Egyptian Journal of Radiation Sciences and Applications最新文献_第6页

The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats 阿魏酸对γ辐射诱导大鼠卵巢功能衰竭的潜在保护作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-08-01 DOI: 10.21608/EJRSA.2019.6608.1058

S. M. A. Fattah, Heba Karam Mohmed, M. Mohamed

{"title":"The potential protective effect of Ferulic acid against gamma irradiation induced ovarian failure in rats","authors":"S. M. A. Fattah, Heba Karam Mohmed, M. Mohamed","doi":"10.21608/EJRSA.2019.6608.1058","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.6608.1058","url":null,"abstract":"This study aims to evaluate the radioprotective effect of Ferulic acid (FA) against ovarian damage in premature female rats. Four groups of female rats were used (ten rats in each group). Group (1): Control, Group (2): Irradiation (IRR) (rats were exposed to 4Gy of whole body gamma irradiation as a single dose), Group (3): FA (rats received 50mg/kgb.wt of Ferulic acid orally for two weeks) and Group (4): FA+IRR (rats received Ferulic acid as group 3 then exposed to 4Gy as group2). The rats were sacrificed after 24h of irradiation. The level of FSH, LH, and E2were estimated in the serum. The level of H2O2 and GPx activity and the gene expression of cytochrome C, P53 and caspase3 were evaluated in ovarian tissue. Histopathological examination of the ovary and uterus tissues was performed. The results revealed that gamma irradiation caused an elevation in FSH, LH, H2O2, cytochrome C, P53 and caspase3 and a decline in E2 and GPx. The administration of FA prior gamma irradiation led to an improvement in female hormones, H2O2, GPx and apoptotic markers and matched the histopathological examination results. It could be concluded that Ferulic acid may exert aradioprotective effect against irradiation induced apoptosis in the ovary of rats and alteration in the level of serum female hormones.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91494047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ameliorative role of Teucrium polium extract on γ-radiation toxicity in brain of albino rats 茯苓提取物对白化大鼠脑γ-辐射毒性的改善作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-08-01 DOI: 10.21608/EJRSA.2019.9867.1065

M. Saif-Elnasr, S. M. A. Fattah, T. Mohamed

{"title":"Ameliorative role of Teucrium polium extract on γ-radiation toxicity in brain of albino rats","authors":"M. Saif-Elnasr, S. M. A. Fattah, T. Mohamed","doi":"10.21608/EJRSA.2019.9867.1065","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.9867.1065","url":null,"abstract":"The impairment to the healthy brain tissue is a crucial factor limiting the application of radiation therapy in patients with nervous system neoplasms. Teucrium polium (TP) L. (family Lamiaceae), a wild-growing flowering plant, has beneficial curative properties. The flavonoids of TP have many valuable biological activities. This study aims atinvestigating theameliorative effect of TP extract on γ-radiation toxicity in brain of albino rats. Thirty adult male albino rats were used. Ionizing irradiation was performed by whole body exposure of rats to 8Gy. TP was administered by intragastric tube in a dose of 200mg/kg body weight. Animals were divided into five groups: Group I (control), Group II (TP), Group III (γ-irradiated), Group IV (TP+γ-irradiated) and Group V (TP+γ-irradiated+TP). The action of TP extract was investigated after one week post irradiation by measuring serum liver and renal functions, and oxidative stress parameters in brain tissue. Moreover, serum S100B and brain-derived neurotrophic factor (BDNF) in brain tissue were measured, in addition tohistopathological examination. TP at a dose of 200mg/kg body weight did not have hepatotoxic or nephrotoxic effects.TP extract significantly ameliorated γ-radiation-induced brain damage by improving radiationinduced oxidative stress. The role of the extract was confirmed by improvement of the levels of S100B in the serum and BDNF in the brain as well as amelioration of histopathological changes induced by radiation. The administration of TP before and after irradiation was more effective than administration only before irradiation. These results revealed that the administration of TP extract might ameliorate γ-radiation-induced brain injury by the attenuation of oxidative stress, the regulation of BDNF and the suppression of S100B.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73654219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Response 5-phosphomevalonate Kinase Enzymes to Low Doses of Gamma Radiation and Its Related to the Production of Terpenoids Indole Alkaloids from Catharanthus rouses 5-磷酸戊酸激酶对低剂量γ辐射的响应及其与花楸萜类吲哚类生物碱生产的关系

