Endocrine regulations最新文献

{"title":"Endogenous intoxication and morpho-functional changes in the liver during experimental acute generalized peritonitis in diabetic rats.","authors":"Bohdana Verveha, Mariana Kondro, Petro Bodnar","doi":"10.2478/enr-2025-0027","DOIUrl":"10.2478/enr-2025-0027","url":null,"abstract":"<p><p><b>Objective.</b> The study aims to evaluate the severity of endogenous intoxication and characterize morpho-functional liver changes during experimental acute generalized peritonitis (AGP) in diabetic rats. <b>Methods.</b> Fifty-six adult male Wistar rats were used, including 8 controls and 48 males with experimental pathology. Diabetes mellitus was induced by an intraperitoneal (i.p.) injection of streptozotocin (60 mg/kg). On day 14, AGP was induced by i.p. injection of a 10% filtered fecal suspension. Endogenous intoxication was assessed by measuring hydrophilic and hydrophobic molecular products in the blood. Liver function was evaluated by serum aminotransferase activity, total protein, and protein fractions. Histological analysis of liver tissue was performed using standard hematoxylin-eosin staining. <b>Results.</b> A progressive increase in endogenous intoxication was observed peaking on day 7. This was marked by a significant elevation in middle molecular weight molecule (MMWM) concentrations at wavelengths of 254 nm and 280 nm by 103.0% (p<0.001) and 340.0% (p<0.001), respectively. The erythrocyte intoxication index (EII) increased by 148.8% (p<0.001) compared to controls. Concurrently, aminotransferase activity increased, while serum total protein and albumin levels decreased. Histologically, inflammatory infiltration and vascular congestion were evident on day 1 progressing to hepatocellular dystrophy and necrosis by day 3. By day 7, signs of hepatic failure were present including disruption of trabecular architecture, hydropic degeneration, intra-cellular cholestasis, and portal tract expansion due to vascular hyperemia. <b>Conclusions.</b> Experimental acute generalized peritonitis in diabetic rats resulted in a pronounced endogenous intoxication accompanied by progressive morpho-functional liver damage culminating in hepatic insufficiency by day 7.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"236-243"},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-radiation hypothyroidism in patients with head and neck tumors: An overview assessment.","authors":"Elena Bukvayova, Maria Kafkova","doi":"10.2478/enr-2025-0029","DOIUrl":"10.2478/enr-2025-0029","url":null,"abstract":"<p><p>Head and neck tumors are common in Slovakia. Although the number of tumors associated with smoking and alcohol is decreasing, the number of tumors associated with human papilloma-virus increases. Radiotherapy plays an important role in their treatment. The thyroid gland, due to its oneself location, is predisposed to the development of post-radiation dysfunction. Nowadays, there are methods able to reduce this risk and also available new options for treatment and dispensary care for these patients. The aim of this work is to analyze the incidence and pathophysiological mechanisms of post-radiation hypothyroidism in patients with head and neck tumors, to highlight the risk factors associated with radiotherapy and evaluation of prevention possibilities and treatments, and an overview of modern therapeutic approaches. Special attention is devoted to the importance of a multidisciplinary approach and the need for a long-term patient monitoring as well as the assessment of thyroid function as an integral part of a comprehensive oncological care.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"255-259"},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperprolactinemia alters insulin resistance profiles in overweight males.","authors":"Hazem Mohamed Rashed, Samah El-Ghlban, Mohamed Khaled Mahfouz, Yasmin Mohamed Abdel-Rahman Marie","doi":"10.2478/enr-2025-0018","DOIUrl":"10.2478/enr-2025-0018","url":null,"abstract":"<p><p><b>Objective.</b> Elevated prolactin levels (hyperprolactinemia) is an endocrine disorder associated with metabolic dysfunctions such as insulin resistance, obesity, dyslipidemia, and glucose intolerance on many occasions. Type 2 diabetes mellitus (T2DM) is a major risk factor for insulin resistance, which is one of the most important determinants of overweight males for hyperprolactinemia. The purpose of this study was to investigate the impact of hyperprolactinemia on insulin resistance parameters including HOMA-IR, QUICKI, TG/HDL, and TyG index values in overweight male patients. <b>Patients and Methods.