Endocrine regulations最新文献

{"title":"HLA DQA1* and HLA-DQB1* alleles and genetic susceptibility to autoimmune thyroiditis in Down syndrome children: An Indonesian study.","authors":"Yuni Hisbiyah, Anang Endaryanto, Bagus Setyoboedi, Nur Rochmah, Muhammad Faizi, Sukmawati Basuki, Asri Maharani","doi":"10.2478/enr-2025-0010","DOIUrl":"10.2478/enr-2025-0010","url":null,"abstract":"<p><p><b>Objective.</b> The purpose of this study was to investigate the role of the HLA-DQA1 and HLADQB1 alleles in Indonesian children who had autoimmune thyroiditis (AITD) and Down syndrome (DS). <b>Methods.</b> At Dr. Soetomo Hospital, 49 DS-AITD patients and 42 controls participated in a cross-sectional study. Alleles of HLA-DQA1*0103 and HLA-DQB1*0401 were genotyped by PCRRFLP assays. Allelic relationships were assessed by statistical studies. <b>Results.</b> In the DS-AITD group, the HLA-DQA1*0103 and HLA-DQB1*0401 alleles were more frequently found. The HLA-DQB1*0303, *0402, and *0501/0604 alleles, on the other hand, were significantly more common in the control group. While the HLA-DQB1 *0303 (odds ratio [OR]=0.169, 95% confidence interval [CI]: 0.065-0.435, p=0.000) alleles significantly reduced AITD risk, the HLA-DQA1*0103 (OR=3.9, 95% CI: 1.552-9.797, p=0.003), and HLA-DQB1*0401 (OR=4.5, 95% CI: 1.326-15.277, p=0.010) alleles considerably increased AITD risk. <b>Conclusion.</b> HLA-DQA1*0103 and HLA-DQB1*0401 are risk alleles, while HLA-DQB1 *0303 are protective alleles for AITD in children with DS. Further studies are required to obtain more data on Indonesians with DS.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"87-94"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes.","authors":"Douglas E Barre, Kazimiera A Mizier-Barre, Odette Griscti","doi":"10.2478/enr-2025-0016","DOIUrl":"10.2478/enr-2025-0016","url":null,"abstract":"<p><p><b>Objective.</b> The objective of the present study was to determine if there would be statistically significant differences among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in persons with type 2 diabetes consuming a flaxseed oil supplement (FOS). The cluster of seven are: abdominal obesity, hypertension, platelet hyperaggregability, hyperglycemia, dyslipidemia (decreased serum levels of high-density lipoprotein cholesterol (HDLc) and increased serum levels of triglycerides), increased serum low-density lipoprotein (LDL) oxidation (LDL conjugated dienes) and increased inflammation. All cluster members exacerbate type 2 diabetes. <b>Methods.</b> Thirty-two patients with well-controlled type 2 diabetes participated in this double-blind, placebo (safflower oil supplementation (SOS))-controlled study consisting of three visits. Apolipoprotein E genotyping was done at visit one. The cluster of seven was assessed at each visit. <b>Results.</b> Only platelet aggregability decreased as the result of the FOS relative to placebo while it appeared that there might be some potential for FOS to decrease LDL conjugated dienes. No apolipoprotein E genotype affected any of the cluster of seven responsiveness. <b>Conclusions.</b> Identified apolipoprotein E genotypes played no role in the responsiveness of any member of the cluster of seven to FOS in this study.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"141-146"},"PeriodicalIF":0.0,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic spectrum and diagnostic challenges in non-21-alpha-hydroxylase deficiency congenital adrenal hyperplasia: a case series from a tertiary care center.","authors":"Anand Sheya, Nayana Tara Vasireddy, Shriraam Mahadevan, Asha Ranjan, Adlyne Reena Asirvatham, Sai Namratha Gogineni","doi":"10.2478/enr-2025-0015","DOIUrl":"10.2478/enr-2025-0015","url":null,"abstract":"<p><p><b>Objectives.</b> The aim of the present study was 1) to describe the phenotypic spectrum of non-21-alfa-hydroxylase deficiency (non-21-OHD) congenital adrenal hyperplasia (CAH) encountered in a tertiary care endocrine center; 2) to identify the key biochemical, hormonal, and genetic markers that aid in differentiating non-21-OHD CAH subtypes; 3) to highlight the diagnostic challenges faced in distinguishing non-21-OHD CAH from classic 21OHD CAH and other adrenal disorders; and 4) to discuss the clinical implications and management challenges associated with non-21-OHD CAH. <b>Methods.</b> A retrospective analysis identified 13 cases of non-21-OHD CAH out of 87 CAH patients between 2008 to 2022. Clinical, biochemical, imaging and genetic data were analyzed. The diagnosis was confirmed by hormonal assays and next-generation sequencing (NGS)-based genetic analysis. <b>Results.