Endocrinology and Metabolism最新文献_第8页

Adequate Dose of Levothyroxine for Thyroid-Stimulating Hormone Suppression after Total Thyroidectomy in Patients with Differentiated Thyroid Cancer. 分化型甲状腺癌患者全甲状腺切除术后抑制甲状腺刺激素的左甲状腺素剂量是否足够？

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-07 DOI: 10.3803/EnM.2023.1896

Hyun Jin Ryu, Min Sun Choi, Hyunju Park, Tae Hyuk Kim, Jae Hoon Chung, So Young Park, Sun Wook Kim

{"title":"Adequate Dose of Levothyroxine for Thyroid-Stimulating Hormone Suppression after Total Thyroidectomy in Patients with Differentiated Thyroid Cancer.","authors":"Hyun Jin Ryu, Min Sun Choi, Hyunju Park, Tae Hyuk Kim, Jae Hoon Chung, So Young Park, Sun Wook Kim","doi":"10.3803/EnM.2023.1896","DOIUrl":"10.3803/EnM.2023.1896","url":null,"abstract":"Backgruound: The adequate dose of levothyroxine (LT4) for patients who have undergone total thyroidectomy (TT) for differentiated thyroid cancer (DTC) is uncertain. We evaluated the LT4 dose required to achieve mild thyroid-stimulating hormone (TSH) suppression in DTC patients after TT.Methods: The electronic medical records of patients who underwent TT for DTC and received mild TSH suppression therapy were reviewed. Linear regression analysis was performed to evaluate the association between LT4 dose (μg/kg) and an ordinal group divided by body mass index (BMI). We also evaluated the trend in LT4 doses among groups divided by BMI and age.Results: In total, 123 patients achieved mild TSH suppression (0.1 to 0.5 mIU/L). The BMI variable was divided into three categories: <23 kg/m2 (n=46), ≥23 and <25 kg/m2 (n=30), and ≥25 kg/m2 (n=47). In the linear regression analysis, BMI was negatively associated with the LT4 dose after adjusting for age and sex (P<0.001). The LT4 doses required to achieve mild TSH suppression based on the BMI categories were 1.86, 1.71, and 1.71 μg/kg, respectively (P for trend <0.001). Further analysis with groups divided by age and BMI revealed that a higher BMI was related to a lower LT4 dose, especially in younger patients aged 20 to 39 (P for trend=0.011).Conclusion: The study results suggest an appropriate LT4 dose for mild TSH suppression after TT based on body weight in patients with DTC. Considering body weight, BMI, and age in estimating LT4 doses might help to achieve the target TSH level promptly.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"615-621"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketonuria as an Indicator of Improvement of Renal Function in Patients with Type 2 Diabetes Receiving SGLT2 Inhibitor Treatment. 酮尿作为接受 SGLT2 抑制剂治疗的 2 型糖尿病患者肾功能改善的指标。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-16 DOI: 10.3803/EnM.2024.1919

Hyun Ah Kim, Han Na Jang, Sung Hye Kong, Young Lee, Sung Hee Choi, Young Min Cho, Hak Chul Jang, Tae Jung Oh

{"title":"Ketonuria as an Indicator of Improvement of Renal Function in Patients with Type 2 Diabetes Receiving SGLT2 Inhibitor Treatment.","authors":"Hyun Ah Kim, Han Na Jang, Sung Hye Kong, Young Lee, Sung Hee Choi, Young Min Cho, Hak Chul Jang, Tae Jung Oh","doi":"10.3803/EnM.2024.1919","DOIUrl":"10.3803/EnM.2024.1919","url":null,"abstract":"We investigated the potential association between ketonuria during treatment with sodium-glucose cotransporter-2 (SGLT2) inhibitors and its renoprotective effect in patients with type 2 diabetes. We included 192 patients who had received SGLT2 inhibitors for more than 6 months. After propensity score matching, 52 patients each were allocated into groups with or without ketonuria, respectively. The estimated glomerular filtration rate exhibited a significant improvement only in subjects with ketonuria (without ketonuria: mean difference, -0.02 mL/min/1.73 m2 [95% confidence interval (CI), -3.87 to 3.83 mL/min/1.73 m2] vs. with ketonuria: mean difference, 6.81 mL/min/1.73 m2 [95% CI, 3.16 to 10.46 mL/min/1.73 m2]; P<0.001). Improvement in estimated glomerular filtration rate at 6 months was associated with female sex and lower baseline body weight, blood pressure, and triglyceride levels in patients with ketonuria. In conclusion, the presence of ketonuria was associated with the renoprotective effect of SGLT2 inhibitors, and female sex and the absence of metabolic syndrome components may serve as additional indicators of these medications' substantial renoprotective effects in individuals with ketonuria.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"653-658"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parathyroid Gland Generation from Pluripotent Stem Cells. 利用多能干细胞生成甲状旁腺

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-06-10 DOI: 10.3803/EnM.2024.1989

