Endocrine journal最新文献_第6页

Dose-response relationship between the fatty liver index and asthma risk: NHANES 2001~2018. 脂肪肝指数与哮喘风险之间的剂量-反应关系：Nhanes 2001~2018.

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-11-12 DOI: 10.1507/endocrj.EJ24-0248

Tengfei Sun, Kexin Fan, Zhuoxiao Han, Hua Qiao

{"title":"Dose-response relationship between the fatty liver index and asthma risk: NHANES 2001~2018.","authors":"Tengfei Sun, Kexin Fan, Zhuoxiao Han, Hua Qiao","doi":"10.1507/endocrj.EJ24-0248","DOIUrl":"10.1507/endocrj.EJ24-0248","url":null,"abstract":"The correlation of obesity and metabolic abnormalities with asthma and non-alcoholic hepatic steatosis has been extensively studied. However, the association between asthma and non-alcoholic hepatic steatosis has been largely overlooked. This study aims to investigate the potential association between asthma risk and the fatty liver index (FLI), a validated indicator of non-alcoholic fatty liver disease (NAFLD). We screened 16,223 adults from National Health and Nutrition Examination Survey (NHANES) data between 2001 and 2018. Logistic regression analysis was performed to identify the association between FLI and asthma risk. We assessed their dose-response relationship using a restricted cubic spline (RCS) model. The threshold effect was analyzed to identify the FLI threshold point. Among the subjects screened, there were 2,192 cases suffered from asthma. After adjusting for all the confounders, using the Q3 group (FLI, 54-83) as the reference, the odds ratios (ORs) were 1.35 for the Q1 group (95% CI, 1.01-1.81), 1.21 for Q2 (95% CI, 0.98-1.49), and 1.48 for Q4 (95% CI, 1.27-1.73). Moreover, the RCS showed a nonlinear relationship between FLI and asthma risk (p < 0.05). Although the nonlinear relationship remained significant after gender-based stratification (p < 0.05), low FLI did not confer an increased risk of asthma in females. The optimal FLI threshold was 65 for the study sample; it was 68 and 63 for males and females, respectively (p < 0.05). This study demonstrated a nonlinear relationship between FLI and asthma risk. Furthermore, maintaining respective index values of 68 and 63 for males and females is likely associated with the lowest asthma risk.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"229-237"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850101/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physiological and pathophysiological actions of insulin in the liver. 胰岛素在肝脏中的生理和病理作用。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-09-03 DOI: 10.1507/endocrj.EJ24-0192

Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki

{"title":"Physiological and pathophysiological actions of insulin in the liver.","authors":"Naoto Kubota, Tetsuya Kubota, Takashi Kadowaki","doi":"10.1507/endocrj.EJ24-0192","DOIUrl":"10.1507/endocrj.EJ24-0192","url":null,"abstract":"The liver plays an important role in the control of glucose homeostasis. When insulin levels are low, such as in the fasting state, gluconeogenesis and glycogenolysis are stimulated to maintain the blood glucose levels. Conversely, in the presence of increased insulin levels, such as after a meal, synthesis of glycogen and lipid occurs to maintain the blood glucose levels within normal range. Insulin receptor signaling regulates glycogenesis, gluconeogenesis and lipogenesis through downstream pathways such as the insulin receptor substrate (IRS)-phosphoinositide 3 (PI3) kinase-Akt pathway. IRS-1 and IRS-2 are abundantly expressed in the liver and are thought to be responsible for transmitting the insulin signal from the insulin receptor to the intracellular effectors involved in the regulation of glucose and lipid homeostasis. Impaired insulin receptor signaling can cause hepatic insulin resistance and lead to type 2 diabetes. In the present study, we focus on a concept called \"selective insulin resistance,\" which has received increasing attention recently: the frequent coexistence of hyperglycemia and hepatic steatosis in people with type 2 diabetes and obesity suggests that it is possible for the insulin signaling regulating gluconeogenesis to be impaired even while that regulating lipogenesis is preserved, suggestive of selective insulin resistance. In this review, we review the progress in research on the insulin actions and insulin signaling in the liver.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"149-159"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism. 嗜铬细胞瘤伴原发性醛固酮增多症的临床比较和基因分析。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-11-26 DOI: 10.1507/endocrj.EJ24-0150

Xurong Mai, Mitsuhiro Kometani, Toshiaki Kato, Ko Aiga, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Koshiro Nishimoto, Kazuyoshi Hosomichi, Atsushi Watanabe, Yuko Noda, Yoshiyu Takeda, Takashi Yoneda