</b> A total of 90 participants were involved in a case-control study including 45 overweight males with hyperprolactinemia and 45 age- and BMI-matched healthy controls. Blood samples were collected for measurement of fasting glucose, insulin, lipid profile, testosterone, and prolactin. HOMA-IR, QUICKI, TyG index, TG/HDL ratio were used to assess insulin resistance. <b>Results.</b> In hyperprolactinemic individuals, fasting insulin levels, HOMA-IR, and the TyG index were elevated, which indicates increased insulin resistance. In addition, these patients had lower QUICKI values corresponding to lower insulin sensitivity. This was also related to the fact that there was a significant elevation in triglycerides and LDL levels as well as a decrease in HDL. Testosterone was turned negatively with high prolactin level (p<0.01), followed by insulin resistance markers, which were positively correlated with increased prolactin (p<0.001). <b>Conclusions.</b> The results suggest that hyperprolactinemia has a strong association with insulin resistance in overweight males. The elevated prolactin levels found in testosterone deficiency also led to a dysregulated glucose metabolism and lipid abnormalities, and hormonal imbalance underlying the rationale for early screening and metabolic interventions.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"160-166"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propylthiouracil-induced agranulocytosis complicated by severe infection in a patient with Graves' disease: A case report.","authors":"Jens Skjoldan Svenningsen, Djordje Marina","doi":"10.2478/enr-2025-0022","DOIUrl":"10.2478/enr-2025-0022","url":null,"abstract":"<p><p><b>Objective.</b> Graves' disease is an autoimmune disease of the thyroid gland causing hyperthyroidism due to thyroid-stimulating hormone receptor autoantibodies. A rare, but serious complication of anti-thyroid drug therapy is agranulocytosis, a critical reduction in granulocytes leading to neutropenia and impaired infection defense. <b>Case report.</b> We report a case of a 32-year-old woman with Graves' disease who developed propylthiouracil-induced agranulocytosis and pancytopenia with concurrent severe infection. The patient was treated with antibiotics and granulocyte colony-stimulating factor ultimately undergoing total thyroidectomy. <b>Conclusion.</b> The case highlights a rare, but potentially life-threatening complication of antithyroid drug therapy. We emphasize the importance of close monitoring of patients treated with anti-thyroid drugs. Early recognition and prompt intervention are crucial as agranulocytosis is not always symptomatic. Additionally, early thyroidectomy should be considered in women of childbearing age as recurrent disease flares and therapeutic switching not only increase the risk of agranulocytosis and infection, but may also delay pregnancy.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"195-198"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of aripiprazole and improved living conditions on behavioral manifestations and neurogenic markers expression in an animal model of PTSD.","authors":"Jana Osacka, Lubica Horvathova, Lila Dziewiczova, Andrej Mifkovic, Alexander Kiss, Andrej Tillinger","doi":"10.2478/enr-2025-0021","DOIUrl":"10.2478/enr-2025-0021","url":null,"abstract":"<p><p><b>Objective.</b> Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop after exposure to a severe traumatic event and is connected with behavioral changes and adult neurogenesis impairment. Atypical antipsychotics including aripiprazole (ARI) or enriched environment can ameliorate disturbances connected to PTSD. This study was aimed to reveal whether ARI treatment supplemented by improved living conditions, i.e. toy rotation (TR), will ameliorate behavioral outcomes and reverse assumed changes in neurogenesis more effectively than sole ARI treatment in a single prolonged stress (SPS) animal model of PTSD. <b>Methods.