Medica Hospitalia : Journal of Clinical Medicine最新文献

{"title":"Effectiveness Of E-Backnshou Exercise To The Improvement Of Neck, Shoulder And Back Pain In Computer Vision Syndrome Patient","authors":"H. Julianti, Trilaksana Nugroho, T. Kesoema, N. Susilaningsih, F. L. Rahmi, Maharani Prizka Pritadesya","doi":"10.36408/mhjcm.v11i1.1017","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.1017","url":null,"abstract":"BACKGROUND : Extra-ocular complaints of Computer Vision Syndrome (CVS) are neck, shoulder, back pain.  The 20-20-20 rule and E-BACKNSHOU exercise are expected to improve accommodative mechanisms, ocular surface of the eye and extra ocular symptoms of CVS.\u0000AIMS :  Proving the effectiveness of E-BACKNSHOU exercise for the improvement of neck, shoulder and back pain in CVS patient.\u0000METHOD : The research design was Pre-Post Test with Control Design. Subjects were 30 medical students of Faculty of Medicine, Diponegoro University, Semarang, Indonesia who experienced CVS and neck, shoulder and back pain. The treatment group got the 20-20-20 rule and E-BACKNSHOU exercise and the control group got the 20-20-20 rule for 1 month. Pain was measured by Visual Analogue Scale (VAS). Statistical test was conducted using paired t-test, unpaired t-test and chi square. Value of significance p<0.05.\u0000RESULT :  There were significant differences in VAS score of neck, shoulder, upper back pain (p=0.00), and low back pain (p=0.022) before and after the intervention in the treatment group and VAS score of neck (p=0,002), shoulder (p=0.020), upper back (p=0.011), and low back pain (p=0.019) in the control group. Delta VAS score of the treatment group was greater than the control group and there was a significant difference in delta VAS score of shoulder pain (p=0,030), but there were no significant differences in delta VAS score of neck (p=0,934), upper back (p=0,356), and low back pain (p=0,150).\u0000CONCLUSION : The effectiveness of 20-20-20 rule and E-BACKNSHOU exercise is better than the 20-20-20 rule alone on treating neck, shoulder and back pain in CVS patient.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"105 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Capacity COVID-19 Survival Among Workers in Koja Public Health Center","authors":"Melinda Harini, Ira Mistivani, W. Kusumaningsih, Peggy Sunarjo, Budiati Laksmitasari, Nelfidayani, R. K. Wardhani, Ni Luh Made M J, Ratna Ekawati, Edvina, Prisca Ockta, Adhitya, Reni Rozanti, Ricky Fakhrazi, Felix Leo, Novita Suprapto Wati, Endang Sri Wahyuningsih, Dwi Oktavia, Rofi Yuliandra, Vinnaria Astuty, Sri Puji Wahyuni, Julieta Tantri, Gilang Rama Putra","doi":"10.36408/mhjcm.v11i1.942","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.942","url":null,"abstract":"Introduction: Coronavirus disease 19 (COVID-19) primarily affects the respiratory system and other organ systems which limit respiratory and physical status. The aim of this study is to evaluate functional capacity COVID-19 survivor among workers in Koja Public Health Center\u0000Methods: participant were enrolled on March-April 2022. Demographics, symptoms, functional scale post COVID-19 questionnaire, risk stratification, and 6-min walk test (6mwt) were analysed. Patients unable to walk were excluded from the study.\u0000Results: 79 participants, 38% was a health care worker, had a median age 33 (21-57) years and 43 women (54.4%). Men had higher 6mwt 518.2 (120-625.8) meter while women had 457 (340-600) meter p (<0.001), VO2max 17.47 (9.74-20.67) in men and 16.45 (14.07-19.19) in women p (<0.001), and METs 5.02 (2.78-5.90) in men and 4.69 (4.02-5.48) in women p (<0.001). Most of the participant had good fitness, 10 participant (12.7%) had functional limitation; 2 participants (2.5%) still had symptom.\u0000Conclusion: Despite being COVID-19 survivors, the workers at the Koja Public Health Center have good functional capacity.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"84 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison Of The Effectiveness Of High Intensity Laser Therapy (HILT) And Low-Level Laser Therapy (LLLT) On Improving Balance In Knee Osteoarthritis","authors":"Kukuh Wibisono, Rudy Handoyo, Erna Setiawati","doi":"10.36408/mhjcm.v11i1.984","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.984","url":null,"abstract":"BACKGROUND : Osteoarthritis (OA) of the knee is a joint disease with a high prevalence among the elderly. OA can cause balance disorders, which are one of the main causes of falls in the elderly. Balance can be measured using several scoring systems, one of which is the Berg Balance Scale (BBS). One of the treatment modalities for OA is laser therapy which is non-invasive and easy to apply. Low level laser therapy (LLLT) has been widely used in patients with knee OA, but recently high intensity laser therapy (HILT) has begun to be used in physical therapy with advantages over a wider range and depth.