European Heart Journal - Quality of Care and Clinical Outcomes最新文献

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Should we routinely measure patient quality of life after acute coronary syndrome? 我们是否应该对急性冠状动脉综合征后患者的生活质量进行常规测量?
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-23 DOI: 10.1093/ehjqcco/qcae098
Marcus Flather, Janavi Shah, Ruth Masterson Creber
{"title":"Should we routinely measure patient quality of life after acute coronary syndrome?","authors":"Marcus Flather, Janavi Shah, Ruth Masterson Creber","doi":"10.1093/ehjqcco/qcae098","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae098","url":null,"abstract":"","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National health expenditure per capita is associated with CRT implantation practice: findings from the ESC CRT Survey II with 11 088 patients. 人均国民健康支出与 CRT 植入实践相关:ESC CRT 调查 II 中 11 088 名患者的调查结果。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-20 DOI: 10.1093/ehjqcco/qcae082
Camilla Normand, Nigussie Bogale, Cecilia Linde, Stelios Tsintzos, Zenichi Ihara, Kenneth Dickstein
{"title":"National health expenditure per capita is associated with CRT implantation practice: findings from the ESC CRT Survey II with 11 088 patients.","authors":"Camilla Normand, Nigussie Bogale, Cecilia Linde, Stelios Tsintzos, Zenichi Ihara, Kenneth Dickstein","doi":"10.1093/ehjqcco/qcae082","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae082","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac resynchronization therapy (CRT) reduces morbidity and mortality in selected patients with heart failure (HF) and electrical dyssynchrony. This treatment receives class IA recommendations in European Society of Cardiology (ESC) guidelines. However, despite these strong recommendations, CRT implantation practice varies greatly in Europe. The purpose of the sub-analysis of CRT Survey II data was to describe how countries' health per capita expenditure affects CRT implantation practice.</p><p><strong>Methods and results: </strong>Between 2015 and 2016, two ESC associations, European Heart Rhythm Association and Heart Failure Association, conducted the CRT Survey II, a survey of CRT implantations in 11 088 patients in 42 ESC member states. We analysed CRT patient selection and guideline adherence in those countries according to high or low health expenditure per capita. There were 21 high health expenditure countries (n = 6844 patients) and 21 (n = 3852) with low health expenditure. The countries with the lowest health expenditure were more likely to implant CRT in patients who had strong guideline recommendations for implantation, younger patients and those recently hospitalized for HF or with symptomatic HF (67% vs. 58%, P < 0.001). The ratio of CRT-Pacemaker (CRT-P) to CRT-Defibrillator (CRT-D) was similar in both spending groups, as was the percentage of CRT implantation in women.</p><p><strong>Conclusion: </strong>CRT Survey II has demonstrated a non-uniform delivery of healthcare. Countries with low health expenditure per capita appear to be reserving CRT therapy for younger patients, those with class IA indication and patients with more severe symptoms of heart failure.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of intravascular ultrasound for coronary bifurcations treated with last generations stents: insights from the BIFURCAT-ULTRA registry. 血管内超声对使用上一代支架治疗冠状动脉分叉的影响:BIFURCAT-ULTRA 登记的启示。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-20 DOI: 10.1093/ehjqcco/qcae091
Francesco Bruno, Ki Hong Choi, Ovidio De Filippo, Hyun Kuk Kim, Mattia Doronzo, Yun-Kyeong Cho, Tineke H Pinxterhuis, Jeehoon Kang, Alessio Mattesini, Young Bin Song, Raffaele Piccolo, Bon-Kwon Koo, Wojciech Wańha, Jong Lee, Bernardo Cortese, Hyeon-Cheol Gwon, Leor Perl, Hyo-Soo Kim, Domenico Tuttolomondo, Mario Iannaccone, Woo Jung Chun, Davide Capodanno, Attilio Leone, Alessandra Truffa Giachet, Seung-Ho Hur, Giulio Stefanini, Seung Hwan Han, Javier Escaned, Antonino Carmeci, Gianluca Campo, Giuseppe Patti, Clemens von Birgelen, Gaetano Maria de Ferrari, Chang-Wook Nam, Fabrizio D'Ascenzo