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-08-01 DOI: 10.21608/EJRSA.2019.7148.1061

I. Salama, G. Ali, M. K. A. el-Megid

{"title":"Response 5-phosphomevalonate Kinase Enzymes to Low Doses of Gamma Radiation and Its Related to the Production of Terpenoids Indole Alkaloids from Catharanthus rouses","authors":"I. Salama, G. Ali, M. K. A. el-Megid","doi":"10.21608/EJRSA.2019.7148.1061","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.7148.1061","url":null,"abstract":"GAMMA rays effect, on different dose levels on the production of ajmalicine as well as 5-phosphomevalonate kinase enzyme activety, was studied in Catharanthus roseus cell suspension cultures. The seedlings were taken from the young leaf puds and grown on MS solid medium for 7 weeks. Calli individual serially sub cultured by transfing to maintenance medium consisting of Gamborg’s B5 medium. Cell suspensions were exposed to gamma rays after 4 weeks at dose levels of 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5 and 8Gy. Ajmalicine quantities were analyzed on VIS–spectrophotometer; also, the 5-phosphomevalonate kinase enzyme was particularly purified by ultrafiltration and activety analayzed, in addition, native PAGE electrophoresis was determined. 5-phosphomevalonate kinase enzyme bands and ajmalicine accumulation quantities were changed after the exposure to low doses from 1 to 6Gy, but the higher doses were lethal. The appropriated doses to activety of 5-phosphomevalonate kinase enzyme and Ajmalicine production were from 1 to 5Gy. Other dose levels (5.5 and 6Gy) did not affect on the 5-phosphomevalonate kinase enzyme activety and Ajmalicine production.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88631055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stimulating Effect of Gamma Radiation on Some Active Compounds in Eggplant Fruits γ辐射对茄子果实中某些活性物质的刺激作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-08-01 DOI: 10.21608/EJRSA.2019.10024.1066

A. Aly, N. Eliwa, M. Abdel-Megid

{"title":"Stimulating Effect of Gamma Radiation on Some Active Compounds in Eggplant Fruits","authors":"A. Aly, N. Eliwa, M. Abdel-Megid","doi":"10.21608/EJRSA.2019.10024.1066","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.10024.1066","url":null,"abstract":"A FIELD experiment was performed to study the effect of gamma irradiation (0.0, 50 and 100Gy) on growth parameters and bioactive compounds of different parts of eggplant. All growth parameters studied showed an increase when using a dose of 50Gy gamma rays. Also, 50Gy increased total phenolic contents (2.140, 4.039 and 2.965mg/g DW) for pulp, peel and whole fruits, respectively. A dose level at 50Gy increased flavonoid contents (0.835, 4.301 and 3.166mg/g DW) for pulp, peel and whole fruits, respectively. Moreover, tannin contents increased at a dose of 50Gy to (5.853, 7.94 and 7.79mg/g DW) for pulp, peel and whole fruits respectively; the highest contents were detected in peels followed by the whole fruits and the pulps. The DPPH radical scavenging activity of eggplant extracts varies according to the plant part. The antioxidant activity in the whole fruit was less than the peel and pulp while the highest antioxidant activity was in the peel. Otherwise, the amino acid and total soluble protein contents were higher in pulp in all treatments. Phenyl alanine ammonia-lyase (PAL) enzyme and polyphenol oxidase enzyme showed increases in their activities as gamma radiation increased to 50Gy, while increasing irradiation dose level to 100Gy reduces both enzyme activities. FT-IR showed the appearance and disappearance of function group in control and irradiated plants. Meanwhile, the results confirmed the presence of C-H stretching phenol (1020cm-1), alkane C-H blending (1450cm-1) and O-H stretching, lipid at (1450cm-1), and carbohydrate amino acids (3940.39cm-1) in eggplant plants different parts control and irradiated.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81667910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Application of Metakaolin-slag Binders to Solidify Rad-waste Glass Sharps: Leaching of 137Cs and 152+154Eu Radionuclides 偏高岭土-矿渣粘结剂固化放射性废料玻璃刀具:137Cs和152+154Eu放射性核素的浸出

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-07-10 DOI: 10.21608/EJRSA.2019.13301.1072

