Cholkamol Sarunket, D. Banomyong, Piyawat Vibulcharoenkitja, S. Sutimuntanakul
{"title":"Radiopacity of Portland Cement and Calcium Silicate-Based Cement with Different Mixed Ratios of Radiopacifiers","authors":"Cholkamol Sarunket, D. Banomyong, Piyawat Vibulcharoenkitja, S. Sutimuntanakul","doi":"10.14744/eej.2021.72691","DOIUrl":"https://doi.org/10.14744/eej.2021.72691","url":null,"abstract":"Objective: The present study aimed to compare the radiopacity of Portland cement (PC) or calcium silicate-based cement (CSC) with different mixed radiopacifiers [bismuth oxide (BO)/ tantalum oxide (TO) and zirconium oxide (ZO)/barium sulfate (BS)] in a ratio of 1:1 or 1:2, with the 3 mm aluminium thickness (mmAl) acceptable value of ISO 6876:2012. Methods: PC and CSC mixed with different ratios of radiopacifiers were evaluated. One of high radiopacity radiopacifiers, BO or TO, was mixed with one of low radiopacity radiopacifiers, ZO or BS, in ratio of 1:1 and 1:2. PC or CSC powder, 1.6 g, was added into 0.4 g mixed radiopacifiers. Disc-shaped specimens of 1-mm thickness were prepared by mixing PC or CSC powder containing radiopacifiers with distilled water; the radiopacity was measured according to ISO 6876:2012. One-way ANOVA/Tukey's test and Welch ANOVA/Games-Howell test were used to compare the radiopacity among the groups. The significance level was set at 0.05. Results: PC groups had a higher radiopacity than CSC groups with the same radiopacifiers and ratio. BO groups showed higher radiopacity than TO groups. The groups with 1:1 ratio provided a higher radiopacity than 1:2 ratio groups (P>0.05). Conclusion: All tested radiopacifiers revealed adequate radiopacity ranging from 3.05-4.25 mmAl, except CSC with TO/BS in ratio of 1:2.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"52 - 57"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49567515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vinoo Subramanaiam RAMACHANDRAN, Mensudar Rathakrishnan, Malathy Balaraman Ravindrran, V. Alagarsamy
{"title":"Comparative Evaluation of the Antimicrobial Effect of Mangosteen, Triphala, Chitosan, and 2% Chlorhexidine on Mono- and Dual-Species Biofilms of – and Candida albicans: An in Vitro Study","authors":"Vinoo Subramanaiam RAMACHANDRAN, Mensudar Rathakrishnan, Malathy Balaraman Ravindrran, V. Alagarsamy","doi":"10.14744/eej.2021.70783","DOIUrl":"https://doi.org/10.14744/eej.2021.70783","url":null,"abstract":"Objective: The purpose of this in vitro study was to compare the antimicrobial effectiveness of 2% chlorhexidine gel, 0.5% chitosan, ethanol extract of mangosteen pericarp, and Triphala used as intracanal medicaments against Enterococcus faecalis and Candida albicans in mono- and dual-species biofilms. Methods: Bioactive components in the ethanol extract of mangosteen pericarp and Triphala were evaluated by gas chromatography-mass spectrometry (GCMS). Quantitative assessment of the biofilm formations of E. faecalis and C. albicans and as a dual-species in the presence of test medicaments was carried out using a crystal violet (CV) assay in a microtiter plate. Following this, 246 single-rooted premolar teeth were collected, and root specimens were prepared. C. albicans and E. faecalis mono- and dual-species biofilms were grown in the root specimens. At the end of 21 days, the samples were divided into five groups and subjected to different types of medicaments: Control group- distilled water; Chlorhexidine group- 2% chlorhexidine gel; Chitosan group- 0.5% chitosan; Mangosteen group- ethanol extract of mangosteen pericarp; and Triphala group- ethanol extract of Triphala. Colony-forming units (CFUs) were assessed on the first and fifth day after medicament placement. Results: Microbial population reduction was measured by one-way analysis of variance, followed by post-hoc Tukey’s multiple comparison test (P<0.05). Chlorhexidine showed maximum log reduction in CFUs of microorganisms, followed by chitosan, which showed a similar log reduction (P>0.05) for both mono- and dual-species biofilms. However, in the mangosteen and Triphala extract groups, the CFU/mL for dual-species on both days did not have a significant reduction in count (P<0.05) when compared to chlorhexidine and chitosan. Conclusion: Chlorhexidine showed maximum antimicrobial activity, followed by chitosan, on both mono- and dual-species biofilms. Mangosteen and Triphala had good antimicrobial action on the mono-species biofilm.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"58 - 66"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41645381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Literature Review of Minimally Invasive Endodontic Access Cavities - Past, Present and Future","authors":"Maggie Yuk Ching CHAN, Venetia Cheung, Angeline Hui Cheng LEE, Chengfei Zhang","doi":"10.14744/eej.2022.62681","DOIUrl":"https://doi.org/10.14744/eej.2022.62681","url":null,"abstract":"Minimally invasive endodontic access cavities have gained popularity in academic discussions for their clinical applications in recent years. Although some studies showed an improved fracture resistance of endodontically-treated teeth accessed with a minimally invasive access cavity design, the resulting effectiveness and efficiency of subsequent root canal treatment procedures may be impaired. Aspects that may be impaired are canal detection and negotiation, chemomechanical debridement of the root canal system, quality of the obturation. These are potentially complicated by the increased incidence of procedural mishaps and compromised aesthetic outcomes. In addition, the inherent flaws presented in the methodology of some in vitro studies and the lack of a universal classification system are also of concern. This literature review aims to present a comprehensive overview of the development of the minimally invasive endodontic access cavity and summarise the currently available from a clinical context.