European Journal of Clinical and Experimental Medicine最新文献

{"title":"Parathyroid adenoma in a 15-year-old girl with recurrent urolithiasis","authors":"Patrycja Kucaba, Katarzyna Dziadzio-Gąsior, R. Podlasek, P. Bar, B. Korczowski","doi":"10.15584/ejcem.2023.2.23","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.23","url":null,"abstract":"Introduction and aim. The incidence of urolithiasis in children has been growing steadily for several decades, and it accounts for an increasing percentage of hospitalizations. Kidney stones are deposits of various mineral salts. Most of them are composed of calcium, favored by hypercalcemia and hypercalciuria. Primary hyperparathyroidism is one of the reasons for increased calcium levels in the blood. Description of the case. A 15-year-old girl was hospitalized due to recurrent urolithiasis. Investigations revealed hypercalcemia with elevated parathyroid hormone. Ultrasound of the thyroid gland showed a local change near the lower pole of its right lobe, and Sestamibi nuclear scan confirmed the presence of the adenoma of the lower right parathyroid gland. Surgical removal of the parathyroid gland with the present adenoma was performed. Calcium and phosphate homeostasis parameters and the kidneys’ ultrasound image were without any significant deviations from the norm. Conclusion. After finding the cause of recurrent urolithiasis, the applied surgical treatment resolved all disease manifestations.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85381631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care dependency in radiation oncology patients and related factors – a descriptive study","authors":"Rukiye Burucu, Zehra Alanyalı, Huriye Öztürk","doi":"10.15584/ejcem.2023.2.10","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.10","url":null,"abstract":"Introduction and aim. The incidence of cancer is increasing on a daily basis. One of the methods used for treatment is radiotherapy. Owing to interventions during the radiotherapy process, the patient may experience care dependency. In this study, the aim was to investigate care dependence and related factors in radiation oncology patients. Material and methods. This was a descriptive and cross-sectional study. Data were collected between September 2020 and September 2021. In the collection of data, a sociodemographic information form and a Care Dependency Scale were used. The sample consisted of 52 people. Results. Number of participants was 52, mean age was 60.25±11.715, mean care dependency score (initial) 66.19±18.966, mean care addiction score (final) 66.27±22.795. Conclusion. The care dependency of patients hospitalized in the radiation oncology clinic is moderate. The care dependency of these patients decreased partially during their stay in the clinic. The patient’s inability to walk, speak and the presence of a companion affected the patient’s condition. By evaluating the care dependency levels of the patients, the awareness of the nurses about their patients can be increased. In addition, it may be appropriate to consider the care dependency levels of the patients for the nurse workforce planning to work in the oncology clinic.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89979664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of weight loss on serum ceruloplasmin levels in obese patients","authors":"Ece Yiğit, Ilknur Sayar","doi":"10.15584/ejcem.2023.2.5","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.5","url":null,"abstract":"Introduction and aim. Serum ceruloplasmin level may be a biomarker associated with obesity and cardiovascular risk. We aimed to evaluate the effect of body weight lost by diet and exercise program on metabolic parameters and serum ceruloplasmin levels in obese patients. Material and methods. A total of 120 obese patients with BMI ≥30 kg/m 2 were enrolled in a 16-week balanced diet program with the goal of losing 10% or more of body weight while maintaining a daily energy deficit of 500-1000 kcal/day. Results. Mean weights of the patients decreased from 93.2±15.1 kg to 83.2±13.1 kg (p<0.001) and mean BMI decreased from 35.8±5.6 kg/m 2 to 31.9±4.9 kg/m 2 (p<0.001). Mean ceruloplasmin decreased from 25.2±4.7 mg/dL to 23.6±4.9 mg/dL (p<0.001), mean total cholesterol from 191.8±37.1 mg/dL to 153.8±28.7 mg/dL (p<0.001), mean LDL from 120.3±31.4 mg/dL to 91.1±27.7 mg/dL (p<0.001) and mean fasting blood glucose from 108.2±35 mg/dL to 103.3±81.1 mg/dL (p<0.001). There was a statistically significant and weak correlation between the change in ceruloplasmin and the change in BMI (p=0.016, R=0.233). There was a statistically significant and weak correlation between ceruloplasmin change and weight change (p=0.010, R=0.251). Conclusion. Obese patients’ serum ceruloplasmin levels were found to decrease with weight loss.