Endocrine journal最新文献_第6页

Microscopic characteristics of adult dyshormonogenetic goiter: attempt to histologically estimate subtypes. 成人甲状腺肿的显微特征：试图从组织学上估计亚型。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-05 DOI: 10.1507/endocrj.EJ25-0222

Mitsuyoshi Hirokawa, Hanna Deguchi-Horiuchi, Shuji Fukata, Miyoko Higuchi, Ayana Suzuki, Eijun Nishihara, Takahiko Kogai, Akira Hishinuma, Akira Miyauchi, Takashi Akamizu

{"title":"Microscopic characteristics of adult dyshormonogenetic goiter: attempt to histologically estimate subtypes.","authors":"Mitsuyoshi Hirokawa, Hanna Deguchi-Horiuchi, Shuji Fukata, Miyoko Higuchi, Ayana Suzuki, Eijun Nishihara, Takahiko Kogai, Akira Hishinuma, Akira Miyauchi, Takashi Akamizu","doi":"10.1507/endocrj.EJ25-0222","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0222","url":null,"abstract":"In adults, cases of dyshormonogenetic goiter (DG) that go undiagnosed during childhood may necessitate thyroidectomy due to unexplained thyroid enlargement, often presenting diagnostic challenges. This study aimed to characterize the histopathological features of the thyroid in adult DG cases, and to evaluate the feasibility of predicting subtypes from the findings. Fifty adult patients with DG confirmed by the presence of gene variants were included. All resected thyroids showed diffuse goiter with microscopically altered thyroid follicles throughout the gland. All patients with SLC5A5 abnormality (iodide transport defect) showed lobulation accentuated by interlobular fibrosis. Follicular cells were enlarged, except in patients with SLC26A4 abnormality (Pendred syndrome). A scant colloid was observed in all patients with thyroglobulin (TG) gene abnormality. Thyroid peroxidase (TPO) gene abnormality and SLC26A4 abnormality were characterized by large follicles with Sanderson's polsters. Multiple non-encapsulated nodular lesions were present except in two patients with SLC26A4 abnormality. These were mainly follicular thyroid adenoma-like nodules associated with TG gene abnormality, TPO gene abnormality, and SLC5A5 variant. With SLC26A4 abnormality, the nodules were follicular nodular disease-like. The proposed histological framework may be particularly valuable for adult patients undergoing thyroidectomy for unexplained diffuse enlargement or multinodularity, particularly when no prior diagnosis of DG is documented.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From cross-section to prognosis: risk factors for renal function deterioration in primary hyperparathyroidism. 从横切面到预后：原发性甲状旁腺功能亢进肾功能恶化的危险因素。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-05-15 DOI: 10.1507/endocrj.EJ25-0616

Takuma Yamoto, Masakazu Notsu, Keizo Kanasaki

{"title":"From cross-section to prognosis: risk factors for renal function deterioration in primary hyperparathyroidism.","authors":"Takuma Yamoto, Masakazu Notsu, Keizo Kanasaki","doi":"10.1507/endocrj.EJ25-0616","DOIUrl":"10.1507/endocrj.EJ25-0616","url":null,"abstract":"Renal dysfunction is an important complication of primary hyperparathyroidism (pHPT). However, the factors associated with a decline in estimated glomerular filtration rate (eGFR) in patients with pHPT have not been fully investigated. This study aimed to identify the factors associated with reduced eGFR at diagnosis in patients with pHPT, and the determinants of longitudinal eGFR decline among those with follow-up data. Eighty-nine patients with pHPT were categorized by renal function at diagnosis. In addition, the annual eGFR decline rate was assessed in 47 patients with more than one year of follow-up. Clinical and biochemical variables were analyzed to determine their association with renal function. Compared with the normal renal function group, the reduced renal function group (eGFR <60 mL/min/1.73 m2) had higher age, and uric acid levels, lower diastolic blood pressure, daily urinary calcium (Ca) excretion, and % tubular reabsorption of phosphate (%TRP). In the multivariable logistic regression analysis, a low %TRP remained significantly associated with reduced renal function at diagnosis. Patients with an eGFR decline faster than -3 mL/min/1.73 m2 per year had significantly higher serum chloride and 25-hydroxyvitamin D levels, and lower HbA1c levels than those with a slower decline. Logistic regression analysis showed, that higher serum chloride levels were associated with a faster annual decline in eGFR. In conclusion, reduced eGFR at pHPT diagnosis was associated with lower %TRP, whereas a faster annual eGFR decline was associated with higher serum chloride levels.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"939-949"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147962591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overlap syndrome between sarcoidosis and Sjögren's disease presenting as hypopituitarism: case report and review of literature. 结节病与Sjögren的重叠综合征表现为垂体功能低下：病例报告及文献复习。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-05-08 DOI: 10.1507/endocrj.EJ26-0063