</b> Of the 13 cases, six patients had 11β-hydroxylase deficiency (11β-OHD), primarily presenting with precocious puberty, hypertension, and hyperpigmentation, with elevated ACTH, 17-hydroxyprogesterone (17-OHP), and suppressed renin levels. Three patients with 3β-hydroxysteroid dehydrogenase type 2 (3β-HSD2) deficiency were diagnosed in early infancy following salt-wasting crises. 17α-hydroxylase deficiency (17α-OHD) was diagnosed in three adolescent females presenting with primary amenorrhea, tall stature, hypertension, and elevated gonadotropins. One case of StAR deficiency was diagnosed at 45 days of life, presenting with adrenal crisis and severe adrenal insufficiency. <b>Conclusion.</b> Non-21-OHD CAH presents diagnostic challenges due to its varied clinical spectrum. Hypertension and hypokalemia are key differentiators for 11β-OHD and 17α-OHD, while steroid profiling (LC-MS) aids in diagnosing 3β-HSD2 deficiency. However, the most crucial aspect is the early diagnosis, which is a significant factor in preventing complications like hypertensive cardiomyopathy and adrenal crises.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"135-140"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of hematological parameters between patients with essential hypertension without cardiovascular comorbidity and in combination with coronary artery disease and chronic heart failure.","authors":"Inna Krynytska, Mariya Marushchak, Lesya Stanovska","doi":"10.2478/enr-2025-0011","DOIUrl":"10.2478/enr-2025-0011","url":null,"abstract":"<p><p><b>Objective.</b> Metabolic disorders such as essential hypertension (EH) have increasingly contributed to the global health burden. The aim of this study was to assess differences in the hematological parameters among hypertensive adults with and without cardiovascular comorbidity and to explore the association between the complete blood count (CBC) indices and the effectiveness of hypertension control, defined by achieving target blood pressure levels (TBPLs) of <140/90 mmHg. <b>Methods.</b> The study involved 140 outpatients with EH of municipal non-profit enterprise \"Hulsk outpatient clinic of general practice of family medicine\" of the Stryiv village council (Hylsk village, Zviahel district, Zhytomyr region, Ukraine), which were divided into 3 groups: 1) hypertensive patients without cardiovascular comorbidity (with EH only), 2) hypertensive patients with coronary artery disease (CAD), and 3) hypertensive patients with CAD and chronic heart failure (CHF). The CBC was examined using an automatic hematological analyzer BC-6000 (\"Mindray\", China). <b>Results.</b> When comparing the CBC indices in patients with EH versus normotensive individuals, statistically significant differences were found in total white blood cells (WBC) count, relative neutrophil, eosinophil, lymphocyte, monocyte counts, mean platelet volume (MPV), and platelet distribution width (PDW). Moreover, relative lymphocyte count (RLC) was lower by 7.05% (p=0.003) in the EH+CAD+CHF group compared to patients with EH only; relative monocyte count (RMC) was higher by 26.09% (p=0.004) and 23.91% (р=0.010) in the EH+CAD+CHF and the EH+CAD groups, respectively, compared to patients with EH only. MPV and PDW were higher by 12.77 % (p=0.022) and 5.66 % (p=0.021) in the EH+CAD group, respectively, compared to patients with EH only. In addition, significant differences were found in the RMC, which was higher in individuals who achieved TBPLs compared to individuals who did not achieve TBPLs (by 25.00% in the EH group, by 26.53% in the EH+CAD group and by 20.00% in the EH+CAD+CHF group). <b>Conclusions.</b> We demonstrated that in patients with EH+CAD relative monocyte count and MPV and PDW were significantly higher vs. patients with EH only; in patients with EH+CAD+CHF relative lymphocyte count was significantly lower and relative monocyte count was significantly higher vs. patients with EH only. Furthermore, both in hypertensive patients with cardiovascular comorbidity and patients without cardiovascular comorbidity, relative monocyte counts in individuals who achieved TBPLs was significantly higher than in individuals who did not achieve TBPLs. Improved understanding of the cellular mechanisms connecting monocyte count to blood pressure regulation could enhance our insight into the pathogenesis of EH and contribute to the development of more effective strategies for the prevention of hypertension incidents.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"95-106"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical IgG4 related hypophysitis revealed by submandibular sialadenitis: a case report.","authors":"Bilel Ben Amor, Ekram Hajji, Ines Bayar, Rym Mesfar, Jamel Saad, Leila Njim, Hanene Sayadi, Ines Khochtali","doi":"10.2478/enr-2025-0014","DOIUrl":"10.2478/enr-2025-0014","url":null,"abstract":"<p><p><b>Objective.