Paediatric respiratory physiology and sleep最新文献_第8页

PERINATAL INFLAMMATION AND INTRAUTERINE GROWTH RETARDATION ARE BOTH ASSOCIATED WITH LUNG FUNCTION IMPAIRMENT AT 12 YEARS OF AGE IN VERY PRETERM INFANTS 围产期炎症和宫内生长迟缓都与12岁时极早产儿的肺功能损害有关

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA562

Cecilia Hagman, I. Pupp-Hansen, L. Björklund, E. Tufvesson

{"title":"PERINATAL INFLAMMATION AND INTRAUTERINE GROWTH RETARDATION ARE BOTH ASSOCIATED WITH LUNG FUNCTION IMPAIRMENT AT 12 YEARS OF AGE IN VERY PRETERM INFANTS","authors":"Cecilia Hagman, I. Pupp-Hansen, L. Björklund, E. Tufvesson","doi":"10.1183/13993003.CONGRESS-2018.PA562","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA562","url":null,"abstract":"PERINATAL INFLAMMATION AND INTRAUTERINE GROWTH RETARDATION ARE BOTH ASSOCIATED WITH LUNG FUNCTION IMPAIRMENT AT 12 YEARS OF AGE IN VERY PRETERM INFANTS Introduction: Pulmonary disease after very preterm birth may cause permanent lung damage and as a consequence, lung function impairment in long-term survivors. Perinatal inflammation is one of several identified risk factors. Aim and objectives The aim of this study was to evaluate if systemic inflammation early after birth in very preterm infants was related to lung function at preadolescent age. Methods: Spirometry and diffusing capacity was done at 12 years of age in 54 children, born at gestational age of 27.8 weeks. Lung function parameters were compared with inflammatory biomarkers (IL-6, IL-8 and IL-10) previously analyzed from cord blood and at 6, 24 and 72 h after birth. Mean cytokine levels were calculated by area under curve (AUC). BPD was defined as need for supplemental oxygen at 36 weeks PMA. Results: Weight deviation at birth was associated with a lower diffusing capacity (p=0,005) and a lower alveolar volume (p=0,009) at 12-13 years of age. Infants diagnosed with BPD had higher AUC for IL-6, IL-8 and IL-10 in the first 72 h after birth (p=0.009, p There were a significant inverse correlation between AUC for IL-6 in the first days of life and FEV1 (p=0,006) and MMEF25-75 (p=0,019) at 12-13 years of age. Conclusion: The presence of growth retardation at birth as well as perinatal inflammation were risk factors for later impaired lung function at the age of 12. Long term follow up with lung function tests might be useful in infants with specific risk factors.","PeriodicalId":116156,"journal":{"name":"Paediatric respiratory physiology and sleep","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130601723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Drug- Induced Sleep Endoscopy in children predict OSA persistence after adenotonsillectomy 儿童药物诱导睡眠内镜能否预测腺扁桃体切除术后OSA的持续

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa553

S. Weber, Jefferson Luis de Barros, A. C. Marão

引用次数: 0

Role of CO2 monitoring in the diagnosis and management of paediatric sleep disordered breathing 二氧化碳监测在儿科睡眠呼吸障碍诊断和治疗中的作用

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.OA3592

F. Trucco, A. Bush, H. Tan

{"title":"Role of CO2 monitoring in the diagnosis and management of paediatric sleep disordered breathing","authors":"F. Trucco, A. Bush, H. Tan","doi":"10.1183/13993003.CONGRESS-2018.OA3592","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.OA3592","url":null,"abstract":"Home sleep studies are potentially a cost-effective way of diagnosing paediatric sleep disordered breathing (SDB). The majority however, do not include CO2 measurement. We hypothesized that CO2 data does not change management in healthy children with SDB, unlike in those with comorbid conditions, when added to cardio-respiratory polygraphy. Retrospective analysis of two years data on children who underwent a first CRPoly and transcutaneous CO2 study. Age, gender, underlying disease and SDB symptoms were recorded. Management recommendations were first made blinded to CO2 data, then after considering transcutaneous CO2. Mean CO2 was abnormal if>6.5kPa. There were 513 patients, 311 (61%) male, median age 4.5 years (IQR 2.3-7.9). 13/513 were on overnight oxygen (O2), 1/513 on Continuous Positive Pressure (CPAP) and O2, 1/513 on non-invasive ventilation (NIV). 130/513 were healthy with obstructive sleep apnoea (OSA) symptoms. 383/513 had co-morbidities (138 upper-airway, 79 lower-airway, 48 heart disease, 112 neurological syndromes, 6 obesity), 189/383 had OSA symptoms. 107/130 otherwise healthy patients had SDB; CO2 data did not change management. Conversely, either high mean levels (17/20) or raised CO2 in REM sleep (3/20), changed management in 20/383 (5%) patients with co-morbidities; in 16/20, CPAP or NIV was started. Overnight CO2 monitoring is not necessary for the diagnosis of SDB in healthy children, but is crucial in those with co-morbidities.","PeriodicalId":116156,"journal":{"name":"Paediatric respiratory physiology and sleep","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127841084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retrospective analysis of sleep breathing disorders in mucopolysaccharidosis type IVA 粘多糖病IVA型睡眠呼吸障碍回顾性分析