Yuichiro Iwamoto, Noriko Yoshimura, Ayaka Harada, Yoshiro Fushimi, Yui Okamoto, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Yo Mizuta, Saeko Tsurui, Seiji Matsumoto, Yoshikazu Koike, Takehiro Nishimura, Hideaki Kaneto

{"title":"Overlap syndrome between sarcoidosis and Sjögren's disease presenting as hypopituitarism: case report and review of literature.","authors":"Yuichiro Iwamoto, Noriko Yoshimura, Ayaka Harada, Yoshiro Fushimi, Yui Okamoto, Tomohiko Kimura, Masashi Shimoda, Shuhei Nakanishi, Yo Mizuta, Saeko Tsurui, Seiji Matsumoto, Yoshikazu Koike, Takehiro Nishimura, Hideaki Kaneto","doi":"10.1507/endocrj.EJ26-0063","DOIUrl":"10.1507/endocrj.EJ26-0063","url":null,"abstract":"Sarcoidosis is a granulomatous disease that affects multiple organs; however, pituitary involvement is extremely rare. Although autoimmune diseases, such as Sjögren's disease (SjD), may coexist, overlapping cases presenting with hypopituitarism are exceedingly rare. A 76-year-old man was admitted with hyponatremia and altered consciousness as chief complaints. Endocrine testing revealed panhypopituitarism, and magnetic resonance imaging showed pituitary gland and pituitary stalk enlargement with homogeneous enhancement. Whole-body imaging revealed extensive lymphadenopathy. Histological examination of lymph node and lung biopsy specimens revealed non-necrotizing granulomas, indicative of sarcoidosis. Salivary gland biopsy and autoantibody testing confirmed the presence of concomitant SjD. Hormone replacement therapy markedly improved pituitary enlargement and pituitary hormone secretion, allowing the discontinuation of replacement therapy after 137 days. However, despite the improvement in pituitary and lymph node lesions, interstitial pneumonia subsequently developed due to SjD, necessitating systemic immunosuppressive therapy. In conclusion, this case demonstrates a rare overlap between sarcoidosis presenting with hypopituitarism and SjD, in which pituitary lesions improved, but immune activity progressed in other organs. Thus, immune-mediated disease activity may differ between organs in overlapping syndromes, and pituitary lesions in sarcoidosis do not necessarily parallel systemic disease activity.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"993-1002"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term survival in MIRAGE syndrome: Insights into systemic manifestations and management with review of literature. MIRAGE综合征的长期生存：对系统表现和管理的见解与文献回顾。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-04-23 DOI: 10.1507/endocrj.EJ25-0656

Yuki Yamada, Hidehito Kondo, Masashi Nishida, Zenro Kizaki, Kanako Tanase-Nakao, Satoshi Narumi, Jun Mori