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"1 - 10"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44272992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kantaporn Kaewchomphoo, D. Banomyong, Yaowaluk Ngoenwiwatkul, Piyapanna Pumpaluk
{"title":"Comparison of the Survival Rate Against Fracture of Endodontically Treated Premolars with Exposed Cervical Lesions Restored with Crowns and Resin Composites: A Retrospective Study","authors":"Kantaporn Kaewchomphoo, D. Banomyong, Yaowaluk Ngoenwiwatkul, Piyapanna Pumpaluk","doi":"10.14744/eej.2021.21939","DOIUrl":"https://doi.org/10.14744/eej.2021.21939","url":null,"abstract":"Objective: The purpose of this study was to evaluate the effect of coronal restorations on the survival rates against fracture of endodontically treated premolars with exposed cervical lesions and to identify the prognostic factors for fracture. Methods: Data of the endodontically treated premolars with exposed cervical lesions restored with resin composites or crowns between 2011 and 2020 were collected. The presence of a fracture was recorded, and the possible prognostic factors were recorded. Statistical analyses were performed, with a significance level of P<0.05, using a Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard models were used to identify the prognostic factors. Results: The survival rates against fracture were not significantly different between the teeth restored with crowns (93.3%) or resin composites (86%) (P≥0.05). A high frequency of non-restorable fractures was observed in both groups. Crestal bone reduction to the middle-third of the root was identified as the significant prognostic factor (P<0.05). Conclusion: For endodontically treated premolars with exposed cervical lesions, resin composite restorations provided a high comparable survival rate that was comparable to that of crowns. A higher risk of fracture was found in endodontically treated premolars with crestal bone loss to the middle-third of the root.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"27 - 32"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45290822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Armita Rouhani, Afshin Javadzadeh, Abbas Tanhaeian, S. Navabi
{"title":"A Comparison of Antibacterial Properties of Tachyplesin, Thanatin, and Enterocin P on Enterococcus faecalis","authors":"Armita Rouhani, Afshin Javadzadeh, Abbas Tanhaeian, S. Navabi","doi":"10.14744/eej.2021.04696","DOIUrl":"https://doi.org/10.14744/eej.2021.04696","url":null,"abstract":"Objective: Enterococcus faecalis (E. faecalis) is one of the persistent microorganisms responsible for the failure of root canal treatments. This study investigated the antibacterial property, the time-killing of 3 peptides, namely Tachyplesin, Thanatin, and Enterocin P, on E. faecalis. Methods: In this study, recombinant peptides were synthesized via secretory synthesis. The peptides were then purified and isolated using affinity chromatography after which their purification was evaluated through SDS-PAGE. The antimicrobial activity of peptides against E. faecalis was tested using the minimum inhibitory concentration test (MIC), the minimum bactericidal concentration test (MBC), and the time-killing assay. Results: Based on antimicrobial tests, a similar value was observed for the MIC and MBC in the recombinant peptide of Enterocin P. The concentration of MBC was twice as much as that of MIC for Tanatin and Tachyplesin. The time-killing-assay antimicrobial test showed that Enterocin P has a better pattern and antimicrobial activity than the other two peptides; all three peptides have weaker antimicrobial activities than sodium hypochlorite. Conclusion: Considering the equivalence of MIC and MBC in the recombinant peptide of Enterocin P, it can be a viable replacement for traditional disinfectants and medicaments used in root canal treatment procedures.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"67 - 72"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41773103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Do Calcium Chelators Play a Role in the Removal of Calcium Hydroxide From Root Canals? A Systematic Review of Laboratory Studies.","authors":"Nandini Suresh, Aswathi Varghese, Sathish Sundar, Venkateshbabu Nagendrababu, Natanasabapathy Velmurugan","doi":"10.14744/eej.2021.73644","DOIUrl":"10.14744/eej.2021.73644","url":null,"abstract":"<p><strong>Objective: </strong>To identify whether root canal irrigants with calcium chelation ability play a role in the removal of calcium hydroxide (CH) from the root canals when compared to non-chelators.