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73807985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemia – a scourge to maternal and child development in Bihar, India","authors":"S. Nirala, R. Rao, B. Naik, S. Patil, M. Verma, C. Singh, S. Pandey","doi":"10.15584/ejcem.2023.2.22","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.22","url":null,"abstract":"Introduction and aim. Anemia remains a leading contributor to years lived with disability (YLDs), being responsible for 50.3 million (5.82%) YLDs worldwide and 19.3 million (12.03%) YLDs in India, respectively. Results of the National Family Health Survey 2019-2021 (NFHS-5) suggest a high burden of anemia in India among women of reproductive age and children aged 6-59 months at the national level (57%, 67.1%), and in the state of Bihar, India (63.5%, 69.4%). Iron deficiency is the leading cause, accounting for more than half the cases. Anemia bodes harmful implications for both the mother and child, with long-lasting consequences for the latter. Anemia control programs have yielded little benefit despite efforts stretching over five decades. This narrative review aims to highlight the burden of anemia and the probable factors behind it among under-5 children and women of reproductive age in the Indian state of Bihar. Material and methods. The paper is a narrative review. The following databases were used to search and select literature: PubMed, Web of Science, Scopus, and Google Scholar. In addition, the websites of relevant government departments and national health programs were searched for pertinent material. Analysis of the literature. A multitude of reasons seem to be behind the unabated high prevalence in Bihar: low socioeconomic status, gender disparities, traditional customs and practices, food insecurity, lack of diverse diets, poor consumption, and no adherence to iron and folic acid (IFA) supplements, groundwater contamination with arsenic and fluoride, and supply chain mismanagement, all playing roles of varying degree. Conclusion. An all-encompassing approach and not merely the provision of IFA supplements are necessary to unravel the intricate web of factors that lead to anemia.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80666039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pandemic awareness and caring behaviors of nurses working in intensive care unit – a multicenter study","authors":"B. Demir, Sevda Türen, D. Doğan","doi":"10.15584/ejcem.2023.2.18","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.18","url":null,"abstract":"Introduction and aim. In the COVID-19 pandemic, which is a global threat, the awareness levels of intensive care nurses who meet all the care needs of patients can affect the quality of care. In this study, pandemic awareness and care behaviors of nurses who undertook the patient’s care needs in intensive care units were examined. Material and methods. The research was carried out with 317 nurses working critical care units of 12 hospitals in different provinces. “Nurse Characteristics Form”, “Pandemic Awareness Scale” and “Caring Behaviors Inventory-24” were used as data collection tools. Data were collected between March and August 2022 in the middle of the COVID-19 pandemic process using an online survey. Results. It was determined that 75.4% of the participants were female and the mean age was 25.56±4.49. Pandemic awareness scale score was 3.04±0.62 (0.11-3.67) and caring behaviors inventory score was 5.48±0.84 (1.00-6.00). A significant, positive, weak relationship was found between nurses’ pandemic awareness and all sub-dimensions of caring behaviors (p≤ 0.05). Conclusion. It was seen that the caring behaviors of nurses with high pandemic awareness were also positively affected. Although it was the first time they had experienced the pandemic, nurses were found to have good caring behaviors.