\u0000AIMS :  to compare the effect of LLLT and HILT therapy on improving functional balance in the elderly with knee OA.\u0000METHOD : This research is a randomized controlled trial pre-test and post-test-controlled group design. The sampling method used in this study is the simple random sampling method. The sample size was 27 subjects and divided into two groups, the LLLT group (n=14) and the HILT group (n=13). Each subject received laser therapy sessions 2 times a week for 4 weeks. Balance was assessed using the BBS before and after the intervention.\u0000RESULT :  There was an increase in BBS scores before and after treatment in the HILT group (p<0.001) and in the LLLT group (p<0.001), with the increase in the HILT group (7.79 ± 2.16) significantly greater than in the LLLT group (3 .08 ± 0.76) (p<0.001).\u0000CONCLUSION : HILT improves balance score better than LLLT.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"67 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences of Dyspareunia in Primipara with 2nd Degree Perineal Laceration Sutured with Rapide Polyglactin 910 and Chromic Catgut Threads","authors":"Satrio Arief Wibowo, Yuli Trisetiyono, Herman Kristanto, Putri Sekar Wiyati, H. Tjahjanto, E. Erwinanto","doi":"10.36408/mhjcm.v11i1.968","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.968","url":null,"abstract":"BACKGROUND: Dyspareunia is persistent or recurrent pain during sexual intercourse. Perineal laceration, spontaneous or episiotomy, is one of the most common causes. Perineal lacerations that occur must be treated through suturing. Chromic catgut is a natural thread that is often used in medical practice, but this thread have a higher inflammatory response compared to Rapide Polyglactin 910.\u0000AIMS: To analyze the difference in the incidence of dyspareunia in primipara with 2nd degree perineal lacerations sutured with Rapide Polyglactin 910 and Chromic catgut threads\u0000METHOD: True experimental research with randomized controlled trial-single blinded method. The research was conducted at dr. Kariadi Semarang, RA Kartini Hospital and dr. Soeselo from August 2022 to February 2023. The research subjects were primipara with 2nd degree perineal lacerations which were divided into 2 groups, namely 45 subjects in the Chromic catgut group and 45 subjects in the Rapide Polyglactin 910 group. Evaluation of dyspareunia after 3 months was carried out using the Female Sexual Function Index (FSFI)\u0000RESULT:  Subjects sutured using Chromic catgut had a 2.7 times greater risk of experiencing dyspareunia when compared to using Rapide Polyglactin 910 (OR=2.7; 95% CI=1.1-6.6). A significant confounding factor was found, namely the act of episiotomy (p=0.047; OR=9.56; 95% CI=1.86 - 48.97). After controlling for these variables, the subjects who were sewn using Chromic had a significant risk (p=0.002, OR=5.39; 95% CI=1.76-16.50)\u0000CONCLUSION: Subjects with Chromic catgut have a higher risk of experiencing dyspareunia than using Rapide Polyglactin 910 threads after 3 months of suturing.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"58 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Associated Plasma Protein-A (PAPP-A) as a Marker to Distinguish Normotensive with Early 2nd Trimester and Late 3rd Trimester Onset of Preeclampsia","authors":"Ragam Pesona Simangunsong, Herman Kristanto, Mirza Iskandar, Syarief Thaufik, B. Pramono, Arufiadi Anityo Mochtar","doi":"10.36408/mhjcm.v11i1.979","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.979","url":null,"abstract":"Introduction: Preeclampsia is a hypertensive condition that occurs after 20 weeks of gestation accompanied by target organ damage. Complications of preeclampsia can cause intrauterine fetal growth retardation, and placental hypoperfusion, even in the most serious situations, namely termination of pregnancy and death of the fetus and/or mother. Pregnancy-associated plasma protein-A (PAPP-A) is a high molecular weight glycoprotein that is produced in the placenta and secreted into the maternal bloodstream. However, based on several studies that have been conducted, there is uncertainty in the results of assessing PAPP-A levels obtained in pregnant women in the second and third trimesters.