Mayuko Kano

引用次数: 0

Effects of Endocrine-Disrupting Chemicals on Bone Health. 干扰内分泌的化学品对骨骼健康的影响。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-07-17 DOI: 10.3803/EnM.2024.1963

So Young Park, Sung Hye Kong, Kyoung Jin Kim, Seong Hee Ahn, Namki Hong, Jeonghoon Ha, Sihoon Lee, Han Seok Choi, Ki-Hyun Baek, Jung-Eun Kim, Sang Wan Kim

{"title":"Effects of Endocrine-Disrupting Chemicals on Bone Health.","authors":"So Young Park, Sung Hye Kong, Kyoung Jin Kim, Seong Hee Ahn, Namki Hong, Jeonghoon Ha, Sihoon Lee, Han Seok Choi, Ki-Hyun Baek, Jung-Eun Kim, Sang Wan Kim","doi":"10.3803/EnM.2024.1963","DOIUrl":"10.3803/EnM.2024.1963","url":null,"abstract":"This comprehensive review critically examines the detrimental impacts of endocrine-disrupting chemicals (EDCs) on bone health, with a specific focus on substances such as bisphenol A (BPA), per- and polyfluoroalkyl substances (PFASs), phthalates, and dioxins. These EDCs, by interfering with the endocrine system's normal functioning, pose a significant risk to bone metabolism, potentially leading to a heightened susceptibility to bone-related disorders and diseases. Notably, BPA has been shown to inhibit the differentiation of osteoblasts and promote the apoptosis of osteoblasts, which results in altered bone turnover status. PFASs, known for their environmental persistence and ability to bioaccumulate in the human body, have been linked to an increased osteoporosis risk. Similarly, phthalates, which are widely used in the production of plastics, have been associated with adverse bone health outcomes, showing an inverse relationship between phthalate exposure and bone mineral density. Dioxins present a more complex picture, with research findings suggesting both potential benefits and adverse effects on bone structure and density, depending on factors such as the timing and level of exposure. This review underscores the urgent need for further research to better understand the specific pathways through which EDCs affect bone health and to develop targeted strategies for mitigating their potentially harmful impacts.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"539-551"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Suppurative Thyroiditis as a Presentation of Disseminated Methicillin-Resistant Staphylococcus aureus Infection in an Adult with Type 1 Diabetes. 1型糖尿病患者急性化脓性甲状腺炎是耐甲氧西林金黄色葡萄球菌播散性感染的一种表现。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-07-17 DOI: 10.3803/EnM.2024.1982

Nami Lee, Ja Young Jeon, Yong Jun Choi, Seung Jin Han

引用次数: 0

Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study. 肢端肥大症患者阻塞性睡眠呼吸暂停筛查和手术效果：一项前瞻性研究

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-06-26 DOI: 10.3803/EnM.2024.1933

Jaeyoung Cho, Jung Hee Kim, Yong Hwy Kim, Jinwoo Lee

{"title":"Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.","authors":"Jaeyoung Cho, Jung Hee Kim, Yong Hwy Kim, Jinwoo Lee","doi":"10.3803/EnM.2024.1933","DOIUrl":"10.3803/EnM.2024.1933","url":null,"abstract":"Backgruound: To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly.Methods: We prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were admitted for a baseline work-up for acromegaly before surgery and surveillance approximately 3 to 6 months after surgery. Respiratory event index (REI) was used as a surrogate for apnea-hypopnea index (Trial Registration: NCT03526016).Results: Of the 35 patients with acromegaly (median age, 47 years; 40% men; median body mass index, 24.4 kg/m2), 24 (68.6%) had OSA (REI ≥5/hour), 15 (42.9%) had moderate-to-severe OSA (REI ≥15/hour). At baseline, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with the REI (ρ=0.53, P=0.001). The sensitivity and negative predictive value of a Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, age, Neck circumference, and Gender (STOP-Bang) score ≥ 3 were 93.3% and 87.5%, respectively, detecting moderate-to-severe OSA. Biochemical acromegaly remission was achieved in 32 (91.4%) patients. The median difference in the REI was -9.5/hour (95% confidence interval, -13.3 to -5.3). Half of the 24 patients diagnosed with OSA preoperatively had REI <5/hour postoperatively. In a linear mixed-effects model, changes in the REI across surgery were related to changes in IGF-1 levels.Conclusion: The STOP-Bang questionnaire is a reliable tool for OSA among patients with acromegaly. Improvement in OSA severity after surgery is related to decreased IGF-1 levels.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"641-652"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

For the Forthcoming Winning Shot in the Battle against Cushing Disease. 为即将到来的对抗库欣病的制胜一击而战。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-08-06 DOI: 10.3803/EnM.2024.2075

Sang Ouk Chin

引用次数: 0

Dynamic Risk Model for the Medical Treatment of Graves' Hyperthyroidism according to Treatment Duration. 根据治疗持续时间确定巴塞杜氏甲状腺功能亢进症药物治疗的动态风险模型。