</b> Adult male Sprague-Dawley rats weighing 176-200 g were randomly assigned to 5 experimental groups: (1) VEH - control non-stressed animals injected with vehicle (VEH, 2% Tween 20 in the saline); (2) SPS - animals exposed to SPS injected with VEH; (3) SPS+ARI - SPS animals injected with ARI (5 mg/kg in VEH); (4) SPS+TR - SPS animals exposed to TR and injected with VEH; (5) SPS+ARI+TR - SPS animals exposed to TR and injected with ARI. Animals in TR groups were housed in the standard cages with two toys per cage, which were replaced every other day. Elevated plus maze (EPM), open field (OF), and novel object recognition test (NOR) were used to assess the anxiety-like behavior and learning/memory. Changes in gene and protein expression of selected neurogenic markers (BDNF, GFAP, Sox2, DCX, NeuN) and transcription factors (ΔFosB, pCREB) in the subventricular zone (SVZ) and the gyrus dentatus (GD) of the hippocampus were determined by semi-quantitative real-time PCR and immunohistochemistry, respectively. <b>Results.</b> SPS animals showed increased anxiety-like behavior that was suppressed by TR and ARI+TR treatment combination. Although SPS did not affect the expression of studied neurogenic markers, ARI treatment increased the expression of doublecortin in the SVZ and TR increased expression of NeuN in the GD of PTSD-like animals. TR enhanced ARI effect on NeuN expression in the SVZ. SPS induced increase of ΔFosB positive cells, which was reduced by ARI+TR complementary treatment. <b>Conclusions.</b> Obtained results indicate that TR, in contrary to ARI, suppressed the anxiety-like behavior in PTSD-like animals. SPS does not affect the neurogenic markers expression in the SVZ or GD, but ARI and TR or their combination seems to increase the survival of the newborn cells.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"181-194"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of GHRL (RS696217) and LEPR (RS1137101) gene polymorphisms on hormonal and anthropometric outcomes after bariatric surgery.","authors":"Andrii Prodan","doi":"10.2478/enr-2025-0019","DOIUrl":"10.2478/enr-2025-0019","url":null,"abstract":"<p><p><b>Objective.</b> The aim of the study was to evaluate the influence of GHRL (rs696217) and LEPR (rs1137101) gene polymorphisms on weight loss dynamics and endocrine marker changes following various bariatric procedures. <b>Patients and Methods.</b> A total of 76 patients undergoing laparoscopic sleeve gastrectomy (LSG), gastric plication (LGCP), and gastric artery embolization (GAE) were genotyped for GHRL (rs696217) and LEPR (rs1137101). Body mass index (BMI), total weight loss (TWL), excess weight loss (EWL), and hormonal markers (ghrelin, leptin, adiponectin, resistin, HbA1c) were assessed preoperatively and at 3, 6, and 12 months postoperatively. <b>Results.</b> Carriers of the T allele of GHRL (rs696217) experienced significantly greater reductions in BMI, TWL, and EWL, particularly following LSG and GAE (p<0.05). A notable reduction in total ghrelin levels was observed in T allele carriers (up to -46.75%, p<0.001) 6 months after surgery. Improvements in resistin (p=0.0002) and HbA1c (p=0.014) levels were also more pronounced in this group. LEPR (rs1137101) polymorphism showed limited impact on outcomes after LGCP, but it was associated with improved TWL and EWL in A allele carriers after LSG (p=0.006 and p=0.016, respectively). <b>Conclusion.</b> The T allele of GHRL (rs696217) appears to be a promising predictive marker for greater metabolic and hormonal improvement following bariatric procedures targeting the ghrelin-producing stomach zones. LEPR (rs1137101) may also influence postoperative outcomes in a procedure-specific manner. These findings support the potential role of genetic screening in optimizing patient selection and predicting surgical success.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"167-170"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral health-related behaviors and prevalence of thyroid diseases in Iranian patients.","authors":"Fatemeh Fadakar Davarani, Mojgan Sanjari, Amir Hossein Nekouei, Maryam Alsadat Hashemipour","doi":"10.2478/enr-2025-0017","DOIUrl":"10.2478/enr-2025-0017","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective.&lt;/b&gt; Thyroid disorders can affect the general health-related quality of life with complications such as fatigue, anxiety, depression, and systemic manifestations. The aim of this study was to investigate the relationship between the oral health-related behaviors, the prevalence of thyroid diseases, and the oral health-related quality of the life. &lt;b&gt;Methods.