{"title":"Impact of intravascular ultrasound for coronary bifurcations treated with last generations stents: insights from the BIFURCAT-ULTRA registry.","authors":"Francesco Bruno, Ki Hong Choi, Ovidio De Filippo, Hyun Kuk Kim, Mattia Doronzo, Yun-Kyeong Cho, Tineke H Pinxterhuis, Jeehoon Kang, Alessio Mattesini, Young Bin Song, Raffaele Piccolo, Bon-Kwon Koo, Wojciech Wańha, Jong Lee, Bernardo Cortese, Hyeon-Cheol Gwon, Leor Perl, Hyo-Soo Kim, Domenico Tuttolomondo, Mario Iannaccone, Woo Jung Chun, Davide Capodanno, Attilio Leone, Alessandra Truffa Giachet, Seung-Ho Hur, Giulio Stefanini, Seung Hwan Han, Javier Escaned, Antonino Carmeci, Gianluca Campo, Giuseppe Patti, Clemens von Birgelen, Gaetano Maria de Ferrari, Chang-Wook Nam, Fabrizio D'Ascenzo","doi":"10.1093/ehjqcco/qcae091","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae091","url":null,"abstract":"<p><strong>Background: </strong>Bifurcation lesions are associated with higher rates of major adverse cardiovascular events (MACE).</p><p><strong>Aim: </strong>To investigate the impact of imaging-guided PCI in a real-world population with coronary bifurcation lesions.</p><p><strong>Methods: </strong>From the ULTRA-BIFURCAT registry, we compared IVUS vs. angiographic guidance in a cohort of 3486 propensity matched patients. MACE a composite of all-cause death, myocardial infarction (MI), target-lesion revascularization (TLR) and stent-thrombosis was the primary endpoint. Subgroup analyses were performed for unprotected left main (ULM) and non-ULM disease.</p><p><strong>Results: </strong>PSM generated 1743 pairs. MACE occurred in 154 (9%) patients in the IVUS guided group and in 199 (11%) patients in the angio-guided group (p = 0.09). IVUS guidance was associated with lower MACE in the ULM population [HR 0.62, 95% CI 0.46-0.83], but had no impact in the non-ULM population [HR 1.12, 95% CI 0.83-1.51], p for interaction = 0.006. IVUS was associated with reduction in all-MI [HR 0.32, 95% CI 0.16-0.64] in the ULM population and with lower ST in the non-ULM population [HR 0.24, 95% CI 0.08-0.71]. Provisional stenting was associated with lower MACE in the ULM population [HR 0.67, 95% CI 0.45-0.98], whereas kissing balloon [HR 0.75, 95% CI 0.56-0.99] and ultra-thin stents [HR 0.44, 95% CI 0.29-0.67] were protective factors in the non-ULM population.</p><p><strong>Conclusions: </strong>In a real-world scenario, IVUS guidance during DES implantation is associated with a lower rate of MACE in patients with ULM coronary bifurcation lesions. In non-ULM bifurcations, no difference was observed on MACE, while IVUS guidance was associated with a lower rate of ST.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment with PCSK9 monoclonal antibodies is associated with discontinuation of oral lipid lowering therapy. 使用 PCSK9 单克隆抗体治疗与停止口服降脂治疗有关。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-19 DOI: 10.1093/ehjqcco/qcae099
Ingrid Engebretsen, Kristina Malene Ødegaard, Sigrun Halvorsen, Christoffer Bugge, Ivar Sønbø Kristiansen, Henrik Støvring, John Munkhaugen
{"title":"Treatment with PCSK9 monoclonal antibodies is associated with discontinuation of oral lipid lowering therapy.","authors":"Ingrid Engebretsen, Kristina Malene Ødegaard, Sigrun Halvorsen, Christoffer Bugge, Ivar Sønbø Kristiansen, Henrik Støvring, John Munkhaugen","doi":"10.1093/ehjqcco/qcae099","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae099","url":null,"abstract":"<p><strong>Aims: </strong>Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9 mAbs) are recommended for high-risk patients if the low-density lipoprotein cholesterol (LDL-C) targets are not achieved with statins and ezetimibe. We studied persistence and adherence to 1) PCSK9 mAbs and 2) statins and ezetimibe in a nationwide cohort of incident PCSK9 mAb users.