\u0000Aim: Proving differences in PAPP-A levels in the second and third trimesters in the incidence of early-onset preeclampsia and normotensive pregnancy.\u0000Methods: An analytic observational study with a cross-sectional approach was carried out in the delivery room of RSUP Dr. Kariadi Semarang, Halmahera Health Center, Ngesrep Health Center, Bulu Health Center, and private midwife practice in Semarang City. The subjects of the study were six 2nd-trimester preeclampsia patients, fourteen 3rd-trimester preeclampsia patients, and twenty normotensive pregnancy patients who met the inclusion and exclusion criteria. Data were analyzed using Mann Whitney with a significance of p<0.05\u0000Results: There was a significant difference in PAPP-A levels (p<0.001) between the preeclampsia and normotensive pregnancy groups, whereas PAPP-A levels were higher in the preeclampsia group. There were significant differences in PAPP-A levels (p<0.001) between the 2nd-trimester preeclampsia, 3rd-trimester preeclampsia, and normotensive pregnancies, where the highest PAPP-A levels were found in the 2nd-trimester preeclampsia group.\u0000Conclusion: There was a significant difference in PAPP-A levels between the second and third trimesters of early-onset preeclampsia compared to normotensive pregnancies, where PAPP-A levels were higher in the second and third trimesters of early-onset preeclampsia. Elevated PAPP-A levels in the second and third trimesters are associated with an increased risk of early-onset preeclampsia.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"16 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Kelly Plication Method on Clinical Improvement in Stress Urinary Incontinence Patients","authors":"Puspitasari Notohatmodjo, B. Pramono, Inu Mulyantoro, Herman Kristanto, Dewi Astri Purnaningtyas, Arufiadi Anityo Mochtar, Erwinanto Mulyantoro","doi":"10.36408/mhjcm.v11i1.1032","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.1032","url":null,"abstract":"BACKGROUND: Patients with pelvic organ prolapse (POP) usually present with POP, but stress urinary incontinence (SUI) is also found during history taking and physical examination. As a result, the complaint of SUI is persistent despite POP surgery. Therefore, SUI found along with POP and undergoing surgery can be performed Kelly plication method.\u0000OBJECTIVES: To examine the effectiveness of Kelly's plication method on clinical changes and quality of life of patients suffering from SUI.\u0000METHODS: A single cohort prospective one-group pretest-posttest design conducted at RSUP Dr. Kariadi Teaching Hospital Semarang involving 31 research subjects. All subjects were measured preoperative IIQ-7 questionnaire and pad test. Then, all subjects will undergo Kelly method surgery. Postoperative evaluation will be conducted 3 months later, including measurement of the IIQ-7 questionnaire and pad test. All data will be analyzed with univariate and bivariate analysis using paired t-test and Wilcoxon test.\u0000RESULTS:  The effectiveness rate of Kelly's plication method was 58.06% in this study. Most of the subjects were aged 50-59 (38.7%) years and had experienced menopause (87.1%). Correlation analysis of baseline data on the degree of preoperative SUI showed that the degree of POP correlated SUI. The Pad test and IIQ-7 questionnaire test showed a significant decrease in postoperative measurements in the treatment group (p: <0.001 & p: <0.001).\u0000CONCLUSIONS: Kelly's plication method is effective in treating SUI.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"141 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Relationship between Neutrophils, Lymphocytes, and Comorbidities with Time to Death in COVID-19 Patients","authors":"Hendra Tanuwijaya, Susanthy Djajalaksana, Rezki Tantular","doi":"10.36408/mhjcm.v11i1.932","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.932","url":null,"abstract":"BACKGROUND: COVID-19 caused 5.4 million deaths in 2021. Various parameters such as comorbidities and laboratory findings are known to be predictors of death in COVID-19, but these findings differ in each country, and their relationship to time of death has not been widely studied. This study was conducted to determine the relationship between levels of neutrophils, lymphocytes, neutrophil to lymphocyte ratio (NLR), and comorbidities with time to death in COVID-19.