{"title":"Long-term survival in MIRAGE syndrome: Insights into systemic manifestations and management with review of literature.","authors":"Yuki Yamada, Hidehito Kondo, Masashi Nishida, Zenro Kizaki, Kanako Tanase-Nakao, Satoshi Narumi, Jun Mori","doi":"10.1507/endocrj.EJ25-0656","DOIUrl":"10.1507/endocrj.EJ25-0656","url":null,"abstract":"MIRAGE syndrome is a multisystemic disorder with a poor prognosis, caused by gain-of-function mutations in the SAMD9 gene. To date, no comprehensive reports on the systemic manifestations and management of MIRAGE syndrome in adult survivors. Here, we present the case of a 22-year-old man long-term survivor of MIRAGE syndrome with a wide range of clinical presentations and complications. From the neonatal period, he exhibited the core features of MIRAGE syndrome: myelodysplasia, recurrent infection, growth retardation, adrenal hypoplasia, atypical external genitalia, and enteropathy. Additionally, brain imaging at 5 years of age revealed new findings, including basal ganglia and white matter lesions, calcification, infarction, and ventricular enlargement. Subsequently, proteinuria was detected at 6 years of age, which gradually progressed to end-stage renal disease. At 21 years of age, he received a living-donor kidney transplant from his father, the first transplant reported for this syndrome. Genetic analysis identified a congenital SAMD9 mutation (p.Gln1286Lys) and three acquired reversion mutations. These revision mutations mitigated his hematologic complications but did not fully restore immune function. In addition to persistent immunological and endocrine dysfunction, the patient has developed progressive neurological and metabolic abnormalities over time. Multidisciplinary management, including prophylactic intravenous immunoglobulin therapy, renal replacement therapy and transplantation, and endocrine support, was provided and may have contributed to his long-term survival. This case highlights the evolving clinical spectrum of MIRAGE syndrome and underscores the importance of careful longitudinal monitoring for patients who survive beyond early childhood.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"975-982"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting. 糖尿病中的可溶性肿瘤坏死因子受体：风险感知和受体解决靶向。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-04-29 DOI: 10.1507/endocrj.EJ26-0050

Qi Zhu, Yu Liu, Chen Yang, Tie Li

{"title":"Soluble tumor necrosis factor receptors in diabetes: risk sensing and receptor-resolved targeting.","authors":"Qi Zhu, Yu Liu, Chen Yang, Tie Li","doi":"10.1507/endocrj.EJ26-0050","DOIUrl":"10.1507/endocrj.EJ26-0050","url":null,"abstract":"Diabetes drives a major burden of kidney failure, cardiovascular disease, and premature mortality, yet current clinical markers incompletely capture individual trajectories of organ decline. Soluble tumor necrosis factor receptors 1 and 2 (sTNFR1/2) have emerged as among the most reproducible circulating predictors of diabetic kidney disease progression, retaining prognostic value after adjustment for estimated glomerular filtration rate (eGFR) and albuminuria across multiple cohorts. Prospective studies in type 2 diabetes also associate higher sTNFR1/2 with incident cardiovascular events and all-cause mortality, supporting a systemic risk phenotype that is not fully explained by baseline kidney measures. Mechanistically, recent work has refined the classical view of tumor necrosis factor (TNF) as a generic inflammatory mediator by identifying proximal checkpoints that govern TNFR1 \"injury-biased\" outputs, including ubiquitination- and lipidation-dependent control of RIPK1, trafficking-dependent restraint of death-receptor signaling, and cross-pathway phosphorylation that retunes downstream complex assembly. In parallel, advances in therapeutic engineering are shifting the field from non-selective TNF neutralization toward receptor-selective modulation, including TNFR1-selective antagonists, allosteric inhibitors, and shedding strategies designed to reduce injury signaling while preserving TNFR2-linked immunoregulatory and reparative programs. This receptor-resolved framework provides a coherent basis for interpreting why soluble receptors outperform circulating TNF as prognostic biomarkers and for developing mechanism-informed interventions in diabetes.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"907-922"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

γ-Secretase inhibitor ameliorates thyroid autoimmune damage via blocking Notch1 signaling and reducing γδT17 cells in EAT mice. γ-分泌酶抑制剂通过阻断Notch1信号和减少γδT17细胞，改善EAT小鼠甲状腺自身免疫损伤。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-05-13 DOI: 10.1507/endocrj.EJ25-0663

Jue Wang, Longfei Ding, Chengyan He, Hao Liu, Yiwen Li, Yujiao Zhu, Yue Li, Haibo Xue