</p><p><strong>Methods: </strong>The protocol is registered in the Open Science Framework registry (doi 10.17605/OSF.IO/CHG2Q). PubMed, Scopus, Embase, Cochrane Library, ProQuest, Google Scholar, Science direct and open grey databases were searched until March 2021. Laboratory studies comparing the effectiveness of calcium chelators in the removal of CH with non-chelators delivered using needle irrigation, irrigation agitation or instrumentation techniques were included. The quality of included studies was appraised using a modified Joanna Briggs Institute critical appraisal checklist for a randomised clinical trial. Two independent reviewers were involved in study selection, data extraction, appraising the quality of studies. Any disagreements were resolved by a third reviewer.</p><p><strong>Results: </strong>The current review included 17 studies, with 16 being of \"moderate\" quality and one of \"low\" quality. Due to methodological differences within the included studies, quantitative analysis was not performed. Laboratory studies were only included in the current review because no clinical study exists on this topic. Evidence from the review indicates that calcium chelators are superior to non-chelators in the removal of CH when used with needle irrigation, passive ultrasonic irrigation and instrumentation techniques.</p><p><strong>Conclusion: </strong>Calcium chelators are superior in the removal of CH from the root canal system over non-chelators.</p>","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"11-19"},"PeriodicalIF":1.6,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9035855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42418610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cleaning Efficacy and Debris Extrusion using XP-Endo Finisher and XP-Endo Finisher R as Supplementary Files during Retreatment: An in Vitro Study","authors":"Ekramy Hassan, M. Sharaan, M. Ragab","doi":"10.14744/eej.2021.44366","DOIUrl":"https://doi.org/10.14744/eej.2021.44366","url":null,"abstract":"Objective: The aim of the study was to examine the efficacy and debris extrusion of XP -Endo Finisher and XP-Endo Finisher R when used in the removal of root canal filling as supplementary files. Methods: Sixty single-rooted mandibular premolars with single canals were selected. After root canal preparation and obturation, roots were distributed across four groups according to the method of retreatment (n=15): H files, D Race files, D Race +XP-Endo Finisher and D Race+ XP -Endo Finisher R. After retreatment completion, the debris was dried in a hot air oven and weighed. Later, the coronal, middle and apical thirds were assessed using the stereomicroscope. One-way ANOVA followed by Tukey’s post hoc test was used to compare across all tested groups. The significance level was set at 0.05 (P<0.05). Results: XP- Endo Finisher R exhibited significantly cleaner root canals than XP- Endo Finisher (41.58±10.56 and 52.68±9.94 respectively) and extruded more debris apically (16.56%±4.07 and 12.82%±3.41 respectively) (P<0.001). Conclusion: Although none of the tested approaches rendered root canals free of filling remnants, the XP-Endo Finisher R cleaned canals significantly more than the XP-Endo Finisher and extruded more debris apically.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"40 - 46"},"PeriodicalIF":1.8,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47442450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Khalilak, E. Esnaashari, Keivan Saati, D. Bineshmarvasti, Hazhir Yousefshahi, Mahsima Nobakht
{"title":"An in Vitro Comparison of Coronal Discolouration Caused by White Mineral Trioxide Aggregate, Theracal, Calcium-Enriched Mixture and Biodentine","authors":"Z. Khalilak, E. Esnaashari, Keivan Saati, D. Bineshmarvasti, Hazhir Yousefshahi, Mahsima Nobakht","doi":"10.14744/eej.2020.83584","DOIUrl":"https://doi.org/10.14744/eej.2020.83584","url":null,"abstract":"Objective: The use of calcium silicate-based cements has greatly increased in the past decade. This study compared coronal discolouration caused by white mineral trioxide aggregate (MTA), TheraCal (TC), calcium enriched mixture (CEM), and Biodentine (BD) on bovine enamel-dentin block. Methods: In this in vitro, experimental study, enamel-dentin blocks (7x7x3.5 mm) were cut out of 60 extracted sound bovine central incisors. A cavity (2.5 mm diameter and 1 mm depth) was created at the center of each block with 1 mm distance from the labial surface. The blocks were randomly divided into four experimental groups (n=12) of MTA, CEM, BD, and TC and two groups of positive (blood) and negative (empty) controls. After filling cavities with experimental materials, the surfaces of the materials were covered with composite resin. The colour parameters were measured using a spectrophotometer, before (T0) and 1 week (T1), 1 month (T2), and 6 months (T3) after the application of the materials. The data was analysed using repeated measures ANOVA and the Kruskal-Wallis test. Results: At 1 week and 1 month, a significant difference in ∆E was noted in the control groups compared to the experimental groups (P<0.001). The difference among the four cements was not significant (P=0.06) at 1 week but it was significant at 1 month. TC showed greater ∆E whereas BD showed lower ∆E in the six-month period (P<0.001). Colour change was significant over time in the MTA and TC groups (P<0.05). Conclusion: TheraCal caused greater discolouration in the bovine tooth blocks after 6 months, which may make it inappropriate for application in the aesthetic zone.","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"7 1","pages":"47 - 51"},"PeriodicalIF":1.8,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46832899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bahram Ranjkesh, Mariantonietta Leo, Ali Vafaei, Henrik Lovschall