</p><p><strong>Methods and results: </strong>Information on all PCSK9 mAb users ≤80 years from 2015 through 2023 were extracted from the Norwegian Drug Registry. Discontinuation was defined as a gap in treatment ≥180 days and ≥90 days. Adherence was measured as the proportion of days covered (PDC) during the initial year of PCSK9 mAb therapy. We analyzed adherence of statins and ezetimibe before and after PCSK9 mAb initiation. Of 4,784 patients initiating PCSK9 mAbs, median age was 63 years, 41% were female, 61% had atherosclerotic disease, and 34% had familial hypercholesterolemia. Within three years after initiation, 17% experienced a PCSK9 mAb treatment gap exceeding 180 days. In the 12-month period preceding PCSK9 mAb initiation, 74% dispensed statins whereas 67% dispensed ezetimibe. These numbers were reduced to 35% for statins and 42% for ezetimibe during the 12-month period after PCSK9 mAb initiation. Atherosclerotic disease, using ≥3 statins previously, and older age were significantly associated with discontinuation of statins and ezetimibe.</p><p><strong>Conclusion: </strong>In this high-risk cohort of incident PCSK9 mAb users, more than 1 out of 2 stopped taking statin treatment whereas 40% discontinued ezetimibe. There is a major potential for improving adherence to oral LLD treatment following initiation of PCSK9 mAb.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality indicators for improved cardiovascular care: learnings from the National Institute for Health and Care Excellence. 改善心血管护理的质量指标:从国家健康与护理卓越研究所汲取的经验。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-14 DOI: 10.1093/ehjqcco/qcae097
Mark Minchin, Chris Wilkinson, Suleman Aktaa, Chris P Gale
{"title":"Quality indicators for improved cardiovascular care: learnings from the National Institute for Health and Care Excellence.","authors":"Mark Minchin, Chris Wilkinson, Suleman Aktaa, Chris P Gale","doi":"10.1093/ehjqcco/qcae097","DOIUrl":"10.1093/ehjqcco/qcae097","url":null,"abstract":"","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Economic evaluation of the Liverpool heart failure virtual ward model. 利物浦心力衰竭虚拟病房模式的经济评估。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-13 DOI: 10.1093/ehjqcco/qcae095
D Rasoul, I Chattopadhyay, T Mayer, J West, H Stollar, C Black, C Oguguo, R Kaur, R MacDonald, J Pocock, B Uzdzinska, B Umpleby, N Hex, G Y H Lip, R Sankaranarayanan
{"title":"Economic evaluation of the Liverpool heart failure virtual ward model.","authors":"D Rasoul, I Chattopadhyay, T Mayer, J West, H Stollar, C Black, C Oguguo, R Kaur, R MacDonald, J Pocock, B Uzdzinska, B Umpleby, N Hex, G Y H Lip, R Sankaranarayanan","doi":"10.1093/ehjqcco/qcae095","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae095","url":null,"abstract":"<p><strong>Background: </strong>A virtual ward (VW) supports patients who would otherwise need hospitalisation by providing acute care, remote monitoring, investigations, and treatment at home. By March 2024 the VW programme had treated 10 950 patients across six speciality VWs, including heart failure (HF). This evaluation presents the economic assessment of the Liverpool HF VW.</p><p><strong>Method: </strong>A comprehensive economic cost comparison model was developed by York Health Economics Consortium (University of York) to compare the costs of the VW to standard hospital inpatient care (SC). The model included direct VW costs and additional costs across the care pathway. Costs and resource use for 648 patients admitted to the HF VW were calculated for 30 days post discharge and total cohort costs were extrapolated to a full year. Primary outcomes included costs related to length of stay, readmissions, and NHS 111 contact.</p><p><strong>Results: </strong>The total cost for the HF VW pathway, including set-up costs, was £467 524. This results in an incremental net cost benefit of £735 512 compared to the total SC cost of £1 203 036, indicating a substantial net cost benefit of £1 135 per patient per episode (PPPE). This advantage remains despite initial setup expenses and ongoing costs such as home visits, virtual consultations, point-of-care (POC) testing and home monitoring equipment.</p><p><strong>Conclusion: </strong>Our HF VW model offers a substantial net cost benefit, driven by reduced hospital stays, fewer emergency department visits, and lower readmission rates. The study highlights the importance of considering system-wide impacts and continuous monitoring of VWs as they develop.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The burden and trends of heart failure caused by ischemic heart disease at the global, regional, and national levels from 1990 to 2021. 1990 至 2021 年全球、地区和国家层面缺血性心脏病导致心力衰竭的负担和趋势。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-13 DOI: 10.1093/ehjqcco/qcae094