{"title":"γ-Secretase inhibitor ameliorates thyroid autoimmune damage via blocking Notch1 signaling and reducing γδT17 cells in EAT mice.","authors":"Jue Wang, Longfei Ding, Chengyan He, Hao Liu, Yiwen Li, Yujiao Zhu, Yue Li, Haibo Xue","doi":"10.1507/endocrj.EJ25-0663","DOIUrl":"10.1507/endocrj.EJ25-0663","url":null,"abstract":"In order to explore if γ-secretase inhibitor can regulate γδT17 cells by blockading Notch1 signaling pathway and then affect thyroid autoimmune damage in experimental autoimmune thyroiditis (EAT) mice. Twenty-four female C57BL/6 mice, 6 to 8-week-old, were randomly divided into NC and EAT groups, and EAT group included EAT-A (pTg treated) and EAT-B (treated with DAPT before pTg) subgroups. HE staining was conducted to observe the pathological changes of thyroid tissue. ELISA was adopted to measure the concentrations of thyroglobulin antibody (TgAb) and interleukin 17A (IL-17A) in serum. The proportions of γδT17 cells were analysed by flow cytometry. The mRNA expressions of Notch1, hairy and split 1 (Hes1) and IL-17A were measured by RT-qPCR and the protein levels of Notch intracellular domain (NICD), Hes1 and IL-17A were examined by Western Blot. The titers of TgAb and IL-17A in serum, the proportions of γδT17 cells in spleen mononuclear cells (SMCs) and thyroid mononuclear cells (TMCs), the Notch1, Hes1, IL-17A mRNA and protein expressions in EAT-A mice were all increased significantly compared with NC group (all p < 0.001). However, in EAT-B group, the above indexes were all reduced significantly than those in EAT-A group (all p < 0.05), as well as the degrees of lymphocyte infiltration in thyroid were alleviated remarkably compared with EAT-A group. Additionally, γδT17 cells percentages of EAT mice were positively correlated with TgAb titers, IL-17A concentrations and Notch1 mRNA expressions. γ-secretase inhibitor is speculated to alleviate thyroid autoimmune injury in EAT by downregulating γδT17 cells via inhibition of the Notch1/Hes1 signaling pathway.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"951-961"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-based prediction of impaired arginine vasopressin secretion during hypertonic saline test. 高渗盐水试验中精氨酸抗利尿激素分泌受损的机器学习预测。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-04-25 DOI: 10.1507/endocrj.EJ26-0094

Satoshi Naito, Daisuke Hagiwara, Masaki Kitamura, Ryosei Ashida, Yohei Kawaguchi, Takashi Miyata, Tomoko Handa, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima

{"title":"Machine learning-based prediction of impaired arginine vasopressin secretion during hypertonic saline test.","authors":"Satoshi Naito, Daisuke Hagiwara, Masaki Kitamura, Ryosei Ashida, Yohei Kawaguchi, Takashi Miyata, Tomoko Handa, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima","doi":"10.1507/endocrj.EJ26-0094","DOIUrl":"10.1507/endocrj.EJ26-0094","url":null,"abstract":"Hypertonic saline infusion and water deprivation tests are commonly used to stimulate arginine vasopressin (AVP) for the diagnosis of AVP deficiency (AVP-D); however, these procedures impose a considerable burden on patients. We aimed to develop machine learning models to predict impaired AVP secretion and thereby reduce the need for AVP stimulation testing. This retrospective cohort study included 64 patients who underwent the hypertonic saline test (HST) at Nagoya University Hospital, Japan, between 2018 and 2024. Impaired AVP secretion was defined as a predicted plasma AVP level <1.0 pg/mL at a serum sodium level of 149 mEq/L during the HST. Feature selection was performed using univariate screening and systematic selection procedures. Logistic regression and support vector machine models were developed using baseline clinical and laboratory parameters obtained before the HST and validated using nested cross-validation. The primary outcome was the area under the receiver operating characteristic curve (AUC); secondary outcomes included the sensitivity, specificity, and positive and negative predictive values. Four variables (urinary osmolality, serum sodium, plasma AVP, and blood urea nitrogen) were selected. The logistic regression model achieved an AUC of 0.862 for predicting impaired AVP secretion. Among 35 patients who underwent the HST for suspected AVP-D, at the optimized threshold, the positive and negative predictive values were 100% (14/14 patients) and 33.3% (7/21 patients), respectively. The developed machine learning model can identify a subset of patients with impaired AVP secretion without requiring the HST, potentially reducing the number of patients who need AVP stimulation testing for AVP-D diagnosis.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"963-973"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acanthosis nigricans as a diagnostic clue for familial partial lipodystrophy type 2: a case report with review of literature on Japanese cases. 黑棘皮病作为家族性2型部分脂肪营养不良的诊断线索：1例报告并复习日本病例的文献。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-05-12 DOI: 10.1507/endocrj.EJ25-0487