</b> IgG4-related disease is a fibro-inflammatory multisystemic condition with lesions mimicking tumors. Involvement of the hypophysis is rare and the first case of IgG4-related hypophysitis was described in 2004. Typically, it is revealed by sellar mass effects, hypopituitarism, and diabetes insipidus. In the present paper, we report a case of IgG4-related hypophysitis revealed by submandibular sialadenitis. <b>Case Report.</b> The subject was a 52-year-old patient presented with swelling of the submandibular gland. His complaints were decreased libido, anorexia, and weight loss for three months. Hormonal assessment found mild hyperprolactinemia, hypogonadotropic hypogonadism, and central hypothyroidism. Pituitary magnetic resonance imaging showed heterogeneous enlargement of the pituitary gland with diffuse gadolinium enhancement. The submandibular gland biopsy revealed submandibular sialadenitis with positive immunohistochemistry to IgG4. Diagnosis of IgG4-related hypophysitis was made based on Leporati criteria 2 and 3. Glucocorticoid therapy was prescribed for this patient, but without improvement of the pituitary function. In fact, the effectiveness of steroid therapy on the pituitary swelling is proven and already represents the fifth diagnostic criterion of Leporati. However, the improvement of the pituitary functions is uncertain. <b>Conclusion.</b> The present case illustrates an atypical presentation of IgG4-related hypophysitis without tumor syndrome or diabetes insipidus. Continuous monitoring of the pituitary function is needed during the long-term follow up given that improvement of the hormonal deficiencies is uncertain.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"130-134"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of a ginger (<i>Zingiber officinale</i> Roscoe, <i>Zingiberaceae</i>) extract on the liver and heart tissues in the bile duct-ligated rats.","authors":"Zeynab Sarlak, Fatemeh Khosravi, Hamidreza Mohammadi, Afshin Nazari, Mehdi Birjandi, Vajihe Ghorbanzadeh","doi":"10.2478/enr-2025-0012","DOIUrl":"10.2478/enr-2025-0012","url":null,"abstract":"<p><p><b>Objective.</b> Cholestasis is a disorder with accumulation of bile acids in the liver that can lead to toxicity and impairment in liver function and heart. In current study, we investigated the protective effect of ginger extract on the liver and heart damages in cholestatic rats. <b>Methods.</b> Thirty-six male Wistar rats were randomly divided into 6 groups (n=6). Cholestasis was induced in the rats by ligating the bile ducts. The animals were treated with different doses of methanol extract of ginger (100, 200, 400 mg/kg/day) for 28 days. Serum factors including ala-nine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin, and the oxidative stress indices, glutathione (GSH), malondialdehyde (MDA), reactive oxygen species (ROS), and total antioxidant capacity in the liver and heart tissues were measured. Histopathological changes were also investigated. <b>Results.</b> The results showed that ligating the bile ducts in rats was associated with an increase in the serum factors including ALT, AST, ALP, and bilirubin. It also increased the amount of ROS, MDA, and decreased the GSH and total antioxidant capacity. On the other hand, severe histo-pathological changes were seen in the liver and heart tissues. The results show that ginger extract reduced the amount of serum factors, modulated the antioxidant indices and improved the histo-pathological changes. <b>Conclusions.</b> According to the results of this study, it can be concluded that the administration of ginger extract can be a new strategy to treat the complication of liver and heart damage caused by cholestasis. The protective effects of ginger against cholestasis and its complications may be mediated by the antioxidant activity of its components.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"107-119"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of gluten-free diet intervention in the treatment of Hashimoto's thyroiditis in non-celiac disease: A systematic review protocol.","authors":"Edilene Maria Queiroz Araujo, Claubert Radames Coutinho-Lima, Lana Mercia Santiago de Souza, Helton Estrela Ramos, Bianca de Almeida-Pititto, Graziela De Luca Canto, Virginia Fernandes Moca Trevisani","doi":"10.2478/enr-2025-0009","DOIUrl":"10.2478/enr-2025-0009","url":null,"abstract":"<p><p><b>Objective.