\u0000METHODS: A retrospective cohort study was conducted from April 2020 to September 2021 in the COVID-19 Inpatient Room at RSUD dr. Saiful Anwar Malang with 300 COVID-19 patient subjects aged 18 years and over. Data on comorbidities (hypertension, CAD, HF, obesity, COPD, CKD, cancer), time to death, and laboratory were taken from medical records. The Kolmogorov-Smirnov test, Chi square test and Mann Whitney test were carried out to analyze the data.\u0000RESULTS: There was a significant relationship between neutrophil levels and time to death, as well as a significant difference in neutrophil levels in the group with time to death >48 hours with comorbidities compared to <48 hours with and without comorbidities. There was a significant difference in lymphocyte levels and NLR in patients with comorbidities with time to death <48 hours and >48 hours (p < 0.05).\u0000CONCLUSION: There is a significant relationship between neutrophil levels and time to death, both in subjects with and without comorbidities showing the potential of neutrophil levels as a predictor of time to death in COVID-19.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"128 49","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Serum Malondialdehyde (MDA) Levels With Seizure Frequency In Epilepsy Patients With Combination Of Phenytoin And Valproic Acid","authors":"Aji Noegroho, A. Bintoro, Dwi Pudjonarko","doi":"10.36408/mhjcm.v11i1.987","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.987","url":null,"abstract":"Background: Oxidative stress is believed to be one of the factors involved in the pathogenesis of epileptogenic where lipid peroxidation occurs which produces Malondialdehyde (MDA). Epilepsy and some Antiepileptic Drugs (AEDs) can improve or worsen seizure frequency thereby significantly changing blood MDA levels.\u0000 \u0000Objective: To determine the relationship between serum MDA levels and seizure frequency in epileptic patients treated with AEDs, a combination of phenytoin and valproic acid.\u0000 \u0000Methods: A cross-sectional study with consecutive sampling of 46 subjects (with epilepsy receiving combination therapy with phenytoin and valproic acid. The research was conducted at the Neurology Policlinic at RSUP Dr. Kariadi in December 2022 – February 2023. MDA levels were measured using the Enzyme Linked Immunosorbent Assay (ELISA) method. The relationship between serum MDA levels and seizure frequency was analyzed using Spearman's test since both of the variables are ordinal scale, the results were significant if p<0.05.\u0000 \u0000Results: There was no relationship between MDA levels and seizure frequency in epileptic patients with the combination of phenytoin and valproic acid. (p=0.516) There is a significant relationship between the frequency of seizures and the length of treatment (p=0.026) with a weak negative correlation (rho=0.328). There is a significant relationship between the frequency of seizures and the age of onset of epilepsy (p=0.037) with a weak negative correlation (rho=0.309).\u0000Conclusion: There is a significant relationship between the frequency of seizures with the length of treatment and the age of onset of epilepsy.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"13 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicular Ameloblastoma of Maxillary: A Case Report","authors":"Athalaila Azzahrasukma Sakuntala, Septa Santiya Arini, Johanna Kezia Prajogo, Muhammad Reza Pahlevi","doi":"10.36408/mhjcm.v11i1.1048","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.1048","url":null,"abstract":"Introduction: Ameloblastoma is a benign odontogenic tumor that appears in the mandible and maxilla. Ameloblastoma has slow growth that takes several years for symptoms to appear, but ameloblastoma in the maxilla has a more aggressive clinical course compared to the mandible. The lack of initial symptoms leading to diagnosis at an advanced disease when the tumour has already extended beyond maxilla. The cancellous structure of the maxillary bone makes it easier for tumors to spread to the nasal cavity, paranasal sinuses, orbitals, parapharyngeal tissue and skull base. This article reports a case of resection of maxillary ameloblastoma.