&lt;/b&gt; This cross-sectional and descriptive-analytical study was conducted on 419 patients with a history of thyroid disease and 100 healthy subjects with no thyroid disease as a control group. Demographic information including age, gender, BMI, smoking, alcohol consumption, and medical history was collected through questionnaires and interviews. An assistant of oral diseases evaluated the oral health-related behaviors and objective conditions of oral health status. The objective periodontal evaluation was based on the community periodontal index (CPI) and probing by WHO. The plaque index was examined by giving dental plaque disclosing tablets and chewing them for 30 seconds. Thyroid disease was based on the endocrinologist's opinion and triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) criteria. In this study, to evaluate the oral health-related quality of life, the Oral Health Impact Profile (OHIP-14) questionnaire was used. The obtained results were analyzed using T-test, Multivariate logistic regression analysis, Chi-Square test, and SPSS-21 software. The significance level in data analysis was p&lt;0.05. &lt;b&gt;Results.&lt;/b&gt; Among the 419 patients with a history of thyroid disorders included in the study, 82 (15.8%) had hyperthyroidism (TSH &lt;0.4 mIU/L), 261 (50.3%) had normal thyroid (TSH &lt;5.0 mIU/L), and 76 (14.6%) had hypothyroidism (TSH &gt;5.0 mIU/L). Regarding the observation of the oral and dental health status in the group of participants with no history of thyroid disorder, 64% of subjects with thyroid disorders observed their oral and dental health well, while in the group of subjects with no history of thyroid disorder, 46.9% observed oral health well (p&lt;0.001). The results revealed a significant relationship between the presence of periodontitis and a history of thyroid disorder (p&lt;0.021). During the study, 11% of hyperthyroid patients, 4.6% of participants with normal thyroid status, and 1.3% of hypothyroid patients suffered from periodontitis. The score of oral health-related quality of life in participants without a thyroid disorder history was significantly lower than that with a history of thyroid disorder indicating that their oral healthrelated quality of life is better (p=0.049). &lt;b&gt;Conclusions.&lt;/b&gt; The results revealed a significant relationship between the presence of periodontitis and a history of thyroid disorder. However, there was no significant difference between two experimental groups regarding the presence of microbial plaque. The score of oral health-related quality of life in participants without a history of thyroid disorder","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"147-159"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia and sarcopenic obesity in type 2 diabetes mellitus and cardiovascular disease: current perspective and narrative review.","authors":"Amanpreet Singh Wasir, Jagroop Singh Doad, Jasjeet Singh Wasir, Manish Bansal, Anuradha Rajiv Joshi","doi":"10.2478/enr-2025-0023","DOIUrl":"10.2478/enr-2025-0023","url":null,"abstract":"<p><p>Sarcopenia, initially described as a disease of the elderly and its coexistence with obesity, now termed as 'sarcopenic obesity' (SO), are now emerging to be important health problems worldwide. Their relatively recent recognition as distinct clinical entities with growing research has shown an increasing prevalence of both sarcopenia and SO. There is a strong independent association, which exists between sarcopenia/SO, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). Studies investigating prevalence of sarcopenia/SO indicate considerable heterogeneity, likely due to the lack of a universally accepted definition, differences in age groups, gender, ethnicity, and socio-demographic factors of the population studied, apart from use of distinct diagnostic criteria and methods of estimation based on either muscle mass or strength.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"199-205"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoxic regulation of insulin receptor substrate 2 gene expression is differently regulated by endoplasmic reticulum stress and hydrocortisone in normal human astrocytes and glioblastoma cells.","authors":"Oleksandr H Minchenko, Yuliia M Viletska, Anastasiia I Abramchuk, Myroslava Y Sliusar, Oleh V Halkin, Yevgen P Khikhlo, Serhiy V Danilovskyi, Olha Y Luzina, Dmytro O Minchenko","doi":"10.2478/enr-2025-0020","DOIUrl":"10.2478/enr-2025-0020","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective.&lt;/b&gt; The insulin receptor substrate 2 (IRS2) is phosphorylated by the tyrosine kinase activity of the insulin receptor and the insulin-like growth factor I (IGF-1) receptor upon receptor stimulation. It mediates insulin signaling controlling metabolism as well as cell proliferation and invasion in tumors. Hypoxia and endoplasmic reticulum (ER) stress are significant factors in regulating the growth of malignant tumors including glioblastoma. The present study aims to investigate the regulation of the IRS2 gene expression in normal human astrocytes and U87MG glioblastoma cells by hypoxia and ER stress in the context of the native stress hormone hydrocortisone, which is widely used for the co-treatment of glioblastoma. &lt;b&gt;Methods.&lt;/b&gt; The normal human astrocytes (line NHA/TS) and U87MG glioblastoma cells were used. Hypoxia was introduced by the HIF1A prolyl hydroxylase inhibitor dimethyloxalylglycine (DMOG), which mimics the effects of hypoxia under normoxic conditions. Tunicamycin and thapsigargin were used for the induction of ER stress. Hydrocortisone-water soluble BioReagent, suitable for cell culture (cyclodextrin-encapsulated hydrocortisone) was used. Cells were treated with DMOG, tunicamycin, thapsigargin, and hydrocortisone for 4 h. RNA was extracted with TRIzol reagent. IRS2 gene expression was examined by quantitative real-time RT-PCR and normalized to beta-actin mRNA. &lt;b&gt;Results.&lt;/b&gt; It was found that hypoxia decreased the IRS2 gene expression in normal human astrocytes, but upregulated it in glioblastoma cells. At the same time, hydrocortisone did not significantly change the expression of this gene in both normal astrocytes and glioblastoma cells. However, hypoxia in combination with hydrocortisone strongly increased IRS2 gene expression in both cell types. Tunicamycin decreased the expression of the IRS2 gene in normal astrocytes, but increased it in glioblastoma cells and this effect of tunicamycin was not significantly altered by hypoxia in both cell types. At the same time, thapsigargin did not significantly alter the expression of the IRS2 gene in normal astrocytes, but it strongly upregulated it in glioblastoma cells. Hypoxia modified the effect of thapsigargin on this gene expression in both cell types, but by different ways: decreased in normal astrocytes and increased in glioblastoma cells. In addition, the impact of tunicamycin and thapsigargin on IRS2 gene expression was significantly upregulated by hydrocortisone in normal astrocytes and especially in glioblastoma cells. At the same time, the combined effect of hypoxia and hydrocortisone enhanced the expression of the IRS2 gene in tunicamycintreated normal astrocytes, especially in the glioblastoma cells. Hydrocortisone also increased the effect of hypoxia on this gene expression in thapsigargin-treated normal astrocytes and decreased it in glioblastoma cells. &lt;b&gt;Conclusion.&lt;/b&gt; Our findings provide evidence that hypoxic regulation of IRS2 gene expression","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"171-180"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of circadian rhythm disruptions in the diabetes pathogenesis.","authors":"Ali Karadeniz","doi":"10.2478/enr-2025-0024","DOIUrl":"10.2478/enr-2025-0024","url":null,"abstract":"<p><p>Diabetes mellitus has become a major global health concern with increasing prevalence worldwide. Recent studies have highlighted the critical role of the circadian rhythm, the body's internal biological clock, in the pathogenesis of diabetes. The circadian system regulates glucose metabolism, insulin secretion, and energy homeostasis. Modern lifestyle factors such as sleep disturbances shift work and irregular eating patterns disrupt circadian rhythms promoting insulin resistance and glucose intolerance. At the molecular level, mutations or altered expression of clock genes contribute to diabetes development. Clinical and experimental evidence suggests that maintaining the circadian integrity can reduce the diabetes risk and the chronotherapy time-based treatment approaches may enhance the therapeutic efficacy. The future advances including genetic profiling, AI-assisted monitoring and microbiota modulation hold promise for improved diabetes management. This review comprehensively examines the relationship between diabetes and circadian disruption emphasizing the importance of circadian biology in preventing and treating the metabolic diseases.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"206-216"},"PeriodicalIF":0.0,"publicationDate":"2025-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145488231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}