</b> Hashimoto's thyroiditis (HT) is a prevalent condition characterized by increased thyroid antibody titers (TAT) in non-celiac disease. The emergence of a gluten-free diet (GFD) as a potential treatment for reducing TAT and HT symptoms is a promising development. However, the potential benefits of gluten withdrawal in HT are not fully understood and the overall evidence is inconclusive. The aim of this review article is to present a systematic protocol for evaluating the effects of a GFD intervention in the treatment of HT in non-celiac disease. <b>Methods.</b> Randomized controlled trials in adults and older people with HT and non-celiac disease following the GFD intervention compared to any gluten dietary and no dietary interventions or placebo (as long as it contains gluten) will be included. We will use Cochrane Central, Medline, Lilacs, Embase, Scopus, and Web of Science for the search. Free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), TAT - anti-thyroid peroxidase (TPO) and anti-thyroglobulin (Tg), C-reactive protein (CRP), vitamin D, adverse effects, body weight, body mass index (BMI), diet adherence and health-related quality of life will be used as the outcomes. We will present the results in a narrative format and if possible, we will conduct a meta-analysis using a random effects model. The certainty of the evidence using the Grading of Recommendations Assessment Development and Evaluation (GRADE) will be assessed. <b>Conclusion.</b> We will disseminate the results through peer-reviewed publications, social networks, and educational talks. The systematic review will provide valuable information on the effects of the GFD in the treatment of HT in non-celiac disease verifying its impact mainly on TAT.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"78-86"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose-dependent control of insulin like growth factor 2 mRNA binding protein 2 and other gene expressions in ERN1 knockdown glioblastoma cells.","authors":"Oleksandr H Minchenko, Yuliia M Viletska, Myroslava Y Sliusar, Oksana S Hnatiuk, Oksana O Ratushna, Taia V Feldman, Halyna E Kozynkevych, Borys H Bezrodnyi, Dmytro O Minchenko","doi":"10.2478/enr-2025-0013","DOIUrl":"10.2478/enr-2025-0013","url":null,"abstract":"<p><p><b>Objective.</b> Endoplasmic reticulum stress and glucose supply are significant factors in glioblastoma growth. The present study aims to investigate the impact of glucose-dependent control of <i>IGF2BP2</i>, <i>TOB1</i>, <i>HBEGF</i>, <i>TWIST1</i>, <i>CCNH</i>, and <i>E2F1</i> gene expression in U87MG glioblastoma cells in response to the inhibition of both enzymatic activities of signaling protein ERN1. <b>Methods.</b> The U87MG glioblastoma cells with inhibited both enzymatic activities of ERN1 (endoribonuclease and protein kinase; dnERN1) were used. Cells transfected with an empty vector served as a control. The expression level of the <i>IGF2BP2</i> and other genes was studied by quantitative RT-PCR. <b>Results.</b> It was shown that the expression level of the <i>IGF2BP2</i> gene is up-regulated, while that of <i>TOB1</i> and <i>E2F1</i> genes is down-regulated in control glioblastoma cells treated with glucose deprivation. Nevertheless, the ERN1 knockdown modified the sensitivity of <i>IGF2BP2</i> and <i>TOB1</i> genes to reduced glucose supply. At the same time, the expression of <i>HBEGF</i>, <i>TWIST1</i>, and <i>CCNH</i> genes in control glioblastoma cells was resistant to glucose deprivation conditions. However, inhibition of the enzymatic activities of ERN1 signaling protein strongly increased the impact of glucose deprivation on <i>HBEGF</i> gene expression, but down-regulated the expression of the <i>TWIST1</i> gene. <b>Conclusion.</b> These results demonstrate that the enzymatic activity of signaling protein ERN1 controls the sensitivity of almost all studied genes to glucose deprivation in U87MG glioblastoma cells in a gene-specific manner. This is important for elucidating the endoplasmic reticulum stress-mediated sensitivity of key regulatory gene expression in glioblastoma cells to glucose supply, a significant factor in tumor growth.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"120-129"},"PeriodicalIF":0.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of medicinal plants in ameliorating the lipid and glucose levels in diabetes: A systematic literature review.","authors":"Phaik Har Yong, Tan Yee Qing, Meram Azzani, Deepa Anbazhagan, Zhi Xiang Ng","doi":"10.2478/enr-2025-0008","DOIUrl":"10.2478/enr-2025-0008","url":null,"abstract":"<p><p><b>Objective.