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4590

Giulia Facchina, A. Amaddeo, S. Khirani, G. Baujat, S. James, S. Breton, B. Fauroux

引用次数: 0

Exercise may improve airway clearance and alleviate hyperinflation in children with Cystic Fibrosis 运动可以改善气道清除率，减轻囊性纤维化儿童的恶性膨胀

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa4581

K. Regan, S. Blacklock, D. Urquhart

引用次数: 0

Should bronchodilator response be assessed in all asthmatic children with normal baseline spirometry? 所有基线肺活量正常的哮喘儿童都应该评估支气管扩张剂反应吗?

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.OA3587

N. Beydon, E. Dufetelle, P. Bokov, C. Delclaux

{"title":"Should bronchodilator response be assessed in all asthmatic children with normal baseline spirometry?","authors":"N. Beydon, E. Dufetelle, P. Bokov, C. Delclaux","doi":"10.1183/13993003.CONGRESS-2018.OA3587","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.OA3587","url":null,"abstract":"Background: Normal lung function is frequent in asthmatic children referred for lung function testing, still a positive bronchodilator response (BDR+) can be evidenced and is therefore often looked for. Objectives: To assess 1) the prevalence of BDR+ among children with normal baseline spirometry; 2) the ability of baseline spirometry indices to detect BDR+. Methods: Monocenter retrospective study between 2009 and 2017 based on the department database including all children referred for asthma. Children with normal (i.e. > -1.64 z-score) baseline forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1/FVC, along with a BDR+ (≥ 12% FEV1 increase) were compared to children with normal baseline spirometry but negative BDR (BDR-) using Z-test. The ability of FEV1 and FEV1/FVC to discriminate a BDR+ was determined after constructing Receiver Operating Characteristic (ROC) curves. Results: BDR was recorded in 7,750 files out of 8,586 (90.3%) with available baseline spirometry. Among these, 5,238 displayed a normal baseline spirometry, of which 4.9% (95% confidence interval (CI): 4.3%-5.5%) had a BDR+. ROC analysis displayed similar areas under the curve (AUC) for FEV1 (AUC=0.69, 95% CI: 0.56-0.83) and FEV1/FVC (AUC=0.71, 95% CI: 0.58-0.85). Detecting 90% of BDR+ (90% sensitivity) could be ensured by testing only cases with FEV1 z-score lower than 0.42 (68.1% total files), or with FEV1/FVC z-score lower than -0.16 (67.4% total files). Conclusions: Systematic BDR testing in asthmatic children with normal baseline spirometry reveals that only 4.9% of cases have a BDR+. Detecting 90% of BDR+ could be achieved by testing two-third of the cases.","PeriodicalId":116156,"journal":{"name":"Paediatric respiratory physiology and sleep","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131325513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Natural variability of lung clearance index and FEV1 in children and young adults with Primary Ciliary Dyskinesia 原发性纤毛运动障碍儿童和年轻人肺清除率指数和FEV1的自然变异性

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA565

F. Singer, A. Schlegtendal, Sylvia Nyilas, P. Latzin, M. Boon, C. Koerner-Rettberg

引用次数: 0

Evaluation of the sleep history in predicting sleep disordered breathing in children 儿童睡眠史预测睡眠呼吸障碍的评价

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA551

M. I. Ahmed, D. Luyt

引用次数: 0

Reference values of impulse oscillometry and their correlation with predictors in healthy Turkish preschool children 土耳其健康学龄前儿童脉冲振荡测量的参考值及其与预测因子的相关性

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4576

Ilkay Er, A. Günlemez, C. Baydemır, F. Kılıçbay, R. Ersu, Z. Uyan

引用次数: 0

Global Lung function Initiative (GLI) prediction equations fit the normal lung function in Bulgarian and Romany children 全球肺功能倡议(GLI)预测方程符合保加利亚和罗姆儿童的正常肺功能

Paediatric respiratory physiology and sleep Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4577

S. Mandadzhieva, Blagoi Marinov, S. Kostianev

引用次数: 1