Journal of Biological & Scientific Opinion最新文献_第4页

Journal of Biological & Scientific Opinion Pub Date : 2018-08-08 DOI: 10.7897/2321-6328.06380

G. Sunitha, V. Acha, Gazala Hussain

引用次数: 0

AN ALTERNATIVE MODEL OF THE RELATIONSHIP BETWEEN THE CARCINOGENIC ACTIVITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND THEIR MOLECULAR STRUCTURE 多环芳烃的致癌活性与其分子结构之间关系的另一种模型

Journal of Biological & Scientific Opinion Pub Date : 2018-08-08 DOI: 10.7897/2321-6328.06383

V. Mukhomorov

{"title":"AN ALTERNATIVE MODEL OF THE RELATIONSHIP BETWEEN THE CARCINOGENIC ACTIVITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND THEIR MOLECULAR STRUCTURE","authors":"V. Mukhomorov","doi":"10.7897/2321-6328.06383","DOIUrl":"https://doi.org/10.7897/2321-6328.06383","url":null,"abstract":"A new model is proposed that connects the carcinogenic activity of polycyclic aromatic hydrocarbons with their molecular structure. The model does not use the representation of the molecule local regions existence responsible for carcinogenic activity. Molecular descriptors determine the electronic and information properties of molecules in general. Representations of the physics of condensed states and methods of information theory are used to determine molecular descriptors. To assess the carcinogenicity of a chemical compound, it is sufficient to know its gross formula. A statistically significant relationship between molecular descriptors and carcinogenic activity of polycyclic aromatic hydrocarbons has been established. The properties of molecules that limit the carcinogenic activity of molecules are considered. The model makes it possible to perform an express assessment of the carcinogenic activity of polycyclic aromatic hydrocarbons. To assess the carcinogenicity of a chemical compound, it is sufficient to know its gross formula. It is analyzed the interrelation between molecular descriptors and the physical properties (the first ionization potential of the molecule, the magnitude of the affinity energy, the energy of the most intensive electronic transition, the value of the pair intermolecular interaction, the electron-donor properties) of chemical compounds. Electronic and information descriptors are derived from various initial principles. However, it is established that the descriptors are closely related. We are demonstrating a comparison of the proposed model and the Pullman’s model.","PeriodicalId":118022,"journal":{"name":"Journal of Biological & Scientific Opinion","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130546225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

ACNE VULGARIS IN PERSPECTIVE OF UNANI LITERATURE: A REVIEW 寻常痤疮的unani文献综述

Journal of Biological & Scientific Opinion Pub Date : 2018-06-05 DOI: 10.7897/2321-6328.06279

Basharat Rashid

引用次数: 0

NEPHROPROTECTIVE ACTIVITY OF SHILAJATU & GOKSHURA KWATHA BHAVITHA SHILAJATU: A COMPARATIVE EXPERIMENTAL STUDY 枇杷膏和枇杷膏肾保护作用的比较实验研究

Journal of Biological & Scientific Opinion Pub Date : 2018-06-05 DOI: 10.7897/2321-6328.06278