Hongwei Zhang, Xiaoyu Zheng, Pingping Huang, Lijun Guo, Yuan Zheng, Dawu Zhang, Xiaochang Ma
{"title":"The burden and trends of heart failure caused by ischemic heart disease at the global, regional, and national levels from 1990 to 2021.","authors":"Hongwei Zhang, Xiaoyu Zheng, Pingping Huang, Lijun Guo, Yuan Zheng, Dawu Zhang, Xiaochang Ma","doi":"10.1093/ehjqcco/qcae094","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae094","url":null,"abstract":"<p><strong>Background: </strong>Ischemic heart disease (IHD) is a major cause of heart failure (HF), a condition expected to increasingly affect global health and economics. This study evaluates the global burden, trends, and disparities of HF linked to IHD, aiming to inform health policy development.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease Study 2021 (GBD2021) is analyzed using Joinpoint regression, decomposition analysis, and Bayesian age-period-cohort analysis (BAPC). Health disparities are assessed through the Socio-demographic Index (SDI) via the Slope Index of Inequality (SII) and the Concentration Index (CI), with future trends projected from 2022 to 2045.</p><p><strong>Results: </strong>In 2021, global HF cases due to IHD were over 19.16 million, with an age-standardized prevalence rate (ASPR) of 228.31 per 100 000 [95% UI, 188.18 to 279.55] and age-standardized years lived with disability (ASYLDs) rate of 20.43 per 100 000 [95% UI, 13.55 to 28.7].In 2021, there was a 2.87% increase in ASPR and ASYLDs compared to 1990, primarily driven by population growth and aging.Significant reductions in global ASPR and ASYLDs disparities are observed, though the disease burden has intensified in countries with lower SDI levels. Projections indicate that by 2045, while the prevalence and YLDs for HF caused by IHD will increase, while the ASPR and ASYLDs are expected to decrease.</p><p><strong>Conclusion: </strong>The global burden of HF from IHD remains a significant concern. Urgent improvements in the allocation of medical resources and the implementation of effective prevention and management strategies are necessary to address this issue.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasis and risk of new-onset degenerative valvular heart disease: a prospective cohort study. 牛皮癣与新发退行性瓣膜性心脏病的风险:一项前瞻性队列研究。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-13 DOI: 10.1093/ehjqcco/qcae096
Zuoxiang Wang, Junxing Lv, Sheng Zhao, Zheng Yin, Wence Shi, Dejing Feng, Can Wang, Ziang Li, Xiaojin Gao, Yongjian Wu
{"title":"Psoriasis and risk of new-onset degenerative valvular heart disease: a prospective cohort study.","authors":"Zuoxiang Wang, Junxing Lv, Sheng Zhao, Zheng Yin, Wence Shi, Dejing Feng, Can Wang, Ziang Li, Xiaojin Gao, Yongjian Wu","doi":"10.1093/ehjqcco/qcae096","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae096","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence indicates that degenerative valvular heart disease (VHD) and psoriasis share overlapping risk factors and simultaneous presence of inflammation, yet this relationship has not been thoroughly explored.</p><p><strong>Methods: </strong>Drawing on the prospective cohort data from the UK Biobank, baseline information on psoriasis and the incidence of eight specific types of degenerative VHD-aortic stenosis (AS), aortic regurgitation, mitral stenosis, mitral regurgitation, tricuspid stenosis, tricuspid regurgitation, pulmonary stenosis, and pulmonary regurgitation-during the follow-up period were recorded. Cox proportional hazards models were conducted to estimate the association between psoriasis and the risk of degenerative VHD, adjusted for demographic indicators, lifestyle factors, comorbidities, and medication.