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-23 DOI: 10.3803/EnM.2024.1918

Meihua Jin, Chae A Kim, Min Ji Jeon, Won Bae Kim, Tae Yong Kim, Won Gu Kim

{"title":"Dynamic Risk Model for the Medical Treatment of Graves' Hyperthyroidism according to Treatment Duration.","authors":"Meihua Jin, Chae A Kim, Min Ji Jeon, Won Bae Kim, Tae Yong Kim, Won Gu Kim","doi":"10.3803/EnM.2024.1918","DOIUrl":"10.3803/EnM.2024.1918","url":null,"abstract":"Backgruound: Changes in thyrotropin receptor antibody (TRAb) levels are associated with the clinical outcomes of Graves' hyperthyroidism. However, the effects of the patterns of TRAb changes on patient prognosis according to the treatment duration of antithyroid drugs (ATDs) are not well established.Methods: In this retrospective cohort study, 1,235 patients with Graves' hyperthyroidism who were treated with ATDs for more than 12 months were included. Patients were divided into two groups according to treatment duration: group 1 (12-24 months) and group 2 (>24 months). Risk prediction models comprising age, sex, and either TRAb levels at ATD withdrawal (model A) or patterns of TRAb changes (model B) were compared.Results: The median treatment duration in groups 1 (n=667, 54%) and 2 (n=568, 46%) was 17.3 and 37.1 months, respectively. The recurrence rate was significantly higher in group 2 (47.9%) than in group 1 (41.4%, P=0.025). Group 2 had significantly more goiter, thyroid eye disease, and fluctuating and smoldering type of TRAb pattern compared with group 1 (all P<0.001). The patterns of TRAb changes were an independent risk factor for recurrence after adjusting for other confounding factors in all patients, except in group 1. Integrated discrimination improvement and net reclassification improvement analyses showed that model B performed better than model A in all patients, except in group 1.Conclusion: The dynamic risk model, including the patterns of TRAb changes, was more suitable for predicting prognosis in patients with Graves' hyperthyroidism who underwent longer ATD treatment duration.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"579-589"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Gaps Amidst Limited Evidence for Glucocorticoid-Induced Adrenal Insufficiency. 在糖皮质激素诱发肾上腺功能不全的有限证据中填补空白

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 DOI: 10.3803/EnM.2024.2065

Seung Hun Lee

引用次数: 0

Differential Impact of Subcutaneous and Visceral Fat on Bone Changes after Gastrectomy. 皮下脂肪和内脏脂肪对胃切除术后骨骼变化的不同影响

IF 3.9 3区医学

Endocrinology and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-07-17 DOI: 10.3803/EnM.2024.1956

Sungjoon Cho, Sungjae Shin, Seunghyun Lee, Yumie Rhee, Hyoung-Il Kim, Namki Hong

{"title":"Differential Impact of Subcutaneous and Visceral Fat on Bone Changes after Gastrectomy.","authors":"Sungjoon Cho, Sungjae Shin, Seunghyun Lee, Yumie Rhee, Hyoung-Il Kim, Namki Hong","doi":"10.3803/EnM.2024.1956","DOIUrl":"10.3803/EnM.2024.1956","url":null,"abstract":"Backgruound: Osteoporosis and fragility fractures are crucial musculoskeletal complications in long-term survivors of gastric cancer. However, the relationship between changes in body composition after gastrectomy and bone loss has not been investigated. Therefore, this study aimed to explore whether computed tomography (CT)-derived body composition parameters are associated with bone loss after gastrectomy in patients with gastric cancer.Methods: We retrospectively reviewed medical records and abdomen CT scans of patients who underwent gastrectomy at Yonsei University Severance Hospital between 2009 and 2018. Patients with non-metastatic gastric adenocarcinoma and preoperative and postoperative non-contrast CT scans were analyzed. Section area of skeletal muscle (SMA), visceral fat (VFA), and subcutaneous fat (SFA) were assessed using semi-automatic segmentation software. Changes in trabecular bone attenuation of L1 mid-vertebra level (L1 Hounsfield units [HU]) were measured.Results: Fifty-seven patients (mean age, 65.5±10.6; 70.2% males) were analyzed, and the median duration was 31 months. Fortyseven patients (82.5%) lost weight after gastrectomy. Baseline SMA and VFA did not differ between the bone loss and preserved groups; however, baseline SFA was significantly higher in the bone preserved group than in the bone loss group (P=0.020). In a multivariable linear regression model adjusted for confounding factors, one standard deviation higher VFA at baseline was associated with greater annualized L1 HU loss (%) (P=0.034). However, higher preoperative SFA was associated with protection against bone loss after gastrectomy (P=0.025).Conclusion: Higher preoperative SFA exhibited a protective effect against bone loss after gastrectomy in patients with non-metastatic gastric cancer, whereas VFA exhibited a negative effect.","PeriodicalId":11636,"journal":{"name":"Endocrinology and Metabolism","volume":" ","pages":"632-640"},"PeriodicalIF":3.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0