{"title":"Pull-Out Bond Strength of Titanium Post Cemented with Novel Fast-Setting Calcium Silicate Cement.","authors":"Bahram Ranjkesh, Mariantonietta Leo, Ali Vafaei, Henrik Lovschall","doi":"10.14744/eej.2021.69875","DOIUrl":"https://doi.org/10.14744/eej.2021.69875","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to compare the pull-out bond strength of prefabricated titanium posts cemented with novel fast-setting calcium silicate, zinc phosphate, or glass ionomer cements.</p><p><strong>Methods: </strong>Sixty extracted human maxillary incisors were selected and received root canal treatment. Post space was prepared for titanium ParaPost XP size 5 (diameter=1.25 mm). The posts were cemented using novel calcium silicate cement, zinc phosphate cement, or glass ionomer cement (n=20). Specimens were stored in phosphate-buffered saline for 4 weeks. Subsequently, the posts were subjected to axial tensile force until bond failure. Data were analyzed by one-way ANOVA followed by multiple comparisons.</p><p><strong>Results: </strong>The posts cemented with novel calcium silicate cement (10.5±3.8 MPa) demonstrated significantly higher bond strength than zinc phosphate (8.0±2.6 MPa) and glass ionomer cements (8.0±2.7 MPa) (P<0.05).</p><p><strong>Conclusion: </strong>Within the limitation of the study, the pull-out bond strength of titanium post cemented with novel calcium silicate cement in endodontically treated teeth was superior to zinc phosphate and glass ionomer cements.</p>","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"6 3","pages":"314-318"},"PeriodicalIF":1.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39772924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas von Arx, Sebastian Bolt, Michael M Bornstein
{"title":"Neurosensory Disturbances After Apical Surgery of Mandibular Premolars and Molars: A Retrospective Analysis and Case-Control Study.","authors":"Thomas von Arx, Sebastian Bolt, Michael M Bornstein","doi":"10.14744/eej.2021.64326","DOIUrl":"https://doi.org/10.14744/eej.2021.64326","url":null,"abstract":"<p><strong>Objective: </strong>Apical surgery is an intervention to treat teeth with persistent or recurrent endodontic infection. The proximity of the mental foramen and mandibular canal may pose a risk of altered sensation when performing surgical interventions in the posterior mandible. The objective of this study was to determine the rate of neurosensory disturbances after apical surgery of mandibular premolars and molars. The secondary objective was to evaluate whether the occurrence of altered sensation correlated with the distances from the apex or the periapical lesion to the relevant anatomical structures.</p><p><strong>Methods: </strong>The charts of patients treated from September 1999 to December 2015 were retrospectively evaluated if an apical surgery had been performed in mandibular premolars or molars, and a minimum period of 1-year follow-up was documented. Patients with trauma or other surgical interventions in the same hemimandible were excluded. Cases with postsurgical altered sensation were defined as the test group. From the pool of unaffected cases, patients were selected to serve as controls. Two- or three-dimensional radiographs of test and control cases were assessed with regard to the shortest distances from the root apices/lesions to the mental foramen or mandibular canal.</p><p><strong>Results: </strong>The study population included 243 patients with 249 apical surgeries, of which 12.9% led to postoperative neurosensory disturbances. Sensation returned to normal within 22 days on average. The most frequent findings were hyperesthesia or paresthesia. With regard to the treated type of tooth, second premolars resulted more frequently (22.6%) in altered sensation than the other teeth (11.2 to 13.0%; p=0.310). There were no significant differences when comparing test and control cases regarding the measured distances in radiographs from the apex/lesion to the relevant anatomical structures.</p><p><strong>Conclusion: </strong>Altered sensation may typically occur following apical surgery in posterior mandibular teeth. However, in all cases of the present study, skin sensitivity in the lip/chin region returned to normal. The clinician must be particularly careful when performing apical surgery of second premolars due to the proximity of the mental foramen.</p>","PeriodicalId":11860,"journal":{"name":"European Endodontic Journal","volume":"6 3","pages":"247-253"},"PeriodicalIF":1.8,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8842425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39772923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}