\u0000Case Report: A 63 year old female patient came with complaints of a lump on her right cheek since 2 years back that gradually increased in size. Since 2 months ago, pus and blood have been coming out of the lump. Extra oral examination revealed a well-defined mass with a solid and hard consistency, there were no ulcers or fistulas. Intraorally, a mass measuring 5x5x3cm was found in the region of teeth 12 to 15 which extended to the buccal-palatal area. History of allergies and weight loss was denied. Supporting examinations including panoramic radiography, PA chest radiography, CT-Scan, FNAB, and biopsy resulted in a diagnosis of ameloblastoma. Treatment was carried out by resection of the right maxillary tumor mass under general anesthesia.\u0000Discussion: In this case, the patient's clinical examination showed a hard and large palpable swelling in the right maxilla area which extended from the region of tooth 12 to tooth 15 which caused facial asymmetry and no tooth mobility was found. This hard and painless swelling takes about 2 years before the patient experiences symptoms of pus and blood discharge. The post-maxillectomy defect in this case was covered with an intraoral prosthesis in the form of a post-surgical obturator made of acrylic resin. The obturator functions to hold the surgical packing, and prevent food or dirt contamination in the defect area which can cause infection and slow healing. The use of a prosthesis also helps restore swallowing and speech function to the patient.\u0000Conlussion: In principle, the treatment for ameloblastoma is resection of the involved bone, as in this case the action taken is a maxillectomy. Maxillectomy can result in facial and oral cavity deformities characterised by facial disfigurement and alterations in oral functionality.Therefore, maxillary reconstruction is needed to treat maxillary defects after surgical procedures involving the loss of part or all of the maxilla.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"96 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Volatile Organic Compounds (VOC) with Leukotriene B4 and Eosinophil Counts in Chronic Obstructive Pulmonary Disease Patients","authors":"Andrew Santosa, Ngakan Putu Parsama Putra, A. Listyoko, Arinto Yudi Ponco Wardoyo, N. Setijowati","doi":"10.36408/mhjcm.v11i1.1035","DOIUrl":"https://doi.org/10.36408/mhjcm.v11i1.1035","url":null,"abstract":"BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disorder characterized by increasing Leukotriene B4 (LTB4) and eosinophil counts. Volatile organic compounds (VOCs) have shown promise as non-invasive biomarkers, reflecting COPD pathophysiology. Identifying specific VOCs associated with increased LTB4 and eosinophil counts could lead to the discovery of potential biomarkers for COPD severity or progression.\u0000AIMS: This study aims to investigate the correlation between VOCs and leukotriene B4 (LTB4) levels, as well as eosinophil counts counts in COPD patients.\u0000METHOD: Using an observational-analytic method with a case-control approach, 20 COPD patients and 20 controls were enrolled from the respiratory outpatient department of Dr. Saiful Anwar General Hospital, Malang. VOC levels were measured using a breath analyzer, while LTB4 levels were determined through enzyme-linked immunosorbent assays. Spearman’s correlation tests examined associations between VOCs, LTB4, eosinophil counts, and comorbidity, with Mann-Whitney tests comparing results against the control group. Data significance was set at p < 0.05.\u0000RESULT: There were 40 COPD patients and 40 controls in this study. There were significant differences between VOCs in the COPD group and the control group (p < 0.05). LTB4 level significantly increased in the COPD group than in the control group (p < 0.001), and there was no difference in the eosinophil level. There was a correlation between LTB4 and VOC level of C2H5OH in COPD patients (p = 0.009; r = 0.410). There was no correlation between eosinophil counts and VOCs (p = 0.939). The level of VOCs was significantly different between patients with only COPD and patients with COPD and comorbid lung cancer (p < 0.05).\u0000CONCLUSION: There is a correlation between VOC and LTB4 in COPD patients.","PeriodicalId":117574,"journal":{"name":"Medica Hospitalia : Journal of Clinical Medicine","volume":"1 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140373319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}