M. R. El-Naggar, M. Ali, A. El‐Sadek, H. El-Said

{"title":"Application of Metakaolin-slag Binders to Solidify Rad-waste Glass Sharps: Leaching of 137Cs and 152+154Eu Radionuclides","authors":"M. R. El-Naggar, M. Ali, A. El‐Sadek, H. El-Said","doi":"10.21608/EJRSA.2019.13301.1072","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.13301.1072","url":null,"abstract":"METAKAOLIN (MK) and blast furnace slag (BFS) were utilized to design alkali activated binders suitable for solidification of waste glass (WG sharps contaminated with 137Cs and 152+154Eu radionuclides). Two forms of WG, powdered and fused, were utilized. Effects of WG forms and BFS addition on the ability of formulations to withstand compression were preliminary studied. When cold powdered WG was solidified the corresponding compressive strength (MPa) values were decreased by increasing the loading percentages. While fused forms were positively affected MPa values till 10.0% loading. Positive relations between BFS addition and MPa values were also detected. Leaching of 137Cs and 152+154Eu from MK-based formulations was followed as affected by WG forms, BFS addition and early age (2hr) curing temperatures. Both studied radionuclides were cumulatively leached in larger fractions from solidified powdered WG than from fused one. The obtained results reflected the ability of the designed formulations to retain 137Cs in greater extents than 152+154Eu. The lowest diffusion coefficient values (2.01×10-11 and 3.92×10-10cm2/s) were recorded when fused forms of WG containing 137Cs and 152+154Eu, respectively, were solidified into slag seeded MK-based formulations, early aged cured at 40°C. Slope values of log(CLF) vs. log(time) plots were < 0.35 indicating that the controlling leaching mechanisms for all studied leaching systems were predicted to be wash-off.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89637203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of 186Re-Cefixime as a Potential Diagnostic and Therapeutic Agent for Bacterial Infection 186re -头孢克肟作为细菌感染潜在诊断和治疗药物的制备

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-07-01 DOI: 10.21608/EJRSA.2019.6992.1059

H. Talaat, M. Aydia, I. T. Ibrahim, H. El-Said, K. M. El-Azony

引用次数: 1

Alteration of Cell Mediated Immunity in Vitiligo Patients Using Narrow Band UVB as a Treatment. 窄带UVB治疗白癜风患者细胞免疫功能的改变。

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-06-11 DOI: 10.21608/EJRSA.2019.11066.1067

N. F. Ibrahim, Nashwa K. Radwan, L. Rashed

引用次数: 0

The Impact of 950mhz Electromagnetic Radiation on the Brain and Liver of Rats and the role of Garlic Treatment 950mhz电磁辐射对大鼠脑、肝的影响及大蒜的治疗作用

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-05-12 DOI: 10.21608/EJRSA.2019.7814.1063

S. Shedid, Ghada A. El-Tawill, Fatma R. Algeda, Neama N. El-Fatih, N. Eltahawy

{"title":"The Impact of 950mhz Electromagnetic Radiation on the Brain and Liver of Rats and the role of Garlic Treatment","authors":"S. Shedid, Ghada A. El-Tawill, Fatma R. Algeda, Neama N. El-Fatih, N. Eltahawy","doi":"10.21608/EJRSA.2019.7814.1063","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.7814.1063","url":null,"abstract":"The use of mobile phones, laptops and wireless networks has become essential components of daily life. However, despite they make life easier, they may also cause a number of health problems.This study aims at investigating the changes induced in the liver and brain of male albino rats caused by the exposure to 950MHz and the role of garlic treatment. Male Albino rats were exposed to 950MHz electromagnetic field (power density of 1mW/cm2). Whole body average specific absorption rates (SAR) were 0.238 and 0.372, respectively, for duration of one hour, thrice a week for a period of seven weeks. Garlic extract was administered to the rats at a doseof 500mg/kg body weight, half an hour before each exposure. Animals were sacrificed one day post the last exposure dose. Exposure to 950MHz has triggered oxidative stress in both tissues verified by a significant increase of malondialdehyde (MDA) and nitric oxide (NO) associated with a significant decrease in the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). Exposure to 950MHz has also induced alteration in the xanthine oxidoreductase system (XOR) identified by a significant increase in the activity of xanthine oxidase (XO) concomitant to a significant decrease of xanthine dehydrogenase. The results showed also accumulation of iron (Fe), and cupper (Cu), and decreases in zinc (Zn) and manganese (Mn). Garlic extract treatment has significantly improved these changes. In conclusion, Garlic might attenuate the impact of 950MHz in liver and brain of male rats.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79036650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Comparative study of gamma radiation and prednisolone induced submandibular salivary gland oxidative damage 伽玛辐射与强的松龙诱导颌下腺氧化损伤的比较研究