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79564856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction of synbiotic of the environment and the endoecosystem as one of the mechanisms of action of balneotherapy","authors":"I. Popovych, W. Zukow, V. Fil, H.Y. Kovalchuk, I. Bryndzia, O. Voloshyn, Iryna Y. Kopko, O. Lupak, T. Skrobach","doi":"10.15584/ejcem.2023.2.26","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.26","url":null,"abstract":"Introduction and aim. Drinking mineral waters are one of the environmental factors that affect the condition of the human body. Of particular interest are therapeutic waters of the Naftussya type, which contain autochthonous microbes and organic oil-like substances and can be considered as a kind of ecosystem. On the other hand, gastrointestinal tract also is an ecosystem that associates a resident microbiota and cells of various phenotypes lining the epithelial wall. We assumed that one of the mechanisms of the therapeutic effect of Naftussya water is the interaction of external and internal ecosystems. This article is the first in a series in support of the hypothesis. Material and methods. The object of clinical-physiological observation were residents of the city of Truskavets’ (21 men aged 24-67 years and 8 women 33-76 years) with chronic pyelonephritis in remission. The objects of study: leukocyturia, bacteriuria, components of microbiota, phagocytosis function of neutrophils, leukocytary adaptation index, plasma and urine electrolytes and nitrogenous metabolites. Results. The weekly use of bioactive Naftussya water from the Opaka deposit causes a favorable normalizing effect on the stool microbiota: it increases the reduced content of Bifidobacteria and Lactobacilli, instead it reduces the increased content of pathogenic strains of Escherichia coli, as well as Klebsiela and Proteus. Reduction of dysbacteriosis is accompanied by an increase in the reduced bactericidal capacity of blood neutrophils against E. coli and Staphylococcus aureus, and reduction of bacteriuria and leukocyturia. At the same time, the elevated level of creatinine in the plasma decreases, instead, the decreased levels of sodium and chloride increase. As expected, the daily diuresis and excretion of urea, creatinine, phosphates, calcium, magnesium and chloride increases, but not sodium and uric acid, the concentrations of which in the urine decrease. The described physiologically beneficial effects are interpreted as adaptogenic, which is confirmed by an increase in the reduced leukocyte adaptation index. Conclusion. The healing effect of Naftussya bioactive water is the result of the interaction of external and internal ecosystems. The next article will consider the role of the nervous and endocrine systems in this interaction.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81792307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global risks of endometriosis in women – an appraisal","authors":"Chhandika Roy, N. Mondal","doi":"10.15584/ejcem.2023.2.27","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.27","url":null,"abstract":"Introduction and aim. Endometriosis is a complex condition in which endometrium, tissue that resembles the uterine lining, develops outside the uterus. It is considered to be a chronic, estrogen-dependent, inflammatory gynecological disorder having multi-factorial origins. This review paper aims to consolidate recent information on ethnic differences, endometriosis risks, and the disease’s etiology in the global context. Material and methods. A systematic search was performed using a variety of international electronic databases, including “PubMed” and “DOAJ”, using the terms endometriosis, endometriosis and infertility, endometriosis and cancer, and treatment of endometriosis. Analysis of the literature. Endometriosis can appear anywhere in the body, including the umbilicus, the cecum and ileum of the digestive tract, the breast, the lungs, and the genitourinary organs. It is typically clinically asymptomatic with no obvious clinical manifestation and expensive treatment, which makes the diagnosis late. There is a complex interplay between socioeconomic status, family history, societal beliefs and laws, personal habits, reproductive and gynaecological conditions, and environmental influences in the development of endometriosis. Conclusion. Women with endometriosis should be given more attention, and specific resources in the healthcare system should be utilized to provide more efficient multidisciplinary healthcare and treatment.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84676489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progestins and combined oral contraceptives in the hormonal treatment of endometriosis – a review","authors":"Kornelia Rojek","doi":"10.15584/ejcem.2023.2.21","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.21","url":null,"abstract":"Introduction and aim. Endometriosis is a common inflammatory disease affecting 6-10% of women of reproductive age. It is defined as the growth of endometrial-like tissue outside the uterine cavity. Dysmenorrhea, pelvic pain, dyspareunia and infertility are the main symptoms of endometriosis patients. Endometriosis treatment methods can be broadly divided into surgical and pharmacological. Currently, hormonal drugs are often used for women with endometriosis to relieve bothersome symptoms. The