Takuya Kitamura, Toru Kusakabe, Yuki Ishihara, Tetsuya Tagami, Kazuwa Nakao

{"title":"Acanthosis nigricans as a diagnostic clue for familial partial lipodystrophy type 2: a case report with review of literature on Japanese cases.","authors":"Takuya Kitamura, Toru Kusakabe, Yuki Ishihara, Tetsuya Tagami, Kazuwa Nakao","doi":"10.1507/endocrj.EJ25-0487","DOIUrl":"10.1507/endocrj.EJ25-0487","url":null,"abstract":"Familial partial lipodystrophy (FPLD) is a rare inherited disorder characterized by limb adipose tissue atrophy and metabolic abnormalities, including severe insulin resistance. However, diagnosis is often delayed because the characteristic physique can be difficult to recognize without a high index of suspicion. We present the case of a 19-year-old Japanese woman diagnosed with FPLD type 2 (FPLD2). She had a history of irregular menses and hirsutism since adolescence. The FPLD2 diagnosis was prompted by her concerns about axillary and inguinal pigmentation. Her mother's online search first suggested acanthosis nigricans (AN). After including \"muscular limb\" as an additional search term, they suspected lipodystrophy, prompting a consultation with an endocrinologist. Clinical examination revealed impaired glucose tolerance, severe insulin resistance, dyslipidemia, fatty liver, and polycystic ovary syndrome. Genetic testing identified a heterozygous LMNA p.R482Q variant, confirming the diagnosis. This case demonstrates that AN, a skin manifestation of insulin resistance, is an important diagnostic clue for FPLD. Although women with FPLD frequently present with menstrual irregularities and hirsutism in their late teens, their insulin levels are rarely measured before diabetes onset. Consequently, the underlying severe insulin resistance is frequently overlooked. Although reported cases of FPLD2 in Japan are limited, many cases may remain undiagnosed. Therefore, clinicians should examine the friction-prone areas in non-severely obese individuals with metabolic or menstrual irregularities. The absence of AN does not rule out insulin resistance. Therefore, even without AN, the presence of other features of insulin resistance warrant consideration of FPLD and careful evaluation for limb fat loss, facilitating early diagnosis.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"983-991"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147927754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease. zfp36 -铁下垂轴作为糖尿病肾病关键的肾保护通路。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-08-03 Epub Date: 2026-04-18 DOI: 10.1507/endocrj.EJ25-0648

Anni Li, Yuxuan Ye, Huimin Cao, Jiawei Hu, Min Shi, Juan Zhang, Yiyuan Zhang, Yuting Liu, Bixia Gu, Hong Zhang