</b> Diabetes is a chronic disease that causes insulin resistance and destruction of β-cells in pancreas. It is highly associated with hyperglycemia and hyperlipidemia, which can cause microvascular and macrovascular complications. The aim of this systematic review was to evaluate the beneficial effects of medicinal plant extracts on ameliorating glucose levels and lipid profile in diabetic rats. <b>Methods.</b> A systematic review search was conducted using PubMed, Scopus, Google Scholar and ScienceDirect databases using combined terms. The data were extracted and selected by two reviewers under the PRISMA guidelines, which included 25 articles. These 25 articles were selected by the inclusion and exclusion criteria. The quality assessments of the articles were carried out by using the Risk of Bias tool and animal intervention studies. <b>Results.</b> A total of 4651 articles were identified by searching the databases. Articles in the amount of 4505 were then excluded after screening the title and abstract. The remaining 146 articles proceeded to eligibility analysis and finally 25 articles were included into systemic review studies. From the 25 articles reviewed, <i>Clerodendrum volubile</i> showed the highest reducing effect on the blood glucose levels and lipid profile in diabetic rats. <i>Solena amplexicaulis</i> showed the lowest effect on ameliorating glucose levels, while <i>Myrtus communis</i> demonstrated the lowest effect on improving lipid profile in diabetic rats. <b>Conclusion.</b> The reviewed medicinal plant extracts reviewed demonstrated promising efficacy in ameliorating the blood glucose and lipid levels in diabetic rats.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"57-77"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of FTO protein with hyperandrogenism metabolic disturbances in women with polycystic ovary syndrome.","authors":"Sadaf Parveen, Saba Khan, Shagufta Moin, Asma Nigar, Mohammad Mustufa Khan, Roshan Alam","doi":"10.2478/enr-2025-0005","DOIUrl":"10.2478/enr-2025-0005","url":null,"abstract":"<p><p><b>Objective.</b> Polycystic ovary syndrome (PCOS) is one of the commonest endocrinopathies in women characterized by hyperandrogenism, ovulatory dysfunction, and insulin resistance affecting 5-20% of reproductive-aged women worldwide. Recent studies have emphasized the role of the fat mass and obesity-associated (FTO) gene in the development of PCOS, specifically the rs9939609 A/T polymorphism, which is linked to an increased risk of PCOS. The study aimed to investigate the levels of FTO protein and its association with luteinizing hormone (LH), follicle-stimulating hormone (FSH) and anthropometric parameters in patients with PCOS compared to healthy controls. <b>Materials.</b> A total of 298 women, comprising 149 patients and 149 healthy controls, enrolled in the study. Anthropometric parameters (body mass index, BMI; waist circumference, WC; hip circumference, HC; waist-to-hip ratio, WHR), and hormonal assays (LH, FSH, LH/FSH ratio) were performed. FTO protein levels were measured by ELISA kit and their association with these parameters was analyzed. A receiver operator characteristic (ROC) curve analysis was performed to evaluate the discriminatory power of FTO protein levels in distinguishing PCOS cases and controls. A value p<0.05 was considered statistically significant. <b>Results.</b> FTO protein levels were significantly elevated in PCOS women with increased BMI, WC, HC, and WHR (p=<0.05). The mean of BMI showed a positive correlation with both WC (r=0.367, p<0.001) and HC (r=0.395, p<0.001). WC strongly correlated with HC (r=0.780, p<0.001) and WHR (r=0.465, p<0.001). LH significantly correlated with FSH (r=0.543, p<.001), and LH/FSH (r=0.553, p<.001). FTO protein showed a positive correlation with LH (r=0.364, p<0.001), and FSH (r=0.166, p<0.001). Additionally, a negative correlation of FTO protein with BMI (r=-0.190, p<0.05), WC (r=-0.277, p<0.05), and WHR (r=-0.408 p<0.001) was observed. The levels of FTO protein were significantly higher in PCOS patients compared to controls. Significant correlations were also found between FTO protein levels and the anthropometric or hormonal parameters. The AUC for FTO protein levels was 0.624 (p=0.550), indicating moderate discriminatory power, but lacking statistical significance. <b>Conclusion.</b> The study found that FTO protein levels are significantly higher in PCOS women correlating with anthropometric and hormonal parameters (increased LH, decreased FSH). This highlights potential involvement of FTO protein in the hormonal and metabolic disturbances characteristics of the syndrome indicating its biomarker character for the condition.</p>","PeriodicalId":11650,"journal":{"name":"Endocrine regulations","volume":"59 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}