{"title":"Clinical comparison and genetic analysis in pheochromocytoma with primary aldosteronism.","authors":"Xurong Mai, Mitsuhiro Kometani, Toshiaki Kato, Ko Aiga, Shigehiro Karashima, Daisuke Aono, Seigo Konishi, Koshiro Nishimoto, Kazuyoshi Hosomichi, Atsushi Watanabe, Yuko Noda, Yoshiyu Takeda, Takashi Yoneda","doi":"10.1507/endocrj.EJ24-0150","DOIUrl":"10.1507/endocrj.EJ24-0150","url":null,"abstract":"Pheochromocytoma is a rare form of adrenal hypertension. This study aimed to investigate the clinical characteristics and associated genetic mutations in patients with pheochromocytoma and primary aldosteronism. We retrospectively analyzed data from 23 patients with pheochromocytoma diagnosed and treated between 2011 and 2022. Three cases were complicated by primary aldosteronism. Compared to 15 other patients without primary aldosteronism complications, these three patients had a greater suppression of plasma renin activity (0.2 vs. 2.3 ng/mL/h, p < 0.01) and a higher aldosterone-to-renin ratio (p < 0.01). No significant differences were found in blood pressure, serum potassium levels, or plasma aldosterone concentrations between the two groups. In genetic analysis, among the three patients with pheochromocytoma and primary aldosteronism, two had a KCNJ5 (G151R) mutation in the pheochromocytoma tumor tissues. However, no CYP11B2- or CYP11B1-positive cells were detected via immunostaining in the pheochromocytoma tissues of these three patients. To our knowledge, this is the first study to reveal the presence of the KCNJ5 mutation, commonly considered specific to primary aldosteronism, in pheochromocytoma cases clinically complicated by primary aldosteronism. The findings suggest that patients with pheochromocytoma and suppressed plasma renin activity should be assessed for primary aldosteronism.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"193-203"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis. 敲除Gfi1可增加BMSCs外泌miR-150-3p，从而通过BTRC/Nrf2轴抑制类固醇诱导的股骨头坏死中的成骨细胞铁凋亡

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-12-14 DOI: 10.1507/endocrj.EJ24-0306

Liwen Zheng, Changjie Zhang, Lele Liao, Zhijie Hai, Xin Luo, Haoliang Xiao

{"title":"Knockdown of Gfi1 increases BMSCs exosomal miR-150-3p to inhibit osteoblast ferroptosis in steroid-induced osteonecrosis of the femoral head through BTRC/Nrf2 axis.","authors":"Liwen Zheng, Changjie Zhang, Lele Liao, Zhijie Hai, Xin Luo, Haoliang Xiao","doi":"10.1507/endocrj.EJ24-0306","DOIUrl":"10.1507/endocrj.EJ24-0306","url":null,"abstract":"The ferroptosis of osteoblasts has been demonstrated to play a significant role in the development of steroid-induced osteonecrosis of the femoral head (SONFH). Additionally, microRNAs (miRNAs) have been identified as regulators of SONFH progression. However, the precise role of miRNAs in the regulation of osteoblast ferroptosis remains unclear. This study explored the role of exosomal miR-150-3p, derived from bone marrow mesenchymal stem cells (BMSCs), in osteoblast ferroptosis in SONFH. Dexamethasone (DEX) was used to treat osteoblasts to induce ferroptosis. BMSCs exosomes with different levels of miR-150-3p were introduced into a co-culture with the cells. To verify the targeting relationship between growth factor independence 1 (Gfi1) and the miR-150-3p promoter, as well as between miR-150-3p and beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), respectively, chromatin immunoprecipitation (ChIP), RNA immunoprecipitation (RIP), and dual luciferase assays were employed. It was found that BMSCs-Exos-miR-150-3p mitigated DEX-triggered ferroptosis in osteoblasts. MiR-150-3p directly targeted BTRC, leading to its downregulation in osteoblasts. The BTRC/Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway was involved in the inhibition of DEX-induced osteoblast ferroptosis by BMSCs-Exos-miR-150-3p. Overexpression of BTRC reversed the inhibitory effect of BMSCs-Exos-miR-150-3p. In a SONFH rat model, BMSCs-Exos-miR-150-3p alleviated ferroptosis in osteoblasts through BTRC/Nrf2. In addition, Gfi1 bonded to the miR-150-3p promoter and inhibited its transcription. Gfi1 silencing elevated miR-150-3p levels and improves cell viability of BMSCs. In conclusion, our results suggest that BMSCs-Exos-miR-150-3p alleviates SONFH by suppressing ferroptosis through the regulation of BTRC/Nrf2 and miR-150-3p may be a potential target for SONFH treatment.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"205-219"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients. 青少年和青壮年患者甲状腺乳头状癌的临床病理和分子特征。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-12-03 DOI: 10.1507/endocrj.EJ24-0504

Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Thi Ngoc Anh Nguyen, Katsuya Matsuda, Yuki Matsuoka, Zhanna Mussazhanova, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova, Masahiro Nakashima

{"title":"Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients.","authors":"Van Phu Thang Nguyen, Hirokazu Kurohama, Yuko Akazawa, Thi Ngoc Anh Nguyen, Katsuya Matsuda, Yuki Matsuoka, Zhanna Mussazhanova, Kenichi Yokota, Shinya Satoh, Hiroyuki Yamashita, Thi Nhung Nguyen, Yerkerzhan Sailaubekova, Masahiro Nakashima","doi":"10.1507/endocrj.EJ24-0504","DOIUrl":"10.1507/endocrj.EJ24-0504","url":null,"abstract":"Adolescent and young adult (AYA, 15-39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). This retrospective study enrolled 1,677 patients diagnosed with PTC from January 2018 to December 2022, with 400 AYA patients and 1,277 older adults. At the time of diagnosis, AYA patients with PTC had higher rates of presentation in females, larger tumor size (>2.0 cm), lymphatic vessel invasion, chronic thyroiditis, clinical lymph node metastasis, and pathologic lymph node metastasis, but lower rates of multifocality and extrathyroidal extension compared with PTC in older adults. The two groups had no significant differences regarding surgical method and distant metastasis. The prevalences of BRAF p.V600E and TERT promoter mutations of PTC were significantly lower in AYA patients (69.1% vs. 82.6% and 1.3% vs. 18.8%, respectively; both p < 0.001). In conclusion, PTC in AYA patients differed from PTC in older patients. Particularly, BRAF p.V600E and TERT promoter mutations in AYA with PTC were less frequently observed than in older adults.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"221-227"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of radiologists in the diagnosis and management of adrenal disorders. 放射科医生在诊断和治疗肾上腺疾病中的作用。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-10-10 DOI: 10.1507/endocrj.EJ24-0156

Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase

{"title":"Role of radiologists in the diagnosis and management of adrenal disorders.","authors":"Sota Oguro, Hiromitsu Tannai, Hideki Ota, Kazumasa Seiji, Hiroki Kamada, Yoshitaka Toyama, Kei Omata, Yuta Tezuka, Yoshikiyo Ono, Fumitoshi Satoh, Sadayoshi Ito, Tetsuhiro Tanaka, Hideki Katagiri, Kei Takase","doi":"10.1507/endocrj.EJ24-0156","DOIUrl":"10.1507/endocrj.EJ24-0156","url":null,"abstract":"This study aimed to focus on the role of radiologists in the diagnosis and management of adrenal lesions, particularly primary aldosteronism (PA) and secondary hypertension. As hypertension affects more than one-third of the population in Japan, identifying secondary causes such as PA and adrenal lesions is crucial. Establishing a radiological differential diagnosis of adrenal lesions using advanced imaging techniques, such as computed tomography and magnetic resonance imaging, is crucial. Knowledge of the imaging findings of various benign and malignant adrenal lesions, such as adrenocortical adenomas, cortisol-producing lesions, pheochromocytomas, adrenocortical carcinoma, malignant lymphoma, and metastatic tumors, is necessary. Adrenal venous sampling (AVS) plays a crucial role in accurately localizing aldosterone hypersecretion in PA, especially when imaging fails to provide a clear diagnosis. This paper details the technical aspects of AVS, emphasizing catheterization techniques, anatomical considerations, and the importance of preprocedural imaging for successful sampling. Furthermore, we explore segmental adrenal venous sampling (SAVS), a more refined technique that samples specific adrenal tributary veins, offering enhanced diagnostic accuracy, particularly for microadenomas or challenging cases that may be missed with conventional AVS. The methodology for performing SAVS, along with the interpretation criteria for successful sampling and lateralization, is also outlined. Furthermore, radiologists have initiated treatments for unilateral PA, such as radiofrequency ablation, and play an integral role in the management of adrenal lesions. Collaborative approaches across clinical departments are required to enhance patient management in medical care involving the adrenal gland.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"131-148"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850109/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142388967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects. 健康男性在口服葡萄糖负荷后肌肉质量与全身振动运动诱导的血浆次黄嘌呤变化之间的关系。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-03 Epub Date: 2024-11-13 DOI: 10.1507/endocrj.EJ24-0358

Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-Aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura

{"title":"Associations between muscle quality and whole-body vibration exercise-induced changes in plasma hypoxanthine following an oral glucose load in healthy male subjects.","authors":"Tomoyuki Hara, Yuya Fujishima, Hitoshi Nishizawa, Yusuke Kawachi, Takashi Nakamura, Seigo Akari, Yoshiyuki Ono, Hirotaka Watanabe, Taka-Aki Sakaue, Yoshinari Obata, Hirofumi Nagao, Shiro Fukuda, Takashi Kanamoto, Mitsuyoshi Takahara, Naoto Katakami, Ken Nakata, Iichiro Shimomura","doi":"10.1507/endocrj.EJ24-0358","DOIUrl":"10.1507/endocrj.EJ24-0358","url":null,"abstract":"Blood levels of hypoxanthine (HX) have been suggested as potential biomarkers associated with intramuscular metabolic dynamics in response to exercise. This pilot randomized crossover trial (UMIN000036520) aimed to investigate the changes in plasma HX after whole-body vibration exercise (WBVE) and their relationships with body composition and muscle-related parameters, enrolling eighteen healthy male volunteers. In the WBVE-alone intervention, the study subjects performed 20-min of WBVE. In the OGTT → WBVE intervention, a 75-g oral glucose load (OGL) was administered 30 min prior to the start of the WBVE intervention. Blood samples were collected before the start and 10 min after the end of WBVE in both interventions. WBVE resulted in a significant increase in plasma HX levels, which was accompanied by increased blood ammonia, pyruvic acid, and lactic acid levels. The HX increase following WBVE was suppressed by prior OGL. In the WBVE-alone intervention, there were no significant correlations between the post-WBVE changes in plasma HX (ΔHX) levels and any of the clinical parameters. On the other hand, in the OGTT → WBVE intervention, ΔHX showed significant negative correlations with muscle mass (ρ = -0.62, p = 0.01), strength (ρ = -0.71, p = 0.005), and muscle quality (ρ = -0.81, p = 0.0007) in the legs. In conclusion, these findings suggest possible associations between post-WBVE increases in plasma HX levels and muscle status, particularly under the glucose-supplemented condition. The measurement of plasma HX concentrations following WBVE may have clinical applications in the identification of high-risk populations for sarcopenia.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"171-181"},"PeriodicalIF":1.3,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between serum thyroglobulin levels and glycemic control in patients with thyroid cancer after radioiodine therapy. 放射性碘治疗后甲状腺癌患者血清甲状腺球蛋白水平与血糖控制的关系。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-02-01 DOI: 10.1507/endocrj.EJ24-0417

Yuji Hataya, Yuko Fujishima, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka

{"title":"Association between serum thyroglobulin levels and glycemic control in patients with thyroid cancer after radioiodine therapy.","authors":"Yuji Hataya, Yuko Fujishima, Kanta Fujimoto, Toshio Iwakura, Naoki Matsuoka","doi":"10.1507/endocrj.EJ24-0417","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0417","url":null,"abstract":"Serum thyroglobulin (Tg) levels are highly sensitive and specific tumor markers in patients with thyroid cancer who have undergone total thyroidectomy and radioiodine (RAI) therapy. Recently, we reported a case wherein serum Tg levels fluctuated according to hemoglobin A1c (HbA1c) levels, demonstrating a strong correlation between serum Tg and HbA1c levels. However, whether this association exists broadly in other patients with thyroid cancer remains unclear. Therefore, we retrospectively investigated this association in six patients with thyroid cancer and diabetes who underwent total thyroidectomy and RAI therapy at our institution. Two patients exhibited a significant correlation between serum Tg and HbA1c levels (r = 0.53, p < 0.01 and r = 0.66, p = 0.01). In these patients, a gradual decrease in serum Tg levels was observed, along with improved glycemic control. Two other patients showed a non-significant correlation between serum Tg and HbA1c levels (r = 0.72, p = 0.11 and r = 0.54, p = 0.17). In these patients, a rapid increase in serum Tg levels was observed, with HbA1c levels showing only small fluctuations. In the remaining two patients, no correlation was found; in these patients, the fluctuations in serum Tg levels were only small, despite fluctuations in HbA1c levels. In conclusion, serum Tg levels may be associated with HbA1c levels in some patients with thyroid cancer and diabetes. The correlation between serum Tg and HbA1c levels was more evident in patients with gradual fluctuations in Tg levels. Future studies with larger cohorts are necessary to clarify the underlying mechanism by which glycemic control influences Tg levels and establish appropriate monitoring methods.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes after a radioactive iodine treatment for a single autonomous functioning thyroid nodule in Japan. 日本单一自主功能甲状腺结节放射性碘治疗后的长期疗效。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-01-23 DOI: 10.1507/endocrj.EJ24-0578

