减肥对肥胖患者血清铜蓝蛋白水平的影响

Ece Yiğit, Ilknur Sayar
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引用次数: 0

摘要

介绍和目的。血清铜蓝蛋白水平可能是与肥胖和心血管风险相关的生物标志物。我们的目的是评估饮食和运动减肥对肥胖患者代谢参数和血清铜蓝蛋白水平的影响。材料和方法。共有120名BMI≥30 kg/ m2的肥胖患者参加了为期16周的均衡饮食计划,目标是体重减轻10%或更多,同时保持每日能量赤字500-1000 kcal/天。结果。患者平均体重由93.2±15.1 kg降至83.2±13.1 kg (p<0.001),平均BMI由35.8±5.6 kg/ m2降至31.9±4.9 kg/ m2 (p<0.001)。平均铜蓝蛋白由25.2±4.7 mg/dL降至23.6±4.9 mg/dL (p<0.001),平均总胆固醇由191.8±37.1 mg/dL降至153.8±28.7 mg/dL (p<0.001),平均LDL由120.3±31.4 mg/dL降至91.1±27.7 mg/dL (p<0.001),平均空腹血糖由108.2±35 mg/dL降至103.3±81.1 mg/dL (p<0.001)。铜蓝蛋白的变化与BMI的变化有统计学意义,相关性较弱(p=0.016, R=0.233)。铜蓝蛋白变化与体重变化呈弱相关,差异有统计学意义(p=0.010, R=0.251)。结论。肥胖患者血清铜蓝蛋白水平随体重减轻而降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of weight loss on serum ceruloplasmin levels in obese patients
Introduction and aim. Serum ceruloplasmin level may be a biomarker associated with obesity and cardiovascular risk. We aimed to evaluate the effect of body weight lost by diet and exercise program on metabolic parameters and serum ceruloplasmin levels in obese patients. Material and methods. A total of 120 obese patients with BMI ≥30 kg/m 2 were enrolled in a 16-week balanced diet program with the goal of losing 10% or more of body weight while maintaining a daily energy deficit of 500-1000 kcal/day. Results. Mean weights of the patients decreased from 93.2±15.1 kg to 83.2±13.1 kg (p<0.001) and mean BMI decreased from 35.8±5.6 kg/m 2 to 31.9±4.9 kg/m 2 (p<0.001). Mean ceruloplasmin decreased from 25.2±4.7 mg/dL to 23.6±4.9 mg/dL (p<0.001), mean total cholesterol from 191.8±37.1 mg/dL to 153.8±28.7 mg/dL (p<0.001), mean LDL from 120.3±31.4 mg/dL to 91.1±27.7 mg/dL (p<0.001) and mean fasting blood glucose from 108.2±35 mg/dL to 103.3±81.1 mg/dL (p<0.001). There was a statistically significant and weak correlation between the change in ceruloplasmin and the change in BMI (p=0.016, R=0.233). There was a statistically significant and weak correlation between ceruloplasmin change and weight change (p=0.010, R=0.251). Conclusion. Obese patients’ serum ceruloplasmin levels were found to decrease with weight loss.
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