventions on the appropriateness and clinical outcomes of anticoagulant therapy: a systematic review and meta-analysis.","authors":"Belayneh Kefale, Gregory M Peterson, Corinne Mirkazemi, Woldesellassie M Bezabhe","doi":"10.1093/ehjqcco/qcae045","DOIUrl":"10.1093/ehjqcco/qcae045","url":null,"abstract":"<p><strong>Aim: </strong>Although pharmacist-led interventions in anticoagulant (AC) therapy are widely accepted, there is a lack of evidence comparing their effectiveness with usual care in terms of AC therapy appropriateness and clinical outcomes. We aimed to estimate the comparative effectiveness of pharmacist-led interventions on the appropriateness and clinical outcomes of AC therapy.</p><p><strong>Methods and results: </strong>Adhering to the PRISMA guidelines, we searched PubMed, EMBASE, and Scopus databases to identify randomized controlled trials and quasi-experimental and cohort studies published between 2010 and 2023. A random-effects model was used to calculate pooled intervention effects. We assessed heterogeneity (using Higgins' I2 and Cochran's Q) and publication bias (using Egger's test, the trim-and-fill method, and visualization of the funnel plot). In total, 35 studies involving 10 374 patients in the intervention groups and 11 840 in the control groups were included. The pharmacist-led interventions significantly improved the appropriateness of AC therapy [odds ratio (OR): 3.43, 95% confidence interval (CI): 2.33-5.06, P < 0.01]. They significantly decreased total bleeding [relative risk (RR): 0.75, 95% CI: 0.58-0.96, P = 0.03) and hospitalization or readmission (RR: 0.64, 95% CI: 0.41-0.99, P = 0.04). However, the impact of the pharmacist-led interventions on thromboembolic events (RR: 0.69, 95% CI: 0.46-1.02, P = 0.07) and mortality (RR: 0.76, 95% CI: 0.51-1.13, P = 0.17) was not significant.</p><p><strong>Conclusion: </strong>Pharmacist-led interventions demonstrated superior outcomes in optimizing AC therapy compared with usual care. Further research is needed to evaluate pharmacist-led interventions' cost-effectiveness and long-term sustainability. PROSPERO registration number: CRD42023487362.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The beginning of wisdom is the definition of terms: counting heart failure hospitalizations. 智慧的开端是术语的定义:计算心力衰竭的住院次数。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcae062
J J Cuthbert, A L Clark
{"title":"The beginning of wisdom is the definition of terms: counting heart failure hospitalizations.","authors":"J J Cuthbert, A L Clark","doi":"10.1093/ehjqcco/qcae062","DOIUrl":"10.1093/ehjqcco/qcae062","url":null,"abstract":"","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":null,"pages":null},"PeriodicalIF":4.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced access to primary care for immigrants increases cardiovascular complications and hospital admissions: the importance of information and education. 移民获得初级保健的机会减少,增加了心血管并发症和入院率。信息和教育的重要性。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-09-13 DOI: 10.1093/ehjqcco/qcae042
Raimondo Gabriele, Immacolata Iannone, Antonio V Sterpetti
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引用次数: 0
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