L. AgajaP, Ravindra Angadi

{"title":"NEPHROPROTECTIVE ACTIVITY OF SHILAJATU & GOKSHURA KWATHA BHAVITHA SHILAJATU: A COMPARATIVE EXPERIMENTAL STUDY","authors":"L. AgajaP, Ravindra Angadi","doi":"10.7897/2321-6328.06278","DOIUrl":"https://doi.org/10.7897/2321-6328.06278","url":null,"abstract":"Shilajatu (Asphaltum punjabinum) is a well-known drug mentioned in brihatrayees and laghutrayees. Acharya Charaka says that there is no sadyarupa vyadhi (curable disease) that cannot be treated with shilajatu. The therapeutic values of shilajatu can be increased by undergoing bhavana (impregnation) like samskara with suitable drugs. So, to analyse the variations caused by samskara process, bhavana was given with gokshurakashaya for shilajatu and its effect in nephrotoxicity was evaluated. Objectives: To evaluate the efficacy of shilajatu and gokshura kwatha bhavitha shilajatu in nephroprotective activity. Methods: Nephroprotective activity of shilajatu was checked on cisplatin induced renal damage in wistar albino mice. Animals were grouped into four categories and group specific drugs were administered for 10 consecutive days. On 8 day an hour after treatment with group specific drugs, Cisplatin20mg/kg was injected intra-peritoneally to all the groups except in normal control mice group. Nephrotoxicity was assessed by biochemical, antioxidant and histological changes in kidney after 72 hrs of cisplatin injection. Results: By the virtue of the ‘mutrala’ and ‘rasayana’ properties and ‘tikta rasa’ the drug ‘shilajatu' (Asphaltum punjabinum) is known to act as nephronprotective.‘Gokshurabhavitashilajatu’ (Asphaltum punjabinum impregnated with decoction of Tribulus terrestris) is comparatively more effective in reversing the nephrotoxicity induced degenerative changes as ‘samskara’ enhanced the properties of the drug.","PeriodicalId":118022,"journal":{"name":"Journal of Biological & Scientific Opinion","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122059741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PHARMACEUTICAL STUDY OF 'SHANKHA DRAAVAKA' AND THE HANDS-ON IMPEDIMENTS “香陀罗瓦卡”的药学研究及实际操作障碍

Journal of Biological & Scientific Opinion Pub Date : 2018-06-05 DOI: 10.7897/2321-6328.06277

N. Parthipan, Ravindra Angadi

引用次数: 0

ANTIPROLIFERATIVE EFFECT OF THE METHANOL EXTRACT OF GONIOTHALAMUS UMBROSUS LEAVES ON HELA CELLS 下丘脑叶甲醇提取物对hela细胞的抗增殖作用

Journal of Biological & Scientific Opinion Pub Date : 2018-06-05 DOI: 10.7897/2321-6328.06276

Zaleha Md Toha, Hani Nadirah Zainoddin, Wan Nuraini Wan Aziz, Hasni Arsad

引用次数: 3

UNDERSTANDING OF QUWA (POWER) IN THE PERSPECTIVE OF UNANI SYSTEM OF MEDICINE: A REVIEW unani医学体系视角下对权力的理解综述

Journal of Biological & Scientific Opinion Pub Date : 1900-01-01 DOI: 10.7897/2321-6328.092141

{"title":"UNDERSTANDING OF QUWA (POWER) IN THE PERSPECTIVE OF UNANI SYSTEM OF MEDICINE: A REVIEW","authors":"","doi":"10.7897/2321-6328.092141","DOIUrl":"https://doi.org/10.7897/2321-6328.092141","url":null,"abstract":"Science is the study of nature and extensionally to the study of man. Unani System of Medicine covers the nature and human body both, as it was evolved in the environment wherein entire of the scholars were pre-owned of philosophical approach. Then their philosophy was holistic and transcendentalist based. The basic blocks of Umoor Tabiya (Basic Principles) interact at many levels and manifest into Kaifiyyat (Mizaj), Akhlat (Humour), Arwah (Pneuma), Quwa (Potentiality for action) and Tabiyat (Physis, the regulatory faculty) which need to be comprehend for proper understanding of discharge of normal function in the state of health. Since, the predominance of metaphysics in understanding of physiological mechanism of human body needs reasoning and logic for their proper comprehension. Quwa are one of them. How it was perceived? What is the function? Why it is necessary? Which corporeal forms provide its existence? What is the relationship in between Quwa, Nafs and Hararat Ghariziya? So, the present paper strives to comprehend the concepts of metaphysics in contemporary learning mode and its application for understanding of mysteries of actions as performed by human body.","PeriodicalId":118022,"journal":{"name":"Journal of Biological & Scientific Opinion","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126089579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0