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-03-06 DOI: 10.21608/EJRSA.2019.4300.1043

S. Ahmed

{"title":"Comparative study of gamma radiation and prednisolone induced submandibular salivary gland oxidative damage","authors":"S. Ahmed","doi":"10.21608/EJRSA.2019.4300.1043","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.4300.1043","url":null,"abstract":"The most pronounced salivary dysfunction occurs in patients taking medications that interfere with salivary secretory processes and those who have received therapeutic irradiation. The aim of the present study is to investigate the effect of gamma radiation and prednisolone treatment on submandibular salivary glands. Forty eight female Albino rats weredivided into four groups. Group C serves as control; group P was treated with Depo-Medrol; group R was exposed to whole body gamma radiation and group PR is similar to the previous one in addition, it has received Depo-Medrol. The submandibular glands were obtained three and seven days post-irradiation. Gamma-irradiation induced vacuolization of all gland compartments, acinar atrophy and degeneration of striated ducts and granular convoluted tubules. In group P, the acini lost their outline with shrinkage of some acini. The striated ducts represented variable degree of degeneration, lumen narrowing. Nuclear fragmentation was detected in duct and granular convoluted tubule cells. All previously mentioned manifestations were detected in an exaggerated manner in group PR. Thetotal glutathione content and glutathione-peroxidase activity significantly decreased in all experimental groups. Activity of superoxide dismutase significantly decreased in R group, while it was not affected in P and PR groups. Total protein content significantly decreased in R group in contrast to P group, where a significant increase was observed. In PR group, it was not affected at day 3, but it significantly decreased at day 7. In conclusion, either gamma radiation orprednisolone induced submandibular salivary gland oxidative stress; however, their combined use ameliorated, to some extent, gamma radiation induced oxidative damage.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90864310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiographic and Histopathologic Evaluation of L-Carnitine and vitamin E Efficacy on Irradiated Jaw Bones 左旋肉碱和维生素E对辐照颌骨的放射学和组织病理学评价

Egyptian Journal of Radiation Sciences and Applications Pub Date : 2019-01-20 DOI: 10.21608/EJRSA.2019.3684.1057

A. Sayed, Osama El-Shall, D. Husseiny, M. Attia, S. Ahmed

{"title":"Radiographic and Histopathologic Evaluation of L-Carnitine and vitamin E Efficacy on Irradiated Jaw Bones","authors":"A. Sayed, Osama El-Shall, D. Husseiny, M. Attia, S. Ahmed","doi":"10.21608/EJRSA.2019.3684.1057","DOIUrl":"https://doi.org/10.21608/EJRSA.2019.3684.1057","url":null,"abstract":"The aim of this study is to evaluate the efficacy of L-Carnitine and vitamin E alone or in combination on irradiated jaw bones in rats through radiographic assessment of the bone density and histopathologic examination of bone morphology. Forty male albino rats were divided randomly into 4 groups each of 10 rats. Group R represented the rats that received fractionated radiation dose (2 Gray per fraction) for one week. Groups LR, ER and LER represented the rats that received L-Carnitine 300mg/kg via intra peritoneal injection, vitamin E 40mg/kg via intramuscular injection or both daily for five days and then exposed to fractionated radiation 2 Gray day after day for one week after the last treatment, respectively. Data revealed a significant improvement of mandibular bone density in the groups received L-Carnitine, vitamin E alone or in combination as compared to the gamma-irradiated group. Moreover, the treated groups showed almost normal morphology of both mandibular bone and periodontal ligament in contrast to the gamma irradiated group where bone resorption and periodontal ligament degeneration and vacuolization were detected. In conclusion, gamma radiation had a deleterious effect on mandibular bone and periodontal ligament as indicated by decreased bone density and altered morphology. In addition, L-Carnitine and vitamin E treatment alone or in combination could, to a large extent, maintain the normal bone density and preserve the morphological architecture of mandibular bone and periodontal ligament.","PeriodicalId":11658,"journal":{"name":"Egyptian Journal of Radiation Sciences and Applications","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83572966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0