</p><p><strong>Results: </strong>A total of 494 510 participants were included in the study. Among the participants without psoriasis, 13 672 events of degenerative VHD were observed during a median follow-up of 13.78 years, yielding an incidence rate of 2.14 per 1 000 person-years. In contrast, In the psoriasis group (n = 10 917), 422 events of degenerative VHD were reported during a median follow-up of 13.70 years, corresponding to an incidence rate of 2.93 per 1 000 person-years. After fully adjusting, participants with psoriasis had a significantly increased risk of AS (HR, 1.24; 95% CI, 1.07-1.43), yet no significant associations were observed between psoriasis and the risk of other degenerative valve diseases. In sex subgroup analyses, there was an interaction between sex and psoriasis in the occurrence of AS (p-interaction = 0.039), suggesting a high risk in women.</p><p><strong>Conclusions: </strong>Psoriasis was significantly associated with the risk of new-onset AS and may be more distinct in females, while no significant associations were observed between psoriasis and the risk of developing other degenerative valve diseases.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Loss of quality of life and increased societal costs in patients with hypertrophic cardiomyopathy: the AFFECT-HCM study. 肥厚型心肌病患者生活质量下降和社会成本增加:AFFECT-HCM 研究。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-08 DOI: 10.1093/ehjqcco/qcae092
S A C Schoonvelde, I Wiethoff, P P Zwetsloot, A Hirsch, C Knackstedt, T Germans, M Sikking, A F L Schinkel, M A van Slegtenhorst, J M A Verhagen, R A de Boer, S M A A Evers, M Hiligsmann, M Michels
{"title":"Loss of quality of life and increased societal costs in patients with hypertrophic cardiomyopathy: the AFFECT-HCM study.","authors":"S A C Schoonvelde, I Wiethoff, P P Zwetsloot, A Hirsch, C Knackstedt, T Germans, M Sikking, A F L Schinkel, M A van Slegtenhorst, J M A Verhagen, R A de Boer, S M A A Evers, M Hiligsmann, M Michels","doi":"10.1093/ehjqcco/qcae092","DOIUrl":"https://doi.org/10.1093/ehjqcco/qcae092","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertrophic cardiomyopathy (HCM) is the most prevalent inherited cardiac disease. The impact of HCM on quality of life (QoL) and societal costs remains poorly understood. This prospective multi-centre burden of disease study estimated QoL and societal costs of genotyped HCM patients and genotype-positive phenotype-negative (G+/P-) subjects.</p><p><strong>Methods: </strong>Participants were categorized into three groups based on genotype and phenotype: 1) G+/P- (left ventricular (LV) wall thickness <13 mm), 2) non-obstructive HCM (nHCM, LV outflow tract (LVOT) gradient <30 mmHg), and 3) obstructive HCM (oHCM, LVOT gradient ≥30 mmHg). We assessed QoL with EQ-5D-5L and Kansas City Cardiomyopathy Questionnaires (KCCQ). Societal costs were measured using medical consumption (iMCQ) and productivity cost (iPCQ) questionnaires. We performed subanalyses within three age groups: <40, 40-59, and ≥60 years.</p><p><strong>Results: </strong>From three Dutch hospitals, 506 subjects were enrolled (84 G+/P-, 313 nHCM, 109 oHCM; median age 59 years, 39% female). HCM (both nHCM and oHCM) patients reported reduced QoL vs G+/P- subjects (KCCQ: 88 vs 98, EQ-5D-5L: 0.88 vs 0.96; both p<0.001). oHCM patients reported lower KCCQ scores than nHCM patients (83 vs 89, p=0.036). Societal costs were significantly higher in HCM patients (€19,035/year vs €7,385/year) compared to G+/P- controls, mainly explained by higher healthcare costs and productivity losses. Being symptomatic and of younger age (<60 years) particularly led to decreased QoL and increased costs.</p><p><strong>Conclusion: </strong>HCM is associated with decreased QoL and increased societal costs, especially in younger and symptomatic patients. oHCM patients were more frequently symptomatic than nHCM patients. This study highlights the substantial disease burden of HCM and can aid in assessing new therapy cost-effectiveness for HCM in the future.</p>","PeriodicalId":11869,"journal":{"name":"European Heart Journal - Quality of Care and Clinical Outcomes","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Low Physical Activity on Cardiovascular Disease Across Regions and Demographic Groups: Insights from the Global Burden of Disease Study. 不同地区和人口组别中低体力活动对心血管疾病的影响:全球疾病负担研究的启示》。
IF 4.8 2区 医学
European Heart Journal - Quality of Care and Clinical Outcomes Pub Date : 2024-11-08 DOI: 10.1093/ehjqcco/qcae093
Changxing Liu, Zhirui Zhang, Boyu Wang, Tianwei Meng, Chengjia Li, Hongwei Liu, Xulong Zhang, Kai Kang
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