{"title":"ZFP36-ferroptosis axis as a key renal protective pathway in diabetic kidney disease.","authors":"Anni Li, Yuxuan Ye, Huimin Cao, Jiawei Hu, Min Shi, Juan Zhang, Yiyuan Zhang, Yuting Liu, Bixia Gu, Hong Zhang","doi":"10.1507/endocrj.EJ25-0648","DOIUrl":"10.1507/endocrj.EJ25-0648","url":null,"abstract":"Diabetic Kidney Disease (DKD) is strongly related to ferroptosis, an iron-dependent form of programmed cell death characterized by the accumulation of lipid peroxides. While ferroptosis is a pivotal mediator in DKD pathogenesis, its upstream regulatory mechanism remains poorly defined, thus impeding the development of targeted therapeutic strategies. In this study, by integrating multi-omics clinical data (GSE96804 and GSE104954) and combining machine learning algorithms, the RNA-binding protein ZFP36 was screened out as the core regulatory factor of ferroptosis in DKD. The results revealed that the expression level of ZFP36 in the DKD group was significantly lower than that in the normal group. Functional experiments demonstrated that overexpression of ZFP36 could significantly alleviate lipid peroxidation, iron ion accumulation, and cellular fibrosis, thereby inhibiting ferroptosis and alleviating kidney damage. Transcriptome analysis further revealed that ZFP36 regulated key genes related to oxidative stress and iron metabolism. Additionally, molecular docking simulations revealed strong binding affinity between ZFP36 and bioactive natural products such as berberine and astragalus, providing a potential mechanism for its renal protective effect. Overall, ZFP36 was hereby established as an important inhibitor of ferroptosis in DKD, highlighting its potential as both a biomarker and a therapeutic target for its precision diagnosis and intervention.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"923-937"},"PeriodicalIF":2.5,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147722312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated autoantibodies against dipeptidyl peptidase-4 are associated with poor prognosis in patients with type 2 diabetes. 抗二肽基肽酶-4自身抗体升高与2型糖尿病患者预后不良相关。

IF 2.5 4区医学

Endocrine journal Pub Date : 2026-07-22 DOI: 10.1507/endocrj.EJ26-0170

Takeshi Yagihashi, Takahide Hashimoto, Naoki Ohtake, Tokiko Okamoto, Bo-Shi Zhang, Yoichi Yoshida, Masaya Yamaga, Tomohiko Yoshida, Amika Kajiyama, Rikako Furukawa, Takaki Hiwasa, Minoru Takemoto

{"title":"Elevated autoantibodies against dipeptidyl peptidase-4 are associated with poor prognosis in patients with type 2 diabetes.","authors":"Takeshi Yagihashi, Takahide Hashimoto, Naoki Ohtake, Tokiko Okamoto, Bo-Shi Zhang, Yoichi Yoshida, Masaya Yamaga, Tomohiko Yoshida, Amika Kajiyama, Rikako Furukawa, Takaki Hiwasa, Minoru Takemoto","doi":"10.1507/endocrj.EJ26-0170","DOIUrl":"https://doi.org/10.1507/endocrj.EJ26-0170","url":null,"abstract":"Dipeptidyl peptidase-4 (DPP4) is involved in immune regulation and metabolic homeostasis. Although DPP4 inhibitors are widely used in type 2 diabetes, the clinical relevance of autoantibodies against DPP4 (DPP4-Ab) remains unclear. In this study, we aimed to investigate the association between circulating DPP4-Ab levels and mortality in 274 patients with type 2 diabetes (mean age, 63 years). Serum DPP4-Ab levels were measured using amplified luminescent proximity homogeneous assay-linked immunosorbent assay (AlphaLISA), and survival was assessed using Kaplan-Meier analysis and Cox proportional hazards regression analysis. During a mean follow-up of approximately 5 years, 32 deaths had occurred. Patients with elevated DPP4-Ab titers (>1,676.8 alpha counts) had a higher mortality rate than those with low titers (22.2% vs. 9.3%, p = 0.0177). In Cox proportional hazards regression analysis, DPP4-Ab titers showed a trend toward association with all-cause mortality when analyzed as a continuous variable per 100 alpha counts (a.c.) increase (hazard ratio [HR], 1.042; 95% confidence interval [CI], 0.996-1.090; p = 0.071). When patients were stratified using the predefined cutoff value of 1,676.8 a.c., the high DPP4-Ab group showed significantly higher mortality risk than the low DPP4-Ab group (HR, 2.30; 95% CI, 1.09-4.84; p = 0.028). Addition of DPP4-Ab to an age-based model only slightly improved predictive discrimination. These findings suggest that elevated DPP4-Ab titers may be associated with mortality risk; however, this association should be interpreted cautiously and warrants further investigation as a potential adjunctive immunometabolic biomarker in type 2 diabetes.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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