Ai Yoshihara, Jaeduk Yoshimura Noh, Kosuke Inoue, Masakazu Koshibu, Rei Hirose, Masahiro Ichikawa, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Natsuko Watanabe, Kiminori Sugino, Koichi Ito

{"title":"Long-term outcomes after a radioactive iodine treatment for a single autonomous functioning thyroid nodule in Japan.","authors":"Ai Yoshihara, Jaeduk Yoshimura Noh, Kosuke Inoue, Masakazu Koshibu, Rei Hirose, Masahiro Ichikawa, Nami Suzuki, Masako Matsumoto, Miho Fukushita, Natsuko Watanabe, Kiminori Sugino, Koichi Ito","doi":"10.1507/endocrj.EJ24-0578","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0578","url":null,"abstract":"We investigated the association between a 500 MBq dose of radioactive iodine treatment (RAIT) and both thyroid nodule volume and thyroid function in patients with a single autonomous functioning thyroid nodule (AFTN). We retrospectively studied 201 patients with an AFTN who received RAIT at a dose of 500 MBq and were followed up for more than 2 years. Thyroid function at diagnosis, thyroid antibody positivity, treatment with antithyroid drugs before RAIT, cystic components of the nodule, and 131I uptake outside the nodule were assessed. Nodule enlargement was observed in 18 patients (9%), persistent hyperthyroidism in 13 patients (6.5%), and hypothyroidism in 45 patients (22.3%). Nodule volume before RAIT was significantly larger in the nodule enlargement group compared to the non-enlargement group. The risk factors for persistent hyperthyroidism were larger nodule volume and absence of a cystic component in multivariate analysis. The cutoff nodule volume before RAIT for predicting nodule enlargement was 15.5 mL, and for predicting persistent hyperthyroidism was 16.6 mL. Nodule volume decreased to 47% in the first year and continued to gradually decrease thereafter. This study provided long-term outcome data regarding nodule volume change and thyroid function in AFTN patients following single fixed-dose RAIT, and it identified risk factors for nodule enlargement and persistent hyperthyroidism after RAIT. Nodule volume before treatment was a good predictor of treatment response.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A narrative review of long-term inorganic iodine monotherapy for Graves' disease with a historical relationship between iodine and thyroid. 对长期单用无机碘治疗巴塞杜氏病的叙述性综述，以及碘与甲状腺之间的历史关系。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-01-06 Epub Date: 2024-09-05 DOI: 10.1507/endocrj.EJ24-0186

Natsuko Watanabe

{"title":"A narrative review of long-term inorganic iodine monotherapy for Graves' disease with a historical relationship between iodine and thyroid.","authors":"Natsuko Watanabe","doi":"10.1507/endocrj.EJ24-0186","DOIUrl":"10.1507/endocrj.EJ24-0186","url":null,"abstract":"Almost a century has passed since Plummer reported the efficacy of short-term preoperative inorganic iodine therapy for Graves' disease in the 1920s. Since there were concerns about the escape phenomenon and exacerbation with inorganic iodine, antithyroid drugs became the mainstay of pharmacotherapy for Graves' disease following their development in the 1940s. With regard to long-term inorganic iodine monotherapy, Trousseau reported a case in the 1860s, and several subsequent reports suggested its efficacy. Around 1930, Thompson et al. published a number of papers and concluded that long-term inorganic iodine monotherapy was useful if limited to mild cases under careful follow-up. From Japan, in 1970, Nagataki et al. reported that, of 12 patients treated with inorganic iodine, three remained eumetabolic for more than two years. Since 2014, some reports have also been published from Japan. A summary of these recent reports is given below. The starting dose of potassium iodide is around 50 mg/day, and candidate responders have mild disease, with FT4 <2.76 ng/dL (35.5 pmol/L), a small goiter, and are female and elderly. Response rates are relatively high, at 60-80%, and the remission rate is about 40%. In cases of insufficient response, changing therapy should be considered. Inorganic iodine can be used as a possible alternative if the patient experiences adverse events with antithyroid drugs and/or prefers conservative treatments, with an understanding of their efficacy and limitations. These recent reports have been published from Japan, where iodine is sufficient, and the dose of inorganic iodine is empirical and requires further study.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"23-36"},"PeriodicalIF":1.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11778387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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