aim of this article is to review new publications presenting the effectiveness as well as side effects of the use of progestins and combined oral contraceptives in the hormonal treatment of endometriosis. Material and methods. A review of the literature regarding progestins and combined oral contraceptives in the treatment of endometriosis was performed using the PubMed database. In the end, 67 articles were included in this review. Analysis of the literature. Progestins and combined oral contraceptives significantly reduce dysmenorrhea, dyspareunia and pelvic pain in women with endometriosis. However, there is a risk of potential side effects, which should be taken into account when choosing a therapy for each patient individually. Conclusion. Endometriosis is a chronic disease that has a significant impact on the health-related quality of life of patients. When choosing a treatment, many aspects should be considered, primarily the patient’s preferences, drug tolerance and safety. Further drug research is needed to determine the most effective treatment for endometriosis.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82966770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of core-stabilization and trunk balance exercises on clinical parameters in patients with non-specific chronic low back pain – a randomized pilot study","authors":"O. Fapojuwo, A. Akodu, Adurayemi Esther Ositelu","doi":"10.15584/ejcem.2023.2.15","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.15","url":null,"abstract":"Introduction and aim. This study compared the efficacy of core stabilization (CSE) and trunk balance exercises (TBE) with flexibility training on pain-related disability (PRD), psychological status (PS) and fear avoidance belief (FAB) in patients with non-specific chronic low back pain (NSCLBP). Material and methods. Twenty-eight (28) participants diagnosed of NSCLBP were randomly assigned into CSE, TBE, and control groups (CG). Participants in CSE (n=10); TBE (n=8) and CG groups (n=10) received core stabilization exercise, trunk balance exercise and back care advice respectively. All participants received flexibility training in addition to treatment in their respective groups. Assessment of outcomes were done at baseline, end of 4 th and 8 th week. Results. There was significant improvement in all outcomes in the CSE, TBE and CG at 8 weeks; PRD (p=0.005, p=0.008, p=0.005), PS: depression (p=0.005, p=0.008, p=0.007); anxiety (p=0.005, p=0.007) and FAB about work (p=0.005, p=0.007, p=0.005); about physical activity (p=0.005, p=0.018, p=0.006). Comparison of outcomes between CSE and TBE groups showed no significant difference (p>0.05) Conclusion. Both CSE and TBE with flexibility training are effective in improving PRD, PS and FAB of patients with NSCLBP.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81842790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"p-Coumaric acid as a potent additive in blood storage solution","authors":"Magdaline Christina Rajanand, Carl Hsieh, M. Pallavi, Ashabaree Nayak, M. John, Shivangi Malik, Vaishnavi Vempati, Yasmin Thacker Thacker, Vani Rajashekaraiah","doi":"10.15584/ejcem.2023.2.24","DOIUrl":"https://doi.org/10.15584/ejcem.2023.2.24","url":null,"abstract":"Introduction and aim. Stored erythrocytes develop lesions involving changes in their structure and function reducing their efficacy. Oxidative Stress (OS) being one of the main causes of storage lesion, can be attenuated by antioxidants as additives in the storage solution. This study aims to evaluate the effect of p-Coumaric acid (CA) on erythrocytes during whole blood storage. Material and methods. Blood collected from Male Wistar rats was stored at 4°C in CPDA-1 solution for 21 days. Blood samples were stored with and without 1mM CA (CA 1) and 10 mM CA (CA 10). The erythrocytes were isolated every week during storage and the biomarkers for OS and antioxidant status were analysed. Results. Superoxide dismutase and catalase elevated on day 14. Conjugate dienes decreased in CA 10 on day 14. Thiobarbituric acid reactive substances increased on day 7 and decreased on day 14 in CA groups. Protein sulfhydryls decreased in controls and CA 1 on day 14 whereas, it was maintained in CA 10. Conclusion. Coumaric acid upregulated the antioxidant enzymes and protected the cells from oxidative damage. Thus, coumaric acid can be employed as a potent additive during storage and opens new avenues of employing it in similar OS situations in erythrocytes.","PeriodicalId":11828,"journal":{"name":"European Journal of Clinical and Experimental Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89697583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}